Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR

Two-dimensional NMR and All-atom Molecular Dynamics of Cytochrome P450 CYP119 Reveal Hidden Conformational Substates

(2010) Jed N. Lampe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using a homology model of cytochrome P450 2D6 to predict substrate site of metabolism

(2010) Rayomand J. Unwalla et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-A Resolution

(2010) S. C. Gay et al.   MOLECULAR PHARMACOLOGY

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through α-Helical Repositioning,

(2009) Sean C. Gay et al.   BIOCHEMISTRY

Time efficient detection of protein–ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment

(2009) Alvar D. Gossert et al.   JOURNAL OF BIOMOLECULAR NMR

13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites

(2009) Christopher R. McCullough et al.   JOURNAL OF BIOMOLECULAR NMR

Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity

(2009) D. F. V. Lewis et al.   XENOBIOTICA

Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone

(2008) Matthew A. Hummel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes

(2008) N. M. DeVore et al.   DRUG METABOLISM AND DISPOSITION

Studying cytochrome P450 kinetics in drug metabolism

(2008) Melissa A Kramer et al.   Expert Opinion on Drug Metabolism & Toxicology

Determinants of Cytochrome P450 2C8 Substrate Binding

(2008) Guillaume A. Schoch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Cytochrome P-450 2E1

(2008) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Plasticity and Flexibility on Docking Results for Cytochrome P450 2D6: A Combined Approach of Molecular Dynamics and Ligand Docking

(2008) Jozef Hritz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Type II Ligands in CYP2C9 and CYP3A4

(2008) Marie M. Ahlström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution NMR Structure of Putidaredoxin–Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling–Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation

(2008) Wei Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Ligand-Induced Conformational Heterogeneity of Cytochrome P450 CYP119 Identified by 2D NMR Spectroscopy with the Unnatural Amino Acid13C-p-Methoxyphenylalanine

(2008) Jed N. Lampe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE