Review
Food Science & Technology
Rebecca A. Haber, Reicelle D. Garcia, Jamie N. Hernandez, Sarah Jamieson, Arijit Mondal, Anupam Bishayee
Summary: This paper provides a comprehensive analysis of the cancer-preventive potential of Carica papaya extracts, fractions, and isolated phytochemicals. It discusses the cellular and molecular mechanisms of action, bioavailability, pharmacokinetics, and safety profiles of these phytochemicals, as well as the limitations, challenges, and future directions of research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Medicine, Research & Experimental
Amanda L. Huff, Elizabeth M. Jaffee, Neeha Zaidi
Summary: The success of mRNA vaccines in protecting against COVID-19 has implications for their potential use in cancer therapeutics, and this article discusses the lessons learned and adaptations needed for optimizing mRNA technology in cancer treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Samantha A. Whiteside, John E. McGinniss, Ronald G. Collman
Summary: The healthy lung is not completely sterile, with bacteria entering from the upper respiratory tract through microaspiration. The nature and dynamics of the lung microbiome differ from other ecological niches with self-sustaining microbial communities, and dysbiosis has been demonstrated in many pulmonary diseases.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Elisa Agostinetto, Veronique Debien, Guilherme Nader Marta, Matteo Lambertini, Martine Piccart-Gebhart, Evandro de Azambuja
Summary: The treatment landscape for HER2+ breast cancer is evolving rapidly, with CDK4/6 and PI3K inhibitors emerging as promising strategies to enhance patient outcomes. Data from preclinical and clinical studies are highlighting the potential of these agents in HER2+ disease and suggesting a potential shift in clinical practice.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Pharmacology & Pharmacy
Jingcao Zheng, Zhengyu Li, Wenjiao Min
Summary: The PARP family consists of 17 members, which play roles in cellular processes such as DNA replication and repair. PARP inhibitors have become an important treatment option for cancer by suppressing DNA repair. PARP inhibition and homologous recombination repair defects have promising therapeutic potential for HRD tumors. However, overlapping hematologic toxicity and lack of selectivity for the PARP family pose challenges.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Chenglong Liu, Mengxuan Yang, Daizhou Zhang, Ming Chen, Di Zhu
Summary: Immune checkpoint therapy utilizing PD-1 antibodies has demonstrated significant clinical value and therapeutic potential, although it is not without limitations such as immune-related adverse events, cytokine storm, and low response rates. This review discusses the basic classification, research progress, and limitations of cancer immunotherapy, as well as providing insights into the development of new anticancer immunotherapy strategies through the analysis of resistance mechanisms and combination therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Guangxiang Xu, Han Wang, Xiaoling Li, Riming Huang, Lianxiang Luo
Summary: Ferroptosis is a novel mode of cell death that has become a target for antitumor therapy. Research has identified various mechanisms regulating the sensitivity of cancer cells to ferroptosis, and progress has been made in exploring ferroptosis-related drugs.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Immunology
Annabelle Small, Katie Lowe, Mihir D. Wechalekar
Summary: This review provides an overview and details of the importance of immune checkpoint pathways in rheumatoid arthritis pathobiology and discusses the relevance of immune checkpoint therapy in cancer to autoimmune inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lizhuo Zhang, Qingqing Feng, Jiafeng Wang, Zhuo Tan, Qinglin Li, Minghua Ge
Summary: Thyroid cancer is a common endocrine malignant tumor, and surgery, chemotherapy, radiotherapy, and radioactive iodine therapy are the standard treatment modalities. However, multi-tyrosine kinase inhibitors and immune checkpoint inhibitors in combination with tyrosine kinase inhibitors have emerged as novel therapies for controlling the progression of thyroid cancer. This article discusses the molecular basis of thyroid cancer, reviews targeted therapeutic drugs in clinical research, and explores potentially novel molecular therapeutic targets.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Biochemistry & Molecular Biology
Xiaojuan Yang, Lu Xu, Li Yang, Shaohong Xu
Summary: STAT3 is a transcription factor that regulates gene levels associated with cell survival, cell cycle, and immune reaction. It is linked to malignancy and the development of various cancers, making targeting STAT3 protein a promising therapeutic strategy. However, the development of STAT3 inhibitors faces challenges such as toxic effects, limited therapeutic effects, and drug resistance.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Sultan Alshehri, Syed Sarim Imam, Md. Rizwanullah, Sohail Akhter, Wael Mahdi, Mohsin Kazi, Javed Ahmad
Summary: Early detection, correct therapeutic intervention, and simultaneous effectiveness mapping are critical factors in successful cancer therapy. Advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system, termed cancer theranostics. However, only a few cancer nanomedicines have been approved and are currently in clinical trials.
Review
Oncology
Diego Teyssonneau, Henri Margot, Mathilde Cabart, Mylene Anonnay, Paul Sargos, Nam-Son Vuong, Isabelle Soubeyran, Nicolas Sevenet, Guilhem Roubaud
Summary: Prostate cancer remains lethal at the metastatic castration-resistant stage, and the development of PARP inhibitors offers a new therapeutic option. Despite progress, there are still issues related to PARP inhibitors that need to be addressed.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Jia Zeng, Jifa Zhang, Ying Sun, Jiaxing Wang, Changyu Ren, Souvik Banerjee, Liang Ouyang, Yuxi Wang
Summary: This article reviews the structure and biological functions of the EZH2 protein, as well as its relationship with various diseases. It also provides an overview of the current development of specific inhibitors for EZH2, and highlights the latest progress in new strategies such as drug combination, dual-target inhibitors, targeted protein degradation technology, and protein-protein interaction inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Polymer Science
Saad Saleh Alghamdi, Sabu John, Namita Roy Choudhury, Naba K. Dutta
Summary: This paper comprehensively reviews the recent advances and achievements in different AM processes for polymers, composites, elastomers, multi materials, shape memory polymers, and thermo-responsive materials, and discusses their applications in various fields such as bio-medical, electronics, textiles, and aerospace industries. Further research needs and future perspectives of AM process with polymeric materials are also outlined.
Review
Cell & Tissue Engineering
Fenggang Yu, Fei Liu, Xiaohua Liang, Linwei Duan, Qiongqiong Li, Ge Pan, Chengyao Ma, Minmin Liu, Mingyue Li, Peng Wang, Xuening Zhao
Summary: This review provides a comprehensive overview of the recent progress in using iPSCs to generate lung epithelial cells and lung organoids, as well as discussing their potential applications and future challenges. The focus is on the technological hurdles that need to be overcome before stem cell therapeutics can be used for clinical treatment.
Article
Oncology
Venkateshwar Madka, Gaurav Kumar, Gopal Pathuri, Yuting Zhang, Stanley Lightfoot, Adam S. Asch, Altaf Mohammed, Vernon E. Steele, Chinthalapally Rao
CANCER PREVENTION RESEARCH
(2020)
Review
Cell Biology
Chinthalapally V. Rao, Adam S. Asch, Daniel J. J. Carr, Hiroshi Y. Yamada
Meeting Abstract
Biochemistry & Molecular Biology
Nagendra Yarla, Gopal Pathuri, Hariprasad Gali, Janani Panneerselvam, Parthasarathy Chandrakesan, Venkateshwar Madka, Chinthalapally Rao
Article
Oncology
Parthasarathy Chandrakesan, Janani Panneerselvam, Randal May, Nathaniel Weygant, Dongfeng Qu, William R. Berry, Kamille Pitts, Ben Z. Stanger, Chinthalapally Rao, Michael S. Bronze, Courtney W. Houchen
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Janani Panneerselvam, Priyanga Mohandoss, Ravi Patel, Hamza Gillan, Michael Li, Kirtana Kumar, DangHuy Nguyen, Nathaniel Weygant, Dongfeng Qu, Kamille Pitts, Stanley Lightfoot, Chinthalapally Rao, Courtney Houchen, Michael Bronze, Parthasarathy Chandrakesan
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Biochemistry & Molecular Biology
Xunhao Xiong, Geeta Rao, Ram Vinod Roy, Yushan Zhang, Nicolas Means, Anindya Dey, Martha Tsaliki, Sounik Saha, Sanjib Bhattacharyya, Shailendra Kumar Dhar Dwivedi, Chinthalapally Rao, Daniel J. McCormick, Danny Dhanasekaran, Kai Ding, Elizabeth Gillies, Min Zhang, Da Yang, Resham Bhattacharya, Priyabrata Mukherjee
Article
Cell Biology
Chinthalapally Rao, Mudassir Farooqui, Avanish Madhavaram, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Article
Multidisciplinary Sciences
Kirk Bergstrom, Xindi Shan, David Casero, Albert Batushansky, Venu Lagishetty, Jonathan P. Jacobs, Christopher Hoover, Yuji Kondo, Bojing Shao, Liang Gao, Wesley Zandberg, Benjamin Noyovitz, J. Michael McDaniel, Deanna L. Gibson, Sepideh Pakpour, Negin Kazemian, Samuel McGee, Courtney W. Houchen, Chinthalapally V. Rao, Timothy M. Griffin, Justin L. Sonnenburg, Rodger P. McEver, Jonathan Braun, Lijun Xia
Article
Oncology
Chinthalapally V. Rao, Chao Xu, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Summary: Genomic instability plays a crucial role in the evolution and treatment of lung adenocarcinoma, with genes associated with survival potentially serving as future therapeutic targets. The immune system has been identified as a key player in suppressing genomic instability and cancer development in the lungs, suggesting potential avenues for chemotherapy, chemoprevention, and immunomodulation approaches.
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Oncology
Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Summary: Colon cancer is a significant health problem that is increasing in occurrence, especially among young adults. Previous studies have shown promising preventive effects of drugs like Sulindac and DFMO, but long-term use at high doses can cause side effects. This study explores alternative strategies for preventing colon cancer using low-dose combinations of these drugs, as well as testing the efficacy of Sulindac derivatives. The results suggest that these treatment regimens can effectively inhibit tumor progression without causing toxicity, making them a promising approach for colon cancer prevention.
Meeting Abstract
Oncology
Altaf Mohammed, Venkateshwar Madka, Gaurav Kumar, Anil Singh, Nicole Stratton, Stanley Lightfoot, Mark S. Miller, Chinthalapally Rao
Meeting Abstract
Oncology
Chinthalapally Rao, Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Niklas K. Finnberg, Howard P. Safran, Jennifer Fox, Shizuko Sei, Elizabeth R. Glaze, Robert Shoemaker, Wafik S. El-Deiry
Meeting Abstract
Oncology
Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Anil Singh, Shizuko Sei, Jennifer Fox, Chinthalapally Rao
Meeting Abstract
Oncology
Venkateshwar Madka, Gopal Pathuri, Hariprasad Gali, Nandini Kumar, Nagendra Sastri Yarla, Anh Bao, Adam S. Asch, Chinthalapally Rao
