Review
Critical Care Medicine
Andrea Carsetti, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Francesco Gasparri, Benedetto Marini, Erica Adrario, Abele Donati
Summary: This study assessed the accuracy of shock index (SI) in predicting the need for massive transfusion (MT) and mortality in adult trauma patients. The results showed that SI may not be a reliable tool for predicting the need for MT in adult trauma patients, but it can be used to identify patients with a low risk of mortality.
Article
Critical Care Medicine
Taleen A. MacArthur, Grant M. Spears, Rosemary A. Kozar, Jing-fei Dong, Matthew Auton, Donald H. Jenkins, Kent R. Bailey, Aneel A. Ashrani, Mike J. Ferrara, Joseph M. Immermann, Timothy M. Halling, Myung S. Park
Summary: This study found that trauma patients with decreased arrival systolic blood pressure, increased INR, and decreased time to peak are at higher risk of requiring a high rate of packed red blood cell transfusions. Patients with accelerated thrombin generation have an increased risk of requiring transfusions.
Article
Veterinary Sciences
Claire Tucker, Anna Winner, Ryan Reeves, Edward S. Cooper, Kelly Hall, Julie Schildt, David Brown, Julien Guillaumin
Summary: This retrospective study examined resuscitation patterns in critically bleeding dogs and found a variety of sources of bleeding. The survival rate of the dogs was low, and survival was associated with total protein levels and prolonged clotting time.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Critical Care Medicine
Christopher Cameron McCoy, Megan Brenner, Juan Duchesne, Derek Roberts, Paula Ferrada, Tal Horer, David Kauvar, Mansoor Khan, Andrew Kirkpatrick, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Bryan A. Cotton
Summary: Whole blood transfusion played a significant role in treating casualties in past wars, but civilian centers have transitioned to blood component therapies. Recent studies suggest that whole blood transfusion may be more effective for treating trauma patients.
Review
Critical Care Medicine
Jonathan A. Black, Virginia S. Pierce, Kavina Juneja, John B. Holcomb
Summary: Trauma remains a leading cause of death, with hemorrhage being the leading preventable cause. In the past 20 years, resuscitation strategies for trauma have significantly changed, moving from large volume crystalloid resuscitation to a 1:1:1 ratio of packed red blood cells, fresh plasma, and platelets.
Article
Critical Care Medicine
Ryan Phillips, Niti Shahi, Shannon N. Acker, Maxene Meier, Gabrielle Shirek, Jenny Stevens, John Recicar, Steven Moulton, Denis Bensard
Summary: The ABCD and BIS scores were developed to predict the need for massive transfusion in pediatric trauma patients, with the BIS score performing the best.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Emergency Medicine
Katherine J. Lee, Morgan M. McGuire, Warren C. Harvey, William D. Bianchi, Alec D. Emerling, Erin R. Reilly, Vikhyat S. Bebarta, Jason J. Lopez, Gregory J. Zarow, Jonathan D. Auten
Summary: In this study, different pressured IO infusion methods were compared in terms of flow rates, pressures, and user ratings. The results showed that the Manual Rapid Infuser and push-pull methods achieved high flow rates but also relatively high pressures.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Christian Zanza, Tatsiana Romenskaya, Fabrizio Racca, Eduardo Rocca, Fabio Piccolella, Andrea Piccioni, Angela Saviano, George Formenti-Ujlaki, Gabriele Savioli, Francesco Franceschi, Yaroslava Longhitano
Summary: Despite preventive measures and innovations in trauma systems, trauma still remains a leading cause of death in adults. Trauma-induced coagulopathy (TIC) is a multifactorial condition resulting from dysregulated coagulation, altered fibrinolysis, endothelial dysfunction, platelet dysfunction, and inflammatory responses. This review focuses on the pathophysiology, early diagnosis, and treatment of TIC, including the use of pharmaceutical hemostatic agents. While our understanding of TIC has increased, ongoing studies are needed to answer remaining questions and improve outcomes for trauma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Joshua P. Hazelton, Anna E. Ssentongo, John S. Oh, Paddy Ssentongo, Mark J. Seamon, James P. Byrne, Isabella G. Armento, Donald H. Jenkins, Maxwell A. Braverman, Caleb Mentzer, Guy C. Leonard, Lindsey L. Perea, Courtney K. Docherty, Julie A. Dunn, Brittany Smoot, Matthew J. Martin, Jayraan Badiee, Alejandro J. Luis, Julie L. Murray, Matthew R. Noorbakhsh, James E. Babowice, Charles Mains, Robert M. Madayag, Haytham M. A. Kaafarani, Ava K. Mokhtari, Sarah A. Moore, Kathleen Madden, Allen Tanner, Diane Redmond, David J. Millia, Amber Brandolino, Uyen Nguyen, Vernon Chinchilli, Scott B. Armen, John M. Porter
Summary: This study aimed to investigate the use of whole blood in the resuscitation of bleeding trauma patients. The results showed that compared to blood component therapy, the use of whole blood was associated with a reduction in mortality and bleeding complications.
Article
Critical Care Medicine
Zachary A. Matthay, Zane J. Hellmann, Rachael A. Callcut, Ellicott C. Matthay, Brenda Nunez-Garcia, William Duong, Jeffry Nahmias, Aimee K. LaRiccia, M. Chance Spalding, Satya S. Dalavayi, Jessica K. Reynolds, Heather Lesch, Yee M. Wong, Amanda M. Chipman, Rosemary A. Kozar, Liz Penaloza, Kaushik Mukherjee, Khaled Taghlabi, Christopher A. Guidry, Sirivan S. Seng, Asanthi Ratnasekera, Amirreza Motameni, Pascal Udekwu, Kathleen Madden, Sarah A. Moore, Jordan Kirsch, Jesse Goddard, James Haan, Kelly Lightwine, Julianne B. Ontengco, Daniel C. Cullinane, Sarabeth A. Spitzer, John C. Kubasiak, Joshua Gish, Joshua P. Hazelton, Alexandria Z. Byskosh, Joseph A. Posluszny, Erin E. Ross, John J. Park, Brittany Robinson, Mary Kathryn Abel, Alexander T. Fields, Jonathan H. Esensten, Ashok Nambiar, Joanne Moore, Claire Hardman, Pranaya Terse, Xian Luo-Owen, Anquonette Stiles, Brenden Pearce, Kimberly Tann, Khaled Abdul Jawad, Gabriel Ruiz, Lucy Z. Kornblith
Summary: Despite modern massive transfusion protocols, some trauma patients receiving ultramassive transfusion experience unbalanced ratios of red blood cells to other blood components, leading to increased mortality rates. Maintaining balanced ratios during ultramassive transfusion and considering certain clinical factors can aid in prognostication for these patients.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Surgery
Jessie G. Jiang, Hunter B. Moore, Ernest E. Moore, Fredric Pieracci, Angela Sauaia
Summary: The study found that tPA-challenge-TEG is the most accurate factor for predicting massive transfusion in trauma patients. It performs the best in early hypotensive patients and is also more accurate in predicting massive transfusion than other factors in delayed hypotensive patients.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Emergency Medicine
Young Tark Lee, Byung Kwan Bae, Young Mo Cho, Soon Chang Park, Chang Ho Jeon, Up Huh, Dae-Sup Lee, Sung-Hwa Ko, Dong-Man Ryu, Il Jae Wang
Summary: rSIG is a useful and accurate predictor for massive transfusion, coagulopathy, in-hospital mortality, and 24-hour mortality in trauma patients, showing high sensitivity and specificity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Critical Care Medicine
Akira Endo, Atsushi Senda, Yasuhiro Otomo, Matthew Firek, Mitsuaki Kojima, Raul Coimbra
Summary: This study aimed to evaluate the benefits of the concurrent use of cryoprecipitate (Cryo) in combination with fresh frozen plasma (FFP) for bleeding trauma patients. The results of propensity score-matching analysis showed that the use of Cryo combined with FFP was significantly associated with reduced in-hospital mortality and no significant difference in the occurrence rate of adverse events. Further randomized controlled trials are needed to confirm these results.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Marisa L. Laing, Kimberly Burtch, Angie Storrer, Cameron Mccoy
Summary: This study found that the addition of standardized calcium replacement improved administration rates of calcium in trauma patients receiving massive transfusion protocol. Ongoing research will ensure the recommended changes improve the identified shortcomings and that patients maintain adequate ionized calcium levels with the current dosing parameters.
JOURNAL OF TRAUMA NURSING
(2023)
Article
Health Care Sciences & Services
Marco Vettorello, Michele Altomare, Andrea Spota, Stefano Piero Bernardo Cioffi, Marta Rossmann, Andrea Mingoli, Osvaldo Chiara, Stefania Cimbanassi
Summary: The rapid identification of patients at risk for massive blood transfusion is crucial as uncontrolled exsanguination may lead to death within a short time. This study aimed to analyze a group of severe trauma patients to identify risk factors associated with massive transfusion requirements and hypocalcemia. The study found that a higher injury severity score (ISS) was an independent but weak predictor of hypocalcemia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Surgery
Patrick B. Murphy, Stephanie A. Savage, Ben L. Zarzaur
JOURNAL OF SURGICAL RESEARCH
(2020)
Review
Surgery
Ben L. Zarzaur, Christopher C. Stahl, Jacob A. Greenberg, Stephanie A. Savage, Rebecca M. Minter
Article
Medicine, Research & Experimental
Damaris Ortiz, Ashley D. Meagher, Heidi Lindroth, Emma Holler, Sujuan Gao, Babar Khan, Sue Lasiter, Malaz Boustani, Ben Zarzaur
Article
Surgery
Esther S. Tseng, Tanya L. Zakrison, Brian Williams, Andrew C. Bernard, Matthew J. Martin, Laura Zebib, Sophie Soklaridis, Haytham M. Kaafarani, Ben L. Zarzaur, Marie Crandall, Mark J. Seamon, Robert D. Winfield, Brandon Bruns
Article
Oncology
Lava R. Timsina, Ben Zarzaur, David A. Haggstrom, Peter C. Jenkins, Maryam Lustberg, Samilia Obeng-Gyasi
Summary: The study found that factors such as low educational achievement, widowed/divorced/separated marital status, and being uninsured were associated with a lower likelihood of cancer survivors receiving SCP. Future research should evaluate how the omission of SCP in these patients affects the quality of care during the transition from oncologists to primary care.
SUPPORTIVE CARE IN CANCER
(2021)
Editorial Material
Surgery
Jeffry Nahmias, Tanya L. Zakrison, Elliott R. Haut, Onaona Gurney, Bellal Joseph, Kimberly Hendershot, Mira Ghneim, Anne Stey, Mark H. Hoofnagle, Zinzi Bailey, Rishi Rattan, Joseph B. Richardson, Ariel P. Santos, Ben Zarzaur
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Editorial Material
Critical Care Medicine
Gail T. Tominaga, Marie Crandall, Chris Cribari, Ben L. Zarzaur, Mark Bernstein, Rosemary A. Kozar
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Surgery
Emma Holler, Ashley D. Meagher, Damaris Ortiz, Sanjay Mohanty, America Newnum, Anthony Perkins, Sujuan Gao, Gabriel Kinnaman, Malaz Boustani, Ben Zarzaur
Summary: A study on older trauma patients found no association between pre-injury Katz ADL functional status and discharge disposition. However, factors such as age, BMI, comorbidity score, marital status, injury severity, and female patients with mental health symptoms were significantly associated with non-home discharge. Early discussions on discharge disposition, especially for older patients exhibiting anxiety or depression symptoms, are crucial during acute hospitalization.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Critical Care Medicine
Patrick B. Murphy, Sarah Severance, Emma Holler, Laura Menard, Stephanie Savage, Ben L. Zarzaur
Summary: This systematic review on the management of asymptomatic BCVI found that any medical management was better than no treatment, but no specific differences were found. Vessel healing was rare and mostly occurred following low-grade injuries.
TRAUMA SURGERY & ACUTE CARE OPEN
(2021)
Article
Health Care Sciences & Services
Christopher C. Stahl, Luke M. Funk, Jessica R. Schumacher, Ben L. Zarzaur, John E. Scarborough
Summary: In older patients undergoing hip fracture repair, postoperative delirium and pneumonia have the highest impact on mortality and resource utilization. These complications should be the focus of quality improvement efforts for this patient population.
JOINT COMMISSION JOURNAL ON QUALITY AND PATIENT SAFETY
(2021)
Article
Health Care Sciences & Services
Edgar Rojas-Munoz, Chengyuan Lin, Natalia Sanchez-Tamayo, Maria Eugenia Cabrera, Daniel Andersen, Voicu Popescu, Juan Antonio Barragan, Ben Zarzaur, Patrick Murphy, Kathryn Anderson, Thomas Douglas, Clare Griffis, Jessica McKee, Andrew W. Kirkpatrick, Juan P. Wachs
NPJ DIGITAL MEDICINE
(2020)
Proceedings Paper
Computer Science, Artificial Intelligence
Chengyuan Lin, Edgar Rojas-Munoz, Maria Eugenia Cabrera, Natalia Sanchez-Tamayo, Daniel Andersen, Voicu Popescu, Juan Antonio Barragan Noguera, Ben Zarzaur, Pat Murphy, Kathryn Anderson, Thomas Douglas, Clare Griffis, Juan Wachs
2020 IEEE CONFERENCE ON VIRTUAL REALITY AND 3D USER INTERFACES (VR 2020)
(2020)
Article
Critical Care Medicine
John A. Harvin, Van Thi Thanh Truong, Charles E. Green, LaDonna Allen, Jason Murry, John J. Radosevich, James N. Bogert, Patrick B. Murphy, Brandy B. Padilla-Jones, Ben L. Zarzaur, John R. Taylor, Kevin W. Sexton, Cassandra Decker, Thomas J. Schroeppel, Charles E. Wade, Lillian S. Kao
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2020)
Article
Surgery
Joseph V. Sakran, Hiba Ezzeddine, C. William Schwab, Stephanie Bonne, Karen J. Brasel, Randall S. Burd, Joseph Cuschieri, James Ficke, Barbara A. Gaines, Joseph T. Giacino, Nicole S. Gibran, Adil Haider, Erin C. Hall, Juan P. Herrera-Escobar, Bellal Joseph, Lillian Kao, Brad G. Kurowski, David Livingston, Samuel P. Mandell, Deepika Nehra, Babak Sarani, Mark Seamon, Peter Yonclas, Ben Zarzaur, Ronald Stewart, Eileen Bulger, Avery B. Nathens
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Review
Critical Care Medicine
John A. Harvin, Ben L. Zarzaur, Raminder Nirula, Benjamin T. King, Ajai K. Malhotra
TRAUMA SURGERY & ACUTE CARE OPEN
(2020)