Article
Biochemistry & Molecular Biology
Eunji Kwak, Taehyung Kim, Kyungjik Yang, Young Min Kim, Hwa Seung Han, Kyung Hoon Park, Ki Young Choi, Young Hoon Roh
Summary: In this study, a triple-targeting moiety-functionalized nanoparticle was developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. The optimized nanoparticle showed almost 10-fold enhanced NHL-specific intracellular delivery and induced significant in vitro anticancer effects.
Review
Instruments & Instrumentation
Indra Rautela, Aditi Sharma, Pallavi Dheer, Priya Thapliyal, Shweta Sahni, Vimlendu Bhushan Sinha, Manish Dev Sharma
Summary: RNA interference has led to the development of siRNA-based therapeutics for gene therapy purposes, particularly in treating cancer. Despite the challenges associated with siRNA delivery systems, advancements have been made in targeted delivery methods using different types of materials.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kiruthiga Chandramohan, Devasahayam Jaya Balan, Kasi Pandima Devi, Seyed Fazel Nabavi, Sara Reshadat, Maryam Khayatkashani, Sepideh Mahmoodifar, Rosanna Filosa, Niloufar Amirkhalili, Soroush Pishvaei, Omolbanin Sargazi-Aval, Seyed Mohammad Nabavi
Summary: Colorectal cancer is a common and deadly disease, especially among older individuals. Chemotherapy has negative effects on both normal and malignant cells. Various signaling pathways, such as Hh, JAK/STAT, Wnt/beta-catenin, TNF-beta, EGFR/MAPK, PI3K, NF-kappa B, and Notch, are involved in the development of colorectal cancer. This study focuses on innovative siRNA therapies and delivery methods for the safe and effective treatment of colorectal cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Huimin Xu, Jianqiao Chang, Hao Wu, Haoyu Wang, Wenjing Xie, Yunchao Li, Xiaohong Li, Yang Zhang, Louzhen Fan
Summary: siRNA-based gene therapy is a promising strategy for tumor treatment. Novel gene vectors, such as LAAM GUA-CDs, which can target tumor cells and deliver siRNA without causing side effects, have been designed and synthesized. LAAM GUA-CDs loaded with siBcl-2 exhibit a high tumor inhibition rate, twice as effective as commercial Lipofectamine 2000. LAAM GUA-CDs provide a versatile approach for tumor-targeted siRNA delivery and cancer therapy.
Correction
Oncology
Miao He, Hai-Gang Sun, Jun-Ying Hao, Yan-Lin Li, Jian-Kun Yu, Yuan-Yuan Yan, Lin Zhao, Na Li, Yan Wang, Xue-Feng BaI, Zhao-Jin Yu, Zhi-Hong Zheng, Xiao-Yi Mi, En-Hua Wang, Min-Jie Wei
Summary: The study showed that silencing of FANCF inhibits the function of the FA/BRCA pathway, resulting in inhibited cell proliferation, increased cell apoptosis, and DNA damage in OVCAR3 cells. Furthermore, silencing of FANCF enhances the antiproliferative effect of ADM in OVCAR3 cells, increases ADM intracellular accumulation, and sensitizes the cells to ADM.
Review
Oncology
Gaohua Deng, Xu Zhang, Yonglan Chen, Sicheng Liang, Sha Liu, Zehui Yu, Muhan Lu
Summary: Gastric cancer is a serious malignant tumor that poses a threat to people's health globally. Single-cell transcriptome sequencing, or scRNA-seq, has been used to explore the heterogeneity of gastric cancer and reveal its complex biological composition and molecular characteristics at the individual cell level. This technique holds potential for facilitating early diagnosis, individualized therapy, and prognosis evaluation of gastric cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
David Hernan Martinez-Puente, Jose Juan Perez-Trujillo, Laura Mireya Zavala-Flores, Aracely Garcia-Garcia, Arnulfo Villanueva-Olivo, Humberto Rodriguez-Rocha, Jesus Valdes, Odila Saucedo-Cardenas, Roberto Montes de Oca-Luna, Maria de Jesus Loera-Arias
Summary: The interest in using nucleic acids for therapeutic applications is increasing. DNA molecules can be manipulated to express genes for gene therapy or vaccine development. DNA vaccination has shown potential for stimulating the immune system against cancer cells, while plasmid DNA can directly kill cancer cells. Promising results in animal models suggest that these DNA strategies may soon be approved for cancer treatment.
Article
Nanoscience & Nanotechnology
Yanghao Zhou, Qiang Yang, Feng Wang, Zunjie Zhou, Jing Xu, Si Cheng, Yuan Cheng
Summary: A novel DNA nanostructure was developed to deliver siRNA effectively and induce apoptosis in glioma cells, showing good stability and targeting ability. Experimental results demonstrated that the nanoparticles efficiently downregulated survivin gene expression, suggesting potential clinical applications in glioma therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jieun Lee, Wooic Son, Juhyeong Hong, Yoonsung Song, Chul-Su Yang, Yong-Hee Kim
Summary: Sepsis is a systemic inflammatory response syndrome caused by bacterial infection. Current sepsis therapy involving antibiotics has limitations such as side effects and high costs. Therefore, there is a growing need for sepsis treatment free from side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhuo Chen, Wenzhi Wu, Chen Zheng, Yanhua Lan, Huizhi Xie, Zhijian Xie
Summary: This study investigated the expression patterns of KLF6 during the development of tooth germ in mice and its role in odontoblastic differentiation. The findings suggest that KLF6 promotes odontoblastic differentiation and inhibits cell proliferation and cell cycle progression through upregulation of p21.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Oncology
Yiwen Xia, Jialun Lv, Tianlu Jiang, Bowen Li, Ying Li, Zhongyuan He, Zhe Xuan, Guangli Sun, Sen Wang, Zheng Li, Weizhi Wang, Linjun Wang, Zekuan Xu
Summary: The study revealed that circFAM73A is upregulated in gastric cancer tissues and is associated with poor prognosis in patients. Upregulation of circFAM73A enhances cell proliferation, migration, cisplatin resistance, and CSC-like properties in gastric cancer. Mechanistically, circFAM73A promotes gastric cancer malignancy through the miR-490-3p/HMGA2 positive feedback loop and recruitment of HNRNPK.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Takahiro Ishii, Ayako Suzuki, Takeshi Kuwata, Shoshi Hisamitsu, Hiroko Hashimoto, Yuuki Ohara, Kazuyoshi Yanagihara, Shuichi Mitsunaga, Takayuki Yoshino, Takahiro Kinoshita, Atsushi Ochiai, Kohei Shitara, Genichiro Ishii
Summary: This study evaluated the impact of drug-exposed CAFs on the growth and migration ability of drug-exposed GC cells, showing that CAFs promoted the migration and invasion of GC cells and higher residual CAFs were associated with increased lymphovascular invasion and recurrence rate. RNA-seq analysis identified gp130 derived from CAFs as a potential factor contributing to enhanced migration of GC cells following drug treatment.
Review
Oncology
Yue Deng, Sicheng Cai, Jian Shen, Huiming Peng
Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yali Feng, Jing Fang, Yan Zhao, Shuyue Ye, Anna Wang, Yuqi Zhang, Jinfeng Zhu, Jiachen Li, Zhengzhong Lv, Zhongsheng Zhao, Haibin Shi
Summary: In this study, a near-infrared light-mediated mitochondrial RNA modification approach was developed for long-term imaging and effective tumor suppression. A tumor-targetable NIR fluorescent probe f-CRI was synthesized and it could covalently bind to mtRNA upon 808 nm irradiation, leading to prolonged retention in tumors. The covalent modification of mtRNA by f-CRI disrupted mitochondrial function and significantly suppressed tumor growth. This approach provides a potential strategy for cancer RNA interference therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Jinho Yoon, Minkyu Shin, Ji-Young Lee, Sang-Nam Lee, Jin-Ha Choi, Jeong-Woo Choi
Summary: RNA interference (RNAi)-based therapeutics have not been used for cancer treatment due to their instability and microRNA (miRNA) delivery challenges. Plasmonic nanoparticle-based RNAi nanotherapeutics have been developed with specific properties for accurate cancer diagnosis and strong therapeutic effects. This review presents recent strategies and advances in plasmonic nanoparticle-based miRNA delivery for cancer detection and treatment, and discusses the challenges and potential opportunities in the field of RNAi-based theragnosis.
JOURNAL OF CONTROLLED RELEASE
(2022)