Review
Endocrinology & Metabolism
Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Stefania Camastra, Mario Miccoli, Gabriella Cavallini, Salvatore Benvenga, Alessandro Antonelli
Summary: GD is an autoimmune disorder affecting the thyroid, potentially leading to hyperthyroidism, with GO being an extra-thyroidal manifestation. Elevated cytokines may be related to the chronic effects of thyroid hormone increase, while a prevalent Th1 immune response plays a crucial role in the immune-pathogenesis of GD and GO.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Bruce D. Cheson, Grzegorz Nowakowski, Gilles Salles
Summary: Newer, more effective and non-cytotoxic therapies are needed for patients with DLBCL and other B-cell malignancies. Approved treatments include various combinations of drugs, CAR-T cell products, and ongoing development of other therapies. Combinations of targeted therapies are expected to further improve the outcomes for patients.
BLOOD CANCER JOURNAL
(2021)
Review
Immunology
Anne Silvestre, Sharvani Shrinivas Shintre, Najma Rachidi
Summary: The efficient manipulation of host cells is crucial for intracellular parasites, and this is achieved through the release of kinases into the host cell cytoplasm and their interaction with host proteins. Kinases play a vital role in subverting host signaling and metabolic pathways, which are important for immune response evasion and parasite survival. However, there is still limited knowledge about the specific roles of parasite-derived kinases in the host cell.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Celine Stoica, Adilson Kleber Ferreira, Kayleigh Hannan, Marica Bakovic
Summary: This review summarizes the changes in phospholipid metabolism during oncogenic transformation and discusses the potential of phospholipid profiling as a diagnostic tool for differentiating between cancer and healthy tissues. The alterations in phosphatidylcholine and phosphatidylethanolamine membrane content, phospholipid metabolite levels, and fatty acid profiles are identified as hallmarks of cancer development. Phospholipids have the potential to serve as biomarkers for cancer diagnostics or as targets for anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Matthew D. Ringel
Summary: Treatment of progressive metastatic follicular cell-derived and medullary thyroid cancers is challenging, with limited complete remissions, short response durations, and common toxicities. Further research into resistance mechanisms, biomarker development, and new therapeutic strategies is needed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Siyu Su, Anhua Lei, Xudong Wang, Hengxing Lu, Shuhang Wang, Yuqi Yang, Ning Li, Yi Zhang, Jin Zhang
Summary: CAR-T cell therapy has achieved progress in treating hematological malignancies, but faces multiple challenges in treating solid tumors. CAR-Ms and CAR-iMacs are considered as efficient and inexpensive alternatives for tumor immune cell therapy. This review outlines the current development of human CAR-macrophages and highlights their crucial functions in the field of tumor immune cell therapy.
Review
Medicine, Research & Experimental
Xiaodan Zhang, Tao Tao, Yishu Qiu, Xiaojun Guo, Xiao Zhu, Xiaorong Zhou
Summary: A new mode of cell death, copper death, has been discovered, which is dependent on intracellular copper levels and has a distinct reliance on mitochondrial respiration. Tumor cells with unique metabolic profiles and elevated copper content may be targeted by copper death, making it a potential therapeutic strategy in the field of cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Romy Boettcher-Loschinski, Judit Rial Saborido, Martin Boettcher, Sascha Kahlfuss, Dimitrios Mougiakakos
Summary: T-cell-based approaches are increasingly important in cancer treatment, and the relationship between immune cell metabolism and immunotherapy success is crucial. Excessive exposure of T cells to fatty acids, known as lipotoxicity, can have detrimental effects in the context of an altered lipid tumor microenvironment. Understanding T cell-related lipotoxicity and developing potential therapeutic approaches is of great importance.
Article
Endocrinology & Metabolism
Liu Liu, Jurgen Wess
Summary: The functional state of adipocytes has a crucial role in metabolic functions. Different types of adipocytes regulate energy and glucose homeostasis in various ways. G protein-coupled receptors and their signaling pathways in adipocytes have been found to be potential targets for developing drugs to treat obesity and related metabolic disorders.
Review
Oncology
Ting Yang, Hongqi Xiao, Xiaoxia Liu, Zhihui Wang, Qingbai Zhang, Nianjin Wei, Xinggang Guo
Summary: The normalization of tumor blood vessels has shown to reduce tumor invasion and metastasis while enhancing the effectiveness of chemotherapy, radiation therapy, and immunotherapy. By maintaining the balance between proangiogenic and antiangiogenic factors and targeting endothelial cell metabolism, microRNAs, and the extracellular matrix, the normalization of tumor blood vessels can be promoted, leading to improved immunotherapy outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Dermatology
P. P. Naik
Summary: Keloids are abnormal tissue scarring resulting from overgrowth of granulation tissue or collagen type III in injured skin, with treatment options ranging from traditional corticosteroid therapy to emerging approaches like stem cell therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Neurosciences
Nirosen Vijiaratnam, Thomas Foltynie
Summary: Treatment of Parkinson's disease is currently limited to symptomatic therapies, with the goal of halting or reversing disease progression remaining unmet. Utilizing new treatment targets and biomarkers may improve outcome measurements in clinical trials. Exploring disease mechanisms and targeting peripheral interfaces may hold promise for disease modification.
Review
Oncology
Chitra Thakur, Yiran Qiu, Yao Fu, Zhuoyue Bi, Wenxuan Zhang, Haoyan Ji, Fei Chen
Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, and factors such as delayed presentation, late stage at diagnosis, limited treatment options, metastasis, and relapse contribute to high mortality rates. The development and progression of breast cancer involve complex genetic and epigenetic alterations, influenced by external environmental factors and internal cellular microenvironmental cues. Understanding the gene-environment interactions in breast cancer through a multidisciplinary approach is crucial. Epigenetic modifications, being reversible and influenced by external and intrinsic stimuli, offer potential avenues for designing effective therapies for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Lun Tsai, Chih-Yang Wang, Yu-Cheng Lee, Wan-Chun Tang, Gangga Anuraga, Hoang Dang Khoa Ta, Yung-Fu Wu, Kuen-Haur Lee
Summary: The development and progression of colorectal cancer involves changes in genetic and epigenetic levels of oncogenes and tumor suppressors, and more research is needed to discover effective biomarkers and targets for diagnosis and treatment. Long non-coding RNAs may play a role in tumor development. The upregulation of CRNDE in CRC patients at an advanced stage is associated with poor outcomes, and knocking down CRNDE can reduce lipid accumulation and induce autophagy in CRC cells through the miR-29b-3p/ANGPTL4 axis.
Review
Oncology
Yue Zheng, Laduona Wang, Limei Yin, Zhuoran Yao, Ruizhan Tong, Jianxin Xue, You Lu
Summary: Cancer stem cells play a crucial role in tumor metastasis, relapse, and therapy resistance. The accuracy and biological function of these cells are still controversial. Biomarkers of cancer stem cells are used for cancer diagnosis, targeted therapy, and prognosis prediction. Lung cancer stem cell markers include surface markers and intracellular markers, and are associated with the stem potential and uncontrollable proliferation of tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ivan Martinez-Monge, Carlos Martinez, Marianne Decker, Isuru A. Udugama, Igor Marin de Mas, Krist Gernaey, Lars K. Nielsen
Summary: A new soft-sensor-based fed-batch strategy has been developed to maintain substrate concentration at optimal levels in cell cultures.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Ines Baptista, Effrosyni Karakitsou, Jean-Baptiste Cazier, Ulrich L. Guenther, Silvia Marin, Marta Cascante
Summary: Through TKTL1 knockdown experiments, it was found that TKTL1 plays a key role in the metabolic adaptation to hypoxia in THP-1 AML cells by modulating the activities of G6PD and GAPDH, which involve changes in redox capacity and transcriptional regulation of key enzymes and transporters related to glucose, PPP, and amino acid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Aysegul Erdem, Silvia Marin, Diego A. Pereira-Martins, Roldan Cortes, Alan Cunningham, Maurien G. Pruis, Bauke de Boer, Fiona A. J. van den Heuvel, Marjan Geugien, Albertus T. J. Wierenga, Annet Z. Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Summary: This study uncovers the metabolic heterogeneity of acute myeloid leukemia (AML) and identifies Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metabolic states in distinct subtypes of AML. This finding provides potential targets for the treatment of AML, a genetically heterogeneous disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Aysegul Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhauser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Summary: This study reveals that FLT3-ITD + acute myeloid leukemia cells rely on oxidative phosphorylation and inhibition of complex II activity leads to increased lactate influx, driving respiration and providing a targetable vulnerability.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Alejandro Lillo, Silvia Marin, Joan Serrano-Marin, Nicolas Binetti, Gemma Navarro, Marta Cascante, Juan Sanchez-Naves, Rafael Franco
Summary: This study aimed to explore the differences in small metabolite concentrations in the aqueous humor of glaucoma patients and healthy subjects, finding that 57 compounds were significantly increased in glaucoma patients. Glaucoma may lead to mitochondrial abnormalities, so the increased glutamine can control the concentration of glutamate, avoiding the risk of neuronal and retinal cell death.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Marta Espanol-Rego, Carlos Fernandez-Martos, Elena Elez, Carles Foguet, Leire Pedrosa, Nuria Rodriguez, Ana Ruiz-Casado, Estela Pineda, Joan Cid, Raquel Cabezon, Helena Oliveres, Miquel Lozano, Angels Gines, Angeles Garcia-Criado, Juan Ramon Ayuso, Mario Pages, Miriam Cuatrecasas, Ferran Torres, Timothy Thomson, Marta Cascante, Daniel Benitez-Ribas, Joan Maurel
Summary: This study investigated the potential of Avelumab combined with ADC vaccine as a treatment for MSS mCRC patients. The results showed that the combination therapy was safe and well tolerated, but had limited clinical activity. Additionally, the study found a post-therapy metabolic rewiring, which could represent novel immunotherapy-induced tumor vulnerabilities.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Lillo, Silvia Marin, Joan Serrano-Marin, David Bernal-Casas, Nicolas Binetti, Gemma Navarro, Marta Cascante, Juan Sanchez-Naves, Rafael Franco
Summary: The composition of aqueous humor in patients with type 2 diabetes is different from that in healthy subjects, and certain molecules can serve as potential markers for discriminating between control and diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Leire Pedrosa, Carles Foguet, Helena Oliveres, Ivan Archilla, Marta Garcia de Herreros, Adela Rodriguez, Antonio Postigo, Daniel Benitez-Ribas, Jordi Camps, Miriam Cuatrecasas, Antoni Castells, Aleix Prat, Timothy M. Thomson, Joan Maurel, Marta Cascante
Summary: In this study, researchers developed an immune-metabolic signature suitable for personalized immune checkpoint inhibitor therapies. The signature classified tumors into three distinct immune-metabolic clusters, providing a new predictive tool for patient selection for specific immune-metabolic therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Artur Mezheyeuski, Max Backman, Johanna Mattsson, Alfonso Martin-Bernabe, Chatarina Larsson, Ina Hrynchyk, Klara Hammarstrom, Simon Strom, Joakim Ekstrom, Siarhei Mauchanski, Salome Khelashvili, Amanda Lindberg, Margret Agnarsdottir, Per-Henrik Edqvist, Jutta Huvila, Ulrika Segersten, Per-Uno Malmstrom, Johan Botling, Bjoern Nodin, Charlotta Hedner, David Borg, Jenny Brandstedt, Hanna Sartor, Karin Leandersson, Bengt Glimelius, Anna Portyanko, Fredrik Ponten, Karin Jirstrom, Patrick Micke, Tobias Sjoblom
Summary: We evaluated 15 immune cell classes in 1481 tumor samples and generated an immune activation signature (SIA) based on the prognostic information of CD8+ lymphocytes and CD68+CD163+ macrophages in various cancer types. The SIA was associated with patient survival and had predictive value for response to checkpoint inhibitor therapy.
Article
Biochemistry & Molecular Biology
Gyorgy Abrusan, Carles Foguet
Summary: It has been suggested that a significant fraction of homomer protein-protein interfaces evolve neutrally, without contributing to function, due to a hydrophobic bias in missense mutations. However, the fraction of such gratuitous complexes is currently unknown. In this study, the researchers quantified the fraction of homodimers where multimerization is unlikely to contribute to their biochemical function. They found that ligand binding-site structure predicts whether a homomer is functional or not, and that the hydrophobicity of interfaces changes little with the strength of selection. Additionally, they observed that MBS homomer interfaces coevolve more strongly with ligand binding sites than the interfaces of SBS homomers.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Yu Xu, Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Usman A. Tahir, Sebastian May-Wilson, Carles Foguet, Asa Johansson, Praveen Surendran, Artika P. Nath, Elodie Persyn, James E. Peters, Clare Oliver-Williams, Shuliang Deng, Bram Prins, Jian'an Luan, Lorenzo Bomba, Nicole Soranzo, Emanuele Di Angelantonio, Nicola Pirastu, E. Shyong Tai, Rob M. van Dam, Helen Parkinson, Emma E. Davenport, Dirk S. Paul, Christopher Yau, Robert E. Gerszten, Anders Maelarstig, John Danesh, Xueling Sim, Claudia Langenberg, James F. Wilson, Adam S. Butterworth, Michael Inouye
Summary: This study investigates the use of omic modalities in dissecting the molecular underpinnings of common diseases and traits. It examines a large cohort with extensive multi-omic data and uses machine learning to train genetic scores for various molecular traits. The study evaluates the performance of these genetic scores through external validation across different ancestral cohorts and highlights key biological insights related to metabolism and disease pathways. A web portal is also developed to provide public access to the genetic scores and validation results.
Article
Biology
Pedro de Atauri, Carles Foguet, Marta Cascante
Summary: Metabolic Control Analysis (MCA) has revealed that control of metabolic pathways is distributed among many enzymes and depends on kinetic determinants in addition to stoichiometric structure. By incorporating kinetic determinants and ruling out enzymes with low control coefficients, MCA can improve the prediction and identification of therapeutic targets in drug discovery.
Article
Biochemistry & Molecular Biology
Xavier Capo, Aina Maria Galmes-Panades, Cayetano Navas-Enamorado, Ana Ortega-Moral, Silvia Marin, Marta Cascante, Andres Sanchez-Polo, Luis Masmiquel, Margalida Torrens-Mas, Marta Gonzalez-Freire
Summary: This study investigated the relationship between circulating serum NFL, muscle function, and aging. The results showed that NFL levels increased with age, particularly in men. There were negative associations between NFL levels and measures of muscle function, indicating a decline in muscle performance with increasing NFL. Additionally, NFL levels were correlated with markers of body composition, such as fat mass and muscle mass, predominantly in men. Metabolomic analysis revealed significant associations between NFL levels and specific metabolites, with gender-dependent relationships observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Helena Oliveres, Marta Cascante, Joan Maurel
Summary: The current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and targeted therapy, but the prognosis remains poor. New drugs combined with immune checkpoint inhibitors have been tested in microsatellite stable metastatic colorectal cancer patients, but with limited benefit. This review focuses on the metabolic interactions between the immune microenvironment and cancer cells, and highlights the potential correlation between tumor immune and metabolic features with transcriptomic classifications. The study concludes that customized strategies for modifying metabolism could improve immunotherapy and targeted therapy efficacy.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
