Article
Cell Biology
Xiang Li, Chen Jin, Qi Chen, Xihua Zheng, Di Xie, Qielan Wu, Lu Wang, Shiyu Bai, Huimin Zhang, Li Bai
Summary: Invariant NK T (iNKT) cells are enriched in the liver, where a liver-specific CD24(+) iNKT subset with high proliferation and metabolism activity is found but lower granzyme B production. The liver microenvironment also influences the differentiation of conventional T cells, leading to the generation of CD24(+) T cells with different functional characteristics. These findings suggest that the liver microenvironment may induce the generation of a liver-specific iNKT subset that plays a crucial role in maintaining liver homeostasis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ho Rim Oh, Min Kyung Ko, Daehee Son, Young Wook Ki, Shin-Il Kim, Seok-Yong Lee, Keon Wook Kang, Gi Jeong Cheon, Do Won Hwang, Hyewon Youn
Summary: Activated hepatic stellate cells (HSCs) play a detrimental role in liver fibrosis progression. Natural killer (NK) cells have therapeutic effects in a CCl4-induced liver cirrhosis mouse model by reducing collagen deposition, HSC marker activation, and macrophage infiltration. The repetitive administration of NK cells alleviates liver fibrosis through anti-fibrotic and anti-inflammatory mechanisms.
Article
Cell Biology
Sophia Papaioannou, Jia-Xiang See, Mingeum Jeong, Carolina De La Torre, Volker Ast, Philipp-Sebastian Reiners-Koch, Ankita Sati, Carolin Mogler, Michael Platten, Adelheid Cerwenka, Ana Stojanovic
Summary: Liver sinusoidal endothelial cells (LSECs) respond to LPS and immune-derived signals, producing chemokines CCL2 and CXCL10. NK cells exposed to LSECs in vitro are primed for higher production of IFN-g in response to IL-12 and IL-18. In inflamed livers, NK cells are the major producers of IFN-g. This positive feedback loop of immune cell attraction and activation is regulated by LSECs and is important in liver inflammation.
Article
Immunology
Zhenya Guo, Junze Chen, Yonglian Zeng, Zefeng Wang, Mei Yao, Stephen Tomlinson, Bin Chen, Guandou Yuan, Songqing He
Summary: In this study, the role of complement in cholestatic liver injury (CLI) was investigated. It was found that complement is involved in the infiltration and activation of neutrophils and macrophage M1 polarization in the liver. C3 deficiency and CR2-Crry significantly alleviated CLI. Inhibition of complement could preserve the protective function of macrophages in clearing lipopolysaccharide (LPS), suggesting that complement inhibition could be useful in treating CLI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dezhao Li, Mei Liu, Jinhuan Wang, Jia Guo, Ningzhi Xu, Jun Lu
Summary: This case report describes a patient with advanced gastric adenocarcinoma who achieved pathological complete response (pCR) after receiving multimodal therapy. The therapy consisted of SOX chemotherapy, anti-programmed cell death-1 (PD-1) therapy, and invariant natural killer T (iNKT) cell immunotherapy. The patient's unresectable liver metastases became resectable after the combined treatment, and surgical resection was performed. This is the first reported case of pCR in a metastatic gastric cancer patient after six months of multimodal therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Robert Ose, Benno Weigmann, Detlef Schuppan, Ari Waisman, Joachim Saloga, Iris Bellinghausen
Summary: CD56(+)CD3(+) iNKT cells promote allergen-specific gut and lung inflammation in PBMC-engrafted humanized mice, opening up new possibilities for therapeutic intervention in allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Chiara Di Censo, Marie Marotel, Irene Mattiola, Lena Mueler, Gianluca Scarno, Giuseppe Pietropaolo, Giovanna Peruzzi, Mattia Laffranchi, Julija Mazej, Mohamed Shaad Hasim, Sara Asif, Eleonora Russo, Luana Tomaipitinca, Helena Stabile, Seung-Hwan Lee, Laura Vian, Massimo Gadina, Angela Gismondi, Han-Yu Shih, Yohei Mikami, Cristina Capuano, Giovanni Bernardini, Michael Bonelli, Silvano Sozzani, Andreas Diefenbach, Michele Ardolino, Angela Santoni, Giuseppe Sciume
Summary: Liver ILC1 exhibit heterogeneity in the expression of distinct effector molecules and surface receptors, with a subset expressing high levels of granzyme A enriched in adult mice. The heterogeneity of GzmA and CD160 expression in hepatic ILC1 begins perinatally and increases with age. ILC1 characterized by the expression of GzmA and CD160 show graded cytotoxic potential and ability to produce IFN-gamma, indicating functional diversification.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Ya Tan, Nan Zhao, Qiaoling Xie, Ziqian Xu, Jin Chai, Xiaoxun Zhang, Yan Li
Summary: Melatonin has been found to ameliorate cholestatic liver injury by inhibiting the inflammatory response. The levels of serum melatonin are significantly elevated in cholestatic patients. Mechanistic studies revealed that melatonin reduces the expression of cytokines through the ERK/Egr1 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Han Jiang, Hao Fu, Tao Min, Ping Hu, Jianlin Shi
Summary: This study proposes a mild magnetocaloric regulation approach using a magnetogenetic nanoplatform (MPFD) to promote the proliferation and activation of tumor-infiltrating NK cells in liver cancer immunotherapy. The magnetothermally responsive MPFD serves as a magnetism-heat nanotransducer to induce the gene transcription of IL-2 cytokine in orthotopic liver tumor for NK cell proliferation and activation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Immunology
Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Jae Hyun Yoon, Seung-Jung Kee, Hyo-Sin Kim, Yong-Wook Park
Summary: This study found that the levels and functions of MAIT cells, NKT cells, and NK cells in alcoholic liver cirrhosis (ALC) patients are decreased and related to clinical parameters. These findings provide important information about the immune responses of ALC patients.
Article
Biochemistry & Molecular Biology
Meng Song, Zijun Chen, Ruian Qiu, Tingwei Zhi, Wenmin Xie, Yingya Zhou, Nachuan Luo, Fuqian Chen, Fang Liu, Chuangpeng Shen, Sheng Lin, Fengxue Zhang, Yong Gao, Changhui Liu
Summary: Excessive accumulation of bile acids (BA) in hepatocytes triggers inflammatory response and recruitment of macrophages, accelerating cholestatic liver injury. This study reveals the importance of crosstalk between hepatocytes and macrophages in the pathogenesis of cholestasis and suggests that blocking this crosstalk by inhibiting NLRP3 inflammasome activation may be a novel therapeutic strategy for cholestasis.
Article
Immunology
Jaya Lakshmi Thangaraj, Seo-Yeon Ahn, Sung-Hoon Jung, Manh-Cuong Vo, Tan-Huy Chu, Minh-Trang Thi Phan, Minsuk Kwon, Kyung-Hwa Lee, Mihee Kim, Ga-Young Song, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Duck Cho, Je-Jung Lee
Summary: The study shows that Dvd treatment enhances the cytotoxicity of NK cells, prolongs mouse survival, and reduces tumor burden. Furthermore, Dvd pretreatment increases NK cell persistence and homing to MM sites.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xiang Jiang, Yanan Peng, Lan Liu, Youwei Wang, Mengting Li, Wenjie Li, Fengxing Huang, Chunlan Zheng, Fei Xu, Qian Hu, Wanhui Wei, Shouquan Dong, Qiu Zhao
Summary: By enhancing the cytotoxicity of NK cells against hepatic stellate cells (HSCs), MAIT cells can ameliorate cholestatic liver fibrosis. A deeper understanding of the regulatory role of MAIT cells may provide valuable immunotherapy strategies for the treatment of liver fibrosis.
LIVER INTERNATIONAL
(2022)
Article
Immunology
Nicola Tumino, Francesca Besi, Stefania Martini, Anna Laura Di Pace, Enrico Munari, Linda Quatrini, Andrea Pelosi, Piera Filomena Fiore, Giulia Fiscon, Paola Paci, Francesca Scordamaglia, Maria Grazia Covesnon, Giuseppe Bogina, Maria Cristina Mingari, Lorenzo Moretta, Paola Vacca
Summary: The presence of polymorphonuclear myeloid-derived suppressor cells (MDSC) in the tumor microenvironment (TME) can inhibit the anti-tumor activity of natural killer (NK) cells. The interaction between MDSC and NK cells leads to the inhibition of major activating NK receptors, NK cytolytic activity, and cytokine production. Exosomes derived from MDSC are responsible for the immunosuppressive effect on NK cell-mediated anti-tumor activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Junqi Wang, Xiaolin Liu, Tianqiang Jin, Yuqing Cao, Yu Tian, Feng Xu
Summary: NK cells have potential in tumor immunotherapy, but their metabolism in the liver cancer microenvironment is not fully understood. The interaction between immune checkpoints and metabolic checkpoints in NK cells plays a role in their development and function. Understanding NK cell metabolic reprogramming is important for improving the efficacy of liver cancer therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Courtney K. Anderson, Alexander I. Salter, Leon E. Toussaint, Emma C. Reilly, Celine Fugere, Neetu Srivastava, William G. Kerr, Laurent Brossay
JOURNAL OF IMMUNOLOGY
(2015)
Review
Immunology
Timothy K. Erick, Laurent Brossay
CURRENT OPINION IN IMMUNOLOGY
(2016)
Review
Genetics & Heredity
Courtney K. Anderson, Laurent Brossay
Article
Immunology
Timothy K. Erick, Courtney K. Anderson, Emma C. Reilly, Jack R. Wands, Laurent Brossay
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
S. M. Shahjahan Miah, Chathuraka T. Jayasuriya, Alexander I. Salter, Emma C. Reilly, Celine Fugere, Wentian Yang, Qian Chen, Laurent Brossay
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Hematology
Cindy Banh, S. M. Shahjahan Miah, William G. Kerr, Laurent Brossay
Article
Multidisciplinary Sciences
Emma C. Reilly, Elizabeth A. Thompson, Sandrine Aspeslagh, Jack R. Wands, Dirk Elewaut, Laurent Brossay
Article
Multidisciplinary Sciences
Jean Guan, S. M. Shahjahan Miah, Zachary S. Wilson, Timothy K. Erick, Cindy Banh, Laurent Brossay
Article
Multidisciplinary Sciences
Charlene Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Courtney K. Anderson, Emma C. Reilly, Angus Y. Lee, Laurent Brossay
Article
Cell Biology
Garvin Dodard, Angela Tata, Timothy K. Erick, Diego Jaime, S. M. Shahjahan Miah, Linda Quatrini, Bertrand Escaliere, Sophie Ugolini, Eric Vivier, Laurent Brossay
Article
Immunology
Courtney K. Anderson, Shanelle P. Reilly, Laurent Brossay
Summary: IL-12, IL-18, and TLRs are dispensable for TCR activation pathway in iNKT cells, but are essential during murine CMV infection. There is an intrinsic requirement for IL-18 signaling by splenic iNKT cells but not liver iNKT cells. The exact contributions of these components for TCR-dependent and -independent activation pathways in iNKT cells are still unclear.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Cyril Seillet, Laurent Brossay, Eric Vivier
Summary: ILC1 and NK cells share common features but have great heterogeneity in tissues, posing a challenge in distinguishing between the two cell types.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Review
Immunology
Eric Vivier, Sophie Ugolini, Didier Blaise, Christian Chabannon, Laurent Brossay
NATURE REVIEWS IMMUNOLOGY
(2012)
Article
Oncology
Angela Tata, Garvin Dodard, Celine Fugere, Corinne Leget, Melody Ors, Benjamin Rossi, Eric Vivier, Laurent Brossay
Summary: Blocking KLRG1 enhances anti-tumor immunity mediated by NK cells and CD8(+) T cells, and synergizes with PD-1 checkpoint therapy to significantly decrease tumor growth. Double blockade therapy leads to decreased tumor size, increased frequency and activation of T cells and NK cells in the tumor microenvironment.