期刊
FUTURE ONCOLOGY
卷 10, 期 5, 页码 835-843出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.13.237
关键词
hematologic toxicity; intensity-modulated radiation therapy; intensity-modulated radiation therapy; prostate cancer
类别
资金
- Philips Research, Aachen, Germany
To assess hematologic changes of modern prostate radiation therapy (RT) comparing different target volumes. Patients & methods: Blood samples were evaluated before (T1), during (T2-T4) and 6-8 weeks after (T5) RT in a group of 113 patients. Whole-pelvic RT up to 46 Gy was applied in 27 cases. The total dose to the prostatic fossa (n = 46)/prostate (n = 67) was 66/76 Gy. Results: Erythrocyte, leukocyte and platelet levels decreased significantly relative to baseline levels at T2-T5. Neoadjuvant hormonal therapy had an impact on hemoglobin levels before and during RT. The cumulative incidence of grade 2 leukopenia was 15 versus 2% (p = 0.02) and grade 2 anemia 8 versus 0% (p = 0.03) with versus without whole-pelvic RT, respectively. Lymphocyte decrease was larger at times T2-T5 (36 vs 3% grade 3 toxicity; p < 0.01). Conclusion: Prostate RT has a small but significant and longer effect on the blood count. Lower lymphocyte levels need to be considered when larger volumes are treated.
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