Review
Chemistry, Analytical
Dongxu Zhao, Jian Cao, Lei Zhang, Shaohua Zhang, Song Wu
Summary: This article summarizes the importance of early diagnosis of hepatocellular carcinoma (HCC) and the limitations of current diagnostic methods. It introduces the applications of molecular imaging and MRI in HCC diagnosis, and discusses the prospects of developing molecular imaging probes.
Review
Chemistry, Multidisciplinary
Zhen Li, Caixia Wang, Meng Zhang, Songjiao Li, Zhiqiang Mao, Zhihong Liu
Summary: The brain, as the most pivotal organ of the human body, is susceptible to various disorders and trauma. Despite considerable efforts in treatment, brain diseases remain a leading cause of death and disability globally, making early diagnosis crucial for prevention and treatment. Luminescent probes, particularly activatable ones, are promising tools for brain disease diagnosis, offering real-time semi-quantification of biomarkers and investigation of pathological mechanisms at the molecular level.
Article
Pharmacology & Pharmacy
Ander Egimendia, Susana Carregal-Romero, Inaki Osorio-Querejeta, Daniel Padro, Jesus Ruiz-Cabello, David Otaegui, Pedro Ramos-Cabrer
Summary: Ex vivo models using multimodal imaging and myelin-targeting liposomes show potential for quantifying myelin content in organotypic cultures. MRI can successfully image brain tissue sections with good contrast, while myelin-targeting liposomes allow for semiquantitative detection by fluorescence. Fine tuning of the probe is necessary to improve specificity when using lipid-based systems.
Review
Chemistry, Inorganic & Nuclear
Qingtao Meng, Miaomiao Wu, Zhuye Shang, Zhiqiang Zhang, Run Zhang
Summary: Magnetic resonance imaging (MRI) is a widely used molecular imaging technology in biomedical and clinical diagnostics. Responsive MRI probes based on gadolinium(III) (Gd(III)) complexes, which can detect and visualize target analytes, have been systematically summarized in this work. The development of strategies, the progresses in developing Gd(III) complex-based responsive MRI probes for different target analytes, and the limitations and future research directions are discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Rebecca R. Baker, Christopher Payne, Yichao Yu, Matin Mohseni, John J. Connell, Fangyu Lin, Ian F. Harrison, Paul Southern, Umesh S. Rudrapatna, Daniel J. Stuckey, Tammy L. Kalber, Bernard Siow, Lewis Thorne, Shonit Punwani, Derek K. Jones, Mark Emberton, Quentin A. Pankhurst, Mark F. Lythgoe
Summary: Magnetic resonance navigation is an emergent technique that allows for remote control of magnetically labeled therapies and devices using an MRI system. The MINIMA technique, a novel MRI-guided ablation technique, has the potential to avoid traditional toxicities and offers precise control over the ablation volume.
Review
Cardiac & Cardiovascular Systems
Anna K. Barton, Evangelos Tzolos, Rong Bing, Trisha Singh, Wolfgang Weber, Markus Schwaiger, Zohreh Varasteh, Riemer H. J. A. Slart, David E. Newby, Marc R. Dweck
Summary: Myocardial fibrosis is a common healing response to heart injury, but it can become maladaptive and lead to adverse outcomes. Current imaging techniques lack specificity in detecting established fibrosis, but novel molecular imaging methods like Ga-68-FAPI PET may provide highly specific imaging of fibrosis activity. These methods can improve early detection, differentiation of disease stages, and assessment of disease progression and treatment response.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Avan Kader, Julia Brangsch, Jan O. Kaufmann, Jing Zhao, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Marcus R. Makowski
Summary: This review summarizes recent developments in molecular imaging markers for magnetic resonance imaging of prostate cancer, aiming to improve the molecular characterization of the tumor and enable targeted therapies to suppress tumor growth or reduce tumor size in a non-invasive manner.
Article
Chemistry, Multidisciplinary
Kun Liu, Bilun Kang, Xiangjie Luo, Zhaoxuan Yang, Chengjie Sun, Ao Li, Yifan Fan, Xiaoyuan Chen, Jinhao Gao, Hongyu Lin
Summary: The study introduces a novel type of nanomaterial as redox-activated probes for real-time visualization of GSH-mediated liver biotransformation using MRI. The technique reveals periodic variations in GSH concentration during the degradation of the nanoparticles, providing direct imaging evidence for carrier-mediated processes in GSH metabolism. This methodology offers a feasible means for in-depth investigations of GSH-related biological processes in liver and real-time assessment of liver functions for early diagnosis of diseases and toxicity evaluation of pharmaceuticals.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yeo Kyung Nam, Ji Eun Park, Seo Young Park, Minkyoung Lee, Minjae Kim, Soo Jung Nam, Ho Sung Kim
Summary: This study aimed to determine MRI parameters predictive of molecular subtype and risk stratification in glioma and develop a structured reporting system. Reproducible imaging parameters such as presence of necrosis, T2/FLAIR mismatch, internal cyst, and predominant contrast enhancement were identified as significant predictors across readers. The highest diagnostic performance was found in predicting risk type 5 with predominant enhancement, followed by risk types 2 and 1 with specific imaging features.
EUROPEAN RADIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jing Zhao, Cong Wang, Wanbing Sun, Cong Li
Summary: Excising epileptic foci (EF) is the most efficient approach for treating drug-resistant epilepsy (DRE), but accurate localization of EF is challenging. Finding biomarkers that represent the status of epilepsy and developing probes with high targeting specificity are important for identifying concealed EF. This review summarizes potential biomarkers of EF and classifies them into functional, molecular, and structural aberrances. It also highlights the materials used in fabricating imaging probes and their performance in preclinical and clinical studies. The review discusses perspectives on developing the next generation of probes and the challenges in clinical translation.
ADVANCED MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiying Zhou, Jianguang Zhang, Xiao Ming Zhang, Tianwu Chen, Jiani Hu, Zonglin Jing, Shunhai Jian
Summary: The study found that renal diffusion kurtosis imaging is valuable for the diagnosis of early diabetic nephropathy, with mean kurtosis values serving as a more sensitive biomarker than mean diffusivity values. The MR DKI technique may be noninvasive and effective in detecting early DN.
EUROPEAN RADIOLOGY
(2021)
Article
Biophysics
Jieli Zhu, Ran Zhu, Qingqing Miao
Summary: In this review, the design methodology and imaging utility of recently emerged activatable polymeric probes are systematically interpreted and summarized. The classification and applications of activatable probes in diverse imaging modes are discussed, along with the current challenges and future advances.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Salvatore Mamone, Anil P. Jagtap, Sergey Korchak, Yonghong Ding, Sonja Sternkopf, Stefan Gloeggler
Summary: Hyperpolarization methods in magnetic resonance enhance signals for real-time investigation of dynamic processes. In this study, a novel pulsed method based on para-hydrogen is proposed to rapidly hyperpolarize C-13-labeled substrates. The method is successfully demonstrated in monitoring metabolic processes in cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Psychology, Clinical
S. J. H. van Rooij, Lauren M. Sippel, William M. McDonald, Paul E. Holtzheimer
Summary: Research suggests that mediating PTSD treatment response may involve downregulating fear learning and threat circuits, and upregulating emotion regulation and executive function circuits. However, the findings are not completely consistent, and further research on treatment effects and additional stimulation targets is needed.
DEPRESSION AND ANXIETY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jiong Liu, Wen Xiu Ren, Jian Shu
Summary: Cholangiocarcinoma (CCA), an aggressive and deadly cancer, poses challenges in early diagnosis. Molecular imaging, a noninvasive diagnostic method that allows visualization of biological events at the cellular and molecular level, shows promise in CCA. This review discusses various molecular imaging techniques for CCA and explores the challenges and future directions in this field.
INSIGHTS INTO IMAGING
(2022)
Article
Chemistry, Physical
M. Santana Vega, L. Munro, D. C. A. Gowland, J. Martinelli, K. Djanashvili, F. Cucinotta
Summary: This study demonstrates the organization of multiple chromophores into host-guest silica-micelle structures through self-assembly strategies to create light-harvesting materials. By varying the content and localization of organometallic complexes and organic dyes, the transfer rate and efficiency inside the materials can be manipulated, with the potential for vast transfer and color tuning capabilities. The results show efficient excitation energy cascade and panchromatic response, with the systems reaching overall light emission spanning the visible range.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Martinelli, Lorenzo Tei, Simonetta Geninatti Crich, Diego Alberti, Kristina Djanashvili
Summary: It is known that phenylboronic acid can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells, and has been explored in the design of diagnostic probes for MRI and PET. Furthermore, the use of multimeric Gd-III complexes can enhance MRI contrast by increasing local concentration of paramagnetic ions, as demonstrated in the synthesis of dimeric analogues.
Article
Chemistry, Physical
Ivy L. Librando, Abdallah G. Mahmoud, Sonia A. C. Carabineiro, M. Fatima C. Guedes da Silva, Francisco J. Maldonado-Hodar, Carlos F. G. C. Geraldes, Armando J. L. Pombeiro
Summary: In this study, a supported gold nanoparticle-catalyzed strategy was used to facilitate the synthesis of 1,2,3-triazoles through click chemistry. The reaction was successfully conducted under microwave irradiation, resulting in the formation of 1,4-disubstituted-1,2,3-triazoles in moderate to high yields without the need for copper catalysts.
Review
Materials Science, Biomaterials
Aastha Gupta, Ankur Sood, Erwin Fuhrer, Kristina Djanashvili, Garima Agrawal
Summary: Theranostics is a unique platform that combines diagnosis and therapeutics, providing real-time imaging for monitoring treatment and enabling personalized therapy. Polysaccharides, as carriers, have innate advantages and can be tuned for desired functionality and characteristics through postmodification.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Sara Lacerda, Wuyuan Zhang, Rafael T. M. de Rosales, Isidro Da Silva, Julien Sobilo, Stephanie Lerondel, Eva Toth, Kristina Djanashvili
Summary: This study successfully radiolabeled nanozeolite Linde type L (LTL) with a positron emission tomography (PET)-tracer zirconium-89 (Zr-89), demonstrating its beneficial biological behavior in vivo. The findings show good stability and integrity of the proposed multimodal probe, paving the way for further theranostic studies utilizing a variety of metal-based radioisotopes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Carlos Bornes, Dusan Stosic, Carlos F. G. C. Geraldes, Svetlana Mintova, Joao Rocha, Luis Mafra
Summary: This study reveals the chemical species on the external surface of zeolite crystals through experimental and computational studies. The external surface of zeolites contains SiOH species and Bronsted acid sites similar to internal acid sites, and there may be external tricoordinate Al-Lewis sites that strongly interact with TMPO.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Alexandre C. Oliveira, Hugo A. . L. Filipe, Joao P. Prates Ramalho, Armindo Salvador, Carlos F. G. C. Geraldes, Maria Joao Moreno, Luis M. S. Loura
Summary: The correct parametrization of lanthanide complexes is crucial for their characterization using computational tools, and this study establishes the best strategies for parametrization and demonstrates the successful capture of dynamic properties.
INORGANIC CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
Mauro Botta, Carlos F. G. C. Geraldes, Lorenzo Tei
Summary: Fe(III) has emerged as a promising alternative to Gd-based compounds for T-1 contrast agents in Magnetic Resonance Imaging (MRI). A variety of nanostructures have been designed for in vivo diagnostic and theranostic applications, due to the favorable magnetic properties and biocompatibility of iron(III). Fe(III)-doped nanoparticles have the potential to compete with Gd(III)-based nanosystems in terms of relaxivity and MR-contrast enhancement optimization.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alexandra Maier, Rogier van Oossanen, Gerard C. van Rhoon, Jean-Philippe Pignol, Iulian Dugulan, Antonia G. Denkova, Kristina Djanashvili
Summary: Heterostructured magnetic nanoparticles have great potential in biomedical applications due to their ability to express multiple functionalities in a single structure. Their magnetic properties are influenced by the morphology and composition of the nanoparticles, which in turn depend on the synthetic conditions. Incorporation of a non-magnetic heterometal also affects the final magnetic behavior. This study focuses on palladium/iron oxide nanoparticles for combined brachytherapy and MRI-guided hyperthermia of tumors. The synthetic mechanisms and their effects on the magnetic properties of the nanoparticles were investigated. The results revealed the most relevant synthetic parameters leading to promising performance in hyperthermia and MRI.
Review
Biochemistry & Molecular Biology
Carlos F. G. C. Geraldes, Joop A. Peters
Summary: Molecular recognition involving glycoprotein-mediated interactions is important in various medical applications, but visualizing these interactions and the extent of sugar expression is challenging.
Article
Oncology
Rogier van Oossanen, Jeremy Godart, Jeremy M. C. Brown, Alexandra Maier, Jean-Philippe Pignol, Antonia G. Denkova, Kristina Djanashvili, Gerard C. van Rhoon
Summary: This study investigated a new treatment for breast cancer using thermal ablation with radioactive magnetic nanoparticles. Through computer simulations, it was found that the dose profiles of these nanoparticles are similar to commercial radioactive sources already used in the clinic. This indicates that this new treatment is feasible for clinical application.
Article
Chemistry, Analytical
Ioannis Androulakis, Riccardo Ferrero, Rogier van Oossanen, Alessandra Manzin, Antonia G. Denkova, Kristina Djanashvili, Robin Nadar, Gerard C. van Rhoon
Summary: This study developed a dedicated electromagnetic field applicator and validated an experimental setup to heat 3D cell spheroids in a conical polypropylene vial, enabling investigation of hyperthermia effects at the cellular scale.
Review
Chemistry, Inorganic & Nuclear
Joop A. Peters, Kristina Djanashvili
Summary: This review examines the chemical mechanisms of the interactions between boronic acids and N-acetylneuraminic acids, which have been widely used in biomedicine. It emphasizes that the affinity of boronic acids for N-acetylneuraminic acids is pH dependent and complementary to their affinity for other common monosaccharides. Various examples from the literature illustrate the unique pH profile of the boronic-N-acetylneuraminic acid interaction and its applications in biomedicine.
COORDINATION CHEMISTRY REVIEWS
(2023)
