Growing PAINS in academic drug discovery

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Current strategies for diversity-oriented synthesis

(2010) Sivaraman Dandapani et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Observations on screening-based research and some concerning trends in the literature

(2010) Jonathan B Baell   Future Medicinal Chemistry

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-Like Property Concepts in Pharmaceutical Design

(2009) Li Di et al.   CURRENT PHARMACEUTICAL DESIGN

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

(2009) Kristin E. D. Coan et al.   JOURNAL OF MEDICINAL CHEMISTRY