Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases

Correction: A Comprehensive Molecular Interaction Map for Rheumatoid Arthritis

(2014) Gang Wu et al.   PLoS One

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

(2010) Jason R. Porter et al.   CHEMICAL COMMUNICATIONS

A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation

(2010) Donghwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening

(2010) Ekaterina V. Bobkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

(2010) Benjamin W. Jester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells

(2010) J Wu et al.   LEUKEMIA

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Rethinking screening

(2010) Thomas Kodadek   Nature Chemical Biology

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors

(2010) Jeroen van Ameijde et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The regulation of protein phosphorylation

(2009) Louise N. Johnson   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of the CHK1 Allosteric Inhibitor Binding Site

(2009) Darin Vanderpool et al.   BIOCHEMISTRY

Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): Optimization and selectivity profiling

(2009) Carolyn D. Shomin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Caspases and Kinases in a Death Grip

(2009) Manabu Kurokawa et al.   CELL

Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

(2009) Darja Lavogina et al.   ChemMedChem

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

(2009) Michelle R Arkin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases

(2009) Zachary B. Hill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α

(2009) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

(2009) J. Viaud et al.   MOLECULAR CANCER THERAPEUTICS

A new screening assay for allosteric inhibitors of cSrc

(2009) Jeffrey R Simard et al.   Nature Chemical Biology

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry

(2009) Karunakaran A. Kalesh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

(2008) Antonella Converso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stepwise Combinatorial Evolution of Akt Bisubstrate Inhibitors

(2008) Jung Hwan Lee et al.   CHEMBIOCHEM

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

(2008) Jana A Lewis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural Analysis of ARC-Type Inhibitor (ARC-1034) Binding to Protein Kinase A Catalytic Subunit and Rational Design of Bisubstrate Analogue Inhibitors of Basophilic Protein Kinases

(2008) Darja Lavogina et al.   JOURNAL OF MEDICINAL CHEMISTRY

A General and Rapid Cell-Free Approach for the Interrogation of Protein−Protein, Protein−DNA, and Protein−RNA Interactions and their Antagonists Utilizing Split-Protein Reporters

(2008) Jason R. Porter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

(2007) John C. Hartnett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS