期刊
GASTROENTEROLOGY
卷 139, 期 6, 页码 1972-1983出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2010.08.051
关键词
Chronic Hepatitis C; Tolerability of High-Dose Pegylated Interferon; Steatosis and Response to HCV Therapy; Tolerability of High-Dose Ribavirin
资金
- Roche
- Gilead Sciences, Inc
- Tibotec
- Bristol-Myers Squibb
- Vertex Pharmaceuticals
- Merck Co, Inc
- Boehringer Ingelheim
- Exalenz
- Biolex
- Celera Diagnostics
- LLC
- Conatus Pharmaceuticals
- Gilead Sciences Inc
- GlaxoSmithKline
- GlobeImmune, Inc
- Human Genome Sciences, Inc
- Idenix Pharmaceuticals
- Johnson & Johnson/Tibotec
- Pharmasset, Inc
- Romark Laboratories
- LC
- Schering-Plough
- Valeant
- Wyeth
- ZymoGenetics
- Genentech Inc
- Pfizer Inc
- Rottapharm
BACKGROUND & AIMS: Patients infected with hepatitis C virus (HCV) genotype 1, body weight >= 85 kg, and high baseline viral load respond poorly to standard doses of pegylated interferon (peginterferon) and ribavirin. We evaluated intensified therapy with peginterferon alfa-2a plus ribavirin. METHODS: This double-blind randomized trial included HCV genotype 1-infected outpatients from hepatology clinics with body weight >= 85 kg and HCV RNA titer >= 400,000 IU/mL. Patients were randomized to 180 mu g/wk peginterferon alfa-2a for 48 weeks plus 1200 mg/day ribavirin (standard of care) (group A, n = 191) or 1400/1600 mg/day ribavirin (group B, n = 189). Additional groups included 360 mu g/wk peginterferon alfa-2a for 12 weeks then 180 mu g/wk peginterferon alfa-2a for 36 weeks plus 1200 mg/day ribavirin (group C, n = 382) or 1400/1600 mg/day ribavirin (group D, n = 383). Follow-up lasted 24 weeks after treatment. RESULTS: Sustained virologic response rates (HCV RNA level <15 IU/mL at end of follow-up) in groups A, B, C, and D were 38%, 43%, 44%, and 41%, respectively. There were no significant differences among the 4 groups or between pooled peginterferon alfa-2a regimens (A + B vs C + D: odds ratio [OR], 1.08; 95% confidence interval [CI], 0.83-1.39; P = .584) or pooled ribavirin regimens (A + C vs B + D: OR, 1.00; 95% CI, 0.79 1.28; P = .974). CONCLUSIONS: In patients infected with HCV genotype 1 who are difficult to treat (high viral load, body weight >= 85 kg), a 12-week induction regimen of peginterferon alfa-2a and/or higher-dose ribavirin is not more effective than the standard regimen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据