Review
Gastroenterology & Hepatology
Paul Cray, Breanna J. Sheahan, Christopher M. Dekaney
Summary: Paneth cells are professional secretory cells that play a crucial role in the innate immune system by secreting antimicrobial factors. They rely on autophagy to regulate their secretory capability, and disruption of this pathway can lead to decreased function and other issues.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
James C. Fleet
Summary: Vitamin D plays a critical role in regulating calcium and bone homeostasis, especially in the absorption of calcium in the intestines. The intestinal absorption of calcium is regulated by the hormone 1,25 dihydroxyvitamin D, which activates gene transcription by binding to the intestinal vitamin D receptor. Various physiological and disease states can affect the regulation of intestinal calcium absorption by vitamin D.
Article
Nutrition & Dietetics
Dajiang Ding, Daolin Mou, Heng Zhu, Xuemei Jiang, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Yong Zhuo, Jian Li, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu, Bin Feng
Summary: Maternal HMSeBA supplementation may alleviate ROS-induced intestinal ER stress in offspring by improving the expression of SELS and GPX4. This could be beneficial for the intestinal health of the offspring.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Cell Biology
Varsha Tandra, Travis Anderson, Juan D. Ayala, Neal L. Weintraub, Nagendra Singh, Honglin Li, Jie Li
Summary: Protein modification by UFM1, called ufmylation, is important in regulating various physiological and pathological processes. UFBP1, the first identified ufmylation substrate, has been shown to play pivotal roles in development, hematopoiesis, intestinal homeostasis, chondrogenesis, and neuronal development. However, the significance of UFBP1 ufmylation in these processes is still unclear.
Article
Biotechnology & Applied Microbiology
Neharika Bhadouria, Alycia G. Berman, Joseph M. Wallace, Nilsson Holguin
Summary: Raloxifene, an estrogen agonist, protects intervertebral discs in mice from degeneration and pain-related substance P expression induced by aging and biological sex.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Juan Tang, Wenxia Bu, Wenxuan Hu, Zixuan Zhao, Lei Liu, Chao Luo, Rui Wang, Susu Fan, Shali Yu, Qiyun Wu, Xiaoke Wang, Xinyuan Zhao
Summary: Exposure to nanoplastics during pregnancy resulted in small intestinal injury in the offspring, with female mice showing a greater decrease in birth weight but higher adult body weights. Histological changes and upregulation of reactive oxygen species were observed in the small intestines of both female and male offspring. Sex-specific differences in gene expression levels were also observed. These findings indicate that PS-NP exposure during pregnancy can cause sex-specific small intestinal toxicity, potentially through reactive oxygen species activation and subsequent ferroptosis.
Review
Endocrinology & Metabolism
C. Szoeke, S. J. Downie, A. F. Parker, S. Phillips
Summary: This paper discusses the role of sex hormones in the intersection of vascular disease and dementia, emphasizing interactive risk factors and the role of inflammation in the evolution of the disease, as well as the impact of estrogen-based hormone therapy on cognition over the past 45 years.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Developmental Biology
Akaljot Singh, Holly M. Poling, Praneet Chaturvedi, Konrad Thorner, Nambirajan Sundaram, Daniel O. Kechele, Charlie J. Childs, Heather A. McCauley, Garrett W. Fisher, Nicole E. Brown, Jason R. Spence, James M. Wells, Michael A. Helmrath
Summary: The in vitro differentiation of pluripotent stem cells into human intestinal organoids (HIOs) is an effective method for creating complex three-dimensional intestinal structures. This study analyzed the developmental stages of HIO engraftment and found that HIO maturation closely resembles fetal human intestinal development. The use of single-nuclear RNA sequencing further validated these findings and solidified the value of transplanted HIOs as a human intestinal model system.
Article
Endocrinology & Metabolism
Yue Xi, Dan Zhang, Yue Liang, Zhongyan Shan, Xiaochun Teng, Weiping Teng
Summary: Thyroid hormone plays a critical role in the development of vertebrates and affects the function of various organs, especially the intestine. This study identified differentially expressed proteins in the distal ileum of homozygous Thra(E403X/E403X) and wild-type Thra(+/+) mice through proteomic analysis. The differentially expressed proteins are involved in metabolic and developmental processes, nutrient transport, and the intestinal immune system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Gastroenterology & Hepatology
Siriporn Chamniansawat, Nasisorn Suksridechacin, Narongrit Thongon
Summary: Magnesium (Mg2+) plays a crucial role in various biological functions, and its deficiency is associated with several diseases. The small intestine is responsible for absorbing digested Mg2+ through both transcellular and paracellular routes, contrary to the previous belief of exclusive paracellular absorption. Several regulatory factors, such as parathyroid hormone and fibroblast growth factor-23, have been identified in small intestinal Mg2+ uptake. Mechanistic factors underlying proton pump inhibitor suppression of small intestinal Mg2+ absorption are currently being investigated.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Branka Sosic-Jurjevic, Dieter Lutjohann, Svetlana Trifunovic, Sladan Pavlovic, Slavica Borkovic Mitic, Ljubisa Jovanovic, Natasa Ristic, Ljiljana Marina, Vladimir Ajdzanovic, Branko Filipovic
Summary: Age and sex have an impact on serum cholesterol levels, with more significant effects observed in aged females. Poorer hepato-intestinal health and increased jejunal cholesterol absorption are associated with the higher serum cholesterol levels in aged females. The local increase in 27-hydroxycholesterol during aging might reduce the hepatoprotective effects of endogenous estrogen in the female liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Quanzhong Ren, Juan Ma, Xiaobo Li, Qingtao Meng, Shenshen Wu, Yusa Xie, Yu Qi, Sijin Liu, Rui Chen
Summary: This study investigated the long-term effects of oral exposure to engineered metal nanoparticles (NPs) on the intestine. It was found that oral exposure to silver NPs resulted in severe damage to the intestine, including epithelial structure damage, reduced mucosal layer thickness, and alteration of intestinal microbiota. The interaction between silver NPs and dendritic cells (DCs) caused abnormal activation of DCs, leading to disordered immune microenvironment in the intestine.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nutrition & Dietetics
Meng-Ying Lu, Jerry Cheng-Yen Lai, Shaw-Ji Chen
Summary: This study aimed to evaluate the influence of sex differences on serum lipid profiles among habitual coffee drinkers. It found that habitual coffee consumption changed the serum lipid profiles of men and women, and coffee drinkers had higher levels of serum total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, as well as lower levels of serum triglycerides compared to non-drinkers. Menopausal status may play an important role in modulating the effect of habitual coffee intake on dyslipidemia, and premenopausal women potentially benefit more from habitual coffee drinking than men and postmenopausal women.
Article
Immunology
Qinghai Meng, Yunhui Bi, Han Feng, Xue Ding, Shurui Zhang, Qi Chen, Liang Wang, Qichun Zhang, Yu Li, Huangjin Tong, Lixing Wu, Huimin Bian
Summary: The incidence of acute cardiovascular events is significantly higher in postmenopausal women. This study aimed to investigate the relationship between estrogen receptor (ER) and plaque stability in postmenopausal women. The findings suggest that activation of ER alpha improves plaque instability in the postmenopausal stage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Jie Zhang, Jin Wei, Shan Jiang, Lan Xu, Lei Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Review
Physiology
Hadi Fattah, Anita Layton, Volker Vallon
Review
Urology & Nephrology
Volker Vallon, Scott C. Thomson
NATURE REVIEWS NEPHROLOGY
(2020)
Review
Physiology
Volker Vallon
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Editorial Material
Physiology
Hermann Koepsell, Volker Vallon
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Editorial Material
Pharmacology & Pharmacy
Volker Vallon, Young Chul Kim
Summary: The therapeutic use of SGLT2 inhibitors to protect the kidneys goes beyond lowering blood glucose by spilling it into the urine.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Cardiac & Cardiovascular Systems
Volker Vallon
HEART FAILURE CLINICS
(2022)
Article
Physiology
Young Chul Kim, Hadi Fattah, Yiling Fu, Josselin Nespoux, Volker Vallon
Summary: This study reveals the expression of leptin receptor splice variants in the kidney, and the role of the tubular leptin receptor in response to a high-fat diet. Leptin replacement in mice reduces hyperphagia, hyperglycemia, and albuminuria, and normalizes kidney mRNA expression of key metabolic markers. Additionally, the study identifies tubular Lepr-sensitive genes, including acetoacetyl-CoA synthetase and gremlin 1. These findings provide valuable insights into the role of the leptin receptor in renal function and metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Physiology
Takahiro Masuda, Ken Ohara, Volker Vallon, Daisuke Nagata
Summary: There are differences in fluid homeostatic responses between SGLT2 inhibitors and loop diuretics. SGLT2 inhibitors increase serum Na+ concentration and stimulate fluid intake and renal water reabsorption, maintaining fluid balance; while loop diuretics do not engage these compensatory mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Broer, Volker Vallon
Summary: B0AT1 plays an important role in the retention of renal glucose and albumin, but may have adverse effects on kidney response following aristolochic acid-induced kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Akira Onishi, Yiling Fu, Manjula Darshi, Maria Crespo-Masip, Winnie Huang, Panai Song, Rohit Patel, Young Chul Kim, Josselin Nespoux, Brent Freeman, Manoocher Soleimani, Scott Thomson, Kumar Sharma, Volker Vallon
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Physiology
Panai Song, Winnie Huang, Akira Onishi, Rohit Patel, Young Chul Kim, Charlotte van Ginkel, Yiling Fu, Brent Freeman, Hermann Koepsell, Scott Thomson, Ruisheng Liu, Volker Vallon
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Physiology
Tosselin Nespoux, Rohit Patel, Kelly L. Hudkins, Winnie Huang, Brent Freeman, Young Chul Kim, Hermann Koepsell, Charles E. Alpers, Volker Vallon
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Physiology
Aleksandra Novikov, Yiling Fu, Winnie Huang, Brent Freeman, Rohit Patel, Charlotte van Ginkel, Hermann Koepsell, Meinrad Busslinger, Akira Onishi, Josselin Nespoux, Volker Vallon
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Physiology
Takahiro Masuda, Yuko Watanabe, Keiko Fukuda, Minami Watanabe, Akira Onishi, Ken Ohara, Toshimi Imai, Hermann Koepsell, Shigeaki Muto, Volker Vallon, Daisuke Nagata
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)