Ubiquitin-specific proteases as cancer drug targets

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of Aurora B

(2011) Renske J. van Leuken et al.   CELL CYCLE

An Atlas of Altered Expression of Deubiquitinating Enzymes in Human Cancer

(2011) Chiara Luise et al.   PLoS One

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

A screen for deubiquitinating enzymes involved in the G2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability

(2010) Bernadette Aressy et al.   CELL CYCLE

Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes

(2010) Matteo Colombo et al.   ChemMedChem

TRE17/Ubiquitin-specific Protease 6 (USP6) Oncogene Translocated in Aneurysmal Bone Cyst Blocks Osteoblastic Maturation via an Autocrine Mechanism Involving Bone Morphogenetic Protein Dysregulation

(2010) Alan W. Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WDR20 Regulates Activity of the USP12·UAF1 Deubiquitinating Enzyme Complex

(2010) Younghoon Kee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

(2010) Yaron Pereg et al.   NATURE CELL BIOLOGY

TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-κB

(2010) Y Ye et al.   ONCOGENE

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

(2010) Z. Du et al.   Science Signaling

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells

(2009) Richard Buus et al.   CURRENT BIOLOGY

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

(2009) Bin Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissection of USP catalytic domains reveals five common insertion points

(2009) Yu Ye et al.   Molecular BioSystems

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

(2009) Jing Shan et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

(2008) Chi-Yuan Chou et al.   BIOCHEMICAL PHARMACOLOGY

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1genes

(2008) Véronique Gelsi-Boyer et al.   BMC CANCER

Tumor suppressor CYLD: negative regulation of NF-κB signaling and more

(2008) G. Courtois   CELLULAR AND MOLECULAR LIFE SCIENCES

UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes

(2008) Martin A. Cohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1

(2008) Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting ubiquitin specific proteases for drug discovery

(2007) Laurent Daviet et al.   BIOCHIMIE