Letter
Gastroenterology & Hepatology
Peng Chen, Fuchao Chen
Summary: This article is related to Ikegami et al's papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Hailan Zhao, Haoming Xu, Shuzhen Chen, Jie He, Youlian Zhou, Yuqiang Nie
Summary: A systematic review and meta-analysis found a negative association between abundance of F. prausnitzii and IBD activity, but a cut-off level of F. prausnitzi for diagnosing and treating IBD has not been determined.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huili Zheng, Xiaofei Liang, Hongli Zhou, Tong Zhou, Xinhui Liu, Jialun Duan, Jin-ao Duan, Yue Zhu
Summary: In this study, the protective effect of Lycium barbarum polysaccharides (LBPs) on premature ovarian insufficiency (POI) was investigated in mice. LBPs improved ovarian reserve, regulated sex hormone levels, normalized estrous cycle, and increased offspring numbers in POI mice. Furthermore, LBPs had positive effects on gut microbiota and metabolism. These findings provide valuable support for the application of LBPs in the treatment of female ovarian function degeneration.
Article
Immunology
Kairuo Wang, Yixuan Guo, Yuanyuan Liu, Xiao Cui, Xiang Gu, Lixiang Li, Yanqing Li, Ming Li
Summary: This study found that the deficiency of F. prausnitzii in the gut is associated with elevated F. prausnitzii-reactive IgA in ulcerative colitis (UC) patients. Forced immunization of rabbits with F. prausnitzii led to intestinal inflammation. PFOR was identified as an IgA-binding antigen of F. prausnitzii and its immunoreactivity was validated in peripheral blood mononuclear cells (PBMCs), which showed elevated expression of inflammatory cytokines. Phylogenetic analysis revealed that PFOR is a common but conserved protein among gut bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Camille Kropp, Katy Le Corf, Karima Relizani, Kevin Tambosco, Ccori Martinez, Florian Chain, Georges Rawadi, Philippe Langella, Sandrine P. Claus, Rebeca Martin
Summary: Christensenella minuta displays strong anti-inflammatory activity by inhibiting the NF-kappa B signaling pathway, protects intestinal epithelial integrity, and shows potential for treating IBDs.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Backhed
Summary: This study successfully co-isolated Faecalibacterium prausnitzii and Desulfovibrio piger and identified their symbiotic relationship in growth and butyrate production. By adapting Faecalibacterium prausnitzii to tolerate oxygen exposure, researchers developed a next-generation probiotic formulation.
Article
Immunology
Hong Ki Min, Hyun Sik Na, JooYeon Jhun, Seon-Yeong Lee, Sun Shim Choi, Go Eun Park, Jeong Su Lee, In Gyu Um, Seung Yoon Lee, Hochan Seo, Tae-Seop Shin, Yoon-Keun Kim, Jennifer Jooha Lee, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Summary: In this study, we compared the gut microbiota of axSpA patients and healthy controls and found an association between specific gut microbiota and SpA pathogenesis. The results showed that axSpA patients had lower alpha-diversity and higher abundance of Bacteroides and Streptococcus, while Faecalibacterium prausnitzii, a butyrate-producing bacteria, was more abundant in healthy controls. Further experiments revealed that introducing F. prausnitzii or butyrate can reduce the polarization of CD4(+) IL-17A(+) T cells and the formation of osteoclasts, and decrease inflammation levels. Therefore, the reduced abundance of butyrate-producing microbes, especially F. prausnitzii, may be associated with axSpA pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Li-ting Jin, Ming-Zhi Xu
Summary: In obese patients, the connection between the gut microbiota and the onset of non-alcoholic fatty liver (NAFLD) is yet unknown. A study comparing the gut microbiota of obese individuals with and without NAFLD found a lower quantity of Faecalibacterium prausnitzii in the NAFLD group. Bacteroides, Clostridium leptum, and Clostridium butyricum were more prevalent in the NAFLD group, while Bacteroides, Clostridium butyricum, and F. prausnitzii were more prevalent in the simple obesity group. Lymphocytes and F. prausnitzii may play a role in determining the development of NAFLD in obese patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Multidisciplinary Sciences
Filip Rob, Dagmar Schierova, Zuzana Stehlikova, Jakub Kreisinger, Radka Roubalova, Stepan Coufal, Martin Mihula, Zuzana Jackova, Miloslav Kverka, Tomas Thon, Klara Kostovcikova, Lukas Bajer, Pavel Drastich, Jana Tresnak Hercogova, Michaela Novakova, Martin Kolar, Martin Vasatko, Milan Lukas, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska
Summary: In this preliminary study, the longitudinal effect of ustekinumab on the immune system, skin and gut microbiota composition, and specific immune response to commensals was examined in patients with IBD. The findings provide valuable information for further understanding of the therapeutic effect and mechanism of ustekinumab.
Article
Nutrition & Dietetics
Wenbing Hu, Wenyu Gao, Zongmin Liu, Zhifeng Fang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Wenwei Lu, Wei Chen
Summary: This study found that certain strains of F. prausnitzii can significantly improve symptoms of NAFLD in mice and regulate the gut microbiota. These strains enhance the production of short-chain fatty acids, modulate specific microbial communities, and alter related metabolic pathways, suggesting their potential therapeutic effects on NAFLD.
Article
Gastroenterology & Hepatology
J. J. Jimenez Loayza, S. Kang, L. Schooth, J. J. Teh, A. de Klerk, E. K. Noon, J. Zhang, J. Hu, A. L. Hamilton, A. Wilson-O'Brien, G. L. Trakman, W. Lin, J. Ching, L. Or, J. J. Y. Sung, J. Yu, S. C. Ng, M. A. Kamm, M. Morrison
Summary: Food additives have been found to affect the microbial dysbiosis associated with Crohn's disease. Sodium sulfite and polysorbate 80 have inhibitory effects on beneficial bacteria, while polysorbate 80 and carboxymethylcellulose can drive changes in the CD mucosa-associated microbiota, leading to early disease recurrence.
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Renate Winkel, Christina Casen, Trygve Hausken, Odd Helge Gilja, Jan Gunnar Hatlebakk
Summary: According to this study, FMT performed according to the protocol resulted in high treatment response rates and long-term effects, with only a few mild self-limited adverse events.
Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Cell Biology
Brendan A. Daisley, David Koenig, Kathleen Engelbrecht, Liz Doney, Kiel Hards, Kait F. Al, Gregor Reid, Jeremy P. Burton
Summary: This article highlights that the traditional viewpoint of single-celled microbial metabolism is insufficient to depict energy flow in host-adapted microbial communities at a system level. Emerging paradigms suggest that interconnected and interdependent electron transport chains develop in microbial communities, relying on cooperative production and sharing of bioenergetic machinery in the extracellular space.