Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes

Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ2

(2014) D. Stepniak et al.   JOURNAL OF IMMUNOLOGY

Structure and Function Relationship in Prolyl Oligopeptidase

(2011) Roos Van Elzen et al.   CNS & Neurological Disorders-Drug Targets

Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders

(2011) Ludvig M Sollid et al.   CURRENT OPINION IN IMMUNOLOGY

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

The Small GTPase Rab5a Is Essential for Intracellular Transport of Proglutelin from the Golgi Apparatus to the Protein Storage Vacuole and Endosomal Membrane Organization in Developing Rice Endosperm

(2011) M. Fukuda et al.   PLANT PHYSIOLOGY

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

(2011) M. M. Mahfouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a prolyl endoprotease from Eurygaster integriceps puton (Sunn pest) infested wheat

(2010) Charles Darkoh et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library

(2010) Ulrike Jüse et al.   HUMAN IMMUNOLOGY

Celiac disease: how complicated can it get?

(2010) Jennifer May-Ling Tjon et al.   IMMUNOGENETICS

Induced-fit Mechanism for Prolyl Endopeptidase

(2010) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference

(2010) J. Gil-Humanes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

(2010) J. A. Tye-Din et al.   Science Translational Medicine

Genetic diversity trends in twentieth century crop cultivars: a meta analysis

(2010) Mark van de Wouw et al.   THEORETICAL AND APPLIED GENETICS

Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease

(2010) Hetty C. van den Broeck et al.   THEORETICAL AND APPLIED GENETICS

Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain

(2009) Jofre Tenorio-Laranga et al.   ANALYTICAL BIOCHEMISTRY

Pathways of Gliadin Transport in Celiac Disease

(2009) Martine Heyman et al.   Annals of the New York Academy of Sciences

Peptidomics of Prolyl Endopeptidase in the Central Nervous System

(2009) Whitney M. Nolte et al.   BIOCHEMISTRY

Increasing prevalence and high incidence of celiac disease in elderly people: A population-based study

(2009) Anitta Vilppula et al.   BMC GASTROENTEROLOGY

Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines

(2009) Hetty C van den Broeck et al.   BMC PLANT BIOLOGY

355 Immune Tolerance Induced By Peptide Immunotherapy in An HLA Dq2-Dependent Mouse Model of Gluten Immunity

(2009) Catherine L. Keech et al.   GASTROENTEROLOGY

Celiac Disease: From Pathogenesis to Novel Therapies

(2009) Detlef Schuppan et al.   GASTROENTEROLOGY

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling

(2009) G. Trynka et al.   GUT

Replication of celiac disease UK genome-wide association study results in a US population

(2009) C.P. Garner et al.   HUMAN MOLECULAR GENETICS

Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab  Dq8 Transgenic Mice

(2009) I. L. Huibregtse et al.   JOURNAL OF IMMUNOLOGY

Association of IL18RAP and CCR3 with coeliac disease in the Spanish population

(2009) B Dema et al.   JOURNAL OF MEDICAL GENETICS

Vacuolar Processing Enzyme plays an Essential Role in the Crystalline Structure of Glutelin in Rice Seed

(2009) Toshihiro Kumamaru et al.   PLANT AND CELL PHYSIOLOGY

Genetic erosion in crops: concept, research results and challenges

(2009) Mark van de Wouw et al.   Plant Genetic Resources-Characterization and Utilization

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

(2009) A. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details

(2009) V. Potapov et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Detailed Analysis of the Expression of an Alpha-gliadin Promoter and the Deposition of Alpha-gliadin Protein During Wheat Grain Development

(2008) T. W. J. M. Van Herpen et al.   ANNALS OF BOTANY

Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease

(2008) Maria Collado et al.   BMC MICROBIOLOGY

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

(2008) Maud Pinier et al.   GASTROENTEROLOGY

Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families

(2008) S Adamovic et al.   GENES AND IMMUNITY

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency

(2008) K Haimila et al.   GENES AND IMMUNITY

Mechanisms of epithelial translocation of the  2-gliadin-33mer in coeliac sprue

(2008) M Schumann et al.   GUT

Association study of the IL18RAP locus in three European populations with coeliac disease

(2008) Lotta L.E. Koskinen et al.   HUMAN MOLECULAR GENETICS

Silencing of γ-gliadins by RNA interference (RNAi) in bread wheat

(2008) Javier Gil-Humanes et al.   JOURNAL OF CEREAL SCIENCE

Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

(2008) M C Collado et al.   JOURNAL OF CLINICAL PATHOLOGY

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS

Genetic Background of Celiac Disease and Its Clinical Implications

(2007) Victorien M Wolters et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Endocannabinoids and the gastrointestinal tract: what are the key questions?

(2007) G J Sanger   BRITISH JOURNAL OF PHARMACOLOGY