Article
Clinical Neurology
Luka Milosevic, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Milos R. Popovic, William D. Hutchison, Milad Lankarany
Summary: This study investigates the brain-region-specific and frequency-dependent effects of deep brain stimulation on neuronal activity. The results show that higher stimulation frequencies lead to neuronal suppression, while site-specific responses are influenced by local neuroanatomical properties and short-term synaptic plasticity.
Article
Neurosciences
Tingting Du, Yingchuan Chen, Lin Shi, Defeng Liu, Yuye Liu, Tianshuo Yuan, Xin Zhang, Guanyu Zhu, Jianguo Zhang
Summary: The study showed that ANT-DBS can decrease seizure frequency, reduce neuronal loss and apoptosis in the basal ganglia, increase D1 and D2 receptor expression, and downregulate overactivation of the GPi, enhancing the antiepileptic function of the basal ganglia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Anatomy & Morphology
Gianpaolo Antonio Basile, Marina Quartu, Salvatore Bertino, Maria Pina Serra, Marcello Trucas, Marianna Boi, Roberto Demontis, Alessia Bramanti, Giuseppe Pio Anastasi, Demetrio Milardi, Rosella Ciurleo, Alberto Cacciola
Summary: This study successfully reconstructed the fiber bundles of the human subthalamic area and created a large-scale normative population atlas using an optimized tractography protocol. This atlas is of great significance in both clinical anatomy and functional neurosurgery, as it improves our understanding of the complex morphology of this important brain region.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Neurosciences
Stefanie Perl, Anika Luettig, Rudiger Koehling, Angelika Richter
Summary: This review provides an overview of DBS research in animal models of dystonia, discussing the research aims, opportunities and limitations of different animal models, and technical challenges.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Vinith Johnson, Robert Wilt, Roee Gilron, Juan Anso, Randy Perrone, Martijn Beudel, Dan Pina-Fuentes, Jeremy Saal, Jill L. Ostrem, Ian Bledsoe, Philip Starr, Simon Little
Summary: The study utilized a novel, sensing-enabled deep brain stimulator device implanted in a patient with cervical dystonia to record neural data and conduct a proof-of-principle trial. It found that low-frequency oscillations are related to dystonia and demonstrated the potential for a novel adaptive stimulation strategy.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Zixiao Yin, Yin Jiang, Timon Merk, Wolf-Julian Neumann, Ruoyu Ma, Qi An, Yutong Bai, Baotian Zhao, Yichen Xu, Houyou Fan, Quan Zhang, Guofan Qin, Ning Zhang, Jun Ma, Hua Zhang, Huanguang Liu, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Jianguo Zhang
Summary: This study found that the oscillatory pattern of the pallidum in multiple movement disorders changes during sleep, and these changes can be used to differentiate sleep stages. Machine learning approaches can classify sleep stages in patients with different diseases based on the pallidal oscillatory features. These findings have broad translational prospects for the development of adaptive deep brain stimulation systems targeting sleep problems.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Jil M. Meier, Dionysios Perdikis, Andre Blickensdoefer, Leon Stefanovski, Qin Liu, Oliver Maith, Helge Ue. Dinkelbach, Javier Baladron, Fred H. Hamker, Petra Ritter
Summary: Deep brain stimulation has been successfully used as an effective treatment for various neurodegenerative diseases, but its mechanisms of action within the brain network are still not well understood. Virtual DBS models can simulate subnetworks around the basal ganglia and show widespread effects on different cortical and subcortical areas. The neuroinformatics platform TVB offers a modeling framework to predict the outcomes of stimulation, including DBS, from a dynamic systems perspective before invasive surgery.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Maja Klarendic, Diego Kaski
Summary: DBS treatment is widely used for movement disorders and other neurological and psychiatric conditions, with effects on eye movements dependent on stimulation location and underlying pathology. Understanding how DBS affects eye movements can provide insights into neural circuits involved in complex eye movement control. Further research is needed to explore the potential effects of DBS on eye movements with less common stimulation targets.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Obstetrics & Gynecology
Masahiro Nakao, Yukiko Nanba, Asumi Okumura, Junichi Hasegawa, Satoshi Toyokawa, Kiyotake Ichizuka, Naohiro Kanayama, Shoji Satoh, Nanako Tamiya, Akihito Nakai, Keiya Fujimori, Tsugio Maeda, Hideaki Suzuki, Mitsutoshi Iwashita, Akira Oka, Tomoaki Ikeda
Summary: This study investigates the association between timing of hypoxic-ischaemic insult and types of brain injury in infants with severe cerebral palsy. The results show that basal ganglia-thalamus is the most common type of brain injury, which occurs mostly in the early stages of hypoxic-ischaemic insult. Placental abruption and small-for-gestational age are associated with basal ganglia-thalamus injury.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Neurosciences
Oliver Bichsel, Lennart Stieglitz, Markus Oertel, Christian Baumann, Roger Gassert, Lukas Imbach
Summary: This study investigated the local field potential (LFP) in the subthalamic nucleus (STN) in Parkinson's disease (PD) patients using deep brain stimulation (DBS) electrodes. The results showed changes in beta-burst activity during movement and self-paced motor control, highlighting the importance of beta-burst modulation in movement generation. These findings support the use of adaptive DBS based on beta-bursts for more effective treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Engineering, Biomedical
Wenjuan Gu, Li Xu, Jin Wang, Yanxia Ou
Summary: In this study, the researchers explored the mechanism of deep brain stimulation (DBS) in controlling pathological low-frequency oscillations in Parkinson's disease (PD). They proposed two mechanisms, increasing and decreasing oscillation frequency, and found that stimulating different nuclei in the basal ganglia can cause opposite changes in discharge frequency to eliminate abnormal oscillations. The simultaneous stimulation of GPi and dMSN was identified as the optimal choice to minimize low-frequency oscillation energy.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Review
Neurosciences
Alfredo Conti, Nicola Maria Gambadauro, Paolo Mantovani, Canio Pietro Picciano, Vittoria Rosetti, Marcello Magnani, Sebastiano Lucerna, Constantin Tuleasca, Pietro Cortelli, Giulia Giannini
Summary: Modern brain atlases derived from neuroimaging and functional information are crucial for accurate neurosurgical procedures. They help avoid targeting errors caused by imaging artifacts or insufficient anatomical details.
Article
Anatomy & Morphology
Anneke Alkemade, Martijn J. Mulder, Anne C. Trutti, Birte U. Forstmann
Summary: This study created protocols for the anatomical delineation of 21 individual subcortical structures and evaluated their effectiveness by calculating Dice similarity coefficients. The results showed that manual parcellations can provide high-quality training data for automated algorithms and can be used for validation of existing procedures.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biology
Jonathan S. Schor, Isabelle Gonzalez Montalvo, Perry W. E. Spratt, Rea J. Brakaj, Jasmine A. Stansil, Emily L. Twedell, Kevin J. Bender, Alexandra B. Nelson
Summary: This study investigated the therapeutic effects and underlying mechanisms of subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease mice. The results suggest that STN DBS exerts its therapeutic effects through disrupting movement-related activity in the subthalamic nucleus. These findings provide new insights for optimizing Parkinson's disease treatments and offer an approach for studying deep brain stimulation in other neuropsychiatric conditions.
Article
Biochemistry & Molecular Biology
Mareike Ahlswede, Patrick Noesel, Andrew A. Maudsley, Sulaiman Sheriff, Nima Mahmoudi, Paul Bronzlik, Heinrich Lanfermann, Xiao-Qi Ding
Summary: In this study, the effects of aging on striato-thalamic metabolism in healthy human brains were investigated using whole brain H-1-MR spectroscopic imaging. The results showed specific decreases in NAA and tCr and increases in mI with age, indicating the individual roles of each brain structure in brain functionality during normal aging.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Article
Clinical Neurology
David Escobar Sanabria, Joshua E. Aman, Valentina Zapata Amaya, Luke A. Johnson, Hafsa Farooqi, Jing Wang, Meghan Hill, Remi Patriat, Kelly Sovell-Brown, Gregory F. Molnar, David Darrow, Robert McGovern, Scott E. Cooper, Noam Harel, Colum D. MacKinnon, Michael C. Park, Jerrold L. Vitek
Summary: Closed-loop evoked interference deep brain stimulation (eiDBS) can predictably suppress or amplify neural activity at specific frequencies in the brains of Parkinson's disease (PD) patients. This study elucidates the role of oscillatory dynamics in PD and other brain conditions, and contributes to the development of personalized neuromodulation systems.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alireza Sadeghi-Tarakameh, Nur Izzati Huda Zulkarnain, Xiaoxuan He, Ergin Atalar, Noam Harel, Yigitcan Eryaman
Summary: This study proposes and validates a workflow based on MR-based current measurement and simple quasi-static EM/thermal simulations to predict the temperature increase around DBS electrodes during MRI scans.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Mark D. Grier, Essa Yacoub, Gregor Adriany, Russell L. Lagoreb, Noam Harel, Ru-Yuan Zhang, Christophe Lenglet, Kamil Ugurbil, Jan Zimmermann, Sarah R. Heilbronner
Summary: Diffusion-weighted magnetic resonance imaging (dMRI) provides information about water molecule diffusion barriers in tissue, particularly in the brain. While useful for studying brain disorders and white matter organization, dMRI faces challenges like biological validation difficulties and low signal-to-noise ratios. Utilizing ultra-high field scanners and denoising techniques can improve the quality of dMRI data.
Article
Neurosciences
Ece Su Sayin, Jacob Schulman, Julien Poublanc, Harrison T. Levine, Lakshmikumar Venkat Raghavan, Kamil Uludag, James Duffin, Joseph A. Fisher, David J. Mikulis, Olivia Sobczyk
Summary: The assessment of resting perfusion measures currently requires a susceptibility contrast agent such as gadolinium. This study compared the perfusion measures obtained using hypoxia-induced deoxyhemoglobin and gadolinium in healthy participants. The results showed that the perfusion measures calculated using hypoxia-induced deoxyhemoglobin were comparable to those obtained with gadolinium injection.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Jerrold L. Vitek, Remi Patriat, Lisa Ingham, Martin M. Reich, Jens Volkmann, Noam Harel
Summary: The location of the stimulating contact within the STN is a critical factor in determining motor outcomes in deep brain stimulation (DBS) treatment for patients with advanced Parkinson's disease (PD). The posterolateral portion of the STN showed the greatest improvement in motor function and reduction in levodopa dosage.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ajay K. Verma, Sergio Francisco Acosta Lenis, Joshua E. Aman, David Escobar Sanabria, Jing Wang, Amy Pearson, Meghan Hill, Remi Patriat, Lauren E. Schrock, Scott E. Cooper, Michael C. Park, Noam Harel, Michael J. Howell, Colum D. MacKinnon, Jerrold L. Vitek, Luke A. Johnson
Summary: The study found that the activity of the basal ganglia in Parkinson's disease patients exhibits different characteristics during movement in REM sleep and wakefulness. In REM sleep, beta oscillations and high-frequency oscillations synchronize, while in wakefulness they show desynchronization.
NPJ PARKINSONS DISEASE
(2022)
Article
Computer Science, Artificial Intelligence
Oren Solomon, Remi Patriat, Henry Braun, Tara E. Palnitkar, Steen Moeller, Edward J. Auerbach, Kamil Ugurbil, Guillermo Sapiro, Noam Harel
Summary: In this study, a method called MOTOR-MRI is proposed to suppress motion artifacts in anatomical magnetic resonance imaging. Unlike other techniques, MOTOR-MRI operates on reconstructed images instead of k-space data. It breaks the standard acquisition protocol into shorter ones and efficiently aggregates locally sharp and consistent information in Fourier space, resulting in a sharp and motion mitigated image. The effectiveness of MOTOR-MRI is demonstrated on T2-weighted turbo spin echo magnetic resonance brain scans with severe motion corruption. It shows significant qualitative and quantitative improvement in image quality. MOTOR-MRI can be used independently or in combination with other motion correction methods.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Neurosciences
Kamil Uludag
Summary: In this primer, the author provides an overview of the physiological processes that contribute to the observed BOLD signal and introduces the physiologically-informed dynamic causal modeling (P-DCM) framework. The author discusses the physiological origin of different components of the BOLD signal and emphasizes the importance of correct physiological assumptions in making accurate inferences about neuronal activity and connectivity between brain regions. Additionally, the author presents the laminar BOLD signal model, which allows for the determination of laminar neuronal activity using high-resolution fMRI data.
Article
Neurosciences
Valentina Zapata Amaya, Joshua E. Aman, Luke A. Johnson, Jing Wang, Remi Patriat, Meghan E. Hill, Colum D. MacKinnon, Scott E. Cooper, David Darrow, Robert McGovern, Noam Harel, Gregory F. Molnar, Michael C. Park, Jerrold L. Vitek, David Escobar Sanabria
Summary: Evidence suggests that stimulation-evoked resonant oscillations in the globus pallidus internal (GPi) of Parkinson's disease patients are correlated with spontaneous beta oscillations, indicating a common neural population and resonance phenomenon generating both types of oscillations. These findings support the development of closed-loop control systems modulating GPi spontaneous oscillations across PD patients using beta band stimulation-evoked responses.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Kathryn R. Marusich, Noam Harel, Matthew D. Johnson, Paul Rothweiler, Arthur G. Erdman
Summary: Deep brain stimulation is a neurosurgical treatment for neurological disorders. A modular graphical user interface was developed to identify patient-specific major blood vessels. This quantitative method can potentially reduce the risk of hemorrhage events during the DBS implantation process.
JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Welton, Septian Hartono, Yao-Chia Shih, Stefan T. Schwarz, Yue Xing, Eng-King Tan, Dorothee P. Auer, Noam Harel, Ling-Ling Chan
Summary: The maturation of ultra-high-field MRI has improved our capability to depict and characterise brain structures efficiently. While there is evidence for improved accuracy and precision of 7T MRI-based measurements for PD, the clinical translation is still limited. Further longitudinal studies are needed to explore the clinical potential of 7T MRI in prodromal, early-stage PD and parkinsonism cohorts.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Dimo Ivanov, Federico De Martino, Elia Formisano, Francisco J. Fritz, Rainer Goebel, Laurentius Huber, Sriranga Kashyap, Valentin G. Kemper, Denizhan Kurban, Alard Roebroeck, Shubharthi Sengupta, Bettina Sorger, Desmond H. Y. Tse, Kamil Uludag, Christopher J. Wiggins, Benedikt A. Poser
Summary: This article reviews the 9.4 T work done in Maastricht, including functional and anatomical imaging experiments. By utilizing specific techniques and optimized coils, the researchers were able to obtain high-quality imaging results and highlight the technical challenges and practical issues associated with ultra-high field MRI.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Salman S. Ikramuddin, Annemarie K. Brinda, Rebecca D. Butler, Meghan E. Hill, Rajiv Dharnipragada, Joshua E. Aman, Lauren E. Schrock, Scott E. Cooper, Tara Palnitkar, Remi Patriat, Noam Harel, Jerrold L. Vitek, Matthew D. Johnson
Summary: The proximity of deep brain stimulation (DBS) active contact locations to the cerebellothalamic tract (CTT) affects clinical outcomes in patients with essential tremor (ET).
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Remi Patriat, Pramod K. Pisharady, Sommer Amundsen-Huffmaster, Maria Linn-Evans, Michael Howell, Jae Woo Chung, Matthew N. Petrucci, Aleksandar Videnovic, Erin Holker, Joshua De Kam, Paul Tuite, Christophe Lenglet, Noam Harel, Colum D. MacKinnon
Summary: This study compared diffusion MRI measures in white matter tracts between Parkinson's disease patients with and without elevated muscle activity during rapid eye movement sleep. The findings suggest that Parkinson's patients with normal muscle tone during REM sleep demonstrate compensatory adaptations in axonal microstructure associated with preserved motor and cognitive function, while those with increased muscle tone during REM sleep show impairments in gait, upper arm speed, and specific cognitive domains.
BRAIN COMMUNICATIONS
(2022)