Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Pengfei Bao, Peng Li, Xiaoqing Zhou, Huijiang Zhang, Shengjie You, Zhaoyu Xu, Qi Wu
Summary: This study aimed to investigate the effects of scaffold matrix attachment region binding protein 1 (SMAR1) on the development of bladder cancer (BCa). The results showed that down-regulation of SMAR1 was associated with worse prognoses in BCa patients. SMAR1 was found to inhibit the viability, proliferation, migration, invasion, and Warburg effect of BCa cells. It is suggested that SMAR1 may suppress the Wnt/beta-catenin signaling pathway to inhibit the progression of BCa.
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tianyu Li, Xue Xiong, Yujing Wang, Yue Li, Yao Liu, Mingxiu Zhang, Chao Li, Tong Yu, Wei Cao, Shuangshuang Chen, Huizhen Zhang, Xiaona Wang, Lifang Lv, Yuhong Zhou, Haihai Liang, Xuelian Li, Hongli Shan
Summary: This study found that the protein level of NET1 is increased in a mouse cardiac fibrosis model, as well as in cardiac fibrosis induced by TGF-beta 1. Overexpression of NET1 promotes beta-catenin expression and increases the proliferation and migration of cardiac fibroblasts. NET1 may interact with beta-catenin through GSK3b. Knockdown of beta-catenin alleviates the effects of NET1 overexpression on collagen production and cell migration. In conclusion, NET1 may regulate the activation of Wnt/beta-catenin and TGF/Smads signaling pathway, promote collagen synthesis in fibroblasts, and participate in cardiac fibrosis.
Article
Virology
Sanchari Chatterjee, Soumyajit Ghosh, Ankita Datey, Chandan Mahish, Subhasis Chattopadhyay, Soma Chattopadhyay
Summary: This study demonstrated the importance of the Wnt/beta-catenin pathway in Chikungunya virus (CHIKV) infection. Using in vitro, in vivo, and ex vivo models, the study showed that CHIKV infection suppresses the active beta-catenin protein, leading to a reduction in cyclin-D1 and an upregulation of glycogen synthase kinase-3 beta. Inhibition of beta-catenin reduced viral RNA, protein, and new viral particles in vitro and reduced disease score and viral load in mice. Knockdown of beta-catenin also reduced viral particle formation. These findings provide mechanistic insights that may contribute to the development of future therapeutics for CHIKV infection.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Runxiao Lv, Lili Du, Lunhao Bai
Summary: This study finds that RNF125 plays an important role in osteoarthritis (OA). Moderate physical exercise can protect cartilage, while the overexpression of RNF125 can inhibit the degradation of extracellular matrix in chondrocytes. RNF125 may be a novel biomarker for OA therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pathology
Li-Juan Jiang, Song-Bin Guo, Zhong-Ying Huang, Xin-Ling Li, Xiao-Han Jin, Wei-Juan Huang, Xiao-Peng Tian
Summary: This study investigated the role of PHB in bladder carcinoma aggressiveness and found that it promotes invasion by binding with beta-catenin to prevent its degradation. Patients with PHB overexpression should receive more aggressive adjuvant anticancer therapies after surgery.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Medicine, Research & Experimental
Xue-qi Chen, Jia-yu Mao, Chun-saier Wang, Wen-bin Li, Tao-tao Han, Ke Lv, Jing-nan Li
Summary: This study reveals that CYP24A1 expression is upregulated in colon cancer cells in response to inflammatory factors, which can activate Wnt signaling through the NF-kappa B pathway.
CURRENT MEDICAL SCIENCE
(2022)
Review
Cell Biology
Rabia Hayat, Maleeha Manzoor, Ali Hussain
Summary: Wnt signaling is an important evolutionary cell-to-cell coordination mechanism that plays a critical role in various physiological processes such as stem cell regeneration, cell division, and migration. This mechanism is regulated by a family of 19 proteins and can impact cellular processes through different pathways, with the Wnt/β-catenin signaling pathway playing a significant role in cancer progression.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Jinhai Luo, Zhiling Yu, Juscelino Tovar, Anne Nilsson, Baojun Xu
Summary: Phytochemicals inhibit adipogenesis and lipid accumulation by activating the Wnt/β-catenin signaling pathway, potentially serving as anti-obesity drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Editorial Material
Urology & Nephrology
Aurelie Kamoun, Aurelien de Reynies, Yves Allory, Gottfrid Sjodahl, A. Gordon Robertson, Roland Seiler, Katherine A. Hoadley, Clarice S. Groeneveld, Hikmat Al-Ahmadie, Woonyoung Choi, Mauro A. A. Castro, Jacqueline Fontugne, Pontus Eriksson, Qianxing Mo, Jordan Kardos, Alexandre Zlotta, Arndt Hartmann, Colin P. Dinney, Joaquim Bellmunt, Thomas Powles, Nuria Malats, Keith S. Chan, William Y. Kim, David J. McConkey, Peter C. Black, Lars Dyrskjot, Mattias Hoglund, Seth P. Lerner, Francisco X. Real, Francois Radvanyi, Mattias Aine, Isabelle Bernard-Pierrot, Bogdan Czerniak, Ewan A. Gibb, Jaegil Kim, David J. Kwiatkowski, Thierry Lebret, Fredrik Liedberg, A. Arlene Siefker-Radtke, Nanor Sirab, Ann Taber, John N. Weinstein
Article
Urology & Nephrology
Badrinath R. Konety, Vikram M. Narayan, Cohn P. N. Dinney
UROLOGIC CLINICS OF NORTH AMERICA
(2020)
Article
Urology & Nephrology
Vikram M. Narayan, Cohn P. N. Dinney
UROLOGIC CLINICS OF NORTH AMERICA
(2020)
Article
Oncology
Vikram M. Narayan, Mohamed A. Seif, Amy H. Lim, Roger Li, Justin T. Matulay, Janet B. Kukreja, Wei Qiao, Hyunsoo Hwang, Jay B. Shah, Louis Pisters, Ashish M. Kamat, Colin Dinney, Neema Navai
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2020)
Article
Oncology
Anna J. Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Adrian S. Fairey, Laura S. Mertens, Colin P. Dinney, Maria C. Mir, Laura-Maria Krabbe, Michael S. Cookson, Niels-Erik Jacobsen, Joshua Griffin, Jeffrey S. Montgomery, Nikhil Vasdev, Evan Y. Yu, Evanguelos Xylinas, Nicholas J. Campain, Wassim Kassouf, Marc A. Dall'Era, Jo-An Seah, Cesar E. Ercole, Simon Horenblas, John S. McGrath, Jonathan Aning, Shahrokh F. Shariat, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Philippe E. Spiess, Siamak Daneshmand, Srikala S. Sridhar, Peter C. Black
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2020)
Article
Urology & Nephrology
Maria Carmen Mir, Michele Marchioni, Homi Zargar, K. Zargar-Shoshtari, A. S. Fairey, Laura S. Mertens, C. P. Dinney, L. M. Krabbe, M. S. Cookson, N. E. Jacobsen, J. Griffin, J. S. Montgomery, N. Vasdev, E. Y. Yu, E. Xylinas, J. S. McGrath, W. Kassouf, M. A. Dall'Era, S. S. Sridhar, J. Aning, S. F. Shariat, J. L. Wright, A. C. Thorpe, T. M. Morgan, J. M. Holzbeierlein, T. J. Bivalacqua, S. North, D. A. Barocas, Y. Lotan, P. Grivas, A. J. Stephenson, J. B. Shah, B. W. van Rhijn, P. E. Spiess, D. Daneshmand, P. C. Black
Summary: A postoperative nomogram for predicting bladder cancer-specific mortality (BCSM) in MIBC patients was developed using international consortium data, with pathological stage, lymph node metastasis, and positive surgical margins identified as significant factors associated with BCSM. The model showed modest net benefit and clinical utility, providing key insights for patient counseling and high-risk patient identification for clinical trials.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Kelly K. Bree, Patrick J. Hensley, Nathan A. Brooks, Justin Matulay, Roger Li, Graciela M. Nogueras Gonzalez, Neema Navai, Herbert Barton Grossman, Surena F. Matin, Colin P. N. Dinney, Ashish M. Kamat
Summary: Patients with UTUC prior to NMIBC diagnosis had higher rates of recurrence and progression after adequate BCG therapy, with high-grade UTUC-P associated with increased NMIBC recurrence.
Article
Urology & Nephrology
Nathan A. Brooks, Andrea Kokorovic, Lianchen Xiao, Justin T. Matulay, Roger Li, Weranja K. B. Ranisinghe, Supriya Nagaraju, Yu Shen, Jianjun Gao, Neema Navai, Colin P. N. Dinney, H. Barton Grossman, Ashish M. Kamat
Summary: The obesity paradox may be present in patients receiving bacillus Calmette-Guerin (BCG) treatment for non-muscle-invasive bladder cancer, with overweight and obese patients showing improved outcomes but those with diabetes mellitus at increased risk of recurrence.
Article
Oncology
Stephen A. Boorjian, Mehrdad Alemozaffar, Badrinath R. Konety, Neal D. Shore, Leonard G. Gomella, Ashish M. Kamat, Trinity J. Bivalacqua, Jeffrey S. Montgomery, Seth P. Lerner, Joseph E. Busby, Michael Poch, Paul L. Crispen, Gary D. Steinberg, Anne K. Schuckman, Tracy M. Downs, Robert S. Svatek, Joseph Mashni, Brian R. Lane, Thomas J. Guzzo, Gennady Bratslavsky, Lawrence I. Karsh, Michael E. Woods, Gordon Brown, Daniel Canter, Adam Luchey, Yair Lotan, Tracey Krupski, Brant A. Inman, Michael B. Williams, Michael S. Cookson, Kirk A. Keegan, Gerald L. Andriole, Alexander I. Sankin, Alan Boyd, Michael A. O'Donnell, David Sawutz, Richard Philipson, Ruth Coll, Vikram M. Narayan, F. Peter Treasure, Seppo Yla-Herttuala, Nigel R. Parker, Colin P. N. Dinney
Summary: The study demonstrates the efficacy of intravesical nadofaragene firadenovec, a novel therapy using a replication-deficient recombinant adenovirus, in patients with BCG-unresponsive non-muscle-invasive bladder cancer, with a favorable benefit:risk ratio. The treatment led to a complete response in a significant proportion of patients with carcinoma in situ, and the adverse events were generally mild, with no treatment-related deaths reported.
Article
Oncology
Janet Baack Kukreja, Mohamed A. Seif, Marissa W. Mery, James R. Incalcaterra, Ashish M. Kamat, Colin P. Dinney, Jay B. Shah, Thomas W. Feeley, Neema Navai
Summary: Using Time-Driven Activity-Based Costing (TDABC), this study identified inpatient care as the major cost driver in radical cystectomy, followed closely by operating room costs and readmission expenses. Efforts to reduce costs in radical cystectomy should be focused on these areas.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Justin T. Matulay, Roger Li, Patrick J. Hensley, Nathan A. Brooks, Vikram M. Narayan, H. Barton Grossman, Neema Navai, Colin P. N. Dinney, Ashish M. Kamat
Summary: The study retrospectively reviewed data of patients with nonmuscle-invasive bladder cancer treated with intravesical bacillus Calmette-Guerin at a tertiary cancer center. Results showed that these patients had improved survival and progression rates compared to previous studies, providing valuable benchmarks for clinical trial design.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Gang Wang, Peter C. Black, Peter J. Goebell, Lingyun Ji, Carlos Cordon-Cardo, Bernd Schmitz-Draeger, Debra Hawes, Bogdan Czerniak, Sarah Minner, Guido Sauter, Frederic Waldman, Susan Groshen, Richard J. Cote, Colin P. Dinney
Summary: The study evaluated the prognostic value of 10 putative tumor markers in locally advanced urothelial cancer of the bladder through immunohistochemistry, finding that altered expression of p53, Rb, and p21 was associated with worse outcome. However, there was poor overall agreement in IHC scoring among laboratories and a lack of clear association between the markers and prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Patrick J. Hensley, Kelly K. Bree, Nathan Brooks, Justin Matulay, Roger Li, Graciela M. Nogueras Gonzalez, Neema Navai, Herbert B. Grossman, Colin P. Dinney, Ashish M. Kamat
Summary: The timing of induction BCG instillation after TURBT does not influence the tolerability and response rates in patients with NMIBC. Early administration of BCG is safe and delays do not impact therapeutic outcomes.
Review
Oncology
Come Tholomier, Alberto Martini, Sharada Mokkapati, Colin P. Dinney
Summary: Gene therapy aims to alter cell properties through nucleotide delivery for disease treatment. Originally developed for genetic disorders, current research focuses on gene therapy strategies for bladder cancer.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Urology & Nephrology
David D'Andrea, Surena Matin, Peter C. Black, Firas G. Petros, Homayoun Zargar, Colin P. Dinney, Michael S. Cookson, Wassim Kassouf, Marc A. Dall'Era, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeffrey M. Holzbeierlein, Trinity J. Bivalacqua, Srikala S. Sridhar, Scott North, Daniel A. Barocas, Yair Lotan, Andrew J. Stephenson, Bas W. van Rhijn, Philippe E. Spiess, Siamak Daneshmand, Shahrokh F. Shariat
Summary: The study found that patients with UTUC had a lower rate of pathological complete response but a higher rate of pathological objective response after NAC treatment. Cox regression analysis revealed that UTUC patients had better overall survival and cancer-specific survival outcomes.
