标题
Inhibition of lactate dehydrogenase activity as an approach to cancer therapy
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 6, Issue 4, Pages 429-445
出版商
Future Science, LTD
发表日期
2014-03-18
DOI
10.4155/fmc.13.206
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
- (2016) Bjørn Quistorff et al. Aging-US
- Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1
- (2013) Marina Vettraino et al. ANTI-CANCER DRUGS
- Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
- (2013) Peter S. Dragovich et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration
- (2013) Robert Arseneault et al. CANCER LETTERS
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors
- (2013) Anna Kohlmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds
- (2013) Carlotta Granchi et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Lactate Dehydrogenase-B Is Silenced by Promoter Methylation in a High Frequency of Human Breast Cancers
- (2013) Nicola J. Brown et al. PLoS One
- Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
- (2013) Yefei Rong et al. TUMOR BIOLOGY
- Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
- (2012) Luigi Fiume et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes
- (2012) Hongpeng He et al. BIOSCIENCE REPORTS
- Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4
- (2012) Yongjie Zhang et al. CANCER LETTERS
- An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer
- (2012) M. L. McCleland et al. CANCER RESEARCH
- Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas
- (2012) M. L. McCleland et al. CLINICAL CANCER RESEARCH
- Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- (2012) F. Farabegoli et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation
- (2012) Richard A. Ward et al. JOURNAL OF MEDICINAL CHEMISTRY
- A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies
- (2012) Hongxia Lin et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma
- (2012) Feng Yao et al. TUMOR BIOLOGY
- Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy
- (2012) Weiqin Lu et al. PLOS BIOLOGY
- Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer
- (2011) G. Sonpavde et al. ANNALS OF ONCOLOGY
- LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
- (2011) Zhi-Yu Wang et al. BREAST CANCER RESEARCH AND TREATMENT
- Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
- (2011) Y. Zhao et al. CANCER RESEARCH
- Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis
- (2011) X. Zha et al. CANCER RESEARCH
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
- (2011) Marcella Manerba et al. ChemMedChem
- Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects
- (2011) June-Hyung Kim et al. EXPERIMENTAL CELL RESEARCH
- Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
- (2011) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
- (2011) Julia Penna-Coutinho et al. PLoS One
- LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo
- (2011) Stefan Langhammer et al. Targeted Oncology
- Differences and similarities in binding of pyruvate and l-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase
- (2010) Katarzyna Świderek et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5
- (2010) Adam D. Moorhouse et al. CHEMICAL COMMUNICATIONS
- Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials
- (2010) C. Granchi et al. CURRENT MEDICINAL CHEMISTRY
- Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
- (2010) Ming Zhou et al. Molecular Cancer
- The engine driving the ship: metabolic steering of cell proliferation and death
- (2010) Marisa R. Buchakjian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
- (2010) M. G. Vander Heiden et al. SCIENCE
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
- (2010) A. J. Levine et al. SCIENCE
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- Computational analyses of mammalian lactate dehydrogenases: Human, mouse, opossum and platypus LDHs
- (2009) Roger S. Holmes et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Cell-cell and intracellular lactate shuttles
- (2009) George A. Brooks JOURNAL OF PHYSIOLOGY-LONDON
- D- and L-lactate dehydrogenases during invertebrate evolution
- (2008) Melania E Cristescu et al. BMC EVOLUTIONARY BIOLOGY
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Mitochondria andl-lactate metabolism
- (2008) Salvatore Passarella et al. FEBS LETTERS
- Histone 2B (H2B) Expression Is Confined to a Proper NAD+/NADH Redox Status
- (2008) Ru-Ping Dai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Causes and Consequences of Increased Glucose Metabolism of Cancers
- (2008) R. J. Gillies et al. JOURNAL OF NUCLEAR MEDICINE
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- Mitochondrial Lactate Dehydrogenase Is Involved in Oxidative-Energy Metabolism in Human Astrocytoma Cells (CCF-STTG1)
- (2008) Joseph Lemire et al. PLoS One
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now