Article
Microbiology
Karen O. Mathews, David Phalen, Jacqueline M. Norris, John Stenos, Jenny-Ann Toribio, Nicholas Wood, Stephen Graves, Paul A. Sheehy, Chelsea Nguyen, Katrina L. Bosward
Summary: This study assessed the exposure levels and risk factors for Rickettsia spp. among Australian wildlife rehabilitators, finding that rehabilitators are more likely to contract Rickettsia-related illnesses. However, the exact source of increased seropositivity remains unclear.
Article
Infectious Diseases
Tetsuro Aita, Eiichiro Sando, Shungo Katoh, Sugihiro Hamaguchi, Hiromi Fujita, Noriaki Kurita
Summary: This study examined the frequency of cross-reactions to Rickettsia typhi in patients with Japanese spotted fever and evaluated the differences between two rickettsiae using antibody endpoint titers. Approximately 20% of cases showed positive cross-reactions. However, with the exception of some cases, we were able to successfully differentiate JSF from murine typhus using each endpoint titer.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hitomi Kinoshita, Yuzo Arima, Mika Shigematsu, Tomimasa Sunagawa, Masayuki Saijo, Kazunori Oishi, Shuji Ando
Summary: This study aimed to describe the epidemiological and clinical characteristics of scrub typhus and Japanese spotted fever in Japan over a 10-year period. The study found that the elderly had higher notification rates and fatalities, with stable notifications for scrub typhus and an increase for Japanese spotted fever expanding towards the east. Seasonality and regional variations in the distribution of the diseases were identified, likely related to the ecology of vectors and etiological agents, providing valuable information for clinical diagnosis and preventative activities.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Clare E. Warrell, Jane Osborne, Laura Nabarro, Barry Gibney, Daniel P. Carter, Jennifer Warner, Catherine F. Houlihan, Timothy J. G. Brooks, Tommy Rampling
Summary: This retrospective study describes the burden of imported rickettsial infection in the UK. Through categorization and analysis of rickettsial cases diagnosed at the national reference laboratory between 2015 and 2022, it was found that there were 220 patients with rickettsioses, with acute spotted fever group infection being the most common import. Thorough history, examination, and timely treatment with doxycycline should be considered if there is suspicion of Rickettsia infection before testing.
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Xiu-Gang Guan, Yue-Hong Wei, Bao-Gui Jiang, Shi-Xia Zhou, An-Ran Zhang, Qing-Bin Lu, Zi-Wei Zhou, Jin-Jin Chen, Hai-Yang Zhang, Yang Ji, Yang Yang, Li-Qun Fang, Hao Li, Zhi-Cong Yang, Wei Liu
Summary: This study compared the clinical features and risk factors for severe disease in pediatric and elderly patients with scrub typhus. The findings showed significant differences in clinical characteristics between the two groups. Risk factors for severe disease also differed, with different factors identified for pediatric and elderly patients. These findings highlight the importance of age-specific methods in the diagnosis and risk assessment of scrub typhus.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Yani Zhou, Qi Wang, Yujuan Shen, Bin Shen, Yan Zhang, Weihong Wang, Xiaofeng Li
Summary: An elderly woman was admitted to the hospital with abdominal pain and fever. Her condition rapidly worsened with severe complications, such as multiple organ failure and central nervous system damage. The presence of Rickettsia japonica was detected by metagenomic next-generation sequencing, leading to the diagnosis of critical Japanese spotted fever. The patient was successfully treated with doxycycline and showed good prognosis. Typical symptoms (eschar and rash) were not observed in the early stage, increasing the difficulty of clinical diagnosis.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Parasitology
Joanna Hildebrand, Agnieszka Perec-Matysiak, Marcin Popiolek, Dorota Merta, Izabella Mysliwy, Katarzyna Bunkowska-Gawlik
Summary: This study provides evidence of the occurrence of Rickettsia pathogens and endosymbionts in the European population of raccoons for the first time. Further research on different species of wild vertebrates, ticks, as potential vectors and hosts for tick-borne pathogens, is needed.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Jihye Um, Yeonghwa Nam, Ji Na Lim, Misuk Kim, Yeonsu An, Se Hee Hwang, Jun-Sun Park
Summary: This study investigated the seroprevalence of antibodies against scrub typhus, murine typhus, and spotted fever groups among North Korean refugees within 1 year of their arrival in South Korea. The findings suggest that rickettsial infections should be considered in the differential diagnosis for North Koreans with fever after entering South Korea.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Mark C. Blaser, Simon Kraler, Thomas F. Luescher, Elena Aikawa
Summary: Calcific aortic valve disease is expected to almost triple in prevalence over the next 3 decades and currently lacks effective pharmacotherapy to halt its progression. Invasive aortic valve replacement remains the only treatment option, highlighting a substantial gap in care due to limited understanding of disease mechanisms and complex valvular microenvironment. Multiomics approaches, single-cell resolution studies, and systems biology strategies hold promise in shedding new light on valvular disease pathogenesis and identifying potential drug targets.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Silvita Fitri Riswari, Susantina Prodjosoewojo, Siti Rasnawati Mony, Imam Megantara, Shelly Iskandar, Wulan Mayasari, Henhen Heryaman, Quirijn de Mast, Andre van der Ven, Herman Kosasih, Bachti Alisjahbana
Summary: The study aimed to describe the clinical characteristics of murine typhus (MT) cases in Bandung, West Java, Indonesia. Results showed that MT is an important cause of acute febrile illness (AFI) in Indonesia, but is rarely reported. Common clinical symptoms in confirmed MT cases included headache, arthralgia, malaise, and myalgia. The study suggested including MT in the differential diagnosis of AFI and considering empirical treatment with doxycycline.
Review
Oncology
Zijian Zou, Wei Sun, Yu Xu, Wanlin Liu, Jingqin Zhong, Xinyi Lin, Yong Chen
Summary: Sarcomas are rare mesenchymal neoplasms with unique genetic characteristics, and their diagnosis relies heavily on pathological examination. Advanced treatments and multi-omics approaches have shown promise in improving outcomes and understanding sarcomas, but further research is needed to optimize their clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Alexander Arsov, Kaloyan Petrov, Penka Petrova
Summary: This article discusses the potential of microbial production of butanol as a new fuel and the challenge of butanol toxicity to microbes. Modern omics approaches have made significant progress in addressing the issue of low butanol tolerance, but a strain capable of both synthesis and tolerance at commercializable concentrations has yet to be discovered or produced.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Infectious Diseases
Hayet Bouchaib, Achour Amrane, Jacques Sevestre, Idir Bitam, Phillipe Parola
Summary: Mediterranean spotted fever (MSF), caused by Rickettsia conorii, is an ancient tick-borne disease primarily found in the Mediterranean region. It is transmitted by the brown dog tick Rhipicephalus sanguineus and typically presents with a skin rash, high fever, and characteristic eschar at the site of the tick bite. The disease can have a benign or life-threatening course, and neurological manifestations are uncommon. We report a case of isolated peripheral facial nerve palsy as a complication of R conorii conorii infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Food Science & Technology
Karolinny Cristiny de Oliveira Vieira, Hevelin Regiane Augusto da Silva, Isabela Poletto Masselli Rocha, Emmanuel Barboza, Lizziane Kretli Winkelstroter Eller
Summary: Outbreaks and deaths related to Foodborne Diseases (FBD) are constantly occurring worldwide, largely due to consumption of contaminated foodstuffs with pathogens. This review discusses the main omic techniques applied in foodborne pathogens and their potential in ensuring food safety. Omics have been shown to integrate variables that contribute to food safety and improve consumer health, costs, and product quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Maozhang He, Lifeng Zhang, Haoran Hu, Xiaohan Liu, Cong Zhang, Yu Xin, Boyu Liu, Zhen Chen, Kehan Xu, Yan Liu
Summary: In this study, a new strain of R. heilongjiangensis was isolated from a patient bitten by a Haemaphysalis longicornis tick in China. Comparative genomics analysis revealed unique genes associated with the pathogenicity of this strain. The findings suggest that this strain may represent a previously undescribed human-pathogenic lineage between R. heilongjiangensis and R. japonica.
EMERGING MICROBES & INFECTIONS
(2023)
