期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 34, 期 2, 页码 95-106出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2012.12.001
关键词
Dietary restriction; Caloric restriction; Aging; Ventromedial hypothalamus; Autonomic; Glucose metabolism
资金
- NIH National Institute of Diabetes and Digestive and Kidney Diseases
- Klarman Family Foundation, Boston, MA
- Hilda and Preston Davis Foundation
- NIH National Institute of Aging [1F31AG042299]
Dietary restriction (DR) can extend lifespan and reduce disease burden across a wide range of animals and yeast but the mechanisms mediating these remarkably protective effects remain to be elucidated despite extensive efforts. Although it has generally been assumed that protective effects of DR are cell-autonomous, there is considerable evidence that many whole-body responses to nutritional state, including DR, are regulated by nutrient-sensing neurons. In this review, we explore the hypothesis that nutrient sensing neurons in the ventromedial hypothalamus hierarchically regulate the protective responses of dietary restriction. We describe multiple peripheral responses that are hierarchically regulated by the hypothalamus and we present evidence for non-cell autonomous signaling of dietary restriction gathered from a diverse range of models including invertebrates, mammalian cell culture, and rodent studies. (C) 2012 Elsevier Inc. All rights reserved.
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