Natural product scaffolds as leads to drugs

Targeting mTOR with rapamycin: One dose does not fit all

(2011) David A. Foster et al.   CELL CYCLE

An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin

(2009) Ryan W. King et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies

(2009) David T. Teachey et al.   BRITISH JOURNAL OF HAEMATOLOGY

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria

(2009) Agustinus Uria et al.   PHYTOCHEMISTRY REVIEWS

Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs

(2008) Chad A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies

(2008) Theodoros Kelesidis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Tigecycline for the treatment of patients with severe sepsis or septic shock: a drug use evaluation in a surgical intensive care unit

(2008) S. Swoboda et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential

(2008) Saleem Ahmad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Innovative Small Molecule Therapeutics

(2008) Magid Abou-Gharbia   JOURNAL OF MEDICINAL CHEMISTRY

A Robust Platform for the Synthesis of New Tetracycline Antibiotics

(2008) Cuixiang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein−Protein Interaction Detection in Vitro and in Cells by Proximity Biotinylation

(2008) Marta Fernández-Suárez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decoding and engineering tetracycline biosynthesis

(2008) Lauren B. Pickens et al.   METABOLIC ENGINEERING

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS

A gift from nature: the birth of the statins

(2008) Akira Endo   NATURE MEDICINE

Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones

(2008) T.-C. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epothilones as Lead Structures for the Synthesis-Based Discovery of New Chemotypes for Microtubule Stabilization

(2007) Fabian Feyen et al.   ACCOUNTS OF CHEMICAL RESEARCH