Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma

Intratumoral conversion of flucytosine to 5-fluorouracil using a novel MLV-based replication-competent retroviral vector carrying the cytosine deaminase gene (Toca 511) in an immune-competent model of glioblastoma.

(2017) J. M. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

Central Nervous System Cancers

(2017)   Journal of the National Comprehensive Cancer Network

Potential therapeutic implications of cancer stem cells in glioblastoma

(2010) Lin Cheng et al.   BIOCHEMICAL PHARMACOLOGY

A reproducible brain tumour model established from human glioblastoma biopsies

(2010) Jian Wang et al.   BMC CANCER

The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase

(2010) Da-Young Chang et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics

(2010) M. Puntel et al.   JOURNAL OF VIROLOGY

Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy

(2010) G. Elizabeth Pluhar et al.   VACCINE

Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo

(2009) A Ardiani et al.   CANCER GENE THERAPY

Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-β

(2009) D H Meijer et al.   CANCER GENE THERAPY

Human neural stem cells transduced with IFN-β and cytosine deaminase genes intensify bystander effect in experimental glioma

(2009) S Ito et al.   CANCER GENE THERAPY

Adenovirus Mediated Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Gene Therapy for Resectable Malignant Glioma

(2009) Ann-Marie Maatta et al.   CURRENT GENE THERAPY

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment

(2009) P C Huszthy et al.   GENE THERAPY

A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro®) after intracerebral administration

(2009) Gillian Langford et al.   JOURNAL OF GENE MEDICINE

Tumor initiating cells in malignant gliomas: biology and implications for therapy

(2009) Costas G. Hadjipanayis et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Oncolytic viral therapy of malignant glioma

(2009) Jacqueline Nuss Parker et al.   Neurotherapeutics

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells as Vectors to Deliver HSV/tk Gene Therapy for Malignant Gliomas

(2009) Prakash Rath et al.   Current Stem Cell Research & Therapy

Homing properties of adipose-derived stem cells to intracerebral glioma and the effects of adenovirus infection

(2008) Martine Lamfers et al.   CANCER LETTERS

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma

(2008) S. M. Kim et al.   CANCER RESEARCH

Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats

(2008) Gang Xu et al.   CELL BIOLOGY INTERNATIONAL

Radiation-Inducible Caspase-8 Gene Therapy for Malignant Brain Tumors

(2008) Hideo Tsurushima et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring

(2008) Anniina Laurema et al.   JOURNAL OF GENE MEDICINE

Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2

(2008) Oszkar Szentirmai et al.   JOURNAL OF NEUROSURGERY

Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide

(2008) S. Hingtgen et al.   MOLECULAR CANCER THERAPEUTICS

Preventing Growth of Brain Tumors by Creating a Zone of Resistance

(2008) Casey A Maguire et al.   MOLECULAR THERAPY

A Phase I Trial of Ad.hIFN-β Gene Therapy for Glioma

(2008) E Antonio Chiocca et al.   MOLECULAR THERAPY

A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas

(2008) Peter Forsyth et al.   MOLECULAR THERAPY

Phase Ib Trial of Oncolytic Herpes Virus G207 Shows Safety of Multiple Injections and Documents Viral Replication

(2008) Manish K Aghi et al.   MOLECULAR THERAPY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY