期刊
FUTURE ONCOLOGY
卷 10, 期 5, 页码 865-876出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.13.229
关键词
inhibitors; pancreatic cancer; PIM kinases; prognosis; tumorigenesis
类别
资金
- National Natural Science Foundation of China [81272484, 81141027]
- Beijing Natural Science Foundation [7132179]
- Beijing Municipal Natural Science Foundation [7100003]
The PIM kinases represent a family of serine/threonine kinases, which is composed of three different members (PIM1, PIM2 and PIM3). Aberrant expression of PIM kinases is observed in variety of tumors, including pancreatic cancer. The PIM kinases play pivotal roles in the regulation of cell cycle, apoptosis, properties of stem cells, metabolism, autophagy, drug resistance and targeted therapy. The roles of PIM kinases in pancreatic cancer include the regulation of proliferation, apoptosis, cell cycle, formation, angiogenesis and prediction prognosis. Blocking the activities of PIM kinases could prevent pancreatic cancer development. PIM kinases may be a novel target for cancer therapy.
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