The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer
出版年份 2014 全文链接
标题
The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer
作者
关键词
-
出版物
Future Oncology
Volume 10, Issue 16, Pages 2659-2674
出版商
Future Medicine Ltd
发表日期
2014-12-23
DOI
10.2217/fon.14.201
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Abstract CT105: MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression
- (2015) Leena Gandhi et al. CANCER RESEARCH
- Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis
- (2015) Chi-Hung Huang et al. NEOPLASIA
- Global microRNA depletion suppresses tumor angiogenesis
- (2014) S. Chen et al. GENES & DEVELOPMENT
- Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor
- (2014) Akiko Murakami et al. PLoS One
- Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1
- (2014) B. Faubert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-regulated microRNAs in human cancer
- (2013) Guomin Shen et al. ACTA PHARMACOLOGICA SINICA
- Pulmonary Fibroblasts Induce Epithelial Mesenchymal Transition and Some Characteristics of Stem Cells in Non-Small Cell Lung Cancer
- (2013) Yasushi Shintani et al. ANNALS OF THORACIC SURGERY
- Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer
- (2013) Wei Ping et al. Asian Pacific Journal of Cancer Prevention
- A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal
- (2013) Yanyan Zheng et al. CANCER CELL
- Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non-Small Cell Lung Cancer
- (2013) I. Kawada et al. CANCER RESEARCH
- SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin
- (2013) D. H. Shin et al. CANCER RESEARCH
- Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53
- (2013) S. Licciulli et al. CANCER RESEARCH
- Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
- (2013) D. Laoui et al. CANCER RESEARCH
- Tumor-Specific Cytotoxic T Cells Are Crucial for Efficacy of Immunomodulatory Antibodies in Patients with Lung Cancer
- (2013) J. G. Aerts et al. CANCER RESEARCH
- Notch Pathway Activity Identifies Cells with Cancer Stem Cell-like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
- (2013) K. A. Hassan et al. CLINICAL CANCER RESEARCH
- Tumor Stromal Architecture Can Define the Intrinsic Tumor Response to VEGF-Targeted Therapy
- (2013) N. R. Smith et al. CLINICAL CANCER RESEARCH
- Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer
- (2013) Laure Belmont et al. INTERNATIONAL JOURNAL OF CANCER
- Harnessing the Immune System for the Treatment of Non–Small-Cell Lung Cancer
- (2013) Julie R. Brahmer JOURNAL OF CLINICAL ONCOLOGY
- Impact of EGFR Inhibitor in Non–Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis
- (2013) Chee Khoon Lee et al. JNCI-Journal of the National Cancer Institute
- Management of non-small-cell lung cancer: recent developments
- (2013) Martin Reck et al. LANCET
- Tumor-associated neutrophils and macrophages in non-small cell lung cancer: No immediate impact on patient outcome
- (2013) Andreas Carus et al. LUNG CANCER
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- Self-renewal as a therapeutic target in human colorectal cancer
- (2013) Antonija Kreso et al. NATURE MEDICINE
- CC-Chemokine Ligand 18 Induces Epithelial to Mesenchymal Transition in Lung Cancer A549 Cells and Elevates the Invasive Potential
- (2013) Till Ploenes et al. PLoS One
- MicroRNA-17, 20a Regulates the Proangiogenic Function of Tumor-Associated Macrophages via Targeting Hypoxia-Inducible Factor 2α
- (2013) Zhenqun Xu et al. PLoS One
- High NOTCH activity induces radiation resistance in non small cell lung cancer
- (2013) Jan Theys et al. RADIOTHERAPY AND ONCOLOGY
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- The frequency of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC): routine screening data for central Europe from a cohort study
- (2013) Christian Boch et al. BMJ Open
- Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells
- (2012) Yuan Xu et al. ARCHIVES OF TOXICOLOGY
- Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling
- (2012) Y.-P. Liu et al. CANCER RESEARCH
- Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors
- (2012) Kunihiko Minakata et al. CANCER SCIENCE
- Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
- (2012) Ramaswamy Govindan et al. CELL
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells
- (2012) M. Morimoto et al. DEVELOPMENT
- Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization
- (2012) Qiyuan Zhou et al. FEBS LETTERS
- Regulators of the hypoxic response: a growing family
- (2012) Katherine S Bridge et al. Future Oncology
- Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
- (2012) Johan Staaf et al. INTERNATIONAL JOURNAL OF CANCER
- Interleukin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage-Dominant Microenvironment in Lung Cancer
- (2012) Lunxu Liu et al. Journal of Thoracic Oncology
- Tumor-Stroma Ratio Is an Independent Predictor for Survival in Esophageal Squamous Cell Carcinoma
- (2012) kai Wang et al. Journal of Thoracic Oncology
- Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)
- (2012) Nasrollah Erfani et al. LUNG CANCER
- SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
- (2012) Marco Montagner et al. NATURE
- The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
- (2012) Daniel E. Foxler et al. NATURE CELL BIOLOGY
- Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1
- (2012) Chii-Wen Chou et al. NEURO-ONCOLOGY
- HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
- (2012) R V Durán et al. ONCOGENE
- EMT and Stem Cell-Like Properties Associated with HIF-2α Are Involved in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells
- (2012) Yuan Xu et al. PLoS One
- Serum Level of CC-Chemokine Ligand 18 Is Increased in Patients with Non-Small-Cell Lung Cancer and Correlates with Survival Time in Adenocarcinomas
- (2012) Till Plönes et al. PLoS One
- NOTCH1 Is Required for Regeneration of Clara Cells During Repair of Airway Injury
- (2012) Yiming Xing et al. STEM CELLS
- Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
- (2012) S Akunuru et al. Cell Death & Disease
- Targeting hypoxic tumour cells to overcome metastasis
- (2011) Kevin L Bennewith et al. BMC CANCER
- Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
- (2011) Yuqing Chen et al. CANCER BIOLOGY & THERAPY
- The HIF-1-Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
- (2011) F. Pez et al. CANCER RESEARCH
- Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma
- (2011) T. D. Allen et al. CANCER RESEARCH
- Notch-Dependent Differentiation of Adult Airway Basal Stem Cells
- (2011) Jason R. Rock et al. Cell Stem Cell
- The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non-Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts
- (2011) M. Saito et al. CLINICAL CANCER RESEARCH
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer
- (2011) Rui Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Hypoxia-Inducible Factor-2 Regulates GM-CSF-Derived Soluble Vascular Endothelial Growth Factor Receptor 1 Production from Macrophages and Inhibits Tumor Growth and Angiogenesis
- (2011) J. M. Roda et al. JOURNAL OF IMMUNOLOGY
- Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression
- (2011) Rui Wang et al. LUNG CANCER
- Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
- (2011) P. T. Mungai et al. MOLECULAR AND CELLULAR BIOLOGY
- Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
- (2011) R. Navab et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CTLA-4 +49A>G Polymorphism Is Associated with Advanced Non-Small Cell Lung Cancer Prognosis
- (2011) Bao Song et al. RESPIRATION
- Progressive 3q Amplification Consistently TargetsSOX2in Preinvasive Squamous Lung Cancer
- (2010) Frank McCaughan et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer
- (2010) Fuqiang Dai et al. BMC CANCER
- Lysyl oxidase: A lung adenocarcinoma biomarker of invasion and survival
- (2010) May-Lin Wilgus et al. CANCER
- Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling
- (2010) J. P. Sullivan et al. CANCER RESEARCH
- TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
- (2010) Muh-Hwa Yang et al. CELL CYCLE
- Glucose metabolism in cancer cells
- (2010) Alessandro Annibaldi et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- The Role of Tumor Stroma in Cancer Progression and Prognosis: Emphasis on Carcinoma-Associated Fibroblasts and Non-small Cell Lung Cancer
- (2010) Roy M. Bremnes et al. Journal of Thoracic Oncology
- Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma
- (2010) Bi Cheng Zhang et al. MEDICAL ONCOLOGY
- Lung cancer stem cells: tools and targets to fight lung cancer
- (2010) A Eramo et al. ONCOGENE
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
- (2010) Y. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIF-2 deletion promotes Kras-driven lung tumor development
- (2010) J. Mazumdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
- (2009) Kandice R. Levental et al. CELL
- Lung Cancer in Never Smokers: Molecular Profiles and Therapeutic Implications
- (2009) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- The Cooperative Induction of Hypoxia-Inducible Factor-1 and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis
- (2009) M. Z. Noman et al. JOURNAL OF IMMUNOLOGY
- SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
- (2009) Adam J Bass et al. NATURE GENETICS
- HIF2 inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
- (2009) J. A. Bertout et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human cancers converge at the HIF-2α oncogenic axis
- (2009) Aleksandra Franovic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stem cells are dispensable for lung homeostasis but restore airways after injury
- (2009) A. Giangreco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prognostic significance of hypoxia-inducible factor-1 , TWIST1 and Snail expression in resectable non-small cell lung cancer
- (2009) J-J Hung et al. THORAX
- Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
- (2008) Alexandra Giatromanolaki et al. CANCER LETTERS
- Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
- (2008) Fuyuki Sato et al. GENES TO CELLS
- Role of Chromosome 3q Amplification in Lung Cancer
- (2008) Jun Qian et al. Journal of Thoracic Oncology
- Somatic mutations affect key pathways in lung adenocarcinoma
- (2008) Li Ding et al. NATURE
- Direct regulation of TWIST by HIF-1α promotes metastasis
- (2008) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
- BHLHB3: a candidate tumor suppressor in lung cancer
- (2008) F S Falvella et al. ONCOGENE
- The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development
- (2008) T. V. Sharp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation