Article
Biotechnology & Applied Microbiology
Janne Spierings, Marloes van den Hengel, Rob P. A. Janssen, Bert Van Rietbergen, Keita Ito, Jasper Foolen
Summary: Anterior cruciate ligament (ACL) rupture is a common knee injury that often leads to osteoarthritis (OA) due to changes in graft mechanical properties during in vivo remodeling. This study used finite element knee models to investigate the influence of decreasing graft stiffness and increasing graft laxity on knee kinematics and cartilage loading. The results showed that in vivo graft remodeling increases knee range of motion and alters cartilage contact pressures, which can contribute to the early onset of OA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Troy Blackburn, Darin A. Padua, Brian Pietrosimone, Todd A. Schwartz, Jeffrey T. Spang, Jonathan S. Goodwin, Derek R. Dewig, Chris D. Johnston
Summary: This study evaluated the effects of whole-body vibration (WBV) and local muscle vibration (LMV) on gait biomechanics in individuals with ACLR. LMV decreased the vGRF loading rate significantly, while WBV increased the peak internal knee extension moment. These findings suggest that vibration has the potential to mitigate aberrant gait biomechanics and reduce the risk of posttraumatic knee osteoarthritis following ACLR.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Elanna K. Arhos, Jacob J. Capin, Thomas S. Buchanan, Lynn Snyder-Mackler
Summary: The study aimed to investigate the relationship between symmetry in isometric quadriceps strength and gait biomechanics after return-to-sport training in athletes after ACLR. Findings showed that after reaching a certain level of quadriceps strength, restoring strength alone may not improve gait asymmetries, suggesting that current clinical interventions and return-to-sport training may not effectively target gait issues.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gisela Sole, Todd Pataky, Niels Hammer, Peter Lamb
Summary: The study examined the effects of wearing a knee sleeve on ground reaction forces and knee joint power during a step-down hop task after anterior cruciate ligament reconstruction. The results showed that wearing a knee sleeve increased knee joint power during the task but had inconsistent effects on ground reaction forces.
Article
Orthopedics
Aly M. Fayed, Ryo Kanto, Taylor M. Price, Michael DiNenna, Monica A. Linde, Patrick Smolinski, Carola van Eck
Summary: There is no significant difference in knee kinematics between ACL-first fixation and PCL-first fixation, but ACL-first fixation can better restore anterior tibial translation.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Immunology
Ruipeng Zhao, Zhengquan Dong, Xiaochun Wei, Xiaodong Gu, Pengfei Han, Hongru Wu, Yanxia Yan, Lingan Huang, Haoqian Li, Chengming Zhang, Fei Li, Pengcui Li
Summary: Idealized anterior cruciate ligament reconstruction (IACL-R) restored normal gait features but caused significant cartilage damage, indicating that significantly elevated inflammatory factors may be crucial for the pathogenesis of post-traumatic osteoarthritis (PTOA).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolo Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J. J. Omeljaniuk, Marco Bigoni, Antonio Torsello
Summary: This study investigated the changes in microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and anterior cruciate ligament (ACL) rupture. The results showed that specific microRNAs were expressed differently in OA and ACL tear samples. These findings may contribute to further research on the mechanisms and treatments of osteoarthritis and ACL rupture.
Review
Orthopedics
Sebastian Cardona-Ramirez, James L. Cook, Aaron M. Stoker, Richard Ma
Summary: This review provides an overview of the use of common small animal laboratory species to model ACL reconstruction, including a discussion on comparative knee anatomy, technical considerations, and laboratory evaluative methods. Small animal ACL reconstruction models, such as mice, rats, and rabbits, are important tools for studying ACL reconstruction healing and outcomes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Tzu-Chieh Liao, Valentina Pedoia, Sharmila Majumdar, Richard B. Souza
Summary: Patients who underwent ACL reconstruction experienced changes in patellar alignment before and after the surgery, but differences between ACLR patients and controls decreased over the course of 3 years.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
James McCammon, Yiyang Zhang, Heather J. Prior, Jeff Leiter, Peter B. MacDonald
Summary: The study found that patients who underwent ACL-R in Manitoba were more likely to undergo TKR compared to the general population, with age being the primary factor influencing the risk of TKR after ACL-R. Other factors such as location, year of surgery, place of residence, income quintile, and RUB did not seem to significantly increase the risk of TKR after ACL-R.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Orthopedics
Ashley A. Williams, Jayme C. B. Koltsov, Alan Brett, Jade He, Constance R. Chu
Summary: Even in the absence of radiographic osteoarthritis, patients who underwent unilateral anterior cruciate ligament reconstruction (ACLR) showed greater bone shape scores and subchondral areas consistent with pre-osteoarthritis in their ACLR knees just 2 years after the surgery. Moreover, greater medial femur bone areas were weakly associated with worse symptoms. Patients who are younger, taller, have meniscal tears, or have bone-patellar tendon-bone grafts may be at increased risk for bony asymmetries 2 years after ACLR.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Mark A. Lyle, Jake C. Jensen, Jennifer L. Hunnicutt, Jonathan J. Brown, Cynthia P. Chambliss, Michael A. Newsome, John W. Xerogeanes, Liang-Ching Tsai
Summary: Muscle strength and spatiotemporal gait values, such as step width and step length, can predict knee moments in patients after anterior cruciate ligament reconstruction (ACLR). These factors could be targeted for biofeedback to improve gait in clinical settings.
JOURNAL OF ATHLETIC TRAINING
(2022)
Article
Chemistry, Analytical
Mazhar Javed Awan, Mohd Shafry Mohd Rahim, Naomie Salim, Amjad Rehman, Begonya Garcia-Zapirain
Summary: This study applies deep learning to automatically segment ACL tears from MRI images. By using the U-Net architecture and semantic segmentation technique, high accuracy segmentation results have been achieved. The method shows promising potential in the field of medical image analysis.
Article
Immunology
Zhiwen Li, Shiyong Zhang, Guping Mao, Yiyang Xu, Yunze Kang, Linli Zheng, Dianbo Long, Weishen Chen, Minghui Gu, Zhiqi Zhang, Yan Kang, Puyi Sheng, Ziji Zhang
Summary: ACL plays an important role in knee homeostasis and disease progression. Degeneration of the ACL alters knee joint homeostasis and influences the microenvironment, contributing to the progression of KOA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Orthopedics
Ayham Jaber, Chang Min Kim, Alexander Barie, Marcus Streit, Holger Schmitt, Michael Clarius, Christian Merle, Yannic Bangert
Summary: The study evaluated the long-term outcomes of combined medial unicompartmental knee arthroplasty and anterior cruciate ligament reconstruction, finding that the procedure led to good long-term outcomes and implant survivorship in patients with isolated medial knee osteoarthritis and ACL deficiency. Improvement in pain scores, functionality, and activity levels were observed postoperatively, with good implant survival rates and stability.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Anthony Hipsley, Michelle Hall, David J. Saxby, Kim L. Bennell, Xinyang Wang, Adam L. Bryant
Summary: Quadriceps strength deficits following anterior cruciate ligament reconstruction (ACLR) are associated with cartilage volume changes. In the early years after ACLR, higher quadriceps strength is correlated with lower cartilage volume on the medial tibia. Restoring quadriceps strength may reduce the likelihood of early tibiofemoral joint cartilage degeneration.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Orthopedics
M. Hall, M. van der Esch, R. S. Hinman, G. Peat, A. de Zwart, J. G. Quicke, J. Runhaar, J. Knoop, M. van der Leeden, M. de Rooij, I. Meulenbelt, T. Vliet Vlieland, W. F. Lems, M. A. Holden, N. E. Foster, K. L. Bennell
Summary: Hip and knee osteoarthritis have distinct characteristics in terms of prevalence, pathophysiology, clinical presentation, and treatment. Researchers should focus on the specificity of hip OA to develop more effective treatments.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Michelle Hall, Kim Allison, Rana S. Hinman, Kim L. Bennell, Libby Spiers, Gabrielle Knox, Melanie Plinsinga, David M. Klyne, Fiona McManus, Karen E. Lamb, Ricardo Da Costa, Nicholas J. Murphy, Fiona L. Dobson
Summary: This study aims to test the hypothesis that adding aerobic physical activity to a muscle strengthening exercise can significantly reduce hip pain and improve physical function compared to a lower-limb muscle strengthening exercise program alone at 3 months. The study will include approximately 196 individuals with symptomatic hip OA and they will be randomly allocated to two groups. The primary outcomes are self-reported hip pain and self-reported physical function.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Michelle Hall, Rana S. Hinman, Gabrielle Knox, Libby Spiers, Priya Sumithran, Nicholas J. Murphy, Fiona McManus, Karen E. Lamb, Flavia Cicuittini, David J. Hunter, Stephen P. Messier, Kim L. Bennell
Summary: This study aims to compare the effectiveness of a combined diet and exercise program with an exercise-only program in relieving hip pain. The study will use a randomized controlled trial to evaluate the effects of the two programs and measure multiple outcomes, including pain, body weight, physical function, and quality of life. The results will provide evidence-based advice for clinicians regarding the effect of a dietary intervention on hip osteoarthritis pain.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Sport Sciences
Scott C. Starkey, Laura E. Diamond, Rana S. Hinman, David J. Saxby, Gabrielle Knox, Michelle Hall
Summary: This study found that individuals with medial knee osteoarthritis and varus malalignment generate higher muscle forces in the knee extensors and flexors during squatting and lunging, but do not increase medial tibiofemoral contact force compared with walking. These findings provide reassurance to clinicians and patients that weight-bearing exercises in these positions do not negatively impact the osteoarthritic joint.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Orthopedics
W. Wu, A. L. Bryant, R. S. Hinman, K. L. Bennell, B. R. Metcalf, M. Hall, P. K. Campbell, K. L. Paterson
Summary: Medial and lateral knee contact forces (KCFs) differ across grades of radiographic knee osteoarthritis (OA) severity, but are not associated with knee pain severity. Medial KCFs during early and middle stance are higher in participants with moderate and severe OA compared to mild OA. In contrast, lateral KCFs are higher in mild OA during middle to late stance. The external loading component (KAM) of medial KCF during middle to late stance is greater in participants with moderate and severe OA, while the internal (muscle) component is greater in participants with moderate and severe OA during early stance. There are no associations between medial KCF and knee pain in any radiographic OA grade.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Multidisciplinary Sciences
Scott Starkey, Rana Hinman, Kade Paterson, David Saxby, Gabrielle Knox, Michelle Hall
Summary: This study compared the effects of stable supportive shoes and flat flexible shoes on MTCF in patients with medial knee osteoarthritis and varus malalignment. The results showed that stable supportive shoes reduced MTCF during loading stance and decreased loading impulse and rates.
Article
Sport Sciences
Michelle Hall, Yuri Lopes Lima, Zoya Huschtscha, Fiona Dobson, Ricardo J. S. Costa
Summary: This study retrospectively analyzed the test-retest reliability of submaximal cardiorespiratory fitness in 41 healthy active older adults. The results showed that although there was at least modest relative reliability, the measurement error associated with absolute and relative VO2 was smaller at a workload of 2.5 W/kgFFM, suggesting that submaximal cardiorespiratory fitness can be more confidently monitored at higher workloads.
SPORTS MEDICINE-OPEN
(2022)
Article
Engineering, Biomedical
Anuja P. Satam, Marike van der van der Leeden, Arjan de Zwart, Simon Verberne, Jim C. Schrijvers, Michelle Hall, Joost Dekker, Willem F. Lems, Jaap Harlaar, Martin van der Esch
Summary: The study found a weak association between muscle steadiness and muscle strength as well as self-reported physical function in patients with knee osteoarthritis. However, there is no convincing evidence that muscle steadiness is an important adjunct in studying physical function in these patients.
CLINICAL BIOMECHANICS
(2022)
Article
Sport Sciences
Trevor N. Savage, David J. Saxby, David G. Lloyd, Hoa X. Hoang, Edin K. Suwarganda, Thor F. Besier, Laura E. Diamond, Jillian Eyles, Camdon Fary, Michelle Hall, Robert Molnar, Nicholas J. Murphy, John O'Donnell, Libby Spiers, Phong Tran, Tim Wrigley, Kim L. Bennell, David J. Hunter, Claudio Pizzolato
Summary: This study used a neuromusculoskeletal model to investigate the impact of hip contact force on articular tissue in individuals with femoroacetabular impingement (FAI) syndrome. The results showed that participants with FAI syndrome walked with lower-magnitude hip contact forces and smaller regional loading on the acetabulum and femoral head compared to controls. These differences in regional loading patterns may contribute to cartilage maladaptation in individuals with FAI syndrome.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Multidisciplinary Sciences
Michelle Hall, Scott Starkey, Rana S. Hinman, Laura E. Diamond, Gavin K. Lenton, Gabrielle Knox, Claudio Pizzolato, David J. Saxby
Summary: This pilot study investigated the effect of a valgus knee brace on medial tibiofemoral contact force (MTCF) during walking. The results showed that wearing the brace significantly reduced peak MTCF and MTCF impulse. Symptoms and quality of life improved over the 8-week intervention, and feasibility outcomes were generally favorable. However, no effect of time on MTCF was observed.
Review
Rheumatology
Yuri Lopes Lima, Hopin Lee, David M. Klyne, Fiona L. Dobson, Rana S. Hinman, Kim L. Bennell, Michelle Hall
Summary: This scoping review identified potential mediators of nonsurgical interventions on pain and physical function in knee osteoarthritis. Variables such as body weight, systemic inflammation, knee muscle strength, and self-efficacy were found to partially mediate the effects of interventions such as diet plus exercise, exercise, and high-expectation communication.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Orthopedics
Tamara M. Grant, Laura E. Diamond, Claudio Pizzolato, Trevor N. Savage, Kim Bennell, Edward J. Dickenson, Jillian Eyles, Nadine E. Foster, Michelle Hall, David J. Hunter, David G. Lloyd, Robert Molnar, Nicholas J. Murphy, John O'Donnell, Parminder Singh, Libby Spiers, Phong Tran, David J. Saxby
Summary: A comparison of physical therapist-led care and arthroscopy for the treatment of femoroacetabular impingement syndrome revealed that personalized hip therapy led to increased peak hip adduction moments, while arthroscopy did not show significant changes in hip biomechanics during walking. This suggests that personalized hip therapy may be more effective in improving hip moments over a 12-month period.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Rana S. Hinman, Michelle Hall, Sarah Comensoli, Kim L. Bennell
Summary: This update Position Statement provides the most recent evidence and guidance for health practitioners managing people with hip/knee osteoarthritis, emphasizing the importance of exercise in reducing joint pain, increasing physical function, and improving quality of life. Exercise dosage should be guided by the principles of the American College of Sports Medicine, and practitioners should actively monitor and promote adherence to exercise for optimal therapeutic benefits.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Rheumatology
Belinda J. Lawford, Kim L. Bennell, Michelle Hall, Thorlene Egerton, Fiona McManus, Karen E. Lamb, Rana S. Hinman
Summary: The addition of an option grid and GP exercise recommendation to general OA information led to more favorable views that exercise was the best management option for the hypothetical knee problem, although the differences were small and of unclear clinical importance.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Neurosciences
Nina Gras, Torsten Brauner, Scott Wearing, Thomas Horstmann
Summary: This study aimed to investigate the challenge posed by progressively unstable balance devices to bipedal stance during early functional rehabilitation in THA patients. The results showed that increasingly compliant balance pads provided a progressive challenge, while the challenge posed by the oscillating platform was lower and independent of the ability to stand independently.
Article
Neurosciences
Sharon M. H. Tsang, Evest H. W. Chan, Jason Y. H. Chan, Gladys P. Y. Huang, Kelly K. T. Lam, Eunice W. Y. Lam, Allan C. L. Fu, Eliza R. Sun
Summary: This study examined the differences in postural adjustments between erect, hyperlordotic, and swayback postures when facing external perturbations. The findings suggest that adopting hyperlordotic and swayback postures alters the contributions of the active and passive subsystems of the spine in postural control, potentially reducing the spine's ability to withstand loading and shear forces.
Article
Neurosciences
Hsin-yi Wang, Cheng-Yi Ho, Min-Chun Pan
Summary: This study investigated the differences in lumbar and hip movements during gait and muscle activities related to knee osteoarthritis (KOA) patients and healthy participants. The results showed that KOA patients used a hyperlordotic lumbar and hip flexed strategy, leading to excessive stress on the lower extremity joints during gait.
Article
Neurosciences
Yoshitaka Otani, Osamu Aoki
Summary: This study found that feelings of fear affect postural control but not the internal focus of attention. This finding may be useful in assessments and interventions for older adults with a fall risk.
Article
Neurosciences
Haruki Toda, Hiroaki Hobara, Mitsunori Tada
Summary: This study investigated sex differences in lower limb dynamic joint stiffness (DJS) during walking in older adults. The results showed that ankle DJS was lower in older women, which was caused by the reduced ankle plantarflexion moment. However, knee DJS did not elucidate the cause of knee osteoarthritis (OA) in older women.
Article
Neurosciences
Luis H. Cubillos, Elliott J. Rouse, Thomas E. Augenstein, Varun Joshi, Edward S. Claflin, Chandramouli Krishnan
Summary: The study found that the reliability of stiffness, viscosity, and inertia of the ankle joint was good to excellent during standing. During walking, the reliability of stiffness and viscosity was also good to excellent, while that of inertia was fair to good. The minimal detectable change (MDC) ranged widely, but was higher for inertia during walking.
Article
Neurosciences
Alexandra F. Dejong Lempke, Danielle L. Hunt, Sarah B. Willwerth, Pierre A. d'Hemecourt, William P. Meehan III, Kristin E. Whitney
Summary: Adolescent athletes alter their gait patterns throughout a marathon race, and there are correlations between biomechanical features and race performance among young marathoners.
Article
Neurosciences
Ali Esmaeili, Sayed Esmaeil Hosseininejad, Amirali Jafarnezhadgero, Valdeci Carlos Dionisio
Summary: This study investigates the effects of footwear type, navicular drop and ankle pronation on lower limb joint stiffness during running. The results show that navicular drop and dynamic ankle pronation do not affect joint stiffness, but footwear type significantly affects joint stiffness. Conventional footwear increases ankle and hip joint stiffness while reducing knee joint stiffness, which may have implications for injury risk.
Article
Neurosciences
Takahiro Watanabe, Tomoya Takabayashi, Takanori Kikumoto, Yudai Kikuchi, Shunsuke Suzuki, Shiori Hiratsuka, Masayoshi Kubo
Summary: This study suggests that there are differences in abductor hallucis activity between individuals with chronic ankle instability and ankle sprain copers, indicating neuromuscular dysfunction in these patients, which leads to pain and instability symptoms.
Letter
Neurosciences
Susan M. Linder, Mandy Miller Koop, Jay L. Alberts
Article
Neurosciences
Elza van Duijnhoven, Marit van der Veen, Fieke S. Koopman, Frans Nollet, Sjoerd M. Bruijn, Merel-Anne Brehm
Summary: Gait stability is impaired in polio survivors with plantarflexor weakness, characterized by increased step width and step length variability and lower MoSAP. These factors are related to the elevated energy cost of walking in polio survivors.
Article
Neurosciences
Rebecca Hemming, Alister du Rose, Liba Sheeran, Robert van Deursen, Valerie Sparkes
Summary: In a forward bending task, there is a relationship between trunk muscle activation and regional thoracic and lumbar kinematics in NSCLBP subgroups, indicating different motor control strategies adopted by different subgroups when performing bending tasks.
Review
Neurosciences
Carina Pohle, Linda Becker, Jochen Baumeister
Summary: This systematic review is the first to compile evidence on the effect of the menstrual cycle on postural control. The evidence regarding the influence of the menstrual cycle on postural control is unclear. However, a trend of decreased postural control from the early follicular phase to the ovulatory phase was observed in balance tasks that eliminated or altered sensory input.
