Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chi Lan Tran, Minji Han, Byungmi Kim, Eun Young Park, Young Il Kim, Jin-Kyoung Oh
Summary: This study found an increased risk of esophageal and laryngeal cancers associated with GERD, while a decreased risk of colorectal, liver, and pancreatic cancers was observed.
Article
Gastroenterology & Hepatology
Annelies Geeraerts, Livia Guadagnoli, Ans Pauwels, Hannelore Geysen, Thomas Neyens, Lukas Van Oudenhove, Tim Vanuytsel, Jan Tack
Summary: This study aimed to investigate the association between psychological symptoms and reflux phenotype along the GERD spectrum in refractory reflux patients. The findings suggest that psychological symptoms do not differ across reflux phenotypes and do not predict reflux phenotype membership in refractory reflux patients.
Article
Pediatrics
Marinde van Lennep, Frederique Lansink, Marc A. Benninga, Michiel P. van Wijk
Summary: The study aimed to determine age-specific normal values in healthy infants using the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R). The results showed that reflux symptoms decrease in the first 24 months of life in healthy infants. Validation as a diagnostic tool for GER-disease using age-appropriate normal values is needed.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Dag Holmberg, Giola Santoni, My Catarina von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren
Summary: This population-based cohort study conducted in Denmark, Finland, Norway, and Sweden from 1979 to 2018 found that negative upper endoscopy in patients with GERD is associated with a significant and long-lasting decrease in both incidence and mortality of upper gastrointestinal cancer. The risk reduction persisted for at least 5 years in incidence and 10 years in mortality after a negative upper endoscopy.
Article
Gastroenterology & Hepatology
Inyoung Hwang, Sang Chun Ji, Jaeseong Oh, Hyojin Kim, Hyunju Cha, John Kim, Chang-Seok Lee, Kyung-Sang Yu, SeungHwan Lee
Summary: This study investigated the safety, tolerability, pharmacodynamics, pharmacokinetics, and pharmacogenomics of zastaprazan. The results showed that zastaprazan effectively suppressed gastric acid secretion and exhibited favorable pharmacokinetic properties. The evaluation indicated that zastaprazan is safe and suitable for the treatment of acid-related diseases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Yung-An Tsou, Sheng-Hwa Chen, Wen-Chieh Wu, Ming-Hsui Tsai, David Bassa, Liang-Chun Shih, Wen-Dien Chang
Summary: This study investigated the clinical assessments and extent of esophageal pressure changes in LRPD patients with varying severities of GERD. It found that patients with more severe GERD had lower esophageal sphincter pressures, with the lowest pressures observed in patients with grade D GERD. No significant differences in esophageal pressures were noted based on age, gender, or BMI among the patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tina L. Samuels, Simon Blaine-Sauer, Ke Yan, Kate Plehhova, Cathal Coyle, Nikki Johnston
Summary: Epithelial barrier dysfunction is a major characteristic of GERD, which is associated with symptom origination, inflammatory remodeling, and carcinogenesis. Alginate-based antireflux medications have been found to protect against peptic barrier disruption, and this study reveals the molecular mechanisms behind the injury and protection. The findings highlight the potential of targeting regulated intramembrane proteolysis and molecular mechanisms induced by weakly acidic reflux to treat GERD and prevent carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhiqiang Liu, Xiaoli Gao, Lirong Liang, Xuan Zhou, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Shu Deng, Zuomin Wang, Chen Wang
Summary: The purpose of this study was to assess the prevalence and identify the risk factors of gastroesophageal reflux disease (GERD) in the Chinese adult population. Data from a nationally representative sample of Chinese adults were collected, and the overall prevalence of GERD was found to be 5.6%. Women, smokers, older individuals, those with higher BMI, urban residents, individuals with lower education level or comorbidities were more likely to have GERD. Symptoms of severe periodontitis and lower frequency of tooth brushing were significantly associated with the risk of GERD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jiatian Li, Na Lu, Houchen Lyu, Guanghua Lei, Chao Zeng, Jie Wei, Yilun Wang, Dongxing Xie
Summary: This population-based cohort study suggests an independent association between the use of proton pump inhibitors (PPIs) and an increased risk of hip fracture in individuals with peptic ulcer disease (PUD).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Suzanna Hirsch, Joel A. Friedlander, Hayat Mousa, Valeria Cohran, Jose M. Garza, Rinarani Sanghavi, Lusine Ambartsumyan, Paul D. Mitchell, Rachel Rosen
Summary: While some practice patterns were similar between groups, aerodigestive providers pursued more testing than nonaerodigestive providers in several clinical scenarios including infants with respiratory symptoms and GE reflux.
JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Lei Chen, Heng Lu, Dunfa Peng, Long Long Cao, Farah Ballout, Kannappan Srirmajayam, Zheng Chen, Ajaz Bhat, Timothy C. Wang, Anthony Capobianco, Jianwen Que, Oliver Gene McDonald, Alexander Zaika, Shutian Zhang, Wael El-Rifai
Summary: This study investigates the role of acidic bile salts in activating NOTCH signaling in oesophageal adenocarcinoma (EAC). The researchers found that there is a crosstalk between APE1 redox function, reflux-induced inflammation, and DLL1 upregulation, which promotes cancer cell stem-like properties in EAC. The overexpression of APE1 and DLL1 is associated with poor overall survival in EAC patients.
Letter
Medicine, General & Internal
Raaj S. Mehta, Long H. Nguyen, Wenjie Ma, Kyle Staller, Mingyang Song, Andrew T. Chan
Summary: This cohort study examined the combined impact of dietary and lifestyle factors on the risk of gastroesophageal reflux disease symptoms in women participating in the Nurses' Health Study II.
JAMA INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Yang Chen, Xiaohong Sun, Wenjuan Fan, Jiao Yu, Peng Wang, Dong Liu, Mingwei Song, Shi Liu, Xiuli Zuo, Rong Zhang, Yuantao Hou, Shaomei Han, Yanqing Li, Jun Zhang, Xiaoqing Li, Meiyun Ke, Xiucai Fang
Summary: This study compared dietary and lifestyle triggers between non-erosive reflux disease (NERD) and reflux esophagitis (RE) in Chinese patients and provided evidence for practical dietary modifications for GERD.
Article
Otorhinolaryngology
Gui Chen, Weixing Liu, Wenjing Liao, Lijuan Song, Pingchang Yang, Xiaowen Zhang
Summary: This study found high detection rates of GERD and LPRD at the digestive endoscopy center in Guangzhou, China. Older age, BMI >= 24.0 kg/m(2), smoking, and drinking history were identified as risk factors for both GERD and LPRD. Neither GerdQ nor RSI scores included common extraesophageal symptoms.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker
Summary: This study assessed the detection rate and positive predictive value (PPV) of advanced serrated polyps (ASPs) in a FIT-based screening program. The results showed that 5.9% of FIT-positive screenees had ASPs, and including ASPs slightly increased the yield of the screening.
Article
Oncology
Emilie C. H. Breekveldt, Esther Toes-Zoutendijk, Manon C. W. Spaander, Hilliene J. van de Schootbrugge-Vandermeer, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian R. B. Ramakers, Evelien Dekker, Iris D. Nagtegaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The Dutch colorectal cancer (CRC) screening programme based on faecal immunochemical testing has shown a decrease in advanced-stage CRC incidence after its introduction in 2014. The incidence initially increased before screening but later decreased and remained below expected levels. These findings provide evidence for the effectiveness of the Dutch screening programme in reducing advanced-stage CRC incidence.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Surgery
W. A. R. Zwaans, J. A. de Bruijn, J. P. Dieleman, E. W. Steyerberg, M. R. M. Scheltinga, R. M. H. Roumen
Summary: The purpose of this study was to examine whether patients tend to overestimate or underestimate their pre-operative pain levels when recalling them in the post-operative phase. The study found that a significant percentage of patients experienced recall bias, leading to misclassification of treatment outcomes.
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Multidisciplinary Sciences
Jesus Villar, Jesus M. Gonzalez-Martin, Jose M. Anon, Carlos Ferrando, Juan A. Soler, Fernando Mosteiro, Juan M. Mora-Ordonez, Alfonso Ambros, Lorena Fernandez, Raquel Montiel, Anxela Vidal, Tomas Munoz, Lina Perez-Mendez, Pedro Rodriguez-Suarez, Cristina Fernandez, Rosa L. L. Fernandez, Tamas Szakmany, Karen E. A. Burns, Ewout W. Steyerberg, Arthur S. Slutsky
Summary: Mortality assessment in clinical studies of acute respiratory distress syndrome (ARDS) has not been well-defined. This study aimed to determine the timing of mortality assessment in ICU patients with moderate-to-severe ARDS, and its predictive value for treatment response. Observational cohorts and a randomized trial were analyzed, and it was found that ICU mortality rates closely approximated 28-day mortality rates. ICU mortality assessment within the first week of a trial could serve as an early predictor of treatment response for moderate-to-severe ARDS patients.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Siri L. van der Meijden, Anne A. H. de Hond, Patrick J. Thoral, Ewout W. Steyerberg, Ilse M. J. Kant, Giovanni Cina, M. Sesmu Arbous
Summary: This study aimed to investigate physicians' perspectives and decision-making behavior before implementing an AI-CDS tool for predicting readmission and mortality risk after ICU discharge. The survey results showed that most physicians had positive attitudes towards AI and AI-CDS tools, believing that they could support their work. Physicians expressed a willingness to incorporate a discharge AI-CDS tool into their daily clinical practice and recognized its value in their workflows.
JMIR HUMAN FACTORS
(2023)
Article
Health Care Sciences & Services
Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg, David van Klaveren
Summary: This study compared easily applicable risk-based methods to find optimal prediction methods for individualized treatment effects. The linear-interaction model showed optimal or close-to-optimal performance in many simulation scenarios. The restricted cubic splines model was optimal for strong non-linear deviations when sample size was larger.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Medicine, General & Internal
Ben Van Calster, Ewout W. W. Steyerberg, Laure Wynants, Maarten van Smeden
Summary: Clinical prediction models should be validated before implementation, as the performance of a model may vary across patient populations and measurement procedures. Validation studies should focus on understanding and quantifying heterogeneity and monitoring performance over time, to ensure that prediction models remain up-to-date and safe for clinical decision-making.
Article
Health Care Sciences & Services
Alexandros Rekkas, David van Klaveren, Patrick B. Ryan, Ewout W. Steyerberg, David M. Kent, Peter R. Rijnbeek
Summary: This study proposes a standardized scalable framework to extend the assessment of treatment effect heterogeneity to the observational setting. The framework consists of five steps: definition of research aim, identification of relevant databases, development of prediction model, estimation of treatment effect within risk strata, and presentation of results. It allows for the evaluation of differential treatment effects across risk strata.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard
Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Ellis L. Eikenboom, Saskia M. Wilting, Teoman Deger, Malgorzata I. Srebniak, Monique Van Veghel-Plandsoen, Ruben G. Boers, Joachim B. Boers, Wilfred F. J. van IJcken, Joost H. Gribnau, Peggy Atmodimedjo, Hendrikus J. Dubbink, John W. M. Martens, Manon C. W. Spaander, Anja Wagner
Summary: We assessed which ctDNA assay might be most suitable for a ctDNA-based CRC screening/surveillance blood test. The results showed that cfDNA methylation profiles could discriminate all microsatellite instable advanced neoplasia, making it a particularly promising tool for Lynch syndrome surveillance. Larger studies are needed to validate these findings.
Article
Health Care Sciences & Services
Shubhayu Bhattacharyay, Pier Francesco Caruso, Cecilia Akerlund, Lindsay D. Wilson, Robert K. Stevens, David W. Menon, Ewout W. Steyerberg, David Nelson, Ari Ercole, CENTER TBI Investigators Participants
Summary: Existing methods to characterise the evolving condition of traumatic brain injury (TBI) patients in the intensive care unit (ICU) do not capture the necessary context for individualising treatment. In this study, the integration of heterogenous data from medical records was used to model the individualised impact of clinical course on 6-month functional outcome. The study showed that static variables accounted for the majority of functional outcome explanation after TBI.
NPJ DIGITAL MEDICINE
(2023)
Article
Surgery
Maria J. Valkema, Manon C. W. Spaander, Jurjen J. Boonstra, Jolanda M. van Dieren, Wouter L. Hazen, G. Willemien Erkelens, I. Lisanne Holster, Andries van der Linden, Klaas van der Linde, Liekele E. Oostenbrug, Rutger Quispel, Erik J. Schoon, Peter D. Siersema, Michail Doukas, Ben M. Eyck, Berend J. van der Wilk, Pieter C. van der Sluis, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, J. Jan B. van Lanschot
Summary: This study aimed to assess the prevalence and severity of dysphagia in patients with preserved esophagus after neoadjuvant chemoradiotherapy. The results showed that dysphagia and clinically relevant stenosis were uncommon during active surveillance.
BRITISH JOURNAL OF SURGERY
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Siri Lise van der Meijden, Anna van Boekel, Laurens Schinkelshoek, Harry van Goor, Mark de Boer, Ewout Steyerberg, Bart Geerts, Sesmu Arbous
Summary: Currently, postoperative infections are identified through manual chart review. In this study, a validated automated labeling method based on registrations and treatments was used to develop a high-quality prediction model (AUC 0.81) for postoperative infections.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)
