Article
Immunology
Dongmiao Chen, Peiting Wu, Duoduo Liu, Tingting Shen, Shangmin Liu, Huayou Zhou, Congrong Wang
Summary: In this study, the levels of serum M. pneumoniae typing antibodies in children with community-acquired pneumonia (CAP) were detected by chemiluminescent immunoassay (CLIA) to explore the clinical role of M. pneumoniae typing antibody (MP-IgM, MP-IgG) in M. pneumoniae pneumonia. The results showed that CLIA has higher specificity and sensitivity for the quantitative detection of MP-IgM and MP-IgG, playing an important role in early diagnosis and prompt intervention to reduce macrolide-resistant strains and sequelae of children with M. pneumoniae pneumonia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Tomohiro Oishi, Daisuke Yoshioka, Takashi Nakano, Kazunobu Ouchi
Summary: Macrolide-resistant Mycoplasma pneumoniae (MRMP) infections are becoming more common in East Asia. Monitoring antibiotic susceptibility and identifying mutations in resistant strains is crucial for managing the disease effectively. A study in Japan found that out of 122 M. pneumoniae strains, 76 were susceptible to macrolides and 46 were resistant. None of the strains showed resistance to tosufloxacin or minocycline. The study also revealed a decrease in susceptibility to clarithromycin and azithromycin, and an increase in susceptibility to tosufloxacin.
Article
Medicine, General & Internal
Naoyuki Miyashita, Yasushi Nakamori, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Yoshihisa Ishiura, Shosaku Nomura
Summary: This study aimed to compare the clinical and radiological differences between Mycoplasma pneumoniae community-acquired pneumonia (M. pneumoniae CAP) and COVID-19 CAP. The study found that patients with M. pneumoniae CAP were significantly younger and more likely to experience cough and sputum. In contrast, patients with COVID-19 CAP often had loss of taste and anosmia, which were not observed in M. pneumoniae CAP. Chest computed tomography (CT) features characteristic of M. pneumoniae CAP were rarely seen in patients with COVID-19 CAP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Fei Fan, Jun Lv, Qianyuan Yang, Fei Jiang
Summary: This study compared the demographic and clinical characteristics, laboratory and imaging findings in children with mycoplasma pneumoniae pneumonia (MPP) and non-MPP (NMPP) children, as well as general MPP (GMPP) children and children with refractory MPP (RMPP). The results showed that children with MPP had longer fever duration and hospital stay, and a higher prevalence of pleural effusion, lung consolidation, and bronchopneumonia on imaging. The levels of inflammatory markers were significantly higher in the MPP group, and the clinical symptoms and pulmonary imaging findings were more severe in the RMPP group. IL-6, IL-10, LDH, PT, and D-dimer were identified as predictive indicators for RMPP.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Bing Wei, Yan-Hong Dang, Xiang-Ping Liu, Miao Li
Summary: This study aimed to investigate the differences in characteristics of Mycoplasma pneumoniae pneumonia (MPP) among children with and without asthma, as well as among children with asthma with and without inhaled corticosteroid (ICS) therapy. The study found that children with asthma had higher chances of wheezing compared to those without asthma. Furthermore, children with asthma who received ICS therapy had fewer and less severe exacerbations of MPP compared to those without ICS therapy. ICS therapy was identified as an independent protective factor against exacerbation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Mengyang Liu, Ke Meng, Jun Jiang, Li Zhang, Shiying Sun
Summary: This study aimed to evaluate the diagnostic value of CLIA, PPA, and IFA in detecting Mycoplasma pneumoniae infection in children. CLIA MP-IgM showed high concordance with PPA and had higher specificity and sensitivity compared to CLIA MP-IgG and IFA MP-IgM. CLIA MP (IgM+IgG) had higher sensitivity and negative predictive value than PPA or IFA, indicating its priority in the diagnosis of MP infection.
Review
Immunology
Ti-An Tsai, Chang-Ku Tsai, Kuang-Che Kuo, Hong-Ren Yu
Summary: Mycoplasma pneumoniae is increasingly becoming resistant to macrolide antibiotics in Taiwan, leading to treatment challenges and the need for alternative therapies such as tetracyclines or fluoroquinolones. Refractory MPP is characterized by an excessive immune response, which may be modulated by corticosteroids as a potential treatment option.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang, Yi Du, Jing Wang, Huilin Li, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Changdi Xu, Yan Liu, Deyu Zhao, Yun Guo, Feng Liu
Summary: This study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from children with MPP and found that the progression of MPP is associated with the host immune response, especially the intrinsic immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Yun Jung Choi, Eun Hee Chung, Eun Lee, Chul-Hong Kim, Yong Ju Lee, Hyo-Bin Kim, Bong-Seong Kim, Hyung Young Kim, Yoojung Cho, Ju-Hee Seo, In Suk Sol, Myongsoon Sung, Dae Jin Song, Young Min Ahn, Hea Lin Oh, Jinho Yu, Sungsu Jung, Kyung Suk Lee, Ju Suk Lee, Gwang Cheon Jang, Yoon-Young Jang, Hai Lee Chung, Sung-Min Choi, Man Yong Han, Jung Yeon Shim, Jin Tack Kim, Chang-Keun Kim, Hyeon-Jong Yang, Dong In Suh
Summary: This study aims to compare the characteristics of macrolide-refractory Mycoplasma pneumoniae pneumonia (MrMP) and macrolide-sensitive Mycoplasma pneumoniae pneumonia (MSMP) in Korean children. The results showed that MrMP patients had longer fever duration and more severe clinical and radiographic findings compared to MSMP patients. Therefore, prompt management with alternative agents is necessary for these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Mingyu Tang, Dong Wang, Xing Tong, Yufen Wu, Jing Zhang, Lei Zhang, Yong Yin, Qing Cao
Summary: The study aimed to compare diagnostic methods for Mycoplasma pneumoniae in children and found that a combination of MP-RNA (SAT) plus MP-IgM (PA) could be a reliable early diagnostic method with higher sensitivity and specificity than single M. pneumoniae detection.
Article
Pediatrics
Jiande Chen, Yong Yin, Liebin Zhao, Lei Zhang, Jing Zhang, Shuhua Yuan
Summary: A nomogram incorporating five factors achieved good predictive accuracy for Mp infection in hospitalized children with CAP, with moderate agreements between the actual outcome and the predicted probability. The model could effectively stratify patients into low, medium, and high risk groups, and outperformed the model developed from age and duration of fever based on AIC and BIC values.
PEDIATRIC PULMONOLOGY
(2021)
Review
Medicine, General & Internal
Lin Tong, Shumin Huang, Chen Zheng, Yuanyuan Zhang, Zhimin Chen
Summary: Refractory Mycoplasma pneumoniae pneumonia is a severe infection that has attracted attention recently. The pathogenesis is unclear, but excessive immune responses and macrolide resistance might play important roles. Detection of resistance, clinical unresponsiveness, and elevated proinflammatory cytokines can help identify and treat this condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Qiaoyi Xie, Xiaote Zhang, Wei Cui, Yajiao Pang
Summary: A retrospective study was conducted to evaluate the relevant data of children with MUMPP who continued to be treated with macrolide. A nomogram was constructed to identify RMPP based on age, leukocyte count, neutrophil proportion, serum procalcitonin, and lactate dehydrogenase. The nomogram showed excellent discrimination and good calibration.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pediatrics
Chenrong Bian, Songtao Li, Shaohu Huo, Beibei Yang, Pingping Wang, Wenhong Li, Shenggang Ding
Summary: This study investigated the severity of Mycoplasma pneumoniae pneumonia (MPP) in atopic vs. nonatopic children and found that atopic children had more severe symptoms in terms of prolonged fever, hospitalization, extra-pulmonary complications, asthma, steroid and oxygen treatment, and increased IgE levels.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Yi-Chen Lee, Chih-Hao Chang, Wei-Ju Lee, Ta-Yu Liu, Chih-Min Tsai, Ti-An Tsai, Chang-Ku Tsai, Kuang-Che Kuo, Chih-Cheng Chen, Chen-Kuang Niu, Hong-Ren Yu
Summary: This study investigated changes in plasma chemokines in children with Mycoplasma pneumoniae pneumonia before and after treatment. Results showed alterations in chemokine profiles after treatment, with distinct manifestations in chemokine profiles between NRMPP and RMPP infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
