Article
Critical Care Medicine
Akira Endo, Atsushi Senda, Yasuhiro Otomo, Matthew Firek, Mitsuaki Kojima, Raul Coimbra
Summary: This study aimed to evaluate the benefits of the concurrent use of cryoprecipitate (Cryo) in combination with fresh frozen plasma (FFP) for bleeding trauma patients. The results of propensity score-matching analysis showed that the use of Cryo combined with FFP was significantly associated with reduced in-hospital mortality and no significant difference in the occurrence rate of adverse events. Further randomized controlled trials are needed to confirm these results.
CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Milomir O. Simovic, Michael J. Falabella, Tuan D. Le, Jurandir J. DalleLucca, Yansong Li
Summary: This study investigated the effects of early administration of DAF on hemorrhage-induced organ damage. The results suggest that DAF treatment can alleviate organ injury and improve metabolic acidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Romein W. G. Dujardin, Derek J. B. Kleinveld, Christine Gaarder, Karim Brohi, Ross A. Davenport, Nicola Curry, Simon Stanworth, Par I. Johansson, Jakob Stensballe, Marc Maegele, Nicole P. Juffermans
Summary: The study finds that ROTEM abnormalities in trauma patients are associated with lower levels of coagulation factors, increased mortality, and depletion of fibrinogen and factor V. Increased fibrinolysis may also be present in the case of ROTEM abnormalities.
Article
Mathematical & Computational Biology
Yun Liu, Jian Lu, Caifu Dong, Limin Zhu, Li Zhou, Kai Zhu
Summary: Effective volumetric resuscitation using hydroxyethyl starch (HES) can increase survival rate and improve immune response in rats with traumatic shock by mediating phosphorylation of ERK signaling pathway proteins. The study suggests that HES is a promising treatment for severe traumatic shock in clinical practice.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Julia Garcia Mancebo, Ryan Patenaude, Kristen Sack, Maksymilian Prondzynski, Alan B. Packard, Jason L. J. Dearling, Ruihan Li, Michelle Balcarcel-Monzon, Saffron Dominguez, Sirisha Emani, John N. Kheir, Brian Polizzotti, Yifeng Peng
Summary: This study proposes a low-fouling zwitterionic polymer as an alternative volume expander for hypovolemic shock. The polymer shows improved biocompatibility and efficacy, with resistance to cell interaction and deposition in major organs. It is rapidly cleared from the body, reducing the risk of long-term side effects. In comparison to existing colloids and plasma, the polymer serves as a more potent oncotic agent for restoring intravascular volume.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Summary: When accompanied by hemorrhagic shock after TBI, PolyhHb may serve as an effective alternative to blood for resuscitation, restoring hemodynamics and oxygen delivery.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jonathan M. Preuss, Ute Burret, Michael Groeger, Sandra Kress, Angelika Scheuerle, Peter Moeller, Jan P. Tuckermann, Martin Wepler, Sabine Vettorazzi
Summary: Impaired GR signaling in GR(dim/dim) mice results in increased lung inflammation and apoptosis, leading to attenuated protection against hemorrhagic shock-induced lung damage.
Article
Physiology
Yuanqun Zhou, Qinghui Li, Xinming Xiang, Yue Wu, Yu Zhu, Xiaoyong Peng, Liangming Liu, Tao Li
Summary: This study investigated the effects of low-dose NE in hypotensive resuscitation and found that it could prolong hypotensive tolerance, protect organ function, reduce blood loss, and improve survival rate. This is of great importance for the early treatment of serious trauma patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lei Kuang, Yu Zhu, Yue Wu, Kunlun Tian, Xiaoyong Peng, Mingying Xue, Xinming Xiang, Billy Lau, Fei Chuen Tzang, Liangming Liu, Tao Li
Summary: YQ23 showed better outcomes compared to LR in hypotensive resuscitation by reducing blood loss and fluid demand, stabilizing hemodynamics, increasing oxygen delivery, reducing organ injury, extending survival time without significant side effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Shuaiyu Jiang, Mengmeng Wu, Xiaoguang Lu, Yilong Zhong, Xin Kang, Yi Song, Zhiwei Fan
Summary: This study indicates that limited fluid resuscitation (LFR) is more beneficial than harmful in patients with hemorrhagic shock or septic shock, reducing mortality, multiple organ dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS), and disseminated intravascular coagulation (DIC) rates.
Article
Critical Care Medicine
Alexis L. Cralley, Ernest E. Moore, Joseph Dubose, Megan L. Brenner, Terry R. Schaid, Margot DeBot, Mitchell Cohen, Christopher Silliman, Charles Fox, Angela Sauaia
Summary: This study compared the outcomes of patients treated with REBOA Zone 3 and REBOA Zone 1 for severe blunt pelvic injuries. The results showed that REBOA Zone 3 had better survival rates and comparable outcomes in other adverse events compared to REBOA Zone 1.
Article
Critical Care Medicine
Kang Qin, You Li, Weiqiang Liang, Philipp Lichte, Xing Zhang, Qun Zhao, Athanassios Fragoulis, Thomas Pufe, Philipp Kobbe, Chunxia Ma, Hongzheng Meng, Elizabeth R. Balmayor, Frank Hildebrand, Johannes Greven
Summary: This study aimed to investigate the immunomodulatory effects of sulforaphane (SFN) on splenic macrophages' immunocompetence after hemorrhagic shock/resuscitation (HS/R). Treatment with SFN was found to enhance the immunocompetence of splenic macrophages and reduce the expression of inflammatory cytokines.
Article
Critical Care Medicine
Taylor E. Wallen, Matthew R. Baucom, Lisa G. England, Rebecca M. Schuster, Timothy A. Pritts, Michael D. Goodman
Summary: The study found that whole blood resuscitation can reduce the acute postinjury neuroinflammatory response after combined TBI/shock compared with HTS. The addition of either propranolol or TXA may modulate the postinjury systemic and cerebral inflammatory response with more improvements noted after propranolol administration. Multimodal treatment with resuscitation and pharmacologic therapy after TBI and hemorrhagic shock may mitigate the inflammatory response to these injuries to improve recovery.
Article
Critical Care Medicine
Jessica E. Schucht, Paul J. Matheson, Brian G. Harbrecht, Logan Bond, Graham R. Ashkettle, Jason W. Smith
Summary: Fresh frozen plasma-based resuscitation plays an important role in reducing ischemia-induced intestinal permeability. Combination therapy with DPR can further stabilize tight junction proteins and attenuate increased intestinal permeability. This new method could be effective in reducing intestinal barrier breakdown and systemic inflammation after trauma.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Surgery
Hai Jiang, Jia Liu, Zhipeng Xu, Chuanming Zheng
Summary: The combination of AR and HES has a significant protective effect on the coagulation function of THS rats, especially when the mean arterial pressure reaches 60 mmHg. The optimal coagulation function was observed in the AR, HES, and AR + HES groups when resuscitated to a mean arterial pressure of 60 mmHg.
JOURNAL OF SURGICAL RESEARCH
(2021)