Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Mengzhu Lv, Simeng Zhang, Yuqing Dong, Liu Cao, Shu Guo
Summary: PolG plays a role in the prognosis of GC patients by affecting the glycolysis process and proliferation of GC cells. Silencing PolG enhances the proliferation ability of GC cells, as confirmed in both in vivo and in vitro experiments. This study identifies PolG as a potential novel therapeutic target for the treatment of GC, providing new insights into clinical GC therapy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Hua-Chuan Zheng, Hang Xue, Cong-Yu Zhang
Summary: The REG4 gene plays a role in infection and inflammation by promoting macrophage polarization and killing inflammatory Escherichia coli. It is closely linked to tumorigenesis and is overexpressed in various cancers, contributing to aggressive behaviors and poor prognosis. REG4 can aggravate cellular phenotypes involved in tumorigenesis, migration, invasion, and resistance to chemotherapy and radiation. It also promotes the formation of colon stem cells by inhibiting Notch and activating Wnt. REG4 could serve as a biomarker and therapeutic target for cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cong-Hui Yao, Joon Seok Park, Kiran Kurmi, Song-Hua Hu, Giulia Notarangelo, Joseph Crowley, Heidi Jacobson, Sheng Hui, Arlene H. Sharpe, Marcia C. Haigis
Summary: The glycerol-3-phosphate shuttle is uncoupled in kidney cancer cells, with the cytosolic reaction being much faster than the mitochondrial reaction. Knocking down mitochondrial GPD has no effect on mitochondrial respiration, but leads to upregulation of cytosolic GPD and increased glycerol-3-phosphate supply, promoting cancer cell proliferation. Inhibition of lipid synthesis can abolish the proliferative advantage of GPD2 knockdown tumor.
Article
Oncology
Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A. Kim, Wooram Choi, Chae Young Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang, Han Gyung Kim, Young-Jun Jeon, Bokyoung Kim, Younghoon Kim, Kyung-Hee Kim, Byong Chul Yoo, Jeung-Whan Han, Narayana Parameswaran, Ji Hye Kim, Hoon Hur, Jae Youl Cho
Summary: The study explored the pathological role of a nonhistone methyltransferase in gastric cancer (GC), identified EEF1AKMT3 as a novel tumor suppressive methyltransferase, and revealed its mechanism of action through regulating the methylation of MAP2K7 and the degradation of TP53. The findings suggest potential targeted therapy in GC by manipulating the dysregulated EEF1AKMT3/MAP2K7/TP53 signaling axis.
Article
Biochemistry & Molecular Biology
Xiaohong Wang, Lianhai Zhang, Francis K. L. Chan, Jiafu Ji, Jun Yu, Jessie Qiaoyi Liang
Summary: GGT7 is frequently downregulated in gastric cancer and its methylation is correlated with patient survival. GGT7 inhibits gastric cancer cell growth and migration by inducing autophagy.
Article
Medicine, Research & Experimental
Qian Zhou, Wensheng Chen, Zhenzhen Fan, Zhipeng Chen, Jinxia Liang, Guandi Zeng, Lu Liu, Wanting Liu, Tong Yang, Xin Cao, Biao Yu, Meng Xu, Ye-Guang Chen, Liang Chen
Summary: In this study, MYOCD was identified as a clinically relevant tumor suppressor gene in lung cancer patients, showing a potent inhibitory effect on lung cancer stem cells. NSCLC cells deficient of MYOCD were found to be particularly sensitive to TGFBR kinase inhibitor, and a synergistic effect was observed when combining TGFBRi with stemness inhibitor to treat MYOCD deficient lung cancers.
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Article
Biology
Changyu Zhu, Yadira M. Soto-Feliciano, John P. Morris, Chun-Hao Huang, Richard P. Koche, Yu-jui Ho, Ana Banito, Chun-Wei Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A. Armstrong, C. David Allis, Darjus F. Tschaharganeh, Scott W. Lowe
Summary: Mutations in genes involved in chromatin modification and remodeling are frequently observed in human cancers. This study shows that MLL3 co-activates the Cdkn2a tumor suppressor gene by linking chromatin remodeling to tumor suppression. Disruption of Kmt2c and Myc overexpression cooperate to promote hepatocellular carcinoma development in mice.
Article
Biochemical Research Methods
Chen Hong, Robin Thiele, Lars Feuerbach
Summary: Analyzing focal copy number variations (CNVs) is crucial for cancer research as it helps identify driver genes. We have developed the GenomeTornadoPlot software package that provides visualizations of CNV types, locations, and lengths, and allows for gene-to-gene comparisons to identify co-mutation patterns or driver-passenger gene hierarchies.
Article
Biochemistry & Molecular Biology
Sandra Tapial, Juan Luis Garcia, Luis Corchete, Andreana N. Holowatyj, Jessica Perez, Daniel Rueda, Miguel Urioste, Rogelio Gonzalez-Sarmiento, Jose Perea
Summary: The study established a cnLOH profile of synchronous colorectal cancer (SCRC) and found associations between cnLOH and polyclonal SCRC, with inactivation of tumor suppressor genes and cnLOH being rare events in SCRC cases. The research defines distinct patterns of cnLOH in SCRC and provides initial evidence of a role for cnLOH in the etiology of SCRC.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Oncology
Wen -Ting Peng, Xi Jin, Xiao-En Xu, Yun-Song Yang, Ding Ma, Zhi-Ming Shao, Yi-Zhou Jiang
Summary: This study identifies ACAA1 as a potential therapeutic target for TNBC, specifically in the LAR subtype. Inhibition of ACAA1 can suppress TNBC proliferation and enhance the response to abemaciclib. The combination of trimetazidine and abemaciclib shows promise in treating ACAA1-high TNBCs.
Article
Oncology
Chao Song, Tianwei Chen, Lan He, Ning Ma, Jian-ang Li, Ye-Fei Rong, Yuan Fang, Mengmeng Liu, Dong Xie, Wenhui Lou
Article
Oncology
Qianzhi Ni, Pingping Chen, Bing Zhu, Jingjing Li, Dong Xie, Xingyuan Ma
Article
Oncology
QianZhi Ni, Zhenhua Chen, Qianwen Zheng, Dong Xie, Jing-Jing Li, Shuqun Cheng, Xingyuan Ma
Article
Hematology
Wenting Zheng, Jun Wei, Caitlin C. Zebley, Lindsay L. Jones, Yogesh Dhungana, Yong-Dong Wang, Jayadev Mavuluri, Lingyun Long, Yiping Fan, Ben Youngblood, Hongbo Chi, Terrence L. Geiger
Summary: This study demonstrates that the deficiency of Regnase-1 enhances CAR-T cell expansion and memory-like cell formation, leading to improved tumor clearance and sustained remission. Regnase-1 deficiency also reduces exhaustion and enhances the activity of CAR-T cells.
Article
Biochemistry & Molecular Biology
Hongling Huang, Peipei Zhou, Jun Wei, Lingyun Long, Hao Shi, Yogesh Dhungana, Nicole M. Chapman, Guotong Fu, Jordy Saravia, Jana L. Raynor, Shaofeng Liu, Gustavo Palacios, Yong-Dong Wang, Chenxi Qian, Jiyang Yu, Hongbo Chi
Summary: This study reveals that amino acid transporters play a role in dampening T-MEM differentiation, while Pofut1 is a key regulator for terminal effector differentiation of T-EFF cells. These findings highlight the importance of nutrient uptake and signaling in determining T cell fate.
Article
Multidisciplinary Sciences
Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel, Hongbo Chi
Summary: Regulatory T cells play a crucial role in immune tolerance and immunosuppression in the tumor microenvironment. Inhibiting lipid synthesis dependent on SREBPs in T-reg cells can enhance antitumor immune responses without autoimmune toxicity, and deletion of SCAP in these cells inhibits tumor growth and enhances immunotherapy. SCAP and SREBPs signaling regulate lipid synthesis and inhibitory receptor signaling in T-reg cells, pointing to new ways of targeting these cells for cancer therapy.
Article
Multidisciplinary Sciences
Guotong Fu, Clifford S. Guy, Nicole M. Chapman, Gustavo Palacios, Jun Wei, Peipei Zhou, Lingyun Long, Yong-Dong Wang, Chenxi Qian, Yogesh Dhungana, Hongling Huang, Anil KC, Hao Shi, Sherri Rankin, Scott A. Brown, Amanda Johnson, Randall Wakefield, Camenzind G. Robinson, Xueyan Liu, Anthony Sheyn, Jiyang Yu, Suzanne Jackowski, Hongbo Chi
Summary: The CDP-ethanolamine pathway plays a crucial role in coordinating the expression and localization of CXCR5 in T-FH cells, impacting humoral immunity. This discovery enhances our understanding of T-FH cell differentiation and humoral immunity.
Article
Multidisciplinary Sciences
Chan Yul Yoo, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G. Chong, Joseph Hahm, Nicholas Morffy, Pei Zhou, Lucia C. Strader, Akira Nagatani, Beixin Mo, Xuemei Chen, Meng Chen
Summary: The study demonstrates that PIF3 possesses a p53-like transcription activation domain, and PHYB can suppress PIF3 transactivation activity by binding adjacent to the domain. This reveals a novel signaling mechanism of PHYB through direct interference of PIF3 transactivation activity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lingyun Long, Jun Wei, Seon Ah Lim, Jana L. Raynor, Hao Shi, Jon P. Connelly, Hong Wang, Cliff Guy, Boer Xie, Nicole M. Chapman, Guotong Fu, Yanyan Wang, Hongling Huang, Wei Su, Jordy Saravia, Isabel Risch, Yong-Dong Wang, Yuxin Li, Mingming Niu, Yogesh Dhungana, K. C. Anil, Peipei Zhou, Peter Vogel, Jiyang Yu, Shondra M. Pruett-Miller, Junmin Peng, Hongbo Chi
Summary: Nutrients play a crucial role in adaptive immunity regulation by interacting with mTORC1. This study identified regulatory modules in mouse regulatory T cells that mediate immune receptor- and nutrient-dependent signaling to mTORC1. Epigenetic and post-translational mechanisms of nutrient transporters, sensors, and transducers in immune signals were unraveled, revealing their pivotal roles in T cell immunity and immune tolerance.
Meeting Abstract
Hematology
Nicole L. Michmerhuizen, Masayuki Umeda, Ilaria Iacobucci, Bright Arthur, Danika Di Giacomo, Ryan Hiltenbrand, Pablo Portola, Sherif Abdelhamed, Hongling Huang, Peipei Zhou, Lingyun Long, Hao Shi, Yu Sun, Evangelia K. Papachristou, Chandra Chilamakuri, Clive S. D'Santos, Hongbo Chi, Jeffery M. Klco, Charles G. Mullighan
Article
Mathematics, Applied
Lingyun Long, Aichao Li, Lili Jin
Summary: This paper proposes a wireless English synchronous QoS control algorithm with low complexity and easy implementation to improve the quality of wireless English multimedia communication. The algorithm maps the wireless English RTP timestamp to the same absolute reference clock and establishes a synchronization detection decision rule based on the synchronization QoS requirements. The state space model is used to describe system behavior and enables real-time synchronization detection and judgment. Experimental results show that the algorithm outperforms the RTP/RTCP-based algorithm in terms of synchronization performance.
APPLIED MATHEMATICS AND NONLINEAR SCIENCES
(2022)
