Article
Gastroenterology & Hepatology
Swathi Eluri, Sumana Reddy, Corey C. Ketchem, Manaswita Tappata, Hanna G. Nettles, Ariel E. Watts, Cary C. Cotton, Evan S. Dellon, Nicholas J. Shaheen
Summary: This study found that only 39% of eligible patients for Barrett's esophagus screening underwent upper esophagogastroduodenoscopy (EGD), with most of the examinations being triggered by refractory symptoms. Improved dissemination and implementation of BE screening are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Sydney R. A. Korsunsky, Leonel Camejo, Diep Nguyen, Rahul Mhaskar, Khattiya Chharath, Joy Gaziano, Joel Richter, Vic Velanovich
Summary: This study retrospectively analyzed the clinical evaluation, treatments, and outcomes of patients with hoarseness suspected to be caused by laryngopharyngeal reflux. Among the 134 included patients, most of them experienced improvement during the treatment and evaluation period, but no specific treatment type showed a clear association with the outcomes. Further research is needed to explore diagnostic criteria, efficient clinical evaluation methods, and potential beneficial treatments for laryngopharyngeal reflux.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Massimo Rugge, Hashem B. El-Serag
Summary: This study examined the prevalence of Barrett's esophagus in a previously unscreened primary care population and evaluated the performance of various BE screening guidelines. The findings suggest that guidelines requiring GERD symptoms have low sensitivity, while those not requiring GERD have low specificity. The study proposes a screening guideline with better utilization of known risk factors.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Chamara Basnayake, Annelies Geeraerts, Ans Pauwels, Ger Koek, Michael Vaezi, Tim Vanuytsel, Jan Tack
Summary: The prevalence of duodenogastroesophageal reflux (DGER) increases with more advanced esophageal lesions in patients with gastroesophageal reflux disease (GERD) and persists in patients on proton pump inhibitor (PPI) therapy. PPIs appear to be effective in treating DGER, but further research is needed for future therapies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mohammed A. Alsaleem, Nabil J. Awadalla, Shehata F. Shehata, Awad Saeed Alsamghan, Mohammed A. AlFlan, Marwan M. Alhumaidi, Mohamed S. Alwadai, Fahad S. Althabet, Mohamad S. Alzahrani, Safar A. Alsaleem, Ahmed A. Mahfouz
Summary: The study conducted in Abha city, Saudi Arabia found a high prevalence of GERD among attendants of primary health care centers. Significant independent factors associated with GERD included being unmarried, smoking, fast food intake, and subjective perception of stress. Community level awareness programs are recommended for GERD prevention and management.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Pediatrics
Emilie Raaum Closs, Karl Marild, Rasmus Gaardskaer Nielsen, Ketil Stordal
Summary: This study examined the use of proton pump inhibitors (PPIs) in Scandinavian children from 2007 to 2020, revealing geographical variation and temporal changes with the highest PPIs use in Norway. Despite similar healthcare systems and no indication of increased incidence of gastroesophageal reflux disease (GERD), the differences in PPIs use across countries and time may suggest current overtreatment.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pediatrics
Marc Martinez, Sandeep Rathod, Hunter J. Friesen, John M. Rosen, Craig A. Friesen, Jennifer V. Schurman
Summary: Rumination syndrome in children and adolescents has a prevalence ranging from 0 to 5.1%, possibly higher in clinical settings. It shares similarities with other functional gastrointestinal disorders, but the underlying cause remains unclear. More research is needed to understand the prevalence and underlying mechanisms of pediatric rumination syndrome.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Elisa Blasi, Ettore Stefanelli, Renato Tambucci, Silvia Salvatore, Paola De Angelis, Paolo Quitadamo, Claudia Pacchiarotti, Giovanni Di Nardo, Fanj Crocco, Enrico Felici, Valentina Giorgio, Nicoletta Staropoli, Simona Sestito, Efstratios Saliakellis, Osvaldo Borrelli, Licia Pensabene
Summary: This study investigated the prevalence of pediatric non-erosive esophageal phenotypes (NEEPs) and their treatment response. The results showed that functional heartburn may be the most common pediatric NEEP. Long-term follow-up revealed a higher rate of symptom resolution with proton pump inhibitor (PPI) therapy in non-erosive reflux disease (NERD) patients, while other groups did not benefit from extended acid-suppressive treatment.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, Research & Experimental
Jerome R. Lechien, Stephane Hans, Lisa G. De Marrez, Didier Dequanter, Alexandra Rodriguez, Vinciane Muls, Fairouz Ben Abdelouahed, Laurence Evrard, Antonino Maniaci, Sven Saussez, Francois Bobin
Summary: This study investigated the prevalence and features of laryngopharyngeal reflux in patients with primary burning mouth syndrome. The results showed that different types of laryngopharyngeal reflux may be involved in the development of BMS. Treatment with a combination of diet, pantoprazole, and alginate led to improvements in symptoms and clinical findings, with improvements in mouth/tongue burning, reflux symptom score, and reflux sign assessment scores post-treatment.
Article
Gastroenterology & Hepatology
Dag Holmberg, Giola Santoni, My Catarina von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren
Summary: This population-based cohort study conducted in Denmark, Finland, Norway, and Sweden from 1979 to 2018 found that negative upper endoscopy in patients with GERD is associated with a significant and long-lasting decrease in both incidence and mortality of upper gastrointestinal cancer. The risk reduction persisted for at least 5 years in incidence and 10 years in mortality after a negative upper endoscopy.
Article
Anesthesiology
Glenys G. Somayajula, Paul Campbell, Joanne Protheroe, Rosie J. Lacey, Kate M. Dunn
Summary: A significant proportion of children/adolescents report chronic widespread pain (CWP). Risk factors associated with CWP onset include mental health issues, neurological symptoms, genitourinary problems, gastrointestinal issues, and throat problems.
Article
Pediatrics
Charlotte Flatres, Madeleine Aumar, Delphine Ley, Rony Sfeir, Audrey Nicolas, Michel Bonnevalle, Alain Duhamel, Frederic Gottrand
Summary: This study demonstrates a high prevalence of acid gastroesophageal reflux disease (GERD) in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with proton pump inhibitors (PPI) is stopped.
PEDIATRIC RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Eugenia S. Flouraki, Ioannis Savvas, George Kazakos, Tilemahos Anagnostou, Dimitrios Raptopoulos
Summary: This study evaluated the effect of different premedication medications on the incidence of gastroesophageal reflux in anesthetized dogs. The results showed that adding opioids increased the incidence of reflux, and castrations had a higher incidence compared to invasive diagnostic procedures. However, the specific type of opioid used did not significantly affect the incidence of reflux.
Article
Gastroenterology & Hepatology
Magnus Halland, Adil E. Bharucha, Michael D. Crowell, Karthik Ravi, David A. Katzka
Summary: The study showed that diaphragmatic breathing can reduce the number of postprandial reflux events in patients with upright GERD by increasing the difference between LES and gastric pressure. These findings support further investigation of diaphragmatic breathing as a therapy for GERD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)