Article
Microbiology
Nicola T. Case, Johannes Westman, Michael T. Hallett, Jonathan Plumb, Aiman Farheen, Michelle E. Maxson, Jessie Macalpine, Sean D. Liston, Bernhard Hube, Nicole Robbins, Luke Whitesell, Sergio Grinstein, Leah E. Cowen
Summary: Metabolic flexibility and the ability to transition between yeast and filamentous growth states are important for Candida albicans' virulence. In this study, the role of mitochondrial ribosome, respiration, and the SNF1 AMP-activated kinase complex in governing filamentous growth within macrophages was uncovered. Downregulation of these genes reduced ATP levels and impeded filamentation and growth under certain conditions. The findings highlight the importance of metabolism in the interaction between C. albicans and macrophages.
Article
Developmental Biology
Toby G. R. Andrews, Wolfram Ponisch, Ewa K. Paluch, Benjamin J. Steventon, Elia Benito-Gutierrez
Summary: This study used a quantitative approach to investigate the dynamic relationship between cell shape and growth in the process of notochord morphogenesis in amphioxus, revealing significant variations in developmental timing and trajectory topology in different regions.
Article
Microbiology
Glaucia S. Arita, Daniella R. Faria, Isis R. G. Capoci, Erika S. Kioshima, Patricia S. Bonfim-Mendonca, Terezinha I. E. Svidzinski
Summary: This review focuses on the studies of C. albicans mutants for genes that encode cell wall-associated proteins, highlighting the importance of these proteins in virulence and hyphal morphogenesis. Some proteins with mutations are associated with attenuated virulence and defective filamentation, while others are still important for C. albicans virulence despite their inactivation not impairing filamentation.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Karl Liboro, Seong-Ryong Yu, Juhyeon Lim, Yee-Seul So, Yong-Sun Bahn, Hyungjin Eoh, Hyunsook Park
Summary: Candida albicans is a part of the normal microbiome of human mucosa and can switch between yeast and hyphal morphologies in response to environmental cues. Loss of CaYck2 in C. albicans disrupts carbon metabolism, leads to a shift in metabolites similar to glucose starvation, and affects genes involved in glucose sensing and glycolysis pathways. Moreover, loss of CaYck2 also induces arginine breakdown and dysregulation of hyphal initiation and elongation, impacting the pseudohyphal phenotype. Metabolome analysis reveals an abundance of methyl citrate cycle intermediates in the yck2 Delta strain, emphasizing the importance of CaYck2 in this pathway.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Anatomy & Morphology
Alexandra A. Vetrova, Tatiana S. Lebedeva, Aleena A. Saidova, Daria M. Kupaeva, Yulia A. Kraus, Stanislav Kremnyov
Summary: Our study focused on the embryonic development of Dynamena pumila, a cnidarian species with apolar gastrulation. We found that morphological polarity in the embryos only appears after gastrulation, while molecular prepatterning already exists during gastrulation. Additionally, we experimentally confirmed that in D. pumila, the oral-aboral axis is robust against perturbations in cWnt activity. Our results suggest that morphogenetic processes are decoupled from molecular axial patterning during gastrulation in D. pumila, which could provide new insights into the relationship between morphological polarization and axial molecular patterning in Metazoa.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Cell Biology
Kevin S. Cannon, Jose M. Vargas-Muniz, Neil Billington, Ian Seim, Joanne Ekena, James R. Sellers, Amy. S. Gladfelter
Summary: In this study, the researchers investigated the impact of different combinations of septin proteins on biophysical properties and cell morphogenesis. They discovered that a gene duplication event gave rise to two similar but distinct septin proteins, Cdc11a and Cdc11b, which showed differences in cell polarity defects and filament length.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Evelyn C. Aviles, Alexandra Krol, Steven J. Henle, Jessica Burroughs-Garcia, Michael R. Deans, Lisa Goodrich
Summary: The polarized flow of information in neural circuits relies on the organization of neurons, their processes, and their synapses. Fat3, a protein similar to Fat cadherins, plays a crucial role in the development of polarized circuits in the mouse retina. It binds to cytoskeletal regulators and synaptic proteins, coordinating different cell behaviors and regulating synapse localization.
Article
Multidisciplinary Sciences
Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klaembt
Summary: In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). The authors demonstrate that Drosophila EG are polarized and form an internal diffusion barrier. EG cell polarity, which requires beta Heavy-Spectrin, is crucial for normal locomotor behavior.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Ramkumar Sambasivan, Benjamin Steventon
Summary: Recent studies have identified a population of bipotent neuromesodermal progenitors in the posterior region of the embryo, which possess the ability to generate spinal cord and paraxial mesoderm cells with a conserved regulatory network. By maintaining this flexible pool of multi-germ layer competent progenitors, the contribution to the elongating body axis can vary depending on relative growth rates in different regions, suggesting a potential role in driving alterations in the timing of embryo growth during evolution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Takamitsu Maruyama, Ronay Stevens, Alan Boka, Laura DiRienzo, Connie Chang, Hsiao-Man Ivy Yu, Katsuhiko Nishimori, Clinton Morrison, Wei Hsu
Summary: Skeletal stem cells known as suture stem cells (SuSCs) exhibit long-term self-renewal, clonal expansion, and multipotency, playing a crucial role in calvarial development, homeostasis, injury repair, and regeneration. BMPR1A is identified as essential for SuSC self-renewal and SuSC-mediated bone formation, and its disruption leads to craniosynostosis. SuSCs show potential for stem cell-based therapy with their ability to maintain stemness properties and osteogenic ability.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Meng Zhu, Clifford J. Tabin
Summary: Heterochrony refers to changes in the timing of developmental processes relative to an ancestral state. Limb development is a suitable system to study the contribution of heterochrony to morphological evolution. We demonstrate how timing mechanisms have been utilized to establish the correct limb pattern and present cases where natural variations in timing have resulted in changes in limb morphology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Daniel S. Levic, Michel Bagnat
Summary: A common phenomenon in animal development is the formation of fluid-filled cavities or lumina, which facilitate the transportation of gases and fluids across tissues and organs. Despite variations in size, scale, and complexity among different species, the processes of lumen formation share fundamental morphogenetic principles. This article explores the role of polarized targeting of membrane and secreted proteins, with a focus on ion transporters in vertebrate model systems, in regulating lumen formation. Mechanistic differences between invertebrates and vertebrates are discussed, as well as the involvement of Na+/K+ ATPase and junctional proteins in the polarization of immature epithelia to build lumina in developing organs.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Katharine Goodwin, Celeste M. Nelson
Summary: Mechanical forces play a crucial role in development, with both intrinsic and extrinsic signals affecting morphogenesis. Recent studies have highlighted the diversity and importance of mechanical influences during development. There are promising avenues for future research in this rapidly expanding field.
DEVELOPMENTAL CELL
(2021)
Article
Agriculture, Dairy & Animal Science
J. Nowosad, K. Kupren, M. Biegaj, D. Kucharczyk
Summary: The study analyzed the anatomical and morphological development of common barbel larvae reared under optimal controlled conditions, revealing that the most significant growth changes in barbel occur during the pre-flexion and flexion periods, which are the fastest developing stages in their life.
Article
Biophysics
Vidhyashree Rajasekar, Priti Darne, Asmita Prabhune, Richard Y. T. Kao, Adline Princy Solomon, Gordon Ramage, Lakshman Samaranayake, Prasanna Neelakantan
Summary: The study found that the curcumin-sophorolipid nanocomplex effectively inhibited fungal adhesion, biofilm development, maturation, and filamentation. This was accompanied by downregulation of key genes involved in biofilm formation and hyphal regulation, indicating the potential of this nanocomplex as a promising anti-fungal agent against Candida albicans.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
