Article
Immunology
Behazine Combadiere, Lucille Adam, Noelline Guillou, Paul Quentric, Pierre Rosenbaum, Karim Dorgham, Olivia Bonduelle, Christophe Parizot, Delphine Sauce, Julien Mayaux, Charles-Edouard Luyt, Alexandre Boissonnas, Zahir Amoura, Valerie Pourcher, Makoto Miyara, Guy Gorochov, Amelie Guihot, Christophe Combadiere
Summary: Neutrophil subsets in COVID-19 patients have prognostic value in predicting disease severity and thrombosis complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soumya Panigrahi, Santosh K. Ghosh, Brian Ferrari, Jonathan M. Wyrick, Eugene A. Podrez, Aaron Weinberg, Scott F. Sieg
Summary: This study demonstrates that human platelets and megakaryocytes contain an important antimicrobial peptide called hBD-3, which can be detected on the surface of activated platelets as well as in platelet derived extracellular vesicles (p-EVs). The presence of hBD-3 in p-EVs can contribute to platelet activation and endothelial dysfunction, potentially creating a pro-thrombotic vascular microenvironment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Hematology
Anthony Sabulski, Sonata Jodele
Summary: Transplant-associated thrombotic microangiopathy is a life-threatening complication of haematopoietic stem cell transplant, and some patients do not respond to current treatment methods. Qi et al. show that HIF-1α may be a previously unrecognized driver of this endothelial injury syndrome.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Mostafa M. Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous, Eunsoo Kim, Asmaa Badr, Cierra Carafice, Kylene Daily, Owen Whitham, Maciej Pietrzak, Amy Webb, Jeffrey Kawahara, Adrian C. Eddy, Parker Denz, Mijia Lu, K. C. Mahesh, Mark E. Peeples, Jianrong Li, Jian Zhu, Jianwen Que, Richard Robinson, Oscar Rosas Mejia, Rachael E. Rayner, Luanne Hall-Stoodley, Stephanie Seveau, Mikhail A. Gavrilin, Xiaoli Zhang, Jeronay Thomas, Jacob E. Kohlmeier, Mehul S. Suthar, Eugene Oltz, Andrea Tedeschi, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Emily A. Hemann, Eman Abdelrazik, Adriana Forero, Shahid M. Nimjee, Prosper N. Boyaka, Estelle Cormet-Boyaka, Jacob S. Yount, Amal O. Amer
Summary: This study found that CASP4/11 is up-regulated in SARS-CoV-2 infections, and CASP4 expression correlates with the severity of infection. Mice lacking CASP11 showed less weight loss and lung pathology compared to wild-type mice, suggesting a protective effect. Additionally, mice lacking CASP1 showed reduced levels of inflammatory mediators and neutrophil functions. These findings indicate that CASP4/11 could be a promising drug target for the treatment and prevention of severe COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Nishant R. Tiwari, Sanat Phatak, Vivek R. Sharma, Sanjay K. Agarwal
Summary: Severe COVID-19 can lead to multiorgan dysfunction, with potential involvement of thrombotic microangiopathy (TMA) contributing to the organ damage. Rapid identification and treatment of TMA may improve outcomes in critically ill patients.
THROMBOSIS RESEARCH
(2021)
Review
Hematology
Gina Perrella, Magdolna Nagy, Steve P. Watson, Johan W. M. Heemskerk
Summary: GPVI is a receptor expressed on megakaryocytes and platelets that plays a role in both arterial and venous thrombus formation, as well as in the formation of platelet-leukocyte complexes. It is emerging as a potential therapeutic target for venous thrombosis, pulmonary thromboembolism, and cancer metastasis due to its involvement in venous thrombus formation and thromboinflammation. Circulating soluble GPVI is also being explored as a biomarker for thrombosis-related complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Liang Zheng, Liyun Cao, X. Long Zheng
Summary: This study reveals the protective role of ADAMTS13 or lack of VWF in reducing irradiation and melanoma-induced thrombotic microangiopathy and mortality. The microenvironment created by plasma ADAMTS13 or lack of VWF may affect melanoma cell phenotypes through alteration of oxidation-reduction and lipid metabolic pathways.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Miquel Blasco, Alexandra Martinez-Roca, Luis G. Rodriguez-Lobato, Adriana Garcia-Herrera, Laura Rosinol, Pedro Castro, Sara Fernandez, Luis F. Quintana, Maria T. Cibeira, Joan Blade, Carlos Fernandez de Larrea, Natalia Tovar, Raquel Jimenez, Esteban Poch, Elena Guillen, Josep M. Campistol, Enric Carreras, Maribel Diaz-Ricart, Marta Palomo
Summary: Carfilzomib has been associated with the development of thrombotic microangiopathy (TMA) in relapsed/refractory multiple myeloma patients. Research suggests that complement overactivation may lead to potential endothelial damage in some patients, and early evaluation of C5b-9 could help identify those who may benefit from complement blockade and treatment monitoring.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Hematology
Gregoire Detriche, Nicolas Gendron, Aurelien Philippe, Maxime Gruest, Paul Billoir, Elisa Rossi, Coralie L. Guerin, Anna Lokajczyk, Severine Brabant, Dominique Prie, Tristan Mirault, David M. Smadja
Summary: Gonadotropins increase ECFC-related angiogenesis and may be involved in thrombin generation in cardiovascular disease. Gonadotropins may act as biomarkers; moreover, we hypothesize that gonadotropin-blocking strategies may be a novel interesting therapeutic approach in atherosclerotic cardiovascular disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Immunology
Guenalp Uzun, Lisann Pelzl, Anurag Singh, Tamam Bakchoul
Summary: Both qualitative and quantitative platelet abnormalities are common in COVID-19 patients, and they are associated with clinical severity and mortality. Activated platelets contribute to the prothrombotic state in COVID-19 patients. Immune-mediated activation of platelets has been observed in critically ill COVID-19 patients. Platelet consumption and thrombosis occur due to activation of platelets by immune complexes through FcγRIIA. A better understanding of platelet activation in COVID-19 and vaccine-induced thrombotic complications will have therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
J. Freire de Carvalho, R. Brandao Neto, T. Skare
Summary: This study compared clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (pAPS) with and without Thrombotic Microangiopathy (TMA). The findings showed that pAPS patients with TMA had a higher frequency of arterial events, stroke, and higher IgG anticardiolipin titers compared to those without TMA, with a lower frequency of deep venous thrombosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Editorial Material
Hematology
Francesca Schieppati
Summary: The report highlights the prolonged platelet hyperactivity observed in the chronic phase of COVID-19 infection, suggesting a potential role of platelets in post-COVID-19 complications and potential therapeutic target.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Nicola J. Mutch, Sam Walters, Elizabeth E. Gardiner, Owen J. T. McCarty, Simon F. De Meyer, Verena Schroeder, Joost C. M. Meijers
Summary: Bleeding and thrombosis are major clinical problems. Basic research in this field is facing funding challenges. The International Society on Thrombosis and Haemostasis (ISTH) established a task force to identify research opportunities and priorities in this area.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Hideo Wada, Katsuya Shiraki, Hideto Shimpo, Motomu Shimaoka, Toshiaki Iba, Katsue Suzuki-Inoue
Summary: Coronavirus disease 2019 (COVID-19) has led to an increasing incidence of thrombotic complications. Unlike bacterial infections, COVID-19 patients experience different types of thrombosis. The incidence of thrombosis in COVID-19 patients varies from 6-26%, with venous thromboembolism and acute arterial thrombosis occurring in 4.8-21.0% and 0.7-3.7% of cases, respectively. COVID-19 is characterized by a hypercoagulable and hypofibrinolytic state with platelet activation, whereas bacterial infections exhibit a hypercoagulable and hyperfibrinolytic state. Marked platelet activation, hypercoagulability, and hypofibrinolytic states are major contributors to thrombosis in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Hematology
Edward M. Conway
Article
Hematology
Manu Thomas Kalathottukaren, Libin Abraham, Piyushkumar R. Kapopara, Benjamin F. L. Lai, Rajesh A. Shenoi, Federico I. Rosell, Edward M. Conway, Edward L. G. Pryzdial, James H. Morrissey, Charles A. Haynes, Jayachandran N. Kizhakkedathu
Article
Immunology
Siew Siew Pang, Lakshmi C. Wijeyewickrema, Lilian Hor, Sheareen Tan, Emilie Lameignere, Edward M. Conway, Anna M. Blom, Frida C. Mohlin, Xuyu Liu, Richard J. Payne, James C. Whisstock, Robert N. Pike
JOURNAL OF IMMUNOLOGY
(2017)
Article
Hematology
Jacob H. Rand, Xiao-Xuan Wu, Lucia R. Wolgast, Victor Lei, Edward M. Conway
THROMBOSIS RESEARCH
(2017)
Review
Hematology
Houra Loghmani, Edward M. Conway
Review
Hematology
Edward M. Conway
BLOOD COAGULATION & FIBRINOLYSIS
(2018)
Editorial Material
Hematology
J. H. Foley, E. M. Conway
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Medicine, General & Internal
Paul Petrus, Tara L. Fernandez, Michelle M. Kwon, Jenny L. Huang, Victor Lei, Nooshin Seyed Safikhan, Subashini Karunakaran, Daniel J. O'Shannessy, Xiaowei Zheng, Sergiu-Bogdan Catrina, Earl Albone, Jukka Laine, Kirsi Virtanen, Susanne M. Clee, Timothy J. Kieffer, Christophe Noll, Andre C. Carpentier, James D. Johnson, Mikael Ryden, Edward M. Conway
Article
Hematology
Edward M. Conway
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2019)
Review
Hematology
Jayachandran N. Kizhakkedathu, Edward M. Conway
Summary: Exposure of blood to foreign surfaces or cells results in a thromboinflammatory response from the host, which can jeopardize the functionality of medical devices and the health of the host. Scientists and clinicians are still seeking innovative solutions to overcome the challenges posed by this innate immune response.
Article
Biochemistry & Molecular Biology
Lin Kang, Ai-Lun Yang, Chao-Han Lai, Tsan-Ju Chen, Sung-Yen Lin, Yan-Hsiung Wang, Chau-Zen Wang, Edward M. Conway, Hua-Lin Wu, Mei-Ling Ho, Je-Ken Chang, Chung-Hwan Chen, Tsung-Lin Cheng
Summary: The study found that thrombomodulin (TM) plays a crucial protective role in osteoarthritis (OA) by enhancing chondrocyte growth and migration, blocking inflammatory signaling, and protecting knee function and bone integrity. Increasing TM expression can effectively protect cartilage from damage. These findings contribute to the development of novel therapeutic approaches against OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Hugh Kim, Edward M. Conway
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2019)
Review
Medicine, General & Internal
Edward M. Conway
FRONTIERS IN MEDICINE
(2019)
Letter
Critical Care Medicine
Chen Xi Yang, Amrit Singh, Young Woong Kim, Edward M. Conway, Christopher Carlsten, Scott J. Tebbutt
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Review
Hematology
Wolfgang Bergmeier, Silvio Antoniak, Edward M. Conway, Cecile V. Denis, Lindsey A. George, Berend Isermann, Nigel S. Key, Sriram Krishnaswamy, Wilbur A. Lam, David Lillicrap, Jian Liu, Mark R. Looney, Jose A. Lopez, Coen Maas, Flora Peyvandi, Wolfram Ruf, Anil K. Sood, Henri H. Versteeg, Alisa S. Wolberg, Pancras C. Wong, Jeremy P. Wood, Hartmut Weiler
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2018)