期刊
FUNGAL BIOLOGY
卷 116, 期 11, 页码 1146-1155出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.funbio.2012.08.006
关键词
Acetamidase gene; Aflatoxins; Aspergillus flavus; O-methyltransferase gene; Phylogeny; Taxonomy
类别
资金
- Spanish 'Ministerio de Educacion y Ciencia' [CGL 2009-08698/BOS]
- FEDER
- CAPES [SWE 4150-08-2]
- CNPq [GM/GD 142051/2007-1]
Aspergillus flavus is the second most common cause of aspergillosis infection in immunocompromised patients and is responsible for the production of aflatoxins. Little is known about the population structure of A. flavus, although recent molecular and phenotypic data seem to demonstrate that different genetic lineages exist within this species. The aim of this study was to carry out a morphological, physiological, and molecular analysis of a set of clinical and environmental isolates to determine whether this variability is due to species divergence or intraspecific diversity, and to assess whether the clinical isolates form a separate group. The amdS and omtA genes were more phylogenetically informative than the other tested genes and their combined analysis inferred three main clades, with no clear distinction between clinical and environmental isolates. No important morphological and physiological differences were found between the members of the different clades, with the exception of the assimilation of D-glucosamine, which differentiates the members of the clade II from the others. (C) 2012 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
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