Article
Veterinary Sciences
Sarmed H. Kathem, Waleed K. Abdulsahib, Munaf H. Zalzala
Summary: Immune-mediated hepatitis poses a severe threat to human health with no effective treatment currently available. The study aimed to investigate the protective effects of BE and TQ in ConA-induced acute liver injury, showing significant reduction in liver damage with both substances. These findings highlight the potential of BE and TQ as new therapeutic agents for treating hepatitis and autoimmune diseases.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Fisheries
Shanjie Zha, Weifeng Zhang, Hongxing Liu, Siyi Huang, Changsen Sun, Yongbo Bao
Summary: Many studies have shown that metal-based nanoparticles (NPs) have excellent bactericidal effects on various bacteria and fungi. However, the effectiveness of NPs as antimicrobial agents against Vibrio parahaemolyticus infection in blood clam, Tegillarca granosa, is poorly understood. In this study, the effect of NPs (nZnO or nCuO) on physiological parameters and immune-related gene expression in clams exposed to V. parahaemolyticus was investigated. The results showed that both NPs had a dose-dependent effect on physiological indexes of clams, especially in terms of their immune responses, when co-exposed with Vibrio. Gene expression analysis also revealed that NPs at a concentration of 0.1 mg/L mitigated the downregulation of immune-related genes after clam exposure to V. parahaemolyticus. The combination of 0.1 mg/mL nZnO and nCuO additives significantly enhanced the humoral immunity of blood clam, indicating its potential as a protective measure against V. parahaemolyticus infection in T. granosa.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Sara Cassibba, Silvia Ippolito, Silvia Pellegrini, Roberto Trevisan, Alessandro Rossini
Summary: This study explores the relationship between denosumab treatment and COVID-19, and suggests a potential protective effect of denosumab in reducing the incidence of symptomatic COVID-19, especially among the elderly.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Hussein Herz, Yang Song, Yuanchao Ye, Liping Tian, Benjamin Linden, Marwa Abu El Haija, Yi Chu, Justin L. Grobe, Randall W. Lengeling, Mohamad Mokadem
Summary: Chronic use of NSAIDs can induce small intestinal ulcerations, which can affect intestinal GLP-1 production, hepatic insulin sensitivity, and hepatic glucose production.
Article
Microbiology
Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Summary: IFN-lambda has antiviral effects during pregnancy, but its effects depend on the gestational stage. Infection with ZIKV earlier in pregnancy enhances transplacental transmission. IFN-lambda signaling in maternal tissues causes fetal resorption and intrauterine growth restriction in dams with robust ZIKV infection. Maternal IFN-lambda signaling also contributes to pregnancy pathology induced by poly(I.C) treatment.
Article
Chemistry, Medicinal
Lucia Caputo, Ilaria Piccialli, Roselia Ciccone, Paolo de Caprariis, Antonio Massa, Vincenzo De Feo, Anna Pannaccione
Summary: This study showed that lavender and coriander essential oils, as well as their main active constituent linalool, have neuroprotective effects against neurotoxicity induced by A beta(1-42) oligomers. They were able to improve cell viability, reduce nuclear morphological abnormalities, counteract reactive oxygen species production, and inhibit the activation of pro-apoptotic enzyme caspase-3. These findings suggest that lavender and coriander essential oils, along with linalool, could be potential natural agents for treating A beta(1-42)-induced neurotoxicity.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Shiyan Zhang, Ziqin Yan, Yafang Li, Yang Gong, Xilin Lyu, Jianfeng Lou, Daizhou Zhang, Xiangjing Meng, Yujun Zhao
Summary: A new small-molecule inhibitor, 31 (YL93), was designed and synthesized to target both MDM2 and MDM4, resulting in stronger antitumor activities in wild-type p53 and MDM4-overexpressing cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Julian R. Smith, Jack W. Dowling, Matthew I. McFadden, Andrew Karp, Johannes Schwerk, Joshua J. Woodward, Ram Savan, Adriana Forero
Summary: Cellular stress can activate signaling cascades to elicit inflammatory responses. This study investigates the role of the transcription factor MEF2A in regulating transcriptional stress responses and preventing R-loop accumulation. Loss of MEF2A leads to activation of the ATR kinase, which positively regulates R-loop-associated inflammatory responses.
Article
Multidisciplinary Sciences
Mi Ra Chang, Patrick R. Griffin
Summary: Osteoarthritis (OA) is a common joint disease that affects the elderly population and is a major cause of disability and impaired mobility. Current treatments focus on pain relief and reducing joint swelling, but there are no effective methods to slow disease progression and prevent cartilage loss. Research suggests that ROR beta plays a critical role in chondrogenesis and identifying mechanisms that control its expression could lead to the development of new therapies for treating OA.
Article
Cell Biology
Qingjie Fan, Yuanhang Wu, Mechou Li, Fan An, Lulu Yao, Meixian Wang, Xiuying Wang, Jieli Yuan, Kui Jiang, Wenzhe Li, Ming Li
Summary: Vaginal dysbiosis is related to the development of cervical cancer, and the abundance of L. iners is positively correlated with core fucosylation levels. Lactate can inhibit the proliferation and migration of cervical cancer cells by activating the Wnt pathway, showing potential in regulating vaginal microecology and preventing cervical cancer.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Amanda K. Jones, Dong Wang, David A. Goldstrohm, Laura D. Brown, Paul J. Rozance, Sean W. Limesand, Stephanie R. Wesolowski
Summary: Hypoxemia decreases fetal glucose oxidation and increases lactate production, potentially due to increased norepinephrine and cortisol levels that inhibit insulin secretion and glucose utilization.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Jinzhong Jing, Xiaoyu Xiang, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Bo Kang, Hua Zhao
Summary: This study aimed to explore the protective effects of a new organic selenium (OH-SeMet) on dietary oxidative stress (DOS)-induced inflammatory responses, as well as the corresponding response of selenotranscriptome in immune organs. Results showed that OH-SeMet supplementation can reduce immunological stress caused by oxidative stress, improve antioxidant capacity, and alter the expression of inflammation-related genes. The response of spleen and thymus to OH-SeMet supplementation differed.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Anna Kosieradzka, Justyna Smagowicz, Cezary Szwed
Summary: This study aimed to analyze the measures used by manufacturing enterprises to protect workers from COVID-19 infection and maintain business continuity. The majority of identified measures were found to be implemented, with additional in-house solutions being developed by the enterprises. Legal and regulatory measures, individual protective measures, and protective measures for groups of workers were applied at similar levels regardless of the occurrence of COVID-19. Measures related to work organization and production organization were generally higher in enterprises without COVID-19.
Article
Cell Biology
Jennifer Maurer, Xinjie Zhao, Martin Irmler, Anders Gudiksen, Nanna S. Pilmark, Qi Li, Thomas Goj, Johannes Beckers, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Andreas Peter, Rainer Lehmann, Henriette Pilegaard, Kristian Karstoft, Guowang Xu, Cora Weigert
Summary: Metformin treatment leads to lactate production and secretion, as well as reduced glucose consumption. It inhibits respiratory chain complex I and alters cellular redox state, decreasing pyruvate oxidation. These findings suggest that metformin induces dose-dependent lactate production in skeletal muscle by shifting the equilibrium of lactate dehydrogenase reaction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Immunology
Natalie Thuma, Daniela Doehler, Dirk Mielenz, Heinrich Sticht, Daniel Radtke, Lena Reimann, Bettina Warscheid, David Voehringer
Summary: This article investigated a newly discovered larval secreted protein Nb-LSA1a of human hookworm in mice immunization. The study found that immunization with Nb-LSA1a induced a strong immune response and provided significant protection against Nb infection. The findings of this study are significant for the development of effective hookworm vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
