Article
Urology & Nephrology
Shubo Fan, Zhongyuan Zhang, Jie Wang, Shengwei Xiong, Xiaofei Dai, Xu Chen, Zhihua Li, Guanpeng Han, Jun Zhu, Han Hao, Wei Yu, Liang Cui, Cheng Shen, Xuesong Li, Liqun Zhou
Summary: This study evaluated the feasibility, safety, and effectiveness of the KD-SR-01 system for robot-assisted radical prostatectomy. The results showed that the system was successfully used in all cases without complications. The surgical outcomes were satisfactory, with low blood loss and good postoperative recovery.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Antonio Galfano, Stefano Tappero, Christopher Eden, Paolo Dell'oglio, Karen Fransis, Hongqian Guo, Keith Kowalczyk, Mattia Longoni, Rabii Madi, Koon H. Rha, Silvia Secco, Xuefeng Qiu, Rashid Sayyid, Aldo M. Bocciardi
Summary: This study retrospectively evaluated the results of Retzius-Sparing robot-assisted radical Prostatectomy (RSP) in high-risk prostate cancer (HR-PCa) patients, performed by expert surgeons in a multicentric setting. The study found that RSP achieved good urinary continence recovery and could predict the occurrence of positive surgical margins (PSMs) to some extent.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Shubo Fan, Han Hao, Silu Chen, Jie Wang, Xiaofei Dai, Meng Zhang, Xu Chen, Zhihua Li, Shengwei Xiong, Guanpeng Han, Jun Zhu, Zhongyuan Zhang, Wei Yu, Liang Cui, Cheng Shen, Liqun Zhou, Xuesong Li
Summary: This study compared the efficacy and safety of robot-assisted laparoscopic radical prostatectomy (RARP) performed using the KangDuo surgical robot system to the da Vinci Si robotic system in clinically localized prostate cancer (KD-RARP vs DV-RARP). The results showed that there were no significant differences between the two groups in basic clinical characteristics, but KD-RARP had a significantly longer operation time. There were also no significant differences between the two groups in terms of postoperative outcomes. Overall, the KangDuo surgical robot system achieved similar short-term oncological and functional outcomes compared to the da Vinci Si robotic system, but with a disadvantage in operation time.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Urology & Nephrology
Mahmoud Abou Zeinab, Alp Tuna Beksac, Tanner Corse, Susan Talamini, Luca Morgantini, Aaron Kaviani, Ethan Ferguson, Mohamed Eltemamy, Simone Crivellaro, Mutahar Ahmed, Michael Stifelman, Jihad Kaouk
Summary: In a multi-institutional setting, single-port robotic-assisted simple prostatectomy (SP RASP) through the transvesical approach promotes a pain-free procedure, same-day discharge, short Foley catheter duration, low complication rate, and quick recovery.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Mohammed Shahait, Joseph G. Cheaib, Elai Davicioni, Yang Liu, Ibrahim Abu Ghaida, Ryan W. Dobbs, Mohamed Alshalalfa, Priti Lal, Daniel J. Lee, David I. Lee
Summary: This study examined the correlation between perioperative testosterone levels and genomic risk scores in men undergoing radical prostatectomy. It found that there was no clinical correlation between pre-defined genomic risk score groups and testosterone groups, suggesting a limited role of endogenous testosterone in the development of de novo high-risk localized prostate cancer.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Praful Ravi, Lucia Kwak, Wanling Xie, Kaitlin Kelleher, Andres M. Acosta, Rana R. McKay, Adam S. Kibel, Mary-Ellen Taplin
Summary: This study compared the outcomes of neoadjuvant therapy with a novel hormonal agent (NHA) prior to radical prostatectomy (RP) and up-front RP in patients with high-risk prostate cancer (HRPC). After adjusting for potential confounding factors, the neoadjuvant RP group showed longer time to biochemical recurrence (BCR) and superior metastasis-free survival (MFS) compared to the up-front RP group. The rates of adjuvant and salvage therapy were also lower in the neoadjuvant RP cohort.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Justin D. Oake, Benjamin Shiff, Oksana Harasemiw, Navdeep Tangri, Thomas W. Ferguson, Bimal Bhindi, Jeff W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir G. Nayak
Summary: The study compared outcomes of patients with nonmetastatic prostate cancer treated with radical prostatectomy or radiation therapy. It found that radical prostatectomy was associated with higher overall survival and lower prostate cancer specific mortality compared to radiation therapy.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Christine White, Ilene Staff, Tara McLaughlin, Joseph Tortora, Kevin Pinto, Akshay Gangakhedkar, Alison Champagne, Joseph Wagner
Summary: The study focused on evaluating the ability of the Decipher test to predict early biochemical recurrence after radical prostatectomy, showing that high-risk Decipher scores were associated with shorter time to biochemical recurrence and receipt of salvage treatment.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Justin D. Oake, Benjamin Shiff, Oksana Harasemiw, Navdeep Tangri, Thomas W. Ferguson, Bimal Bhindi, Jeff W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir G. Nayak
Summary: This study compared the outcomes of radiation therapy (RT) and radical prostatectomy (RP) for nonmetastatic prostate cancer patients. The findings showed that RT was associated with higher all-cause mortality and prostate cancer specific mortality rates compared to RP.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Maggie C. Lee, Tyler R. Erickson, Shannon Stock, Lauren E. Howard, Amanda M. De Hoedt, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Martha K. Terris, Zachary Klaassen, Stephen J. Freedland, Christopher J. D. Wallis
Summary: The study found that among men with intermediate/high-risk prostate cancer, delayed treatment up to 1 year following diagnosis did not significantly increase the risk of adverse long-term outcomes, including castration-resistant prostate cancer, metastasis, and death.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Francesco Chierigo, Mike Wenzel, Christoph Wuernschimmel, Rocco Simone Flammia, Benedikt Horlemann, Zhe Tian, Fred Saad, Felix K. H. Chun, Markus Graefen, Michele Gallucci, Shahrokh F. Shariat, Guglielmo Mantica, Marco Borghesi, Nazareno Suardi, Carlo Terrone, Pierre Karakiewicz
Summary: This study compared the survival rates between hormone therapy and hormone therapy plus chemotherapy in high-risk patients. The results showed that hormone therapy had a better cancer-specific survival rate in the overall NCCN high-risk cohort and the JH high-risk and very high-risk subgroup.
JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Enrico Checcucci, Angela Pecoraro, Sabrina De Cillis, Matteo Manfredi, Daniele Amparore, Roberta Aimar, Federico Piramide, Stefano Granato, Gabriele Volpi, Riccardo Autorino, Cristian Fiori, Francesco Porpiglia
Summary: In patients undergoing RARP, total reconstruction (TR) facilitates faster and higher continence recovery compared to the standard approach or anterior only (AR) or posterior only (PR). At 12 weeks, TR showed the highest continence rates, followed by AR and PR.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Review
Oncology
Li Wang, Jing-ya Deng, Cai Liang, Ping-yu Zhu
Summary: This study compared the outcomes of robotic partial nephrectomy (RPN) and laparoscopic partial nephrectomy (LPN) for treating complex renal tumors. The results showed that RPN was associated with shorter operative time, warm ischemia time, length of stay, lower transfusion rate, and incidence of intraoperative complications compared to LPN, while maintaining oncological control and avoiding renal function decline.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Oliver Best, Ashan Canagasingham, Zhixin Liu, Paul Doan, Anne-Maree Haynes, Warick Delprado, Fiona Maclean, Carlo Yuen, Phillip Stricker, James Thompson
Summary: The pathological grade of prostate cancer is the strongest predictor of recurrence. This study aims to determine whether the composite or index grade group is a better predictor of biochemical recurrence (BCR) in prostate cancer patients who underwent radical prostatectomy. The results showed that patients with a higher index grade group had a higher risk of BCR. Therefore, the index grade group should be used for post-operative counseling regarding prognosis and follow-up.
Article
Urology & Nephrology
Behfar Ehdaie, Ghalib Jibara, Daniel D. Sjoberg, Vincent Laudone, James Eastham, Karim Touijer, Peter Scardino, Timothy Donahue, Alvin Goh, Andrew Vickers
Summary: Prophylactic antibiotics for 1 day after catheter removal post-RP were found to be noninferior to a 3-day regimen in reducing urinary tract infections, offering surgeons a more efficient treatment option.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Jose Batista da Costa, Ewan A. Gibb, Timo K. Nykopp, Miles Mannas, Alexander W. Wyatt, Peter C. Black
Summary: This review discusses the inter- and intratumor heterogeneity in muscle invasive bladder cancer (MIBC) and explores the clinical implications of this heterogeneity for biomarker-driven strategies and the development of new therapies. Molecular subtyping and genomic alterations may help explain variations in treatment response among patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Computer Science, Information Systems
Hongzhi Zhu, Yasmin Halwani, Robert Rohling, Sidney Fels, Septimiu Salcudean
Summary: This paper aims to study the HCI control logic used in ultrasound (US) machines through surveying sonographers. The research discovers that the control logic for the most frequently used functions in US machines is identical across different manufacturers. Using the unified modeling language (UML), the study visualizes and formulates control logic to optimize logical interactions and simplify suboptimal ones. This research provides insights into HCI approaches in US machines and establishes a UML-based framework for future machine design.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Computer Science, Information Systems
Yanan Shao, Hoda S. Hashemi, Paula Gordon, Linda Warren, Jane Wang, Robert Rohling, Septimiu Salcudean
Summary: In this study, a new processing pipeline for breast cancer classification using S-WAVE data was proposed and evaluated on a dataset of 40 patients. The best results outperformed the state-of-the-art reported S-WAVE breast cancer classification performance, and the sensitivity of the classification results to feature selection and changes in breast lesion contours was studied.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Review
Engineering, Electrical & Electronic
Septimiu E. Salcudean, Hamid Moradi, David G. Black, Nassir Navab
Summary: Robot-assisted medical imaging utilizes robots to acquire medical images, enabling precise and accurate trajectory control of the imaging system. This technology provides valuable information to physicians and facilitates the alignment of preoperative imaging with patients. This review article describes recent advancements in ultrasound, endoscopy, X-ray, optical coherence tomography, and nuclear medicine, and discusses research directions in autonomous scanning and physics-driven approaches for accurate placement and trajectory control of the imaging system.
PROCEEDINGS OF THE IEEE
(2022)
Article
Computer Science, Interdisciplinary Applications
Shahed Mohammed, Mohammad Honarvar, Qi Zeng, Hoda Hashemi, Robert Rohling, Piotr Kozlowski, Septimiu Salcudean
Summary: In this paper, we introduce two model-based iterative methods for obtaining shear modulus images of tissue using magnetic resonance elastography. The methods utilize sparsifying regularization, wave equation constraint, and have fast convergence and improved contrast to noise.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Review
Urology & Nephrology
Moritz Maas, Tilman Todenhoefer, Peter C. Black
Summary: The detection of bladder cancer through urine markers has been a long-standing research topic. While the idea of urine as a vector of tumor information is attractive, the use of urine markers in clinical practice is currently limited despite the availability of numerous markers and efforts in research and development. Prospective trials are underway to increase the evidence on urinary biomarkers in bladder cancer and promote their implementation in guidelines. This Review provides a comprehensive overview of current status, limitations, and future perspectives of urine markers.
NATURE REVIEWS UROLOGY
(2023)
Article
Robotics
Hyunwoo Song, Hamid Moradi, Baichuan Jiang, Keshuai Xu, Yixuan Wu, Russell H. H. Taylor, Anton Deguet, Jin U. U. Kang, Septimiu E. E. Salcudean, Emad M. M. Boctor
Summary: This study introduces an integrated real-time intraoperative surgical guidance system that co-registers an endoscope camera of the da Vinci surgical robot and a transrectal ultrasound (TRUS) transducer using photoacoustic markers. The system enables tracking of the laser spot illuminated by a pulsed-laser-diode attached to the surgical instrument, providing both fluorescence (FL) and photoacoustic (PA) images of the surgical region-of-interest (ROI). Quantitative evaluation shows that the average registration and tracking errors are 0.84 mm and 1.16°, respectively. This study demonstrates the effectiveness of co-registered photoacoustic marker tracking using TRUS+PA imaging for functional guidance of the surgical ROI.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2023)
Article
Urology & Nephrology
Peter C. Black, Catherine M. Tangen, Parminder Singh, David J. McConkey, M. Scott Lucia, William T. Lowrance, Vadim S. Koshkin, Kelly L. Stratton, Trinity J. Bivalacqua, Wassim Kassouf, Sima P. Porten, Rick Bangs, Melissa Plets, Ian M. Thompson, Seth P. Lerner
Summary: This study evaluated the efficacy and safety of atezolizumab in BCG-unresponsive high-risk NMIBC patients who were ineligible for or declined surgery. The results showed that atezolizumab had a good pathological complete response rate in patients with carcinoma in situ, and some patients had durable responses. However, there were severe treatment-related adverse events in some patients.
Article
Computer Science, Cybernetics
David Black, Yas Oloumi Yazdi, Amir Hossein Hadi Hosseinabadi, Septimiu Salcudean
Summary: Current teleultrasound methods trade off between precision and latency versus flexibility and cost. This paper presents a novel concept of human teleoperation, where an expert remotely operates a person wearing a mixed-reality headset by controlling a virtual ultrasound probe. The system shows promise with lower latency and measurement errors compared to audiovisual teleguidance.
HUMAN-COMPUTER INTERACTION
(2023)
Article
Acoustics
Hoda S. Hashemi, Shahed K. Mohammed, Qi Zeng, Reza Zahiri Azar, Robert N. Rohling, Septimiu E. Salcudean
Summary: Real-time ultrasound imaging is crucial in ultrasound-guided interventions, providing more spatial information compared to conventional 2-D frames. However, the long data acquisition time of 3-D imaging can be a bottleneck, reducing practicality and introducing artifacts. This article introduces a real-time volumetric acquisition method using a matrix array transducer, which addresses the issues and allows for accurate tissue elasticity estimation. The method has been validated on various phantoms and shows promising results. Rating: 9/10.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Acoustics
Tajwar Abrar Aleef, Qi Zeng, Hamid Moradi, Shahed Mohammed, Tom Curran, Mohammad Honarvar, Robert Rohling, S. Sara Mahdavi, Septimiu E. Salcudean
Summary: This article presents a first-of-a-kind 3-D hand-operated endorectal shear wave absolute vibro-elastography system, which allows quantitative and volumetric assessment of tissue stiffness during systematic prostate biopsy. The system shows high correlations with 3-D magnetic resonance elastography and an existing 3-D shear wave absolute vibro-elastography system.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Oncology
Siamak Daneshmand, Clint Cary, Timothy Masterson, Lawrence Einhorn, Nabil Adra, Stephen A. Boorjian, Christian Kollmannsberger, Anne Schuckman, Alan So, Peter Black, Aditya Bagrodia, Eila Skinner, Mehrdad Alemozaffar, Timothy Brand, Scott Eggener, Phillip Pierorazio, Kelly Stratton, Lucia Nappi, Craig Nichols, Chunqiao Luo, Ming Li, Brian Hu
Summary: This study aimed to investigate the efficacy of RPLND as a first-line treatment for testicular seminoma with clinically low-volume retroperitoneal lymphadenopathy. The results showed that the 2-year recurrence-free survival rate was 81%, the recurrence rate was 22%, and the 2-year overall survival rate was 100%. The study concluded that RPLND is a viable treatment option with low long-term morbidity.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Zhongliang Jiang, Septimiu E. Salcudean, Nassir Navab
Summary: Ultrasound (US) is widely used in clinical intervention and diagnosis due to its non-invasive and real-time imaging capabilities. However, free-hand US examinations are dependent on the operator's skills. Robotic US Systems (RUSS) aim to overcome this limitation by offering reproducibility and intelligent imaging. This paper categorizes RUSS as teleoperated or autonomous and reviews recent developments in both categories. Machine learning and artificial intelligence play a key role in enabling motion and deformation-aware robotic image acquisition. The recovery of the language of sonography through artificial intelligence research is valuable. The article provides a comprehensive understanding of RUSS and presents challenges in developing intelligent robotic sonographer colleagues.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Engineering, Biomedical
Tajwar Abrar Aleef, Qi Zeng, W. James Morris, S. Sara Mahdavi, Septimiu E. Salcudean
Summary: This study proposes a framework for registering trans-perineal template mapping biopsy (TTMB) cores to advanced volumetric ultrasound data, such as multi-parametric transrectal ultrasound (mpTRUS). The framework allows for quick localization of the cores and can be used to train cancer classifiers.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Review
Oncology
Omid Yassaie, Cyrus Chehroudi, Peter C. Black
Summary: Non-muscle invasive bladder cancer is traditionally managed with transurethral resection and intravesical therapy, but alternative treatment options with acceptable oncological outcomes are critical for BCG-unresponsive patients to preserve the bladder.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)