Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Rob J. van der Geest, Luuk H. G. A. Hopman, Lourens F. H. J. Robbers, M. Louis Handoko, Robin Nijveldt, John P. Greenwood, Sven Plein, Pankaj Garg
Summary: LV hemodynamic assessment by LV blood flow kinetic energetics in STEMI patients shows a significant inverse association with adverse LV-remodeling. Late-diastolic LV blood flow kinetic energetics early after acute MI is independently associated with adverse LV-remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianing Cui, Yanan Zhao, Geng Qian, Xiuzheng Yue, Chuncai Luo, Tao Li
Summary: This study evaluated the changes in cardiac magnetic resonance (CMR) characteristics and identified predictors of reverse left ventricular remodeling (r-LVR) in ST-segment elevation myocardial infarction (STEMI) patients. The r-LVR group exhibited higher infarct zone displacements and better recovery of cardiac function. Microvascular obstruction (MVO) mass and infarct zone peak longitudinal displacement (PLD) were identified as independent predictors of r-LVR.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Article
Cell Biology
Ferhat Eyyupkoca, Karabekir Ercan, Emrullah Kiziltunc, Ilgin Burcu Ugurlu, Ajar Kocak, Nilnur Eyerci
Summary: Increasing evidence suggests that miRNA plays an important role in myocardial healing and ventricular remodeling after acute myocardial infarction (AMI). A study found that there are 8 miRNAs associated with adverse left ventricular remodeling in ST-elevated MI patients. Among them, 3 miRNAs show significant differences during the follow-up period, while the rest show differences during the acute phase of AMI. Further mechanistic studies are needed to understand the complex remodeling process after AMI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Stefan Heber, Paul M. Haller, Attila Kiss, Bernhard Jaeger, Kurt Huber, Michael J. M. Fischer
Summary: This study found that methylglyoxal (MG) levels increase in the plasma of humans following acute myocardial infarction (AMI), and this increase is associated with a decrease in left ventricular ejection fraction (LVEF). MG levels increase after reperfusion and gradually decrease after 24 hours. The increase in MG is largely independent of cardiac necrosis markers, suggesting the presence of mechanisms independent of myocardial necrosis. The study also found that the increase in MG explains 23% of the variation in LVEF. Therefore, inhibiting MG generation or scavenging MG may be a novel therapeutic strategy to target post-AMI myocardial remodeling and dysfunction.
Article
Biochemistry & Molecular Biology
Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maass, Juergen Konradi, Dennis Mehrkens, Simon Geissen, Felix S. Nettersheim, Simon Braumann, Erik Michaelsson, Richard J. Nies, Samuel Lee, Marie-Christin Redzinski, Vera B. M. Peters, Harshal N. Nemade, Philipp von Stein, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Martin Mollenhauer
Summary: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, and ischemic cardiomyopathy is becoming a leading reason for hospitalization in the western world. Neutrophils (PMN) play a key role in the inflammatory response of the ischemic myocardium, and the enzyme myeloperoxidase (MPO) expressed in PMN is an important mediator of their inflammatory capacities. Reducing PMN count and inhibiting MPO showed positive effects on scar formation and cardiac function in murine models of MI, suggesting that MPO could be a promising pharmacological target for preventing long-term morbidity after MI.
Review
Cell Biology
Kyoko Komai, Nicholas K. Kawasaki, Jason K. Higa, Takashi Matsui
Summary: Ferroptosis is an iron-dependent form of regulated cell death characterized by dysfunction of the GPX4 antioxidant system. Inhibiting ferroptosis restores cardiac function and provides protection against I/R injury.
Article
Cardiac & Cardiovascular Systems
Shohei Fujii, Shigeki Kobayashi, Yaowei Chang, Junya Nawata, Ryosuke Yoshitomi, Shinji Tanaka, Michiaki Kohno, Yoshihide Nakamura, Hironori Ishiguchi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takayuki Okamura, Takeshi Yamamoto, Masafumi Yano
Summary: This study demonstrated that the chronic administration of dantrolene or the genetic stabilization of RyR2 tetrameric structure could prevent left ventricular remodeling and ventricular tachycardia after myocardial infarction by enhancing the binding affinity of calmodulin to RyR2. These interventions improved survival rates by suppressing LV remodeling and proarrhythmia.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Biology
Sabina Andreea Leanca, Daniela Crisu, Antoniu Octavian Petris, Irina Afrasanie, Antonia Genes, Alexandru Dan Costache, Dan Nicolae Tesloianu, Irina Iuliana Costache
Summary: Myocardial infarction is the most common cause of death and morbidity worldwide. It is mainly caused by thrombotic occlusion in the coronary circulation. Current therapies aim to restore coronary flow and counteract neurohormonal activation, but myocardial ischemia still leads to left ventricular remodeling and eventually heart failure.
Article
Cardiac & Cardiovascular Systems
Camilla Calvieri, Nicola Galea, Francesco Cilia, Giacomo Pambianchi, Giuseppe Mancuso, Domenico Filomena, Sara Cimino, Iacopo Carbone, Marco Francone, Luciano Agati, Carlo Catalano
Summary: CMR feature tracking analysis offers an accurate method to assess myocardial damage and early left ventricular (LV) remodeling. This study found that a loading dose of 500 mg aspirin before primary coronary angioplasty (pPCI) can reduce myocardial damage and adverse LV remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Yong He, Min Ma, Qin Zhao, Hua-yan Xu, Chun-chao Xia, Wan-lin Peng, Zhen-lin Li, Hong Li, Ying-kun Guo, Zhi-gang Yang
Summary: ECVAI is associated with LV remodeling in all patients while native T1(AI) may be feasible when MVO is absent.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Article
Cardiac & Cardiovascular Systems
Miranda D. Diaz, Elaine Tran, Martin Spang, Raymond Wang, Roberto Gaetani, Colin G. Luo, Rebecca Braden, Ryan C. Hill, Kirk C. Hansen, Anthony N. DeMaria, Karen L. Christman
Summary: The myocardial matrix hydrogel shows potential efficacy in chronic myocardial infarction patients by mitigating negative left ventricular remodeling through modulation of the immune response, down-regulation of pathways involved in heart failure progression and fibrosis, and up-regulation of genes important for cardiac muscle contraction.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hadar Ben-Arzi, Arka Das, Christopher Kelly, Rob J. van der Geest, Sven Plein, Erica Dall'Armellina
Summary: This study investigated the longitudinal changes in intraventricular flow post-STEMI and its predictive relevance of long-term cardiac remodeling. The results showed that patients with reduced ejection fraction retained significantly higher systolic kinetic energy, while preserved ejection fraction patients had persistently higher peakE-wave kinetic energy throughout the study period.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Nikolay Bogush, Lin Tan, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain
Summary: Combining metoprolol and T3 can muscularize the heart through cardiomyocyte proliferation, leading to potential treatment for ischemic heart failure.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
C. Hue-Beauvais, E. Koch, P. Chavatte-Palmer, L. Galio, S. Chat, M. Letheule, D. Rousseau-Ralliard, F. Jaffrezic, D. Laloe, E. Aujean, F. Revillion, V. Lhotellier, A. Gertler, E. Devinoy, M. Charlier
JOURNAL OF ANIMAL SCIENCE
(2015)
Article
Toxicology
Sarah A. Valentino, Anne Tarrade, Josiane Aioun, Eve Mourier, Christophe Richard, Michele Dahirel, Delphine Rousseau-Ralliard, Natalie Fournier, Marie-Christine Aubriere, Marie-Sylvie Lallemand, Sylvaine Camous, Marine Guinot, Madia Charlier, Etienne Aujean, Hala Al Adhami, Paul H. Fokkens, Lydiane Agier, John A. Boere, Flemming R. Cassee, Remy Slama, Pascale Chavatte-Palmer
PARTICLE AND FIBRE TOXICOLOGY
(2016)
Article
Reproductive Biology
Karin Sorig Hougaard, Luisa Campagnolo, Pascale Chavatte-Palmer, Anne Tarrade, Delphine Rousseau-Ralliard, Sarah Valentino, Margriet V. D. Z. Park, Wim H. de Jong, Gerrit Wolterink, Aldert H. Piersma, Bryony L. Ross, Gary R. Hutchison, Jitka Stilund Hansen, Ulla Vogel, Petra Jackson, Remy Slama, Antonio Pietroiusti, Flemming R. Cassee
REPRODUCTIVE TOXICOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Natalie Fournier, Sylviane Tardivel, Jean-Francois Benoist, Benoit Vedie, Delphine Rousseau-Ralliard, Maxime Nowak, Fatima Allaoui, Jean-Louis Paul
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Environmental Sciences
Pascale Chavatte-Palmer, Anne Tarrade, Delphine Rousseau-Ralliard
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2016)
Article
Public, Environmental & Occupational Health
M. Bourdon, L. Torres-Rovira, D. Monniaux, C. Faure, R. Levy, A. Tarrade, D. Rousseau-Ralliard, P. Chavatte-Palmer, G. Jolivet
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Aline Doublet, Veronique Robert, Benoit Vedie, Delphine Rousseau-Ralliard, Anne Reboulleau, Alain Grynberg, Jean-Louis Paul, Natalie Fournier
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2014)
Article
Multidisciplinary Sciences
Anne Tarrade, Delphine Rousseau-Ralliard, Marie-Christine Aubriere, Nathalie Peynot, Michele Dahirel, Justine Bertrand-Michel, Tiphaine Aguirre-Lavin, Olivier Morel, Nathalie Beaujean, Veronique Duranthon, Pascale Chavatte-Palmer
Article
Multidisciplinary Sciences
Teddy Leguillier, Marylin Lecso-Bornet, Christelle Lemus, Delphine Rousseau-Ralliard, Nicolas Lebouvier, Edouard Hnawia, Mohammed Nour, William Aalbersberg, Kamelia Ghazi, Phila Raharivelomanana, Patrice Rat
Article
Public, Environmental & Occupational Health
C. Dupont, D. Ralliard-Rousseau, A. Tarrade, C. Faure, M. Dahirel, B. Sion, F. Brugnon, R. Levy, P. Chavatte-Palmer
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2014)
Article
Multidisciplinary Sciences
Helene Kiefer, Luc Jouneau, Evelyne Campion, Delphine Rousseau-Ralliard, Thibaut Larcher, Marie-Laure Martin-Magniette, Sandrine Balzergue, Mireille Ledevin, Audrey Prezelin, Pascale Chavatte-Palmer, Yvan Heyman, Christophe Richard, Daniel Le Bourhis, Jean-Paul Renard, Helene Jammes
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Delphine Rousseau-Ralliard, Anne Couturier-Tarrade, Rene Thieme, Roselyne Brat, Audrey Rolland, Pascal Boileau, Marie-Christine Aubriere, Nathalie Daniel, Michele Dahirel, Emilie Derisoud, Natalie Fournier, Maria Schindler, Veronique Duranthon, Bernd Fischer, Anne Navarrete Santos, Pascale Chavatte-Palmer
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Nutrition & Dietetics
Sofiane Safi-Stibler, Etienne A. Thevenot, Luc Jouneau, Melanie Jouin, Alexandre Seyer, Helene Jammes, Delphine Rousseau-Ralliard, Christine Baly, Anne Gabory
Article
Environmental Sciences
Delphine Rousseau-Ralliard, Christophe Richard, Pauline Hoarau, Marie-Sylvie Lallemand, Lucie Morillon, Marie-Christine Aubriere, Sarah A. Valentino, Michele Dahirel, Marine Guinot, Natalie Fournier, Gwendoline Morin, Eve Mourier, Sylvaine Camous, Remy Slama, Flemming R. Cassee, Anne Couturier-Tarrade, Pascale Chavatte-Palmer
Summary: Exposure to diesel engine exhaust during gestation may predispose rabbit offspring to cardiometabolic disorders in adulthood, with sex-specific responses observed. Males exposed to DE showed metabolic syndrome indicators, while females exhibited trends toward higher triglycerides and decreased bone density compared to controls. Metabolic challenges further amplified some biological responses, particularly in females.
ENVIRONMENTAL RESEARCH
(2021)
Article
Veterinary Sciences
Emilie Derisoud, Juliette Auclair-Ronzaud, Delphine Rousseau-Ralliard, Sabrina Philau, Etienne Aujean, Alexia Durand, Michele Dahirel, Madia Charlier, Marion Boutinaud, Laurence Wimel, Pascale Chavatte-Palmer
Summary: Nulliparity and nursing at conception affect mare's colostrum and milk production, which in turn have an impact on foal growth and development. Primiparous mares produce colostrum with higher immunoglobulin G content but lower production, while old mares' milk is richer in proteins and sodium. The age and parity of the mare also affect the foal's average daily weight gain.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)