Review
Immunology
Zhimin Lu, Shu Yu, Weijun Wang, Wenxian Chen, Xinyan Wang, Keke Wu, Xiaowen Li, Shuangqi Fan, Hongxing Ding, Lin Yi, Jingding Chen
Summary: FMD is a serious disease that affects the global livestock industry, and the development of vaccines plays a key role in controlling outbreaks of FMD.
Article
Virology
Danielle M. M. Pierce, Connor Hayward, David J. J. Rowlands, Nicola J. J. Stonehouse, Morgan R. R. Herod
Summary: FMDV is the causative agent of FMD, a significant disease in farmed animals that can result in major economic losses. The replication of this virus involves a highly coordinated processing of nonstructural proteins within membrane-associated compartments. Mutations at the 3B(3)-3C boundary increase the rate of proteolysis and affect the production of enzymatic nonstructural proteins.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Ntungufhadzeni M. Rathogwa, Katherine A. Scott, Pamela Opperman, Jacques Theron, Francois F. Maree
Summary: This study compared the efficacy of two adjuvant formulations combined with a structurally stabilized SAT2 vaccine antigen and found that the Montanide ISA 206B-adjuvanted vaccine elicited a higher SAT2 neutralizing antibody response and three times higher systemic IFN-gamma responses compared to the Quil-A Saponin-adjuvanted vaccine group at 14- and 28-days post-vaccination. Serum antibodies from the immunized animals reacted similarly to both the parental vaccine virus and mutated viruses simulating antigenic drift in nature.
Article
Immunology
W. A. Gayan Chathuranga, Chamith Hewawaduge, N. A. Nadeeka Nethmini, Tae-Hwan Kim, Ju Hun Kim, Young-Hoon Ahn, In-Joong Yoon, Sung-Sik Yoo, Jong-Hyeon Park, Jong-Soo Lee
Summary: This study developed two multiepitope recombinant proteins as potential vaccine candidates for foot-and-mouth disease. The results showed that these proteins effectively induced immune responses and protected animals from the virus. By using appropriate adjuvants, the protective efficacy of the vaccine candidates can be enhanced, providing a method for developing effective and safe vaccines for the prevention and control of foot-and-mouth disease.
Article
Virology
Michael Puckette, Victoria Primavera, Erica Martel, Jose Barrera, William Hurtle, Benjamin Clark, Barbara Kamicker, Mariceny Zurita, David Brake, John Neilan
Summary: This report describes a plasmid-based virus-like particle (VLP) production platform that combines the advantages of nucleic-acid-based vaccines with intact capsid epitopes, and can quickly adapt to new viral strains and serotypes.
Article
Microbiology
Zhidong Zhang, Ryan Waters, Yanmin Li
Summary: Foot-and-mouth disease virus (FMDV) infection causes epithelial cell lesions and muscle-associated lesions in cloven-hoofed animals, leading to high mortality. Current knowledge about the non-epithelial tropism of FMDV remains limited.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Jonathan Arzt, Ian H. Fish, Miranda R. Bertram, George R. Smoliga, Ethan J. Hartwig, Steven J. Pauszek, Lauren Holinka-Patterson, Fayna C. Diaz-San Segundo, Tatjana Sitt, Elizabeth Rieder, Carolina Stenfeldt
Summary: Research showed that cattle can be simultaneously infected with two different serotypes of foot-and-mouth disease virus (FMDV), with different outcomes depending on the timing of exposure to the viruses. Dominant interserotypic recombinant FMDVs were discovered in upper respiratory tract samples of superinfected animals, indicating the potential role of persistently infected FMDV carriers in generating novel viral strains.
JOURNAL OF VIROLOGY
(2021)
Review
Virology
Jef M. Hammond, Badi Maulidi, Nina Henning
Summary: Foot and mouth disease (FMD) is a highly infectious livestock disease that poses a global threat to animal trade and national economies. The disease leads to production losses, closure of valuable livestock markets, and is clustered into seven virus pools that require tailored vaccines for effective control.
Review
Virology
Xiangchuan He, Miaomiao Zhang, Chen Zhao, Peiyong Zheng, Xiaoyan Zhang, Jianqing Xu
Summary: The recent emergence of Hand, Foot, and Mouth Disease (HFMD) as a global public threat has prompted the development of a vaccine for control. Challenges include changes in pathogen spectrum and the need for multivalent vaccines against different serotypes. Recent advances in HFMD vaccine development aim to establish a cross-protective antibody response.
Article
Infectious Diseases
Carolina Stenfeldt, Miranda R. Bertram, Haillie C. Meek, Ethan J. Hartwig, George R. Smoliga, Megan C. Niederwerder, Diego G. Diel, Scott A. Dee, Jonathan Arzt
Summary: The study investigated the infectivity of foot-and-mouth disease virus (FMDV) in commercial pig feed and feed ingredients, determining the minimum infectious dose required for pigs to develop the disease. The results indicated that FMDV can remain infectious in pig feed ingredients for durations compatible with transoceanic transport, with variations in feeding conditions and virus strains affecting the probability of infection. This information can be used to model the risk of FMDV incursions and regulate feed importation to minimize the risk of unintentional importation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Pharmacology & Pharmacy
Tatsuya Nishi, Katsuhiko Fukai, Kentaro Masujin, Rie Kawaguchi, Mitsutaka Ikezawa, Manabu Yamada, Nozomi Nakajima, Takashi Komeno, Yousuke Furuta, Hiromi Sugihara, Chie Kurosaki, Kenichi Sakamoto, Kazuki Morioka
Summary: This study found that the pyrazinecarboxamide derivative T-1105 has strong antiviral activity against foot-and-mouth disease virus (FMDV) and can effectively control the spread of FMDV in pigs.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Kay Childs, Yongjie Harvey, Ryan Waters, Timothy Woma, Ginette Wilsden, Hualu Sun, Peng Sun, Julian Seago
Summary: Foot-and-mouth disease is a highly contagious viral disease of livestock that has a severe economic impact on the agriculture industry in many regions. Current vaccines are not effective against the contemporary strains of the disease, particularly in East Africa. Researchers have identified stable strains of the virus and developed a quadrivalent vaccine that generates high neutralizing antibody titers and provides good cross-protection against regional strains.
Article
Immunology
Ben Jackson, Yongjie Harvey, Eva Perez-Martin, Ginette Wilsden, Nicholas Juleff, Bryan Charleston, Julian Seago
Summary: Foot-and-mouth disease (FMD) is a global burden on the livestock industry, with vaccination being the most effective control strategy in endemic regions. However, challenges such as the instability of FMDV and the emergence of new strains exist in the development of efficient vaccines. Currently, vaccines in East Africa are comprised of relatively historic strains with unknown stabilities.
Article
Immunology
Nagendrakumar Balasubramanian Singanallur, Aldo Dekker, Phaedra Lydia Eble, Froukje van Hemert-Kluitenberg, Klaas Weerdmeester, Jacquelyn J. Horsington, Wilna Vosloo
Summary: Vaccination is a key tool in controlling and eradicating foot-and-mouth disease, but the effectiveness of vaccines against different virus strains needs to be considered. This study examined the protective effects of the O3039 vaccine strain against a new virus variant, showing promising results in terms of protection.
Article
Biotechnology & Applied Microbiology
Zhixun Zhao, Caiyun Huang, Xueliang Zhu, Zheng Qi, Yimei Cao, Pinghua Li, Huifang Bao, Pu Sun, Xingwen Bai, Yuanfang Fu, Kun Li, Jing Zhang, Xueqing Ma, Jian Wang, Hong Yuan, Dong Li, Zaixin Liu, Qiang Zhang, Zengjun Lu
Summary: In this study, a dual live vector vaccine against Foot-and-mouth disease (FMD) and Peste des petits ruminant disease (PPR) was constructed using the MVA-GFP recombinant virus skeleton. The recombinant virus successfully expressed the target proteins and the empty capsid of FMDV. This study laid the foundation for the successful construction of a live vector vaccine against FMD and PPR.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)