期刊
FUTURE MICROBIOLOGY
卷 4, 期 7, 页码 891-902出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.64
关键词
biosynthesis; cardiovascular system; classification; distribution; molecular approach; oral cavity; polysaccharide; serological approach; serotype; Streptococcus mutans
类别
Streptococcus mutans, generally known as a major pathogen of dental caries, is also a possible causative agent of bacteremia and infective endocarditis. S. mutans is classified into serotypes c, e, f and k based on the chemical composition of serotype-specific polysaccharides, with approximately 70-80% of strains found in the oral cavity classified as serotype c, followed by e (similar to 20%), and f and k (less than 5% each). Serotype k was recently designated as a novel serotype and shown to possess unique features, the most prominent being a defect of the glucose side chain in serotype-specific rhamnose-glucose polymers, which is related to a higher incidence of detection in cardiovascular specimens, owing to phagocytosis resistance, Molecular analyses of cardiovascular specimens showed a high detection frequency for S. mutans DNA, among which the detection rate for serotype k was quite high. These findings suggest that serotype k S. mutans possibly has a high level of virulence for systemic diseases.
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