Article
Multidisciplinary Sciences
Camille Kropp, Katy Le Corf, Karima Relizani, Kevin Tambosco, Ccori Martinez, Florian Chain, Georges Rawadi, Philippe Langella, Sandrine P. Claus, Rebeca Martin
Summary: Christensenella minuta displays strong anti-inflammatory activity by inhibiting the NF-kappa B signaling pathway, protects intestinal epithelial integrity, and shows potential for treating IBDs.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Jianbo Zhang, Victor Hernandez-Gordillo, Martin Trapecar, Charles Wright, Mao Taketani, Kirsten Schneider, Wen Li Kelly Chen, Eric Stas, David T. Breault, Rebecca L. Carrier, Christopher A. Voigt, Linda G. Griffith
Summary: The protocol allows for coculture of primary human colon cells with aerotolerant bacteria, providing a useful mucosal barrier system to assess the effects of bacterial cells that respond to the colonic microenvironment.
Article
Gastroenterology & Hepatology
He Kaiyin, Guo Li-Liangzi, Tang Huijun, Peng Xiaojuan, Li Juan, Feng Shufen, Bie Caiqun, Chen Weiwei, Li Yuting, Wang Min, Tang Shaohui
Summary: This study found that increasing the intake of freshwater fish can regulate gut microbiota and its metabolites, benefiting patients with NAFLD. Moreover, alternating intake of freshwater fish and red meat does not exacerbate NAFLD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Microbiology
Caroline Tawk, Bentley Lim, Natasha A. Bencivenga-Barry, Hannah J. Lees, Ruben J. F. Ramos, Justin Cross, Andrew L. Goodman
Summary: Gastrointestinal infection can alter microbiome composition and gene expression. This study reveals that enteric infection also leads to rapid genetic adaptation in gut commensals. By studying Bacteroides thetaiotaomicron population dynamics in gnotobiotic mice, it was observed that the introduction of the enteropathogen Citrobacter rodentium promotes selection of a single-nucleotide variant with increased fitness. This variant mutation enhances resistance to oxidative stress by affecting the sequence of a fitness essential protein, IctA. Furthermore, it was found that certain commensal species can attenuate the selection of this variant during infection and this attenuation is associated with increased levels of vitamin B6 in the gut lumen. Direct administration of vitamin B6 significantly reduces variant expansion in infected mice, indicating its potential as a therapeutic target in enteric infections.
CELL HOST & MICROBE
(2023)
Article
Medicine, Research & Experimental
Jessica D. Hathaway-Schrader, Matthew D. Carson, Joy E. Gerasco, Amy J. Warner, Brooks A. Swanson, J. Ignacio Aguirre, Caroline Westwater, Bei Liu, Chad M. Novince
Summary: The study demonstrated that commensal gut microbes modulate osteoimmune processes and skeletal homeostasis in alveolar bone, challenging the conventional belief that oral microbes solely regulate alveolar bone health.
LABORATORY INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Gengfeng Li, Xiaohan Wu, Xiang Gao, Ritian Lin, Liang Chen, Mingming Sun, Junwan Jia, Zhanju Liu, Leilei Fang, Wei Wu
Summary: Long-term exclusive enteral nutrition (EEN) can remodel the composition of gut microbiota and alleviate intestinal mucosal inflammation.
Review
Microbiology
Lara Kern, Denise Kviatcovsky, Yiming He, Eran Elinav
Summary: The impact of restrictive diets on gut microbiota composition and function, as well as their overall influences on host health and disease risk, are discussed. The evidence of long-term efficacy, adverse effects, and mechanisms of activity of caloric restriction and related diets is currently incomplete.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fabian Frost, Tim Kacprowski, Malte Ruehlemann, Stefan Weiss, Corinna Bang, Andre Franke, Maik Pietzner, Ali A. Aghdassi, Matthias Sendler, Uwe Voelker, Henry Voelzke, Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch
Summary: The study found no significant differences in gut microbiota composition between gallstone carriers and healthy controls, but individuals post-cholecystectomy exhibited reduced microbiota diversity and an increase in potentially harmful bacteria. This suggests that there is no clear association between gut microbiota and gallstone formation, but cholecystectomy is associated with distinct microbiota changes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
R. Martin, A. Benitez-Cabello, S. Kulakauskas, M. V. C. Viana, C. Chamignon, P. Courtin, C. Carbonne, F. Chain, H. P. Pham, Muriel Derrien, L. G. Bermudez-Humaran, M. P. Chapot-Chartier, T. Smokvina, P. Langella
Summary: In this study, ten variants of Lacticaseibacillus rhamnosus CNCM I-3690 with different EPS production were generated and studied. It was found that increased EPS production impairs the protective effects of this strain, highlighting the importance of correct EPS synthesis.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Jessica Spring, Aly A. Khan, Sophie Lara, Kelly O'Grady, Jessica Wilks, Sandeep Gurbuxani, Steven Erickson, Michael Fischbach, Amy Jacobson, Alexander Chervonsky, Tatyana Golovkina
Summary: The microbiota plays a significant role in retroviral pathogenesis by promoting leukemia development through suppression of the immune response. The upregulation of negative regulators of immunity by commensal bacteria suggests potential targets for cancer therapy.
Article
Endocrinology & Metabolism
Esther Bandala-Sanchez, Alexandra J. Roth-Schulze, Helena Oakey, Megan A. S. Penno, Naiara G. Bediaga, Gaetano Naselli, Katrina M. Ngui, Alannah D. Smith, Dexing Huang, Enrique Zozaya-Valdes, Rebecca L. Thomson, James D. Brown, Peter J. Vuillermin, Simon C. Barry, Maria E. Craig, William D. Rawlinson, Elizabeth A. Davis, Mark Harris, Georgia Soldatos, Peter G. Colman, John M. Wentworth, Aveni Haynes, Grant Morahan, Richard O. Sinnott, Anthony T. Papenfuss, Jennifer J. Couper, Leonard C. Harrison
Summary: The study reveals that pregnant women with type 1 diabetes experience changes in their gut fungal microbiome during pregnancy, accompanied by intestinal inflammation and impaired intestinal barrier function.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Immunology
Olga Kalinina, Sarah Talley, Jesus Zamora-Pineda, Wonbeom Paik, Edward M. Campbell, Katherine L. Knight
Summary: Research showed that treatment with exopolysaccharide (EPS) from Bacillus subtilis significantly increased the survival rate of mice in acute graft-versus-host disease (aGvHD), by inducing dendritic cells with inhibitory characteristics to inhibit T cell activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yasuhiko Matsumoto, Eri Sato, Takashi Sugita
Summary: In this study, it was discovered that Cutibacterium acnes rapidly causes melanization of the silkworm hemolymph, while Staphylococcus aureus does not. Even heat-killed C. acnes cells caused melanization, and treatment with DNase, RNase, and protease did not decrease the melanization. However, treatment with peptidoglycan-degrading enzymes reduced the induced melanization by heat-treated C. acnes cells. These findings suggest that silkworm hemolymph melanization may be a useful indicator to evaluate innate immune activation by C. acnes and that C. acnes peptidoglycans are involved in the induction of innate immunity in silkworms.
Article
Immunology
Kritika Ramani, Taylor Cormack, Adam N. R. Cartwright, Aula Alami, Pooja Parameswaran, Marynawal Abdou, Iris Wang, Kristie Hilliard-Barth, Shannon Argueta, Divya Raghunathan, Will Caffry, Christopher J. H. Davitt, Fabian B. Romano, Aylwin Ng, Valeria Kravitz, Tyler Rommel, Maria Sizova, Esra Uckun Kiran, Pallavi Pradeep, Holly E. Ponichtera, Tanmoy Ganguly, Mark Bodmer, Andrea Itano
Summary: The gastrointestinal tract is an important surface that interacts with the outside world and plays a crucial role in identifying and defending against pathogens while tolerating foreign antigens. Commensal bacteria in the gut maintain local tissue stability, and non-viable strains of these bacteria can transiently occupy the gastrointestinal tract to produce potent anti-inflammatory effects in peripheral tissues. This finding supports the potential development of non-living bacterial strains for therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Florian Plaza Onate, Celia Chamignon, Sebastian D. Burz, Nicolas Lapaque, Magali Monnoye, Catherine Philippe, Maxime Bredel, Laurent Chene, William Farin, Jean-Michel Paillarse, Jerome Boursier, Vlad Ratziu, Pierre-Yves Mousset, Joel Dore, Philippe Gerard, Herve M. Blottiere
Summary: Non-alcoholic fatty liver disease (NAFLD) affects a significant portion of the adult population in high-income countries and is a leading indication for liver transplantation. The link between gut microbiota dysbiosis and NAFLD severity is established, with Adlercreutzia equolifaciens being depleted in NAFLD patients and showing anti-inflammatory properties that may be beneficial for treatment. Counterbalancing dysbiosis with A. equolifaciens could be a promising strategy for liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
