Article
Neurosciences
Ting-Ting Zhan, Zhi-Yu Dong, Li-Sha Yi, Yan Zhang, Hui-Hui Sun, Hai-Qin Zhang, Jun-Wen Wang, Ying Chen, Ying Huang, Shu-Chang Xu
Summary: Tandospirone, a third-generation antianxiety agent, activates 5-HT1A receptors to alleviate stress-induced anxiety and visceral hypersensitivity. In a rat model of chronic water avoidance stress, tandospirone reduced anxiety-like behavior and visceral hypersensitivity. It also decreased theta oscillation enhancement in the anterior cingulate cortex (ACC), thereby relieving anxiety and visceral hypersensitivity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pedro Gomes, Valerie Laroute, Catherine Beaufrand, Marie-Line Daveran-Mingot, Nathalie Aubry, Chloe Liebgott, Nathalie Ballet, Sophie Legrain-Raspaud, Vassilia Theodorou, Muriel Mercier-Bonin, Muriel Cocaign-Bousquet, Helene Eutamene
Summary: Irritable bowel syndrome is a gastrointestinal disorder characterized by visceral hypersensitivity, which is exacerbated by stress. Gut bacteria that produce gamma-amino butyric acid (GABA) show promise in alleviating IBS symptoms. This study identified a strain of lactococcus lactis, CNCM I-5388, with increased GABA production rate and demonstrated its potential as a therapeutic agent for managing visceral hypersensitivity in IBS patients.
Article
Biochemistry & Molecular Biology
Xiuwen Li, Chunlei Miao, Lin Wang, Mengyan Liu, Huanchao Chang, Bo Tian, Di Wang
Summary: Epithelial ovarian cancer (EOC) is strongly associated with estrogen, and PTEN serves as a tumor suppressor regulating cell proliferation, migration, and survival. This research reveals that estrogen decreases PTEN expression via the ESR1 genomic pathway and phosphorylates PTEN via the GPR30-PKC non-genomic pathway. These pathways activate the PI3K/AKT/mTOR signaling pathway, affecting the fate of EOC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Neurosciences
Si-Ting Huang, Bin-Bin Chen, Zhi-Jing Song, Hui-Li Tang, Rong Hua, Yong-Mei Zhang
Summary: The Epac1-SOCS3 signaling pathway plays a significant role in visceral hypersensitivity. In this study, changes in the expression of Epac1 and SOCS3, as well as elevated levels of IL-6, were observed in a neonatal colorectal distension-induced visceral hypersensitivity model. Interventions targeting Epac1, SOCS3, or IL-6 were found to alleviate the symptoms of visceral hypersensitivity.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
H. Eutamene, C. Beaufrand, N. Bekkat, H. Mathiex-fortunet, V. Theodorou
Summary: Diosmectite treatment attenuates stress-induced visceral hypersensitivity and may contribute to the therapeutic effect in irritable bowel syndrome.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H. Winston
Summary: The study found that female offspring of dams subjected to chronic prenatal stress develop enhanced visceral hypersensitivity following exposure to chronic stress in adult life, which is mediated by up-regulation of spinal cord BDNF, estrogen receptor alpha, and an increase in spinal serotonin signaling.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Neurosciences
Enfu Tao, Gao Long, Ting Yang, Bo Chen, Rui Guo, Diya Ye, Marong Fang, Mizu Jiang
Summary: Maternal separation in early life induces visceral hypersensitivity in post-weaning mice. The development of a novel and small size distention balloon allows for better evaluation of visceral sensitivity and further study of the pathophysiology of IBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang
Summary: The microglia-GABAergic neuron circuit in the limbic area, specifically BNST, plays a crucial role in the development of colorectal hypersensitivity and visceral pain. The decrease in GABAergic neuron activity and increase in proinflammatory microglia activity are associated with chronic visceral pain. Inhibition of microglial activity and neutralization of proinflammatory cytokines can alleviate visceral pain. This study provides new insights and potential targets for treating IBS-related visceral pain.
NEUROBIOLOGY OF STRESS
(2022)
Article
Integrative & Complementary Medicine
Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu
Summary: The study demonstrated that acupuncture at the Shangjuxu (ST37) acupoint can significantly alleviate inflammatory pain in acute visceral hyperalgesia by regulating the NGF-induced PI3K/Akt pathway. In contrast, acupuncture at the Quchi (LI11) acupoint did not show similar effects in this rat model. This suggests that the TRPV1 regulation via the NGF-induced PI3K/Akt pathway plays a vital role in the effects of acupuncture-mediated amelioration of acute visceral hyperalgesia.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Sergio Lopez-Estevez, Josep Manuel Lopez-Torrellardona, Marc Parera, Vicente Martinez
Summary: This study explores the validity of DSS-induced colitis in rats as a model to mimic chronic intestinal hypersensitivity. The results indicate that DSS-induced colitis can generate a long-lasting state of visceral hypersensitivity and reproduce the changes in intestinal sensitivity characteristics of inflammatory and functional gastrointestinal disorders in humans. This research is of great importance for the development of new pharmacological treatments against visceral pain.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, Research & Experimental
Mohadeseh Chahkandi, Gholamreza Komeili, Gholamreza Sepehri, Mohammad Khaksari, Sedigheh Amiresmaili
Summary: This study examined the interference of marijuana and estrogen (E2) on spatial learning and memory in young female rats, finding that they interact in affecting spatial learning and memory, with GPR30 seemingly playing no role in this interaction.
Article
Pharmacology & Pharmacy
Yanmeng Zhou, Bingbing Xu, Haiyang Yu, Wei Zhao, Xinxin Song, Yan Liu, Kainan Wang, Nikoli Peacher, Xiaomin Zhao, Han-Ting Zhang
Summary: BCA can improve memory in postmenopausal women with estrogen deficiency by reducing oxidative damage, enhancing intracellular antioxidant enzyme activity, promoting neuronal viability, reversing apoptosis and ROS accumulation, and protecting neurons from damage.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Su-Hong Chen, Li-Jie Zhu, Yi-Hui Zhi, Han-Song Wu, Lin-Zi Li, Bo Li, Shu-Hua Shen, Gui-Yuan Lv, Kun-Gen Wang
Summary: The aim of this study was to explore the efficacy and mechanism of action of PTS on rats with FD induced by iodoacetamide gavage and tail clamping. Network pharmacology approach identified 139 bioactive components and 17 potential targets of PTS, indicating that PTS could reduce 5-HT secretion and alleviate FD symptoms through the serotonergic synaptic pathway. Animal experiments showed that PTS increased body weight and food intake, improved autonomous activity, and decreased gastric acidity and secretion. Furthermore, PTS significantly decreased gastric sensitivity and improved gastrointestinal motility and the levels of GAS and MTL in FD rats.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Cell Biology
Elena Lucarini, Alessio Nocentini, Alessandro Bonardi, Niccolo Chiaramonte, Carmen Parisio, Laura Micheli, Alessandra Toti, Valentina Ferrara, Donatello Carrino, Alessandra Pacini, Maria Novella Romanelli, Claudiu T. Supuran, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Summary: This study showed that selective CA IV inhibitors AB-118 and NIK-67 effectively counteracted visceral pain induced by DNBS in rats, with AB-118 also showing a protective effect against colon damage.
Article
Geriatrics & Gerontology
Yifan Lv, Fengliang Wang, Yunlu Sheng, Fan Xia, Yi Jin, Guoxian Ding, Xiaodong Wang, Jing Yu
Summary: Increased visceral fat in postmenopausal women is associated with metabolic complications and cardiovascular events. The effect of estrogen replacement therapy on visceral adipose tissue and its underlying mechanism are still controversial. This study investigated the function of visceral adipose tissue and found that estrogen supplementation in postmenopausal women led to adverse effects on visceral fat function, potentially through the ERp pathway.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Health Care Sciences & Services
Rodrigo Vazquez Guillamet, Oleg Ursu, Gary Iwamoto, Pope L. Moseley, Tudor Oprea
HEALTH INFORMATICS JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Oleg Ursu, Jayme Holmes, Cristian G. Bologa, Jeremy J. Yang, Stephen L. Mathias, Vasileios Stathias, Dac-Trung Nguyen, Stephan Schurer, Tudor Oprea
NUCLEIC ACIDS RESEARCH
(2019)
Review
Pharmacology & Pharmacy
Andreu Bofill, Xavier Jalencas, Tudor Oprea, Jordi Mestres
DRUG DISCOVERY TODAY
(2019)
Article
Clinical Neurology
Anastasiya Nestsiarovich, Berit Kerner, Aurelien J. Mazurie, Daniel C. Cannon, Nathaniel G. Hurwitz, Yiliang Zhu, Stuart J. Nelson, Tudor Oprea, Mark L. Unruh, Annette S. Crisanti, Mauricio Tohen, Douglas J. Perkins, Christophe G. Lamberet
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Review
Biochemistry & Molecular Biology
Tudor I. Oprea
Editorial Material
Biotechnology & Applied Microbiology
Melissa Haendel, Nicole Vasilevsky, Deepak Unni, Cristian Bologa, Nomi Harris, Heidi Rehm, Ada Hamosh, Gareth Baynam, Tudor Groza, Julie McMurry, Hugh Dawkins, Ana Rath, Courtney Thaxon, Giovanni Bocci, Marcin P. Joachimiak, Sebastian Koehler, Peter N. Robinson, Chris Mungall, Tudor I. Oprea
NATURE REVIEWS DRUG DISCOVERY
(2020)
Review
Pharmacology & Pharmacy
Alex Zhavoronkov, Quentin Vanhaelen, Tudor I. Oprea
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Review
Pharmacology & Pharmacy
Giovanni Bocci, Leslie Z. Benet, Tudor Oprea
DRUG DISCOVERY TODAY
(2019)
Correction
Biotechnology & Applied Microbiology
Erik Tambuyzer, Benjamin Vandendriessche, Christopher P. Austin, Philip J. Brooks, Kristina Larsson, Katherine I. Miller Needleman, James Valentine, Kay Davies, Stephen C. Groft, Robert Preti, Tudor I. Oprea, Marco Prunotto
NATURE REVIEWS DRUG DISCOVERY
(2020)
Review
Biotechnology & Applied Microbiology
Erik Tambuyzer, Benjamin Vandendriessche, Christopher P. Austin, Philip J. Brooks, Kristina Larsson, Katherine I. Miller Needleman, James Valentine, Kay Davies, Stephen C. Groft, Robert Preti, Tudor I. Oprea, Marco Prunotto
NATURE REVIEWS DRUG DISCOVERY
(2020)
Article
Endocrinology & Metabolism
Anastasiya Nestsiarovich, Bent Kerner, Aurelien J. Mazurie, Daniel C. Cannon, Nathaniel G. Hurwitz, Yiliang Zhu, Stuart J. Nelson, Tudor I. Oprea, Annette S. Crisanti, Mauricio Tohen, Douglas J. Perkins, Christophe G. Lambert
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Gergely Zahoranszky-Kohalmi, Timothy Sheils, Tudor I. Oprea
JOURNAL OF CHEMINFORMATICS
(2020)
Editorial Material
Biotechnology & Applied Microbiology
Jeremy M. Levin, Tudor I. Oprea, Sagie Davidovich, Thomas Clozel, John P. Overington, Quentin Vanhaelen, Charles R. Cantor, Evelyne Bischof, Alex Zhavoronkov
NATURE BIOTECHNOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Eugene N. Muratov, Jurgen Bajorath, Robert P. Sheridan, Igor Tetko, Dmitry Filimonov, Vladimir Poroikov, Tudor Oprea, Igor I. Baskin, Alexandre Varnek, Adrian Roitberg, Olexandr Isayev, Stefano Curtarolo, Denis Fourches, Yoram Cohen, Alan Aspuru-Guzik, David A. Winkler, Dimitris Agrafiotis, Artem Cherkasov, Alexander Tropsha
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Biochemistry & Molecular Biology
Chetana M. Revankar, Cristian G. Bologa, Richard A. Pepermans, Geetanjali Sharma, Whitney K. Petrie, Sara N. Alcon, Angela S. Field, Chinnasamy Ramesh, Matthew A. Parker, Nikolay P. Savchuk, Larry A. Sklar, Helen J. Hathaway, Jeffrey B. Arterburn, Tudor Oprea, Eric R. Prossnitz
CELL CHEMICAL BIOLOGY
(2019)