Review
Microbiology
Yi Shi, Chengxi Zhang, Shuo Pan, Yi Chen, Xingguo Miao, Guoqiang He, Yanchan Wu, Hui Ye, Chujun Weng, Huanhuan Zhang, Wenya Zhou, Xiaojie Yang, Chenglong Liang, Dong Chen, Liang Hong, Feifei Su
Summary: This article reviews the efficacy of emerging technologies in the diagnosis and management of tuberculous meningitis (TBM). Advanced diagnostic technologies like targeted gene sequencing, real-time polymerase chain reaction (RT-PCR), miRNA assays, and metagenomic next-generation sequencing (mNGS) offer promising avenues for early TBM detection. Machine learning algorithms can enhance diagnostic accuracy and guide treatment strategies. However, these emerging technologies still face challenges in clinical implementation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Michelle C. Sabo, Nguyen T. T. Thuong, Xuling Chang, Edwin Ardiansyah, Trinh T. B. Tram, Hoang T. Hai, Ho D. T. Nghia, Nguyen D. Bang, Sofiati Dian, A. Rizal Ganiem, Shima Shaporifar, Vinod Kumar, Zheng Li, Martin Hibberd, Chiea Chuen Khor, Guy E. Thwaites, Dorothee Heemskerk, Arjan van Laarhoven, Reinout van Crevel, Sarah J. Dunstan, Javeed A. Shah
Summary: This study reveals an association between a polymorphism in MUC5AC gene and susceptibility to and mortality from tuberculous meningitis. MUC5AC variants may affect immune response and thus influence the outcomes of tuberculous meningitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Public, Environmental & Occupational Health
Sayyed Gholamreza Mortazavi-Moghaddam, Abdol Sattar Pagheh, Ehsan Ahmadpour, Alacsandra Barac, Azadeh Ebrahimzadeh
Summary: The number of extrapulmonary tuberculosis cases has increased in recent years in Iran. This study aimed to determine the epidemiological status, clinical symptoms, diagnostic methods, and treatment strategies of extrapulmonary tuberculosis, specifically focusing on tuberculosis meningitis and miliary tuberculosis. The study found a higher prevalence of tuberculosis meningitis in certain provinces and identified the common symptoms and diagnostic procedures for both tuberculosis meningitis and miliary tuberculosis. The conventional 6-month treatment approach was used for all participants in the investigations.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Review
Immunology
An Wen, Er-Ling Leng, Shi-Min Liu, Yong-Liang Zhou, Wen-Feng Cao, Dong-Yuan Yao, Fan Hu
Summary: In this meta-analysis, we found that cerebrospinal fluid (CSF) interferon release assays (IGRAs) exhibited a better diagnostic accuracy than blood IGRAs in diagnosing tuberculous meningitis (TBM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Christian M. Lo Cascio, Viren Kaul, Sahajal Dhooria, Abhinav Agrawal, Udit Chaddha
Summary: Tuberculous pleural effusion is a common presentation of extrapulmonary tuberculosis, posing diagnostic challenges. In addition to biomarkers and PCR methods, pleural biopsies are important for confirming the diagnosis.
RESPIRATORY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Abhishek Shridhar, Ravindra Kumar Garg, Imran Rizvi, Mili Jain, Wahid Ali, Hardeep Singh Malhotra, Neeraj Kumar, Praveen Kumar Sharma, Rajesh Verma, Ravi Uniyal, Shweta Pandey
Summary: This study evaluated the proportion of underlying primary immunodeficiency in patients with tuberculous meningitis and its impact on the outcome. The results showed that absolute lymphocyte count and CD4+ T-cell count were lower in tuberculous meningitis cases, and higher serum IgG levels may be associated with a poor outcome.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Microbiology
Robindra Basu Roy, Sabrina Bakeera-Kitaka, Chishala Chabala, Diana M. Gibb, Julie Huynh, Hilda Mujuru, Naveen Sankhyan, James A. Seddon, Suvasini Sharma, Varinder Singh, Eric Wobudeya, Suzanne T. Anderson
Summary: Children affected by tuberculous meningitis have complex needs that may not be fully addressed within current tuberculosis and meningitis programs. By applying the five pillars outlined in the global roadmap, specific goals and activities can be implemented to defeat TBM in children. Integration between meningitis and TB programs at both the WHO and national levels is crucial for addressing these needs effectively.
Article
Clinical Neurology
Karen du Preez, Helen E. Jenkins, Peter R. Donald, Regan S. Solomons, Stephen M. Graham, H. Simon Schaaf, Jeffrey R. Starke, Anneke C. Hesseling, James A. Seddon
Summary: Tuberculous meningitis (TBM) is a significant cause of illness and death in children with tuberculosis (TB), but there are currently no estimates of the global burden of pediatric TBM. Due to non-specific symptoms and limited diagnostic tests, children with TBM are often diagnosed late or not at all. Even with diagnosis and treatment, 20% of children with TBM still die and survivors often have significant neurological disabilities. Improved surveillance of pediatric TBM is crucial for prevention, early diagnosis, and improved care.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Aiqing Lin, Baotao Cheng, Xiaochun Han, Hong Zhang, Xiaoli Liu, Xueping Liu
Summary: The study aimed to evaluate the application of next-generation sequencing (NGS) technology in the early diagnosis of TBM patients. The results showed that NGS technology combined with MTB culture could increase the detection rate of TBM.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Jaime Soria, Alfredo Chiappe, Jorge Gallardo, Joseph R. Zunt, Andres G. Lescano
Summary: The impact of treatment initiation timing on mortality was studied in adult hospitalized patients with confirmed tuberculous meningitis. The high mortality rate among these patients was associated with delay in treatment initiation, older age, HIV infection, and higher disease severity at admission.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Clinical Neurology
Kenneth Ssebambulidde, Jane Gakuru, Jayne Ellis, Fiona V. Cresswell, Nathan C. Bahr
Summary: Diagnosis of TBM remains challenging due to the limitations of current diagnostic methods. A combination of clinical factors and various investigations are utilized for diagnosis. Starting empiric therapy promptly is crucial for good outcomes in many cases.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ali Purmohamad, Taher Azimi, Mohammad J. Nasiri, Mehdi Goudarzi, Moein Zangiabadian, Hamid Sedighian, Abbas A. Fooladi
Summary: The study revealed a high prevalence of TBM-HIV co-infection, emphasizing the importance of establishing proper diagnostic criteria and preventive measures to prevent and manage TBM infections effectively, especially TBM-HIV co-infection.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Neurosciences
Julianto Tomidy, Gede Bagus Yoga Satriadinatha, Filbert Kurnia Liwang, Kartika Maharani, Darma Imran, Riwanti Estiasari
Summary: This study conducted a systematic review and meta-analysis to identify predictors of stroke in patients with tuberculous meningitis. The results showed that clinical presentations of vomiting, cranial nerve deficit, focal deficit, altered consciousness; comorbidity of diabetes mellitus, hypertension, smoking history, ischemic heart disease; and radiological findings of meningeal enhancement and hydrocephalus were significantly associated with stroke incidence in tuberculous meningitis.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Mailing Huang, Yan Ma, Xinyu Ji, Hui Jiang, Fangchao Liu, Naihui Chu, Qi Li
Summary: This study aimed to identify the risk factors for tuberculous meningitis (TBM) among patients with tuberculosis (TB). A retrospective analysis was conducted on TB patients admitted to Beijing Chest Hospital between January 2012 and December 2019. The study found that being younger than 30, being a farmer, and having disseminated tuberculosis were identified as risk factors for TBM. Screening TB patients with these risk factors could aid in early detection of TBM.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Haiko Schurz, Brigitte Glanzmann, Nicholas Bowker, Ronald van Toorn, Regan Solomons, Johan Schoeman, Paul D. van Helden, Craig J. Kinnear, Eileen G. Hoal, Marlo Moeller
Summary: This study investigated the involvement of the host genome in susceptibility to tuberculous meningitis (TBM) using genotyping and sequencing methods. The results suggest that genes NOD2 and CYP4F2 may play important roles in the pathogenesis of TBM, while Centriolar Coiled-Coil Protein 110 (CCP110) may be associated with susceptibility to TBM.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Monica Campo, April K. Randhawa, Sarah Dunstan, Jeremy Farrar, Maxine Caws, Nguyen Duc Bang, Nguyen Ngoc Lan, Tran Thi Hong Chau, David J. Horne, Nguyen Thuong Thuong, Guy E. Thwaites, Thomas R. Hawn
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2015)
Article
Public, Environmental & Occupational Health
Walter R. Taylor, Annette Fox, Khuong Thi Pham, Hoa Nguyen Minh Le, Ninh Thi Hai Tran, Giang Van Tran, Binh Thanh Nguyen, My Van Nguyen, Lien Thi Nguyen, Sophie Yacoub, Hoai Thi Thu Nguyen, Ha Hong Nguyen, Hien Duc Nguyen, Heiman Wertheim, Peter Horby, Jeremy Farrar, Lien Thi Minh Trinh, Kinh Van Nguyen
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Public, Environmental & Occupational Health
Corinne N. Thompson, Stuart D. Blacksell, Daniel H. Paris, Amit Arjyal, Abhilasha Karkey, Sabina Dongol, Abhishek Giri, Christiane Dolecek, Nick Day, Stephen Baker, Guy Thwaites, Jeremy Farrar, Buddha Basnyat
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Microbiology
Christopher M. Parry, Nga Tran Vu Thieu, Christiane Dolecek, Abhilasha Karkey, Ruchi Gupta, Paul Turner, David Dance, Rapeephan R. Maude, Vinh Ha, Chinh Nguyen Tran, Phuong Le Thi, Bay Pham Van Be, La Tran Thi Phi, Rang Nguyen Ngoc, Aniruddha Ghose, Sabina Dongol, James I. Campbell, Duy Pham Thanh, Tuyen Ha Thanh, Catrin E. Moore, Soeng Sona, Rajni Gaind, Monorama Deb, Ho Van Anh, Sach Nguyen Van, Hien Tran Tinh, Nicholas P. J. Day, Arjen Dondorp, Guy Thwaites, Mohamed Abul Faiz, Rattanaphone Phetsouvanh, Paul Newton, Buddha Basnyat, Jeremy J. Farrar, Stephen Baker
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Correction
Microbiology
Christopher M. Parry, Nga Tran Vu Thieu, Christiane Dolecek, Abhilasha Karkey, Ruchi Gupta, Paul Turner, David Dance, Rapeephan R. Maude, Vinh Ha, Chinh Nguyen Tran, Phuong Le Thi, Bay Pham Van Be, La Tran Thi Phi, Rang Nguyen Ngoc, Aniruddha Ghose, Sabina Dongol, James I. Campbell, Duy Pham Thanh, Tuyen Ha Thanh, Catrin E. Moore, Soeng Sona, Rajni Gaind, Monorama Deb, Ho Van Anh, Sach Nguyen Van, Hien Tran Tinh, Nicholas P. J. Day, Arjen Dondorp, Guy Thwaites, Mohamed Abul Faiz, Rattanaphone Phetsouvanh, Paul Newton, Buddha Basnyat, Jeremy J. Farrar, Stephen Baker
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Biotechnology & Applied Microbiology
Lien Anh Ha Do, Andreas Wilm, H. Rogier van Doorn, Ha Minh Lam, Shuzhen Sim, Rashmi Sukumaran, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Khanh Le, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Jeremy Farrar, Menno de Jong, Swaine Chen, Niranjan Nagarajan, Juliet E. Bryant, Martin L. Hibberd
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Infectious Diseases
Annette Fox, Le Quynh Mai, Le Thi Thanh, Marcel Wolbers, Nguyen Le Khanh Hang, Pham Quang Thai, Nguyen Thi Thu Yen, Le Nguyen Minh Hoa, Juliet E. Bryant, Tran Nhu Duong, Dang Dinh Thoang, Ian G. Barr, Heiman Wertheim, Jeremy Farrar, Nguyen Tran Hien, Peter Horby
JOURNAL OF INFECTION
(2015)
Editorial Material
Medicine, General & Internal
Christopher J. M. Whitty, Trevor Mundel, Jeremy Farrar, David L. Heymann, Sally C. Davies, Mark J. Walport
Letter
Medicine, General & Internal
Buddha Basnyat, Harry R. Dalton, Nassim Kamar, David B. Rein, Alain Labrique, Jeremy Farrar, Peter Piot
Article
Medicine, General & Internal
Vu Phuong Thao, Vo Minh Quang, Marcel Wolbers, Nguyen Duc Anh, Cecilia Shikuma, Jeremy Farrar, Sarah Dunstan, Nguyen Van Vinh Chau, Jeremy Day, Guy Thwaites, Thuy Le
Article
Genetics & Heredity
Vanessa K. Wong, Stephen Baker, Derek J. Pickard, Julian Parkhill, Andrew J. Page, Nicholas A. Feasey, Robert A. Kingsley, Nicholas R. Thomson, Jacqueline A. Keanel, Francois-Xavier Weill, David J. Edwards, Jane Hawkey, Simon R. Harris, Alison E. Mather, Amy K. Cain, James Hadfield, Peter J. Hart, Nga Tran Vu Thieu, Elizabeth J. Klemm, Dafni A. Glinos, Robert F. Breiman, Conall H. Watson, Samuel Kariuki, Melita A. Gordon, Robert S. Heyderman, Chinyere Okoro, Jan Jacobs, Octavie Lunguya, W. John Edmunds, Chisorno Msefula, Jose A. Chabalgoity, Mike Kama, Kylie Jenkins, Shanta Dutta, Florian Marks, Josefina Campos, Corinne Thompson, Stephen Obaro, Calman A. MacLennan, Christiane Dolecek, Karen H. Keddy, Anthony M. Smith, Christopher M. Parry, Abhilasha Karkey, E. Kim Mulholland, James I. Campbell, Sabina Dongol, Buddha Basnyat, Muriel Dufour, Don Bandaranayake, Take Toleafoa Naseri, Shalini Pravin Singh, Mochammad Hatta, Paul Newton, Robert S. Onsare, Lupeoletalalei Isaia, David Dance, Viengmon Davong, Guy Thwaites, Lalith Wijedoru, John A. Crump, Elizabeth De Pinna, Satheesh Nair, Eric J. Nilles, Duy Pham Thanh, Paul Turner, Sona Soeng, Mary Valcanis, Joan Powling, Karolina Dimovski, Geoff Hogg, Jeremy Farrar, Kathryn E. Holt, Gordon Dougan
Correction
Immunology
Wanwisa Dejnirattisai, Wiyada Wongwiwat, Sunpetchuda Supasa, Xiaokang Zhang, Xinghong Dai, Alexander Rouvinsky, Amonrat Jumnainsong, Carolyn Edwards, Nguyen Than Ha Quyen, Thaneeya Duangchinda, Jonathan M. Grimes, Wen-Yang Tsai, Chih-Yun Lai, Wei-Kung Wang, Prida Malasit, Jeremy Farrar, Cameron P. Simmons, Z. Hong Zhou, Felix A. Rey, Juthathip Mongkolsapaya, Gavin R. Screaton
Correction
Immunology
Wanwisa Dejnirattisai, Wiyada Wongwiwat, Sunpetchuda Supasa, Xiaokang Zhang, Xinghong Dai, Alexander Rouvinski, Amonrat Jumnainsong, Carolyn Edwards, Nguyen Than Ha Quyen, Thaneeya Duangchinda, Jonathan M. Grimes, Wen-Yang Tsai, Chih-Yun Lai, Wei-Kung Wang, Prida Malasit, Jeremy Farrar, Cameron P. Simmons, Z. Hong Zhou, Felix A. Rey, Juthathip Mongkolsapaya, Gavin R. Screaton
Editorial Material
Medicine, General & Internal
Stanley A. Plotkin, Adel A. F. Mahmoud, Jeremy Farrar
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Infectious Diseases
Michael Osterholm, Kristine Moore, Julie Ostrowsky, Kathleen Kimball-Baker, Jeremy Farrar
LANCET INFECTIOUS DISEASES
(2016)