Article
Obstetrics & Gynecology
Delnya Gholami, Farzane Amirmahani, Reza Salman Yazdi, Tahereh Hasheminia, Hossein Teimori
Summary: The study found that up-regulation of miR-182-5p, miR-192-5p, and miR-493-5p may serve as potential biomarkers for TZ. Additionally, the expression level of the CRISP3 glycosylated isoform was significantly lower in TZ patients compared to those with normal sperm. These results suggest a significant role of CRISP3 protein and miRs in male infertility.
REPRODUCTIVE SCIENCES
(2021)
Article
Developmental Biology
Huanping Guo, Xipeng Shen, Hua Hu, Peng Zhou, Tong He, Lin Xia, Dongmei Tan, Xi Zhang, Yunfang Zhang
Summary: This study characterized the RNA modification signature of human sperm for the first time using a high-throughput detection platform, revealing RNA modifications with high linear correlations with clinical sperm motility. These findings provide promising candidates for clinical sperm quality assessment and offer new research insights into the underlying pathological mechanisms of human male infertility syndromes.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Ling-Yu Yeh, Robert Kuo-Kuang Lee, Ming-Huei Lin, Chih-Hung Huang, Sheng-Hsiang Li
Summary: This study aimed to assess the correlation between sperm miRNA levels and ICSI outcomes. The results showed that miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia. However, these miRNAs were not associated with fertilization rate and early embryo development, but with implantation, pregnancy, and live birth rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Saleem A. Banihani, Shefa M. Aljabali
Summary: This study aimed to investigate the contribution of pyridoxine on poor semen quality. The concentrations of seminal plasma pyridoxine were significantly lower in men with oligozoospermia compared to normozoospermic men. Furthermore, the level of pyridoxine was not significantly correlated with sperm motility, sperm concentration, and semen volume, but it was positively correlated with male age in the oligozoospermic group.
Article
Medicine, General & Internal
Yieh-Loong Tsai, Tsung-Hsuan Lai, Hsuan-Che Liu, Ya-Yun Wang, Yu-Hua Lin, Chih-Chun Ke, Ming-Ting Chung, Chying-Chyuan Chan, Ying-Hung Lin
Summary: This study found that RAB3C is more abundant than RAB3A, 3B, and 3D in human testicular tissues. During human spermatogenesis, RAB3C protein is mainly enriched in elongated spermatids, and in mature human spermatozoa, it is concentrated in the postacrosomal region, neck, and midpiece. The delocalization of RAB3C signals was observed in human spermatozoa with SEPT14 mutation, along with defective head and tail.
MEDICINA-LITHUANIA
(2022)
Review
Andrology
Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Renata Finelli, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Damayanthi Durairajanayagam, Camila Pompeu, Sarah Madani, Andrea Belo, Neha Singh, Simryn Covarrubias, Sara Darbandi, Raha Sadeghi, Mahsa Darbandi, Paraskevi Vogiatzi, Florence Boitrelle, Mara Simopoulou, Ramadan Saleh, Mohamed Arafa, Ahmad Majzoub, Hussein Kandil, Armand Zini, Edmund Ko, Juan G. Alvarez, Marlon Martinez, Jonathan Ramsay, Sunil Jindal, Gian Maria Busetto, Hassan Sallam, Israel Maldonado, Christina Anagnostopoulou, Marco G. Alves, Pallav Sengupta, Kambiz Gilany, Donald P. Evenson, Sheena E. M. Lewis, Jaime Gosalvez, Rafael F. Ambar, Rupin Shah
Summary: Semen analysis is the first step in evaluating male fertility, but sperm morphology assessment is difficult to standardize and obtain reproducible results. Standardization of laboratory protocols is crucial in ensuring reliable laboratory results.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Biology
Maja Tomic, Luka Bolha, Joze Pizem, Helena Ban-Frangez, Eda Vrtacnik-Bokal, Martin Stimpfel
Summary: This study identified 9 miRNAs that could serve as biomarkers for sperm quality in relation to teratozoospermia, highlighting the need for objective markers to personalize the treatment of male infertility.
Article
Endocrinology & Metabolism
Agnieszka Bielska, Magdalena Niemira, Witold Bauer, Iwona Sidorkiewicz, Anna Szalkowska, Anna Skwarska, Justyna Raczkowska, Damian Ostrowski, Kamil Gugala, Slawomir Dobrzycki, Adam Kretowski
Summary: The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight the urgent need to identify early biomarkers for IHD development in diabetic individuals. This study suggests that circulating serum-derived micro RNAs (miRNAs) may serve as potential biomarkers for early diagnosis of IHD in T2DM patients. Six miRNAs were significantly upregulated in T2DM IHD patients and were associated with multiple signaling pathways. These miRNAs showed high diagnostic value, indicating their potential as biomarkers for early IHD detection in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Maria-Anna Kyrgiafini, Themistoklis Giannoulis, Alexia Chatziparasidou, Nikolaos Christoforidis, Zissis Mamuris
Summary: This study identified new variants associated with teratozoospermia and explored the role of genes in the Greek population. Known genes associated with male infertility as well as novel genes related to teratozoospermia were found. The study also highlighted the important role of the extracellular matrix in teratozoospermia.
Article
Genetics & Heredity
Jiaxiong Wang, Xiaoran Liu, Ce Zhang, Yongle Xu, Weizhuo Wang, Hong Li, Shenmin Yang, Jing Zhao
Summary: By observing the morphology of the patient's sperm and conducting genetic testing, we identified a novel ARMC2 mutation that contributes to male infertility and multiple morphological abnormalities of sperm flagella (MMAF). We also discovered several proteins interacting with ARMC2. After undergoing ICSI treatment, the patient successfully achieved pregnancy and gave birth to boy-girl twins. This study provides important insights into the genetic basis of male infertility.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Andrology
Ping Ping, Zhong Zheng, Yi Ma, Sha-Sha Zou, Xiang-Feng Chen
Summary: This study evaluated the impact of different spermatogenic conditions on the outcomes of intracytoplasmic sperm injection (ICSI) and the risk of major birth defects. The results showed that nonobstructive azoospermia (NOA) had a negative effect on fertilization rate, but did not affect other embryological and clinical outcomes. Spermatogenic failure and sperm origin did not affect the clinical outcomes of ICSI treatment.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Obstetrics & Gynecology
M. Torra-Massana, R. Vassena, A. Rodriguez
Summary: After controlling for confounders, the use of cryopreserved semen from normozoospermic patients does not affect pregnancy and live birth rates after elective ICSI.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Mohan Liu, Jinhui Li, Chuan Jiang, Yanning Zhou, Yongkang Sun, Yihong Yang, Ying Shen
Summary: A novel homozygous frameshift mutation in DNAJB13 was found to be associated with the teratozoospermia phenotype. This study expands the spectrum of DNAJB13 mutations and provides a better understanding for genetic counseling and treatment of male infertility.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Pharmacology & Pharmacy
L. Ma, Y. Sun
Summary: This study compared the effects of L-carnitine vs. CoQ10 and Vitamin E therapy on sperm parameters and hormonal levels in patients with asthenozoospermia and teratozoospermia. The results showed that L-carnitine significantly improved sperm motility, morphology, and concentration, as well as testosterone and luteinizing hormone levels. On the other hand, CoQ10 and Vitamin E only improved sperm motility, morphology, and testosterone levels. Therefore, L-carnitine was found to be superior to the combination of CoQ10 and Vitamin E in improving sperm parameters.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Xiangfeng Chen, Bin Wu, XiaoRong Shen, Xin Wang, Ping Ping, Maohua Miao, Ningning Liang, Huiyong Yin, Huijuan Shi, Jun Qian, Tiancheng Zhang
Summary: This study aimed to investigate the effects of PUFA-derived metabolites in seminal plasma on male fertility and evaluate the potential of PUFA as a biomarker for normozoospermic male infertility. Semen samples were collected from 564 men, and the levels of PUFA-derived metabolites were analyzed. The results showed significant differences in the concentrations of certain metabolites between fertile and infertile men with normozoospermia and oligoasthenozoospermia. The metabolites 7(R)-MaR1, 11,12-DHET, 17(S)-HDHA, LXA5, and PGJ2 were identified as potential diagnostic biomarkers for infertility in normozoospermic men.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Darius A. Paduch, Stephanie Hilz, Andrew Grimson, Peter N. Schlegel, Anne E. Jedlicka, William W. Wright
Review
Urology & Nephrology
Ryan Flannigan, Linda Heier, Henning Voss, J. Levi Chazen, Darius A. Paduch
JOURNAL OF SEXUAL MEDICINE
(2019)
Correction
Multidisciplinary Sciences
Darius A. Paduch, Stephanie Hilz, Andrew Grimson, Peter N. Schlegel, Anne E. Jedlicka, William W. Wright
Article
Developmental Biology
Priti Singh, Ravi K. Patel, Nathan Palmer, Jennifer K. Grenier, Darius Paduch, Philipp Kaldis, Andrew Grimson, John C. Schimenti
Article
Surgery
Patrick McLeroth, Darius A. Paduch, Markus Abt, Richard Hughes, Suzanne Moore, Nadejda Mudie
TRANSPLANT INTERNATIONAL
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Roudenko, Rand N. Wilcox Vanden Berg, Christopher Song, Martin R. Prince, Darius A. Paduch, Daniel Margolis
ABDOMINAL RADIOLOGY
(2020)
Meeting Abstract
Urology & Nephrology
Ryan Flannigan, Russell Hayden, Anna Mielnik, Alex Bolyakov, Peter Schlegel, Darius Paduch
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Russell Hayden, Anna Mielnik, Peter Schlegel, Darius Paduch
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Russell Hayden, Alexander Bolyakov, Darius Paduch
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Russell Hayden, Anna Mielnik, Ryan Flannigan, Peter Schlegel, Darius Paduch
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
R. Hayden, A. Mielnik, A. Bolyakov, R. Flannigan, D. Paduch
FERTILITY AND STERILITY
(2018)
Meeting Abstract
Obstetrics & Gynecology
R. Hayden, R. Flannigan, A. Mielnik, A. Bolyakov, P. Schlegel, D. Paduch
FERTILITY AND STERILITY
(2018)
Review
Urology & Nephrology
Ryan Flannigan, Premal Patel, Darius A. Paduch
SEXUAL MEDICINE REVIEWS
(2018)
Review
Urology & Nephrology
Connor M. Forbes, Ryan Flannigan, Darius A. Paduch
SEXUAL MEDICINE REVIEWS
(2018)
Meeting Abstract
Urology & Nephrology
R. Flannigan, L. Heier, L. Chazen, D. Paduch
JOURNAL OF SEXUAL MEDICINE
(2018)
