Article
Neurosciences
Minji Son, Sang-Myung Cheon, Changhong Youm, Jae Woo Kim
Summary: This study comprehensively analyzed the walking characteristics of patients with PD and found that they had narrower step length, slower walking speed, and difficulties in turning. These characteristics were found to be associated with the severity of FoG.
Review
Orthopedics
Aileen E. Scully, Keith D. Hill, Dawn Tan, Ross Clark, Yong-Hao Pua, Beatriz I. R. de Oliveira
Summary: Parkinson's disease is the second most common neurodegenerative condition globally, with freezing of gait being a common motor symptom. Assessing freezing of gait severity accurately is crucial for guiding management. The Freezing of Gait Questionnaire and Dynamic Parkinson Gait Scale are currently the best-performing outcome measures, but further validation and reliability studies are needed to strengthen evidence for their use.
Article
Engineering, Biomedical
Martina Mancini, Vrutangkumar V. Shah, Samuel Stuart, Carolin Curtze, Fay B. Horak, Delaram Safarpour, John G. Nutt
Summary: Despite growing research on measuring freezing of gait (FoG) in laboratory settings, few studies have attempted to detect FoG during daily life using body-worn sensors. A novel algorithm was presented to detect FoG in people with Parkinson's disease (PD) in the lab and at home. The results showed promising agreement between clinical scores and objective measures of freezing in the lab, but further validation is needed for daily life monitoring.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Rehabilitation
Paula T. Bezerra, Lorenna M. Santiago, Isaira A. Silva, Aline A. Souza, Camila L. Pegado, Clecia M. Damascena, Tatiana S. Ribeiro, Ana R. Lindquist
Summary: Combining action observation, motor imagery, and gait training did not show greater effectiveness than isolated gait training for balance and freezing of gait in individuals with Parkinson's disease. However, motor imagery training can moderate the effects of action observation and enhance motor learning when used together.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Jae Jung Lee, Jin Yong Hong, Jong Sam Baik
Summary: This study found that olfactory dysfunction is a significant risk factor for the development of freezing of gait in Parkinson's disease. Patients with hyposmia had less improvement in UPDRS III scores and a higher rate of FOG compared to normosmic patients. The findings suggest that PD patients with olfactory dysfunction should be closely monitored for the occurrence of FOG in clinical practice.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Clinical Neurology
Gabriele Imbalzano, Domiziana Rinaldi, Giovanna Calandra-Buonaura, Manuela Contin, Federica Amato, Giulia Giannini, Luisa Sambati, Claudia Ledda, Alberto Romagnolo, Gabriella Olmo, Pietro Cortelli, Maurizio Zibetti, Leonardo Lopiano, Carlo Alberto Artusi
Summary: This study aimed to explore the challenges in treating FoG and other PD axial symptoms and analyze the effects of progressively increasing levodopa doses on the resistance of FoG, posture, speech, and altered gait features. The results showed that in a short-term evaluation, increasing LCIG dose can improve dopa-resistant FoG and gait issues in most advanced PD patients with good overall control of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Orthopedics
Lina Goh, Serene S. Paul, Colleen G. Canning, Kaylena A. Ehgoetz Martens, Jooeun Song, Stephanie L. Campoy, Natalie E. Allen
Summary: The purpose of this study was to assess the reliability and validity of the Ziegler test in measuring the severity of freezing of gait (FOG) in people with Parkinson disease. The results suggest that the Ziegler test has good interrater and test-retest reliability, and is a valid measure of FOG severity. The duration of the Ziegler test also shows moderate correlation with the percentage of time frozen and can be considered as a proxy measure for FOG severity.
Article
Clinical Neurology
Rebecca Chow, Bryan P. Tripp, Daniel Rzondzinski, Quincy J. Almeida
Summary: This study investigated the effects of cognitive training, cognitive behavioral therapy (CBT), and proprioceptive training on Freezing of Gait (FOG) in Parkinson's disease (PD) patients. The results showed that cognitive intervention significantly improved FOG severity, while CBT worsened FOG. On the other hand, proprioceptive training significantly improved FOG severity, suggesting it may be a viable treatment option for FOG.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Amir Besharat, Sheri I. Imsdahl, Momona Yamagami, Nawat Nhan, Olivia Bellatin, Samuel A. Burden, Kathleen Cummer, Sujata D. Pradhan, Valerie E. Kelly
Summary: The experiment showed that PD+FoG patients exhibited kinematic changes associated with FoG episodes in virtual doorway and hallway environments. These changes included reduced joint excursions, swing phase toe clearance, arm swing, and inclination angle, as well as slower walking with shorter, wider steps.
Article
Neurosciences
Zi-Yan Chen, Hong-Jiao Yan, Lin Qi, Qiao-Xia Zhen, Cui Liu, Ping Wang, Yong-Hong Liu, Rui-Dan Wang, Yan-Jun Liu, Jin-Ping Fang, Yuan Su, Xiao-Yan Yan, Ai-Xian Liu, Jianing Xi, Boyan Fang
Summary: Efficient methods for assessing walking adaptability in individuals with Parkinson's disease are urgently needed. The C-Gait assessment provided additional value in identifying freezers in the PD population.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Amgad Droby, Elisa Pelosin, Martina Putzolu, Giulia Bommarito, Roberta Marchese, Luca Mazzella, Laura Avanzino, Matilde Inglese
Summary: This study investigated the patterns of whole-brain functional connectivity alterations within midbrain inter-connected regions in PD-FOG patients, and found that midbrain structural damage as well as decreased connectivity within the brainstem network might contribute to FOG occurrence in PD patients. The study also showed associations between cognitive and motor function scores and connectivity levels in several brain regions.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Anouk Tosserams, Masood Mazaheri, Priya Vart, Bastiaan R. Bloem, Jorik Nonnekes
Summary: The prevalence of freezing of gait (FOG) in persons with Parkinson's disease (PD) does not differ significantly between men and women, but women are significantly underrepresented in intervention trials targeting FOG.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Reyisha Taximaimaiti, Xiao-Ping Wang
Summary: Freezing of gait (FOG) is a common walking problem in Parkinson's disease (PD) and impaired cognitive function is believed to play a crucial role in FOG development and severity. While traditional neuropsychological testing may not be sensitive enough to detect cognitive impairment in PD, motor symptoms such as rigidity and unilateral initiation may be important predictors of FOG. PD patients with FOG also exhibit worse motor and non-motor symptoms compared to those without FOG.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Yuzhu Guo, Debin Huang, Wei Zhang, Lipeng Wang, Yang Li, Gabriella Olmo, Qiao Wang, Fangang Meng, Piu Chan
Summary: This study proposes a wearable FoG detection method that combines acceleration and EEG information for accurate FoG detection. Experimental results show that pseudo-multimodal features achieve the most promising performance, with high detection accuracy and stability. The study suggests that wearable FoG detection can be enhanced through cross-modal information fusion, providing a new method for multimodal information fusion and long-term monitoring of FoG in living environments.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Behavioral Sciences
A. S. Monaghan, E. Gordon, L. Graham, E. Hughes, D. S. Peterson, R. Morris
Summary: Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PwPD), and it is associated with worse cognition. This systematic review and meta-analysis found that PwPD who experience FOG have poorer cognitive function compared to those without FOG across various cognitive domains. Disease severity and medication status also influence the relationship between FOG and cognition. The findings highlight the importance of considering disease severity and medication status in the management of FOG in PwPD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Christian Schlenstedt, Daniel S. Peterson, Martina Mancini
Article
Neurosciences
Rosie Morrist, Katrijn Smulders, Daniel S. Peterson, Martina Mancini, Patricia Carlson-Kuhta, John G. Nutt, Fay B. Horak
NPJ PARKINSONS DISEASE
(2020)
Article
Neurosciences
Gretchen Roman, Daniel S. Peterson, Edward Ofori, Meghan E. Vidt
Summary: This study aimed to develop a composite measure of injury risk unique to signers and found that non-native signers tend to report greater pain compared to native signers, but there was no significant difference between the two groups in terms of biomechanical tasks. Further evidence-based adjustments are needed to enhance the robustness of the composite measure.
JOURNAL OF MOTOR BEHAVIOR
(2021)
Review
Behavioral Sciences
Kaylena A. Ehgoetz Martens, Daniel S. Peterson, Quincy J. Almeida, Simon J. G. Lewis, Jeffrey M. Hausdorff, Alice Nieuwboer
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Clinical Neurology
Daniel S. Peterson, Charles Van Liew, Samuel Stuart, Patricia Carlson-Kuhta, Fay B. Horak, Martina Mancini
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Clinical Neurology
Sutton B. Richmond, Clayton W. Swanson, Daniel S. Peterson, Brett W. Fling
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Neurosciences
Sutton B. Richmond, Tyler T. Whittier, Daniel S. Peterson, Brett W. Fling
Summary: This study is the first to establish connections between the microstructural integrity of the CSP and multi-dimensional postural control performance in individuals with MS. The results indicate that a reduction in the CSP microstructural integrity is associated with poorer postural control in PwMS.
Article
Clinical Neurology
Daniel S. Peterson, Katrijn Smulders, Martina Mancini, John G. Nutt, Fay B. Horak, Brett W. Fling
Summary: The study found that freezing of gait (FoG) in Parkinson's disease (PD) is not associated with inefficient response inhibition. PD patients exhibited white matter loss in the response inhibition network, but this was not related to FoG, suggesting that FoG-specific neural changes may occur outside the response inhibition network.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2021)
Article
Neurosciences
Daniel S. Peterson, Allison Moore, Edward Ofori
Summary: In individuals with Charcot-Marie-Tooth disease, gait outcomes change significantly with fatigue, correlating with general life satisfaction but not perceived fatigue. This suggests performance fatigability during gait could be a target for rehabilitation for individuals with Charcot-Marie-Tooth disease.
Article
Neurosciences
Andrew S. Monaghan, Daniel S. Peterson
Summary: The study found that responses to in-place support-surface perturbations did not differ significantly between PwMS and neurotypical adults in terms of torque production and timing. The rate of torque development and maximal torque were correlated with functional postural response outcomes.
Article
Biophysics
B. Sutton Richmond, W. Brett Fling, Hyunglae Lee, S. Daniel Peterson
Summary: This article reviews the traditional use of CoP and CoM in measuring standing, as well as the technological advancements allowing for measurements outside the lab setting. Emphasizing the importance of balance performance, it discusses future research directions and the need for further understanding and predictive capacity of balance outcomes in different populations.
JOURNAL OF BIOMECHANICS
(2021)
Article
Multidisciplinary Sciences
Andrew S. Monaghan, Jessie M. Huisinga, Daniel S. Peterson
Summary: This study identified six distinct gait domains in people with multiple sclerosis, with fallers showing significantly worse outcomes in pace and asymmetry. These findings may help reduce redundancy in reporting gait outcomes and inform targeted interventions for specific gait domains.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Charles Van Liew, Mark Gudesblatt, Thomas J. Covey, Jeffrey Wilken, Daniel Golan, Myassar Zarif, Barbara Bumstead, Marijean Buhse, Edward Ofori, Daniel Peterson
Summary: The study found that the dual-task walking speed of people with multiple sclerosis is related to various physical and cognitive factors. Depressive symptoms and falls self-efficacy moderate the relationship between single-task walking and dual-task walking speeds. Dual-task walking costs are not related to cognitive and motor predictors.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Brian J. Loyd, Annie Fangman, Daniel S. Peterson, Eduard Gappmaier, Anne Thackeray, Michael C. Schubert, Leland E. Dibble
Summary: This study compared the efficacy of gaze and postural stability (GPS) retraining intervention to strength and endurance (SAE) intervention in individuals with multiple sclerosis (PwMS) who experienced dizziness or imbalance. The results showed that both GPS and SAE interventions resulted in significant improvements in dizziness handicap and balance from baseline to 6 weeks, with no significant difference between the two groups.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Hanna Johansson, Urban Ekman, Linda Rennie, Daniel S. Peterson, Breiffni Leavy, Erika Franzen
Summary: This study examined the difficulties PD patients face during DT walking, factors influencing DT costs, and the impact of cognitive status on strategies used during DT paradigms. The results showed that PD MCI patients had larger DT costs on gait and different strategies compared to PD non-MCI patients.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Nina Gras, Torsten Brauner, Scott Wearing, Thomas Horstmann
Summary: This study aimed to investigate the challenge posed by progressively unstable balance devices to bipedal stance during early functional rehabilitation in THA patients. The results showed that increasingly compliant balance pads provided a progressive challenge, while the challenge posed by the oscillating platform was lower and independent of the ability to stand independently.
Article
Neurosciences
Sharon M. H. Tsang, Evest H. W. Chan, Jason Y. H. Chan, Gladys P. Y. Huang, Kelly K. T. Lam, Eunice W. Y. Lam, Allan C. L. Fu, Eliza R. Sun
Summary: This study examined the differences in postural adjustments between erect, hyperlordotic, and swayback postures when facing external perturbations. The findings suggest that adopting hyperlordotic and swayback postures alters the contributions of the active and passive subsystems of the spine in postural control, potentially reducing the spine's ability to withstand loading and shear forces.
Article
Neurosciences
Hsin-yi Wang, Cheng-Yi Ho, Min-Chun Pan
Summary: This study investigated the differences in lumbar and hip movements during gait and muscle activities related to knee osteoarthritis (KOA) patients and healthy participants. The results showed that KOA patients used a hyperlordotic lumbar and hip flexed strategy, leading to excessive stress on the lower extremity joints during gait.
Article
Neurosciences
Yoshitaka Otani, Osamu Aoki
Summary: This study found that feelings of fear affect postural control but not the internal focus of attention. This finding may be useful in assessments and interventions for older adults with a fall risk.
Article
Neurosciences
Haruki Toda, Hiroaki Hobara, Mitsunori Tada
Summary: This study investigated sex differences in lower limb dynamic joint stiffness (DJS) during walking in older adults. The results showed that ankle DJS was lower in older women, which was caused by the reduced ankle plantarflexion moment. However, knee DJS did not elucidate the cause of knee osteoarthritis (OA) in older women.
Article
Neurosciences
Luis H. Cubillos, Elliott J. Rouse, Thomas E. Augenstein, Varun Joshi, Edward S. Claflin, Chandramouli Krishnan
Summary: The study found that the reliability of stiffness, viscosity, and inertia of the ankle joint was good to excellent during standing. During walking, the reliability of stiffness and viscosity was also good to excellent, while that of inertia was fair to good. The minimal detectable change (MDC) ranged widely, but was higher for inertia during walking.
Article
Neurosciences
Alexandra F. Dejong Lempke, Danielle L. Hunt, Sarah B. Willwerth, Pierre A. d'Hemecourt, William P. Meehan III, Kristin E. Whitney
Summary: Adolescent athletes alter their gait patterns throughout a marathon race, and there are correlations between biomechanical features and race performance among young marathoners.
Article
Neurosciences
Ali Esmaeili, Sayed Esmaeil Hosseininejad, Amirali Jafarnezhadgero, Valdeci Carlos Dionisio
Summary: This study investigates the effects of footwear type, navicular drop and ankle pronation on lower limb joint stiffness during running. The results show that navicular drop and dynamic ankle pronation do not affect joint stiffness, but footwear type significantly affects joint stiffness. Conventional footwear increases ankle and hip joint stiffness while reducing knee joint stiffness, which may have implications for injury risk.
Article
Neurosciences
Takahiro Watanabe, Tomoya Takabayashi, Takanori Kikumoto, Yudai Kikuchi, Shunsuke Suzuki, Shiori Hiratsuka, Masayoshi Kubo
Summary: This study suggests that there are differences in abductor hallucis activity between individuals with chronic ankle instability and ankle sprain copers, indicating neuromuscular dysfunction in these patients, which leads to pain and instability symptoms.
Letter
Neurosciences
Susan M. Linder, Mandy Miller Koop, Jay L. Alberts
Article
Neurosciences
Elza van Duijnhoven, Marit van der Veen, Fieke S. Koopman, Frans Nollet, Sjoerd M. Bruijn, Merel-Anne Brehm
Summary: Gait stability is impaired in polio survivors with plantarflexor weakness, characterized by increased step width and step length variability and lower MoSAP. These factors are related to the elevated energy cost of walking in polio survivors.
Article
Neurosciences
Rebecca Hemming, Alister du Rose, Liba Sheeran, Robert van Deursen, Valerie Sparkes
Summary: In a forward bending task, there is a relationship between trunk muscle activation and regional thoracic and lumbar kinematics in NSCLBP subgroups, indicating different motor control strategies adopted by different subgroups when performing bending tasks.
Review
Neurosciences
Carina Pohle, Linda Becker, Jochen Baumeister
Summary: This systematic review is the first to compile evidence on the effect of the menstrual cycle on postural control. The evidence regarding the influence of the menstrual cycle on postural control is unclear. However, a trend of decreased postural control from the early follicular phase to the ovulatory phase was observed in balance tasks that eliminated or altered sensory input.