Article
Veterinary Sciences
Sarah Gough, Gayle Hallowell, David Rendle
Summary: This study compared the efficacy of oral omeprazole and injectable omeprazole in the treatment of equine glandular gastric disease (EGGD). The results showed that injectable omeprazole had better healing rates and reduction in lesion severity at 4 weeks compared to oral omeprazole, demonstrating non-inferiority. However, the study had limitations including its retrospective design and small sample size.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Oncology
Muzaffer Ugrakli, Mehmet Zahid Kocak, Gulhan Dinc, Tugrul Burak Genc, Melek Caglayan, Selin Ugrakli, Engin Hendem, Muhammed Muhiddin Er, Dilek Caglayan, Melek Karakurt Eryilmaz, Murat Araz, Caglayan Geredeli, Ali Murat Tatli, Orhan Onder Eren, Mehmet Artac
Summary: This study aimed to evaluate the impact of concurrent proton pump inhibitor (PPI) use on survival outcomes in second-line nivolumab therapy for metastatic renal cell carcinoma (mRCC). A multicenter retrospective study was conducted on 109 patients, dividing them into two groups based on whether they used PPI concurrently with nivolumab. Overall survival (OS) and progression-free survival (PFS) were compared between the two groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Rachel Rosen
Summary: The treatment of gastroesophageal reflux varies greatly in different age groups of children. Nutritional interventions are commonly used for infants, while medications are more frequently utilized for older children. However, if treatment does not produce the desired results, it is important to reassess the diagnosis being treated and conduct additional testing to provide a more precise approach to care.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hee Gyu Yang, Dong-Kyu Kim
Summary: Antiplatelet therapy combined with proton-pump inhibitors (PPIs) in patients with acute coronary syndrome increases the risk of mortality, myocardial infarction, and coronary revascularization events. The use of PPIs can alter the pharmacokinetics of antiplatelet agents. Middle-aged patients and those with shorter duration of concomitant use are at a higher risk. This study highlights the potential adverse cardiovascular effects of combining antiplatelet therapy with PPIs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Microbiology
Yi-Ting Lin, Ting-Yun Lin, Szu-Chun Hung, Po-Yu Liu, Ping-Hsun Wu, Yun-Shiuan Chuang, Wei-Chun Hung, Yi-Wen Chiu, Mei-Chuan Kuo, Chun-Ying Wu
Summary: This study investigated the differences in gut microbiota composition among hemodialysis patients receiving different anti-acid drugs, revealing that PPI significantly altered the gut microbiota compared to H-2 blocker users or controls. Importantly, there was a significant enrichment of the genus Streptococcus in PPI users.
Article
Oncology
Bao-Dong Qin, Xiao-Dong Jiao, Xin-Cheng Zhou, Bin Shi, Jian Wang, Ke Liu, Ying Wu, Yan Ling, Yuan-Sheng Zang
Summary: The study evaluated the impact of concomitant PPI use on the efficacy of ICIs in advanced cancer patients, finding that PPI use was associated with reduced PFS and OS.
Article
Biochemistry & Molecular Biology
Cynthia Fernandez-Lainez, Ignacio de la Mora-de la Mora, Itzhel Garcia-Torres, Sergio Enriquez-Flores, Luis Flores-Lopez, Pedro Gutierrez-Castrellon, Lilian Yepez-Mulia, Felix Matadamas-Martinez, Paul de Vos, Gabriel Lopez-Velazquez
Summary: The study suggests that GlADI may serve as a potential target for treating giardiasis, with several drugs showing potential efficacy against Giardia through inhibition of GlADI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Benita Wiatrak, Tomasz Gebarowski, Eddie Czwojdzinski, Kazimierz Gasiorowski, Beata Tylinska
Summary: Ellipticine and olivacine have cytotoxic effects on various cell lines, especially on doxorubicin-resistant cells. Olivacine is less cytotoxic to cancer cells and normal cells compared to ellipticine. Both compounds may exert their anticancer activity by affecting cell cycle progression and inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Zhao-Hui Ding, Yu Huang, Jin-Nan Chen, Lai-Sheng Luo, Wei Zhang, Xiao Liang, Hong Lu
Summary: This study compared the efficacy and safety of high-dose proton pump inhibitor (PPI) and amoxicillin dual therapy with triple therapy containing high-dose PPI, amoxicillin, and metronidazole in patients who failed H. pylori treatment. The results showed that the triple therapy had significantly higher H.pylori eradication rates than the dual therapy, even in areas with metronidazole resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Surgery
Sophia K. McKinley, Rebecca C. Dirks, Danielle Walsh, Celeste Hollands, Lauren E. Arthur, Noe Rodriguez, Joyce Jhang, Ahmed Abou-Setta, Aurora Pryor, Dimitrios Stefanidis, Bethany J. Slater
Summary: The review found that surgical treatment of GERD can improve short-term quality of life, but does not show significant superiority in short-term symptom control. Compared to total fundoplication, partial fundoplication leads to higher rates of prolonged PPI usage.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biochemistry & Molecular Biology
Shuitu Feng, Guoqin Qiu, Lihong Yang, Lihua Feng, Xin Fan, Fang Ren, Kaida Huang, Yide Chen
Summary: The study found that omeprazole can enhance the inhibitory effect of chemotherapy drugs on gastric cancer cells by regulating m(6)A modification and the FTO eraser, which is important for improving chemosensitivity.
BIOSCIENCE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Lucas Wauters, Matthias Ceulemans, Dennis Frings, Maarten Lambaerts, Alison Accarie, Joran Toth, Raf Mols, Patrick Augustijns, Gert De Hertogh, Lukas Van Oudenhove, Jan Tack, Tim Vanuytsel
Summary: This study found that the numbers of eosinophils and immune cells in the duodenum, as well as permeability, were significantly higher in patients with functional dyspepsia, and decreased after PPI therapy. In contrast, immune cells and permeability increased in healthy volunteers on PPIs.
Article
Multidisciplinary Sciences
Eunkyeong Jang, Minju Park, Ji Eun Jeong, Ji Young Lee, Myeong Gyu Kim
Summary: This study aimed to identify adverse events (AEs) of rebamipide that are more common than other drugs for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) in the elderly population. A total of 101,735 AE reports from the KIDS-KAERS database were analyzed, and 14 signals were detected. Four signals were not listed on drug labels. Common AEs in the elderly population were analyzed, with 11 AEs identified. These AEs were not serious and occurred within 2-9 days.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Takuto Fujii, Kenji Sugimoto, Takafumi Noda, Takahiro Shimizu, Yuji Matsuya, Hideki Sakai
Summary: A newly synthesized dihydropyrazole derivative KYY-008 was found to selectively inhibit the activity of gastric H+,K+-ATPase, with no effect on other P2-type ATPases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
J. Starup-Linde, B. Langdahl, P. Vestergaard, T. Harslof
Summary: This study investigated whether concomitant use of oral bisphosphonates and direct oral anticoagulants increases the risk of upper gastrointestinal ulcers compared to the use of either drug alone, and found no increased risk when individuals with previous upper gastrointestinal ulcers were excluded.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
William J. Sandborn, Julian Panes, Silvio Danese, Zaineb Sharafali, Azra Hassanali, Rhian Jacob-Moffatt, Christopher Eden, Marco Daperno, John F. Valentine, David Laharie, Carolina Baia, Raja Atreya, Remo Panaccione, Grazyna Rydzewska, Humberto Aguilar, Severine Vermeire
Summary: This study compared the safety and efficacy of two doses of Etrolizumab with placebo in patients with Crohn's disease. The results showed that during the maintenance phase, Etrolizumab significantly improved clinical remission and endoscopic improvement in patients with moderately to severely active Crohn's disease compared to placebo. However, there was no significant difference in the effects of Etrolizumab and placebo on clinical remission and endoscopic improvement during the induction phase.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Javier P. Gisbert, Maria Chaparro
Summary: Infants exposed to biological drugs in utero have adequate serological responses to vaccines, and there are no relevant adverse events for non-live inactivated vaccines. Live-attenuated vaccines should be avoided in children with detectable levels of biological drugs. Breastfeeding by mothers treated with biologics is considered safe for infants, and the benefits of breastfeeding while receiving treatment and adhering to infant immunization programs outweigh any potential risk.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Health Care Sciences & Services
Ana Echarri, Jose L. Perez-Calle, Marta Calvo, Gema Molina, Monica Sierra-Ausin, Maria C. Morete-Perez, Noemi Mancenido, Belen Botella, Noelia Cano, Beatriz Castro, Daniel Martin-Rodriguez, Yolanda Sanchez-Ortega, Pilar Corsino, Mercedes Canas, Ana M. Lopez-Calleja, Pilar Nos, Javier Muniz
Summary: This study investigated the information habits of patients with inflammatory bowel disease (IBD) and the perceptions of both patients and professionals regarding a national website as an educational resource. The results showed that 80% of patients searched the internet for information on their disease, and most patients valued a website recommended by their professional, showing willingness to participate in online educational initiatives and provide feedback to improve its usefulness. Professionals believed that this type of website is the best supplementary information source for patients and prescribed it to a majority of patients, especially those who were newly diagnosed.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Biotechnology & Applied Microbiology
Bernd Bokemeyer, Tibor Hlavaty, Matthieu Allez, Pamela Selema, Shahrzad Moosavi, Mary Jane Cadatal, Heather Fowler, Markus Mueller, Katherine F. Liau, Javier P. Gisbert
Summary: This study investigated the use of CT-P13 in the treatment of patients with Crohn's disease and ulcerative colitis. The results showed that the safety information for CT-P13 was consistent with the known safety profile for IFX and did not alter the established benefit-risk profile of CT-P13.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Gastroenterology & Hepatology
Julian Panes, Severine R. Vermeire, Geert D'Haens, Silvio Danese, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana R. Bravata, Daniel Gaya, Laurent Peyrin-Biroulet, Axel Dignass
Summary: This study compared two treatment strategies for Crohn's disease patients and found that regardless of whether the treatment was "treat-to-target" or "standard of care", ustekinumab was effective in improving the health-related quality of life and work productivity of patients over a 2-year follow-up period.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Johan Burisch, Mirabella Zhao, Selwyn Odes, Peter De Cruz, Severine Vermeire, Charles N. Bernstein, Gilaad G. Kaplan, Dana Duricova, Dan Greenberg, Hans O. Melberg, Mamoru Watanabe, Hyeong Sik Ahn, Laura Targownik, Valerie E. H. Pittet, Vito Annese, K. T. Park, Konstantinos H. Katsanos, Marte L. Hoivik, Zeljko Krznaric, Maria Chaparro, Edward V. Loftus, Peter L. Lakatos, Javier P. Gisbert, Willem Bemelman, Bjorn Moum, Richard B. Gearry, Michael D. Kappelman, Ailsa Hart, Marieke J. Pierik, Jane M. Andrews, Siew C. Ng, Renata D'Inca, Pia Munkholm
Summary: The cost of caring for patients with inflammatory bowel disease (IBD) continues to increase worldwide due to the steady increase in prevalence, the chronic nature of the diseases, expensive treatments, intensive monitoring, and their impact on productivity. This Commission urges evaluation of cost increases against improved disease management and the need for data interoperability and big data approaches to assess effectiveness and cost-effectiveness. International collaborations and novel care models should be sought to enhance education and training for clinicians, patients, and policy makers.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Javier P. Gisbert, Maria Chaparro
Summary: Surgery is not a cure for Crohn's disease, and postoperative recurrence is common. This article critically reviews the role of anti-TNF agents and new biologics in preventing and treating postoperative recurrence in Crohn's disease. Anti-TNFs have been shown to be the most effective agents in preventing and treating postoperative recurrence, while the effectiveness of vedolizumab and ustekinumab is still unclear.
Article
Gastroenterology & Hepatology
Laila Aldars-Garcia, Ruben Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutierrez, Iago Rodriguez-Lago, Luis Fernandez-Salazar, Daniel Ceballos, Jose Manuel Benitez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, Maria Jose Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, Maria Esteve, Ruth de Francisco, Maria Jose Garcia, Ruben Frances, Ainhoa Rodriguez Pescador, Benito Velayos, Elena Guerra del Rio, Sandra Marin Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldan-Martin, Cristina Ramirez, Ancor Sanz-Garcia, Juan J. Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P. Gisbert, Maria Chaparro
Summary: This study investigates the metabolic differences in different subgroups of newly diagnosed treatment-naive IBD patients. The results indicate alterations in energy and amino acid metabolism in IBD patients, with an increased demand for ketone bodies. The differences in metabolites are more pronounced in Crohn's disease patients compared to ulcerative colitis patients, and in serum compared to urine. Cluster analysis identifies three distinct patient profiles with significant differences in clinical, anthropometric, and metabolomic variables.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Angeles Perez-Aisa, Olga P. Nyssen, Alma Keco-Huerga, Luis Rodrigo, Alfredo J. Lucendo, Blas J. Gomez-Rodriguez, Juan Ortuno, Monica Perona, Jose Maria Huguet, Oscar Nunez, Luis Fernandez-Bermejo, Jesus Barrio, Angel Lanas, Eduardo Iyo, Pilar Mata Romero, Miguel Fernandez-Bermej, Barbara Gomez, Ana Garre, Judith Gomez-Camarero, Luis Javier Lamuela, Ana Campillo, Luisa de la Pena-Negro, Manuel Dominguez Cajal, Luis Bujanda, Diego Burgos-Santamaria, Fernando Bermejo, Victor Gonzalez-Carrera, Ramon Pajares, Pedro Almela Notari, Javier Tejedor-Tejada, Montserrat Planella, Itxaso Jimenez, Yolanda Arguedas Lazaro, Antonio Cuadrado-Lavin, Isabel Perez-Martinez, Edurne Amorena, Jesus M. Gonzalez-Santiago, Teresa Angueira, Virginia Flores, Samuel J. Martinez-Dominguez, Manuel Pabon-Carrasco, Benito Velayos, Alicia Algaba, Consuelo Ramirez, Enrique Alfaro Almajano, Manuel Castro-Fernandez, Noelia Alcaide, Patricia Sanz Segura, Anna Cano-Catala, Natalia Garcia-Morales, Leticia Moreira, Francis Megraud, Colm O'Morain, Xavier Calvet, Javier P. Gisbert
Summary: This study analyzed the effectiveness and safety of triple-dose administration of single capsule bismuth quadruple therapy (scBQT) in patients included in the European Registry on Helicobacter pylori Management. The results showed that the three times a day treatment schedule was more effective than the traditional four times a day schedule in terms of overall cure rates. There were no differences observed in treatment adherence or safety between the two regimens.
Meeting Abstract
Gastroenterology & Hepatology
M. Baldan-Martin, M. Azkargorta, I. Lloro, I. Soleto Fernandez, M. Orejudo, C. Ramirez, S. Garcia, J. Mercado, S. Riestra, M. Rivero, A. Gutierrez, I. Rodriguez-Lago, L. Fernandez-Salazar, D. Ceballos, J. M. Benitez, M. Aguas, I. Baston-Rey, F. Bermejo, M. J. Casanova, R. Lorente, Y. Ber, V. Royo, M. Esteve, F. Elortza, J. P. Gisbert, M. Chaparro
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Baldan-Martin, I. Lloro, M. Azkargorta, C. Ramirez, I. Soleto Fernandez, M. Orejudo, S. Garcia, J. Mercado, C. H. Gordillo, S. Riestra, M. Rivero, A. Gutierrez, I. Rodriguez-Lago, L. Fernandez-Salazar, D. Ceballos, J. M. Benitez, M. Aguas, I. Baston-Rey, F. Bermejo, M. J. Casanova, R. Lorente, Y. Ber, V. Royo, M. Esteve, F. Elortza, J. P. Gisbert, M. Chaparro
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
I. Guerra Marina, F. Barros, M. Chaparro, J. M. Benitez, M. D. Martin Arranz, R. de Francisco, M. Piqueras, L. de Castro, A. Y. Carbajo, F. Bermejo, M. Minguez, A. Gutierrez, F. Mesonero, F. Canete, C. Gonzalez-Munoza, M. Calvo, B. Sicilia, E. Alfambra, C. A. Tardillo, M. Rivero, A. J. Lucendo, L. Bujanda, M. Van Domselaar, P. Almela, L. Ramos, M. Fernandez Sanchez, E. Hinojosa, C. Verdejo, A. Gimenez, I. Rodriguez-Lago, N. Mancenido, J. L. Perez Calle, M. D. P. Moreno, P. G. Delgado-Guillena, B. Antolin, P. Ramirez de la Piscina, M. J. Casanova, A. Carracedo, E. Domenech, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
A. B. Julian, D. Casas-Deza, R. Vicente-Lidon, B. Beltran, E. Domenech, A. Gutierrez-Casbas, M. Manosa, Y. Zabana, E. Caudevilla-Biota, P. Corsino-Roche, E. Sierra-Moros, L. E. Franco-Fobe, S. Pina-Echevarria, E. Garcia-Gonzalez, E. Alfambra, C. Gargallo-Pueyo, B. Sicilia, L. Arias, M. J. Alcala-Escriche, L. Madero-Velazquez, R. Ferreiro-Iglesias, A. Palmero-Perez, M. Calafat, S. Rubio-Iturria, I. Moraleja-Yudego, Y. Ber-Nieto, S. Garcia-Mateo, J. P. Gisbert, M. Barreiro-de Acosta, S. Garcia-Lopez
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
I. Guerra Marina, L. Bujanda, M. Manosa, I. Perez-Martinez, M. J. Casanova, L. de la Pena, M. de Benito, M. Rivero, P. Varela, L. Bernal, A. C. Franco, Y. Ber, M. Piqueras, C. Tardillo, A. Ponferrada, S. Olivares, A. J. Lucendo, P. Gilabert, M. Sierra Ausin, M. Bellart, A. Herrarte, M. Calafat, R. de Francisco, J. P. Gisbert, J. Guardiola, E. Domenech, F. Bermejo
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. F. Munoz Nunez, C. Rodriguez, J. P. Gisbert, S. Bernardo, J. Aparicio, I. Tagarro, F. Casellas
JOURNAL OF CROHNS & COLITIS
(2023)