Review
Biochemistry & Molecular Biology
Hela Mkaouar, Vincent Mariaule, Soufien Rhimi, Juan Hernandez, Aicha Kriaa, Amin Jablaoui, Nizar Akermi, Emmanuelle Maguin, Adam Lesner, Brice Korkmaz, Moez Rhimi
Summary: Inflammatory bowel diseases are incurable disorders with increasing prevalence and global socioeconomic impact. Gut microbiota dysbiosis and increased activity of serine proteases may play roles in the onset and maintenance of the disease, with potential therapeutic relevance of gut microbiota serpins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Shunying Yu, Yibin Sun, Xinyu Shao, Yuqing Zhou, Yang Yu, Xiaoyi Kuai, Chunli Zhou
Summary: Inflammatory bowel disease (IBD) is a global disease with increasing incidence. The gut, containing abundant lymphoid tissue and nervous system components, plays a crucial role in maintaining intestinal homeostasis. Disruption of the intestinal barrier, referred to as a leaky gut, is associated with changes leading to IBD. The interaction between the intestinal barrier and gut microbiota is particularly important in the development of IBD.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Food Science & Technology
Zongxin Ling, Xia Liu, Yiwen Cheng, Xiumei Yan, Shaochang Wu
Summary: The altered assembly, structure and dynamics of the gut microbiota actively participate in the aging process, affecting healthy aging and age-associated diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Dermatology
Alireza Beheshti-Maal, Shabnam Shahrokh, Saham Ansari, Elnaz Sadat Mirsamadi, Abbas Yadegar, Hamed Mirjalali, Mohammad Reza Zali
Summary: The inflammatory bowel disease is a multi-factorial autoimmune disorder with unknown causative agents. The gut microbiota, mainly composed of bacteria, plays a crucial role in maintaining gut homeostasis and mucosal immune responses, and the interaction between gut bacteria and fungi seems to be an important subject in IBD patients.
Article
Microbiology
Yuanyuan Ma, Tianyao Liu, Xin Li, Anqi Kong, Rui Xiao, Ruxin Xie, Junwei Gao, Zhongke Wang, Yun Cai, Jiao Zou, Ling Yang, Lian Wang, Jinghui Zhao, Haiwei Xu, Warner Margaret, Xingshun Xu, Jan-Ake Gustafsson, Xiaotang Fan
Summary: The gut microbiota plays a critical role in mediating the development of colitis and anxiety-like behaviors. Lack of ER beta leads to changes in the gut microbiota composition, exacerbating colitis and anxiety-like behaviors. Remodeling of the gut microbiota can inhibit the development of colitis and anxiety-like behaviors.
Article
Biochemistry & Molecular Biology
Luis Mayorga, Gerard Serrano-Gomez, Zixuan Xie, Natalia Borruel, Chaysavanh Manichanh
Summary: The study found that geographical location, disease activity status, and other environmental factors are important contributing factors to microbiota changes in inflammatory bowel disease (IBD). CD patients from different countries may have similar microbial taxonomic profiles. Therefore, these factors should be considered in future IBD research to obtain globally valid and reproducible biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Pauline Raoul, Marco Cintoni, Marta Palombaro, Luisa Basso, Emanuele Rinninella, Antonio Gasbarrini, Maria Cristina Mele
Summary: Diet is a crucial factor in causing and treating inflammatory bowel disease (IBD). Food additives, such as artificial emulsifiers and sweeteners, can disrupt the gut microbiota and lead to chronic inflammation in the intestines, accelerating the onset of IBD. While more research is needed, it is advisable for IBD patients to avoid processed foods containing artificial food additives.
Article
Microbiology
Caijun Zhao, Xiaoyu Hu, Min Qiu, Lijuan Bao, Keyi Wu, Xiangyue Meng, Yihong Zhao, Lianjun Feng, Shiyu Duan, Yuhong He, Naisheng Zhang, Yunhe Fu
Summary: This study demonstrates that gut microbiota disturbance caused by metabolic abnormalities of gut microbiota is associated with the occurrence and development of mastitis. The underlying mechanism of how gut dysbiosis leads to mastitis pathogenesis remains unclear. Additionally, the regulation of commensal bacteria and gut metabolism may provide a potential strategy for mastitis intervention.
Review
Immunology
Kazuma Yagi, Nobuhiro Asai, Gary B. Huffnagle, Nicholas W. Lukacs, Wendy Fonseca
Summary: Several environmental factors can impact the development of early-life microbiota, which in turn affects the occurrence of respiratory tract infections and diseases. The role of gut and lung microbiota in airway diseases, particularly in the context of respiratory syncytial virus (RSV) infection, is of increasing interest.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler
Summary: Colorectal cancer is a complex condition caused by a combination of environmental, genetic, and epigenetic factors, with disruptions in gut microbiota structure associated with various intestinal diseases, including cancer. Bacteria can induce cellular transformation and promote tumor progression through mechanisms such as biofilm formation and genotoxin secretion. The gut microbiota is also involved in drug metabolism, radiotherapy responses, and targeted immunotherapy, with therapy efficacy varying based on the composition of the host's gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Microbiology
Nicolas Benech, Nathalie Rolhion, Harry Sokol
Summary: This study demonstrates a new mechanism by which bacteria can control intestinal motility and vagal neuronal activation through tryptophan catabolites acting on the TrpA1 receptor of enteroendocrine cells.
CELL HOST & MICROBE
(2021)
Review
Microbiology
Ganggang Chen, Fenglei Shi, Wei Yin, Yao Guo, Anru Liu, Jiacheng Shuai, Jinhao Sun
Summary: Alcohol use disorder (AUD) disrupts the gut barrier and alters gut microbiota composition, leading to impaired brain function and worsening mental status of patients. This review explores the potential mechanisms by which alcohol affects gut and brain function through the gut microbiota and discusses the regulation of neurotransmitter release. Fecal microbiota transplantation could be a potential intervention for alcohol addiction.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Nidhi Singh, Veer Singh, Sachchida Nand Rai, Vishal Mishra, Emanuel Vamanu, Mohan P. Singh
Summary: The central nervous system plays an essential role in regulating the physiological condition of the human body. Gut microbes can affect brain function by releasing neuroactive metabolites, and they also play a role in neurological diseases. The microbiota-gut-brain axis serves as a communication pathway between the gut and brain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Harry Sokol, Tatiana Galperine, Nathalie Kapel, Pierre Bourlioux, Philippe Seksik, Frederic Barbut, Julien Scanzi, Francois Chast, Rui Batista, Francisca Joly, Anne-Christine Joly, Anne Collignon, Benoit Guery, Laurent Beaugerie
DIGESTIVE AND LIVER DISEASE
(2016)
Article
Gastroenterology & Hepatology
Franck Carbonnel, Jean Frederic Colombel, Jerome Filippi, Konstantinos H. Katsanos, Laurent Peyrin-Biroulet, Mathieu Allez, Maria Nachury, Gottfried Novacek, Silvio Danese, Vered Abitbol, Fabrizio Bossa, Jacques Moreau, Gilles Bommelaer, Arnaud Bourreille, Mathurin Fumery, Xavier Roblin, Walter Reinisch, Yoram Bouhnik, Hedia Brixi, Philippe Seksik, Georgia Malamut, Martti Farkkila, Baya Coulibaly, Olivier Dewit, Edouard Louis, Dominique Deplanque, Pierre Michetti, Helene Sarter, David Laharie
Article
Gastroenterology & Hepatology
Harry Sokol, Valentin Leducq, Hugues Aschard, Hang-Phuong Pham, Sarah Jegou, Cecilia Landman, David Cohen, Giuseppina Liguori, Anne Bourrier, Isabelle Nion-Larmurier, Jacques Cosnes, Philippe Seksik, Philippe Langella, David Skurnik, Mathias L. Richard, Laurent Beaugerie
Article
Gastroenterology & Hepatology
Florian Poullenot, Philippe Seksik, Laurent Beaugerie, Aurelien Amiot, Maria Nachury, Vered Abitbol, Carmen Stefanescu, Catherine Reenaers, Mathurin Fumery, Anne-Laure Pelletier, Stephane Nancey, Laurent Peyrin-Biroulet, Arnaud Bourreille, Xavier Hebuterne, Hedia Brixi, Guillaume Savoye, Nelson Lourenco, Romain Altwegg, Anthony Buisson, Christine Cazelles-Boudier, Antoine Racine, Julien Vergniol, David Laharie
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Biochemistry & Molecular Biology
Bruno Lamas, Mathias L. Richard, Valentin Leducq, Hang-Phuong Pham, Marie-Laure Michel, Gregory Da Costa, Chantal Bridonneau, Sarah Jegou, Thomas W. Hoffmann, Jane M. Natividad, Loic Brot, Soraya Taleb, Aurelie Couturier-Maillard, Isabelle Nion-Larmurier, Fatiha Merabtene, Philippe Seksik, Anne Bourrier, Jacques Cosnes, Bernhard Ryffel, Laurent Beaugerie, Jean-Marie Launay, Philippe Langella, Ramnik J. Xavier, Harry Sokol
Article
Gastroenterology & Hepatology
Charlotte Gagniere, Anne Bourrier, Philippe Seksik, Jean-Marc Gornet, Olivier DeWit, Stephane Nancey, Romain Altwegg, Vered Abitbol, David Laharie, Catherine Reenaers, Anthony Buisson, Benjamin Pariente, Stephanie Viennot, Lucine Vuitton, Carmen Stefanescu, Philippe Marteau, Guillaume Bouguen, Jacques Cosnes, Aurelien Amiot
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Magali Svrcek, Guillaume Le Gall, Cecilia Landman, Xavier Dray, Anne Bourrier, Isabelle Nion-Larmurier, Nadia Hoyeau, Harry Sokol, Philippe Seksik, Jacques Cosnes, Jean-Francois Flejou, Laurent Beaugerie, Lionel Arrive, Laurent Beaugerie, Anne Bourrier, Marine Camus, Najim Chafai, Edouard Chambenois, Ulriikka Chaput, Clotilde Debove, Charlotte Delattre, Xavier Dray, Jean-Francois Flejou, Guillaume Le Gall, Nadia Hoyeau, Julien Kirchgesner, Cecilia Landman, Jeremie H. Lefevre, Philippe Marteau, Chloe Martineau, Laurence Monnier-Cholley, Violaine Ozenne, Yann Parc, Philippe Seksik, Harry Sokol, Magali Svrcek, Emmanuel Tiret
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sara Ghezzal, Barbara Graziela Postal, Elodie Quevrain, Loic Brot, Philippe Seksik, Armelle Leturque, Sophie Thenet, Veronique Carriere
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Review
Immunology
Garance Coquant, Jean-Pierre Grill, Philippe Seksik
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Agathe Peyrottes, Garance Coquant, Loic Brot, Dominique Rainteau, Philippe Seksik, Jean-Pierre Grill, Jean-Maurice Mallet
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Gabrielle Schanne, Martha Zoumpoulaki, Geraldine Gazzah, Amandine Vincent, Hugues Preud'homme, Ryszard Lobinski, Sylvie Demignot, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
Summary: Oxidative stress is important in the pathogenesis of inflammatory bowel diseases (IBDs). Superoxide dismutase (SOD) defenses are weakened in IBD patients. A Mn(II) complex SOD mimic (Mn1) based on an open-chain diaminoethane ligand has antioxidant and anti-inflammatory effects. Metal exchanges occur between the manganese center and metal ions in the biological environment. New Mn(II) complexes with cyclohexyl and/or propyl groups show improved SOD activity and kinetic inertness in metal ion exchange processes. They provide anti-inflammatory and antioxidant effects in cells at lower doses than Mn1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Multidisciplinary
Martha Zoumpoulaki, Gabrielle Schanne, Nicolas Delsuc, Hugues Preud'homme, Elodie Quevrain, Nicolas Eskenazi, Geraldine Gazzah, Regis Guillot, Philippe Seksik, Joelle Vinh, Ryszard Lobinski, Clotilde Policar
Summary: The detection and quantification of exogenous metal complexes are crucial in understanding their activity in complex biological media. This study used ion mobility spectrometry-mass spectrometry (IMS-MS) to demonstrate the intracellular presence and concentration of Mn1 and Mn1P complexes, which are superoxide dismutase (SOD) mimics, in cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Nathan Grellier, Marcelino T. Suzuki, Loic Brot, Alice M. S. Rodrigues, Lydie Humbert, Karine Escoubeyrou, Dominique Rainteau, Jean-Pierre Grill, Raphael Lami, Philippe Seksik
Summary: The study found that the luxR gene from Bacteroides dorei was under-expressed in IBD patients, while one luxR receptor gene from Bacteroides fragilis appeared to be over-expressed. Targeting LuxR receptors of bacterial quorum sensing might represent a new approach to modulate the gut microbiota in IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Francesco Morandini, Kevin Perez, Loic Brot, Sidy Mohammed Seck, Laurence Tibere, Jean-Pierre Grill, Enguerran Macia, Philippe Seksik
Summary: This study compared the gut microbiomes of mother and infant pairs from rural and urban areas of Senegal. The results showed that urban mothers had different gut microbiome compositions than rural mothers, while urban infants had delayed gut microbiome maturation and higher susceptibility to infectious diseases. These findings suggest that industrialization is associated with gut microbiome alterations and may be linked to disease.
Article
Surgery
Mathieu Uzzan, Jacques Cosnes, Aurelien Amiot, Jean-Marc Gornet, Philippe Seksik, Eddy Cotte, Emmanuel Tiret, Yves Panis, Xavier Treton