期刊
FUTURE ONCOLOGY
卷 4, 期 5, 页码 647-660出版社
FUTURE MEDICINE LTD
DOI: 10.2217/14796694.4.5.647
关键词
beta-catenin; hepatocellular carcinoma; liver; metabolic zonation; Wnt pathway
类别
资金
- CNRS-CANAM/AP-HP
- Association Charles Debray
- INSERM
- CNRS
- Ligue Nationale Contre Le Cancer [ANR-07-Physio]
The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma, Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.
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