Targeting metallo-β-lactamase enzymes in antibiotic resistance

Binuclear Metallohydrolases: Complex Mechanistic Strategies for a Simple Chemical Reaction

(2012) Gerhard Schenk et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria

(2012) Lei Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Kinetic Testing of Tetrahydropyrimidine-2-thione and Pyrrole Derivatives as Inhibitors of the Metallo-β-lactamase fromKlebsiella pneumoniaandPseudomonas aeruginosa

(2012) Waleed M. Hussein et al.   Chemical Biology & Drug Design

New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

(2012) Dustin T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

(2011) Mosaad S. Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Crystal Structure of Serratia fonticola Sfh-I: Activation of the Nucleophile in Mono-Zinc Metallo-β-Lactamases

(2011) Fátima Fonseca et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

(2011) Youngchang Kim et al.   PLoS One

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo- -Lactamase Inhibitor, against Metallo- -Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates

(2010) Y. Ishii et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Calcium-EDTA as an Inhibitor for Metallo- -Lactamase in a Mouse Model of Pseudomonas aeruginosa Pneumonia

(2010) N. Aoki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Detection of NDM-1-ProducingKlebsiella pneumoniaein Kenya

(2010) Laurent Poirel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo- -lactamases

(2010) M. Merino et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cyclobutanone Analogues of β-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-β-Lactamases

(2010) Jarrod W. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

(2010) Timo Weide et al.   ACS Medicinal Chemistry Letters

Metallo-β-lactamase inhibitory activity of phthalic acid derivatives

(2009) Yukiko Hiraiwa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antibiotic Resistance in Bacteria: Novel Metalloenzyme Inhibitors

(2009) Sung-Kun Kim et al.   Chemical Biology & Drug Design

The Mechanisms of Catalysis by Metallo -Lactamases

(2008) Michael I. Page et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Cyclobutanone Mimics of Penicillins: Effects of Substitution on Conformation and Hemiketal Stability

(2008) Jarrod W. Johnson et al.   JOURNAL OF ORGANIC CHEMISTRY

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols

(2008) Benoît M. R. Liénard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural Insights into the Design of Inhibitors for the L1 Metallo-β-lactamase from Stenotrophomonas maltophilia

(2007) L. Nauton et al.   JOURNAL OF MOLECULAR BIOLOGY

The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form

(2007) I. Garcia-Saez et al.   JOURNAL OF MOLECULAR BIOLOGY