Review
Cell Biology
Tina Suoangbaji, Vanilla Xin Zhang, Irene Oi-Lin Ng, Daniel Wai-Hung Ho
Summary: Primary liver cancer (PLC), including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is a major cause of cancer-related deaths worldwide. Surgical resection and liver transplantation are curative therapies for PLC, but many cases are inoperable and have a high rate of recurrence. Mouse models and single-cell RNA sequencing have played crucial roles in understanding PLC and identifying potential targets for treatment. This review summarizes recent studies that used these approaches, focusing on cellular and molecular components, and discusses the potential insights they can provide.
Article
Multidisciplinary Sciences
Saptaparna Mukherjee, Martino Maddalena, YiQing Lu, Sebastien Martinez, Nishanth Belugali Nataraj, Ashish Noronha, Sansrity Sinha, Katie Teng, Victoria Cohen-Kaplan, Tamar Ziv, Sharathchandra Arandkar, Ori Hassin, Rishita Chatterjee, Anna-Chiara Pirona, Michal Shreberk-Shaked, Anat Gershoni, Yael Aylon, Zvulun Elazar, Yosef Yarden, Daniel Schramek, Moshe Oren
Summary: The p53R273H mutant interacts with SQSTM1/p62 and promotes cancer cell migration and invasion in a p62-dependent manner by driving the proteasomal degradation of cell junction-associated proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Xiao Qi, Zihao Li, Jinrui Zhang, Hongru Li, Guangxin Zhang, Meng Li, Baofeng Li, Yilin Fu, Mingjun Cai, Hongda Wang, Ti Tong, Jing Gao
Summary: CDCP1 is a transmembrane protein involved in important biological processes and is upregulated in human solid malignancies. However, its spatial distribution and variation at the molecular level are unclear. This study analyzed CDCP1 expression and prognostic implications in lung cancer, and used super-resolution microscopy to reveal its spatial organization. The findings showed significant differences in CDCP1 clustering characteristics between cancer and normal cells, highlighting its potential as a target for lung cancer drugs.
Article
Oncology
Hao Li, Jing Jin, Jianchun Xian, Wei Wang
Summary: TPT1-AS1, a long non-coding RNA, is upregulated in liver cancer tissues and cell lines, and its overexpression is associated with poor prognosis, TNM stage lymph node metastasis. Knockdown of TPT1-AS1 inhibits cell proliferation, migration, and invasion, suggesting its potential as a therapeutic target for liver cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biology
Campbell D. Lawson, Samantha Peel, Asier Jayo, Adam Corrigan, Preeti Iyer, Mabel Baxter Dalrymple, Richard J. Marsh, Susan Cox, Isabel Van Audenhove, Jan Gettemans, Maddy Parsons
Summary: Fascin is an important regulator of F-actin bundling in tumor cells. It has been found that Fascin bundles F-actin within the nucleus, supporting chromatin organization and efficient DNA damage response. Increased nuclear accumulation of Fascin leads to sustained nuclear F-actin bundling, resulting in reduced invasion, viability, and apoptosis of cancer cells.
Article
Oncology
Yingcheng Wu, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, Siyuan Huang, Yifei Liu, Shan Jiang, Jinxia Liu, Xiaowu Huang, Xiaoying Wang, Shuangjian Qiu, Jianmin Xu, Ruibin Xi, Fan Bai, Jian Zhou, Jia Fan, Xiaoming Zhang, Qiang Gao
Summary: This study presents a single-cell and spatial atlas of colorectal liver metastasis, revealing highly metabolically activated MRCP+ CCL18(+) M2-like macrophages at the metastatic sites. Effective neoadjuvant chemotherapy can slow down this metabolic activation, raising the possibility of targeting metabolic pathways in metastasis.
Article
Biochemistry & Molecular Biology
Yanguo Liu, Yongming Zhang, Sen Chen, Xinning Zhong, Qing Liu
Summary: The study aimed to investigate the effect of LGR4 with epidermal growth factor receptor (EGFR) in hepatocellular carcinoma (HCC) cells. It was found that overexpression of LGR4 promoted cell proliferation, migration, and invasion, while knockdown of LGR4 or EGFR inhibited these biological activities. In addition, LGR4 overexpression promoted the expression of RSPO2, β-catenin, EGFR, and cancer stem cells (CSCs) markers, while silencing LGR4 or EGFR reduced the expression levels of β-catenin and CSCs markers. Knockdown of LGR4 or EGFR also inhibited tumor growth and reduced the expression levels of RSPO2, CD133, CD44, Nanog, and β-catenin in vivo. The findings suggest that the LGR4/EGFR signaling pathway plays a role in HCC tumor growth and stem cell characteristics, providing a potential target for HCC treatment.
Article
Gastroenterology & Hepatology
Elizabeth P. Newberry, Zoe Hall, Yan Xie, Elizabeth A. Molitor, Peter O. Bayguinov, Gregory W. Strout, James A. J. Fitzpatrick, Elizabeth M. Brunt, Julian L. Griffin, Nicholas O. Davidson
Summary: The study demonstrates that liver-specific Tm6SF2 deletion impairs VLDL secretion, leading to hepatic steatosis, fibrosis, and accelerated development of HCC. This impact can be mitigated with AAV8-mediated rescue, showing promise for potential therapeutic interventions.
Article
Cell Biology
Shuyuan Zhang, Evgeny Zatulovskiy, Julia Arand, Julien Sage, Jan M. M. Skotheim
Summary: Every type of cell in an animal maintains a specific size, and the RB-dilution mechanism plays a role in controlling cell size by linking cell growth to the G1/S transition, as demonstrated in the mouse liver.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mingwei Sheng, Yuanbang Lin, Dongwei Xu, Yizhu Tian, Yongqiang Zhan, Changyong Li, Douglas G. Farmer, Jerzy W. Kupiec-Weglinski, Bibo Ke
Summary: The CD47-SIRP alpha signaling pathway plays a crucial role in MSC-mediated immune regulation during sterile inflammatory liver injury. Activation of this pathway controls NEK7/NLRP3 activity through a direct interaction between Gli1 and NICD, which modulates the inflammatory response in MSC-immunotherapy.
Article
Cell Biology
Katsuhiko Sato
Summary: Many fundamental biological processes depend on cell migration. While the mechanisms of single-cell migration are well understood, cluster migration involving multiple cells adhered to each other is poorly understood. This paper presents a two-dimensional cell membrane model that simulates cluster migration by representing cells as polygons and applying various mechanical forces on the cell surface.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hui Han, Shenkang Zhou, Gengzhen Chen, Yandi Lu, Hui Lin
Summary: This study found that ABAT is inactivated in liver cancer tissues and cells, and patients with low ABAT expression have a poor prognosis. Overexpression of ABAT inhibits cancer cell behaviors and tumor formation. Meanwhile, miR-183-5p is highly expressed in liver cancer tissues and cells, targeting and downregulating ABAT expression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Yue, Xiaozhang Xu, Shipeng Dai, Fan Xu, Wenhu Zhao, Jian Gu, Xinzheng Dai, Xiaofeng Qian
Summary: In this study, ORM1 was identified as a biomarker for predicting liver metastasis in patients with colorectal cancer. ORM1 promoted tumor cell growth, epithelial-mesenchymal transition, and activated the PI3K/AKT signaling pathway. It also induced macrophage M2 polarization and elevated interleukin-10 (IL-10) expression, contributing to tumor immune tolerance.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Yoshinobu Kariya, Midori Oyama, Yukiko Kariya, Yasuhiro Hashimoto
Summary: Phosphorylated OPN secreted from cancer cells plays a regulatory role in cancer cell motility, with higher OPN expression levels correlating with increased cell migration capability. The presence of phosphorylated OPN in cell culture media affects cancer cell motility, indicating a potential mechanism for regulating cancer cell migration through the secretion of phosphorylated OPN.
Article
Engineering, Environmental
Xiuting Wu, Caishuo Yin, Mengfan Zhang, Yaqian Xie, Jingjing Hu, Ruilai Long, Xianming Wu, Xianwen Wu
Summary: This study demonstrates a novel cathode material, ZnVO-800, derived from zeolitic imidazolate framework-8 (ZIF-8) by a self-sacrificed route. The ZnVO-800 cathode exhibits outstanding electrochemical performance, with high reversible capacity and excellent cycleability in aqueous zinc ion batteries. The electrochemical mechanism involves the transformation of ZnVO-800 into ZnxV2O5·nH(2)O with high electrochemical activity through in-situ electrochemical activation process, and the heterojunction with hierarchical structure enhances the dynamics and long-term cycleability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Integrative & Complementary Medicine
Fengxiao Wang, Pinwei Peng, Yixin Zheng, Shuqun Cheng, Yunfei Chen
Summary: This study aimed to evaluate the efficacy and safety of acupuncture compared to parecoxib sodium on postoperative pain, postoperative nausea and vomiting, and the Bruggemann Comfort Scale in patients following laparoscopic cholecystectomy. The results showed that the pain score in the acupuncture group was lower than the control group at 6 h and 9 h after the operation, and the number of patients requesting parecoxib sodium was also lower in the acupuncture group. The acupuncture group also had lower levels of postoperative nausea and vomiting at 6 h after the operation. Acupuncture may be a potential method for treating postoperative pain following laparoscopic cholecystectomy.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Article
Pathology
Wei-Xing Guo, Shi-Ye Yang, Lei Guo, Jin-Kai Feng, Jie Xue, Jie Shi, Wan Yee Lau, Dong Yu, Shu-Qun Cheng
Summary: PVTT-HCC is a rare type of HCC with poor survival outcomes. RNA-Seq analysis revealed differential gene expression between PVTT-HCC and HCC-PVTT, suggesting distinct biological characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Qian-Zhi Ni, Bing Zhu, Yan Ji, Qian-Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng-Kun Zhang, Yu-Rong Shang, Yi-Kang Wang, Sheng Xu, Er-Bin Zhang, Yan-Mei Yuan, Tian-Wei Chen, Fen-Fen Yin, Hui-Jun Cao, Jing-Yi Huang, Ji Xia, Xu-Fen Ding, Xiao-Song Qiu, Kai Ding, Chao Song, Wen-Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi-Gang Li, Shu-Qun Cheng, Xiao-Fan Wang, Dong Xie, Jing-Jing Li
Summary: This study reveals that PPDPF functions as an important regulator of SOS1 and promotes tumor development in pancreatic ductal adenocarcinoma (PDAC) through the PPDPF-SOS1 axis. This finding provides a potential therapeutic target for PDAC.
Article
Psychology, Multidisciplinary
Pengcheng Zhang, Min Zhu, Jingjing Hu, Xiangping Gao
Summary: This study integrates three coping tendencies and uses a spatial cues experimental task to investigate individual coping tendencies towards excluders and non-excluders with different close and distant relationships. The results showed that negative tendencies such as aggression and avoidance may be triggered regardless of the relationship with the excluder. Individuals may adopt friendly tendencies towards close relationship excluders, but not towards stranger excluders. When being excluded by a close relationship person, individuals may show avoidance and aggression towards other non-excluders, but exhibit friendlier tendencies towards other close relationship non-excluders compared to strangers. Negative tendencies will not be generalized to close relationship non-excluders after being excluded by more distant relationship individuals, but rather show more friendly tendencies towards close relationship non-excluders. These findings highlight the role of close and distant relationships in regulating individuals' attitudes towards excluders and non-excluders after experiencing exclusion.
CURRENT PSYCHOLOGY
(2023)
Article
Chemistry, Physical
Yaru Qu, Li Sun, Feng Xie, Jingjing Hu, Hankun Tan, Yihe Zhang
Summary: Metal sulfides derived from metal-organic framework (MOF) have high porosity and easily changed morphology, which makes them widely used in supercapacitors. However, they still have shortcomings such as poor cycle performance and low specific capacitance. This research focuses on preparing porous nickel sulfide derived from Ni-based MOF and introducing sulfur vacancies at room temperature.
APPLIED SURFACE SCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Jingjing Hu, Xiaojun Xu, Jin Hao, Xiuqi Yang, Kefan Qiu, Yuanzhang Li
Summary: This paper proposes a microservice combination approach based on the QoS model and a CGWO algorithm for the optimization computation. Experimental results show that the error rate of the method is only 0.528% on the non-functional combination optimization problem, and the computational efficiency of the algorithm increases by 97.29%. CGWO improves the accuracy of optimization by 65.97% and 81.25% respectively compared to the prototype algorithm (GWO), and has a stable optimization performance.
CONNECTION SCIENCE
(2023)
Article
Chemistry, Physical
Hankun Tan, Li Sun, Feng Xie, Jingjing Hu, Yaru Qu, Yihe Zhang
Summary: An alkali-treated MXene-SnS hybrid was prepared through hydrothermal methods. The alkali treatment improved the binding strength of MXene and enabled the SnS nanosheets to remain firmly bound to the MXene substrate. The synergy between the two components resulted in excellent electrochemical properties, including high electronic/ionic conductivity and superior kinetic properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Oncology
Zong-Han Liu, Zong-Tao Chai, Jin-Kai Feng, Yu-Chao Hou, Xiu-Ping Zhang, Zhen-Hua Chen, Yan-Jun Xiang, Wei-Xing Guo, Jie Shi, Shu-Qun Cheng
Summary: The definition of early recurrence for hepatocellular carcinoma (HCC) remains controversial. This study aimed to identify the early recurrence time for HCC and evaluate the efficacy of postoperative adjuvant TACE for HCC with MVI within this interval. The results showed that 13 months may be a reasonable early recurrence time point for HCC patients with MVI who underwent R0 resection, and within this interval, adjuvant TACE may result in longer survival.
Article
Immunology
Kang Wang, Yan-Jun Xiang, Hong-Ming Yu, Yu-Qiang Cheng, Zong-Han Liu, Jing-Ya Zhong, Shuang Feng, Qian-Zhi Ni, Hong-Fei Zhu, Wei-Wei Pan, Jing-Jing Li, Chao Liang, Hong-Kun Zhou, Yan Meng, Wan Yee Lau, Shu-Qun Cheng
Summary: This study aimed to investigate the efficacy and safety of combining intensity-modulated radiotherapy (IMRT) with systemic atezo/bev in the treatment of hepatocellular carcinoma (HCC) patients with extrahepatic portal vein tumor thrombus (ePVTT). The results showed that IMRT combined with atezo/bev demonstrated promising treatment efficacy and an acceptable safety profile for HCC patients with ePVTT, making it a promising option.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Fei-Fei Mao, Shan-Shan Gao, Yan-Jie Huang, Nian Zhou, Jin-Kai Feng, Zong-Han Liu, Yu-Qing Zhang, Lu-Yun Yuan, Gang Wei, Shu-Qun Cheng
Summary: Ganoderma triterpenoids (GTs), especially Resinacein S, have been found to regulate lipid metabolism and mitochondrial biogenesis, which may have potential protective effects against nonalcoholic fatty liver disease (NAFLD).
FRONTIERS IN NUTRITION
(2023)
Article
Biophysics
Yi Ma, Haiping Wu, Shan Chen, Chunmei Xie, Jingjing Hu, Xiemin Qi, Xueping Ma, Yanan Chu, Jingwen Shan, Yan Lu, Lunbiao Cui, Bingjie Zou, Guohua Zhou
Summary: In this study, a highly specific and multiplex nucleic acid detection platform called FEN1-aided RPA (FARPA) was developed by combining flap endonuclease 1 (FEN1)-catalyzed invasive reactions with recombinase polymerase amplification (RPA). FARPA exhibits high specificity, fast detection time, and low detection limit, making it suitable for pathogen screening and discrimination of viral variants, especially for SARS-CoV-2 detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Jingjing Hu, Yan Shi, Li Sun, Feng Xie, Kaiyue Gao, Yaru Qu, Hankun Tan, Yihe Zhang
Summary: This study demonstrates the use of a simple Ni-MOF material to generate a uniform Ni/C metal-carbon hybrid structure through in-situ pyrolysis. The resulting B-NixSy/C composite exhibits high specific capacity and excellent rate performance, making it a promising candidate for energy storage devices. The inclusion of boron and the porous and conductive carbon framework derived from MOF contribute to the enhanced electrochemical performances of metal sulfides.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jingjing Hu, Li Sun, Feng Xie, Yaru Qu, Hankun Tan, Yihe Zhang
Summary: In this study, a 3D urchin-like Co-NiBTC nanorod array was synthesized using trimesic acid (H3BTC) as an organic ligand, and Co-NiS2/C was obtained through one-step pyrolysis. Co-NiS2/C exhibited stable urchin-like morphology, enriched sulfur vacancies and porosity, increased density of free electrons due to Co-doping, and enhanced electron transmission from the carbon matrix. Compared to Co-NiO and Co-NiS2, Co-NiS2/C showed higher capacitance, longer cycle life, and higher rate capability. It is of great significance for the design principles of MOF-derived metal compound materials in electrochemical energy storage.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jingjing Hu
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)