期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 35, 期 4, 页码 420-438出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2014.02.001
关键词
Arcuate nucleus; Dopamine; Electrophysiology; Feedback; Ion channel; Lactation; Neuromodulator; Oscillation; Prolactin; Tuberoinfundibular
资金
- European Research Council [ENDO-SWITCH 261286]
- Swedish Research Council [2010-3250, 2011-3317]
- Strategic Research Programme in Diabetes Research at Karolinska Institutet
- Novo Nordisk Fond
- Wenner-Gren Foundations
- Novo Nordisk Fonden [NNF14OC0011061] Funding Source: researchfish
Neuroendocrine tuberoinfundibular dopamine (TIDA) neurons tonically inhibit pituitary release of the hormone, prolactin. Through the powerful actions of prolactin in promoting lactation and maternal behaviour while suppressing sexual drive and fertility, TIDA neurons play a key role in reproduction. We summarize insights from recent in vitro studies into the membrane properties and network behaviour of TIDA neurons including the observations that TIDA neurons exhibit a robust oscillation that is synchronized between cells and depends on intact gap junction communication. Comparisons are made with phasic firing patterns in other neuronal populations. Modulators involved in the control of lactation - including serotonin, thyrotropin-releasing hormone and prolactin itself - have been shown to change the electrical behaviour of TIDA cells. We propose that TIDA discharge mode may play a central role in tuning the amount of dopamine delivered to the pituitary and hence circulating prolactin concentrations in different reproductive states and pathological conditions. (C) 2014 Elsevier Inc. All rights reserved.
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