Article
Oncology
Hans-Olov Adami, Ina Trolle Andersen, Uffe Heide-Jorgensen, Ellen T. Chang, Mette Norgaard, Henrik Toft Sorensen
Summary: A large prospective study using high-quality data found no evidence to support the hypothesis that ranitidine increases the risk of upper gastrointestinal cancers. There was no consistent association observed in comparison with other histamine-2 receptor blockers or proton pump inhibitors. These results should be reassuring for past users of ranitidine.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Environmental Sciences
Arash Etemadi, Ian D. Buller, Maryam Hashemian, Gholamreza Roshandel, Hossein Poustchi, Maria Morel Espinosa, Benjamin C. Blount, Christine M. Pfeiffer, Behnam Keshavarzi, Abigail R. Flory, Siavosh Nasseri-Moghaddam, Sanford M. Dawsey, Neal D. Freedman, Christian C. Abnet, Reza Malekzadeh, Mary H. Ward
Summary: Nitrate excretion is associated with living at a higher elevation and using groundwater for drinking in a rural population at high risk for esophageal and gastric cancers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biodiversity Conservation
Enrico Bazzicalupo, Maria Lucena-Perez, Daniel Kleinman-Ruiz, Aleksandar Pavlov, Aleksander Trajce, Bledi Hoxha, Bardh Sanaja, Zurab Gurielidze, Niko Kerdikoshvili, Jimsher Mamuchadze, Yuriy A. Yarovenko, Muzigit Akkiev, Miroslaw Ratkiewicz, Alexander P. Saveljev, Dime Melovski, Alexander Gavashelishvili, Krzysztof Schmidt, Jose A. Godoy
Summary: Genome-wide genetic assessment of Balkan and Caucasian Eurasian lynx populations revealed close relationship and low genetic diversity with high inbreeding in Balkan lynx, while Caucasian lynx showed a long history of isolation with high genetic diversity and good genetic health, suggesting the need for genetic rescue in Balkan lynx and the recognition of Caucasian lynx as a separate subspecies.
DIVERSITY AND DISTRIBUTIONS
(2022)
Article
Biochemistry & Molecular Biology
Hans Dieter Nischalke, Franziska Schmalz, Stephan Buch, Janett Fischer, Christine Moeller, Madlen Matz-Soja, Benjamin Kraemer, Bettina Langhans, Alexandra Klueners, Michael Soyka, Felix Stickel, Jacob Nattermann, Thomas Berg, Christian P. Strassburg, Philipp Lutz
Summary: Hepatocellular carcinoma (HCC) is a severe complication of advanced alcoholic liver disease. This study found an association between genetic variation in SAMM50 and HCC in patients with alcoholic liver disease. Although minor variants of SAMM50 were strongly associated with alcoholic HCC, this association was found to be dependent on the presence of the well-known risk variant PNPLA3 148M.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Violet Kayamba
Summary: Upper gastrointestinal (UGI) cancers are common and have significant associations with certain types of food. Fruit and vegetables are believed to reduce UGI cancer risk, while processed foods increase the risk. Specific diets may be associated with reduced cancer risk, but their effectiveness in high-risk locations is unclear.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Rita Maliza, Wan-Hsuan Chou, Wen-Hung Wang, Yen-Hsu Chen, Dyah Aryani Perwitasari, Wei-Chiao Chang
Summary: Dengue is a global arboviral disease that has become a major public health concern. This study investigated the associations of variations in the MICB and PLCE1 genes with dengue severity and thrombocytopenia in Indonesian and Taiwanese populations. The results showed associations between MICB rs3132468 and dengue shock syndrome (DSS), as well as between PLCE1 rs3740360 and secondary dengue hemorrhagic fever (DHF) in Indonesian patients.
Letter
Oncology
Hans-Olov Adami, Ina Trolle Andersen, Uffe Heide-Jorgensen, Mette Norgaard, Henrik T. Sorensen
Summary: This study highlights the limitations of RCTs in studying harm, leading to reliance on nonrandomized studies to assess the cancer risk associated with ranitidine. Despite issues in the existing epidemiologic literature, the study aims to provide the most informative data available globally.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Biochemistry & Molecular Biology
Noel E. Donlon, Robert Power, Conall Hayes, Maria Davern, John V. Reynolds, Joanne Lysaght
Summary: Combining radiotherapy with immune checkpoint therapy can modulate the tumor microenvironment to enhance anti-tumor immunity, showing promising results for the treatment of locally advanced operable and metastatic upper gastrointestinal tract diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Marcela Forgerini, Gustavo Urbano, Tales Rubens de Nadai, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Patricia de Carvalho Mastroianni
Summary: The study found that genetic variants rs10306114 in PTGS1 and rs2070744 in NOS3 were associated with an increased risk of upper gastrointestinal bleeding. The presence of these genetic variants may modify the risk of upper gastrointestinal bleeding in low-dose aspirin and nonsteroidal anti-inflammatory drugs users.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhen Li, Jing Liu, Chao-Ran Ji, Fei-Xue Chen, Fu-Guo Liu, Jian Ge, Yong Chen, Xue-Guo Sun, Yan-Yan Lu, Gui-Hua Cheng, Jie Zhang, Peng Li, Ji-Yong Liu, Chong-Mei Yang, Xiu-Li Zuo, Yan-Qing Li
Summary: The medical consortium successfully detected upper GI cancers through MCCG screening, with a high detection rate of early gastric cancer. Various gastric abnormalities were also identified in asymptomatic subjects, demonstrating the feasibility and tolerability of the screening process. Further studies are needed to improve operational quality control.
Article
Surgery
Hanna H. Kakish, Alexander W. Loftus, Fasih Ali Ahmed, Mohamedraed Elshami, Lee M. Ocuin, Luke D. Rothermel, Richard S. Hoehn
Summary: Surgery is the main treatment for non-metastatic upper gastrointestinal cancers, but some patients refuse or are unable to undergo surgery. Refusal and contraindications for surgery significantly impact overall survival, and factors such as race, socioeconomic status, hospital volume, and hospital type are predictors of these outcomes.
Article
Oncology
Theodore M. M. Brasky, Roberta M. M. Ray, Alison M. M. Newton, Sandi L. L. Navarro, Jeannette M. M. Schenk, Holli A. A. Loomans-Kropp, Rhonda S. S. Arthur, Linda G. G. Snetselaar, John Hays, Marian L. L. Neuhouser
Summary: B-vitamins do not seem to have a significant association with the risk of upper gastrointestinal cancers. A study conducted on 159,401 postmenopausal women over 19 years found no evidence that supplemental B-vitamin intake increases the risk of gastric or esophageal cancers. This study suggests that postmenopausal women can safely use B-vitamin supplements without concern for their impact on upper gastrointestinal cancer risk.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Review
Nutrition & Dietetics
Fatemeh Sadeghi, David Mockler, Emer M. Guinan, Juliette Hussey, Suzanne L. Doyle
Summary: The study evaluated the effectiveness of combined nutritional and exercise interventions in improving muscle wasting, physical functioning, and quality of life in patients with upper GI cancer. Promising effects of multimodal interventions on physical functioning were shown, but no significant differences in postoperative complications and hospital stay were observed. Limited evidence showed conflicting results regarding the effectiveness of these interventions on muscle mass preservation and health-related quality of life, indicating a need for further research.
Review
Medicine, Research & Experimental
Natalia Calanzani, Paige E. Druce, Claudia Snudden, Kristi M. Milley, Rachel Boscott, Dawnya Behiyat, Smiji Saji, Javiera Martinez-Gutierrez, Jasmeen Oberoi, Garth Funston, Mike Messenger, Jon Emery, Fiona M. Walter
Summary: Detecting upper GI cancers in primary care is difficult due to common and non-specific symptoms. This study aimed to identify validated biomarkers for evaluation in low-prevalence populations. 149 eligible studies were identified, involving 22,264 cancer cases and 49,474 controls, with most biomarkers still at an early stage of validation.
ADVANCES IN THERAPY
(2021)
Review
Oncology
Leo R. Brown, Barry J. A. Laird, Stephen J. Wigmore, Richard J. E. Skipworth
Summary: Considerable advances have been made in the investigation and management of oesophagogastric cancer, but outcomes remain poor. Cancer cachexia, often neglected, is a critical factor that limits progress in care. Host factors can influence treatment efficacy, and most patients do not respond to current treatments. Utilizing this information in clinical decision-making can enhance patient outcomes.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
